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Inflammatory Mechanisms in Diabetes Uncovered by Tissue Imaging and Machine Learning
- Abstract
- Type 1 Diabetes (T1D) is an organ specific autoimmune disease that results in a loss of insulin producing beta cells in the pancreas. We hypothesize that the crosstalk between immune cells and beta cells in the islets of Langerhans induces a cascade of immune and stress responses that are causal for the decline in beta cell mass. MIDAS aims to thoroughly analyze the timing and nature of immune cell infiltration and the interaction of immune cells and beta cells in different stages of T1D.
- Keywords
- Autoimmunität
- Krankheitsentsehung
- Maschinelles Lernen
- Typ 1 Diabetes
- Project Leader:
- Pieber Thomas
- Duration:
- 01.01.2020-31.12.2023
- Type of Research
- basic research
- Staff
- Pieber, Thomas, Project Leader
- Kotzbeck, Petra, Co-worker
- Einsiedler, Johanna Elena, Co-worker
- Franz, Joakim, Co-worker
- Schoiswohl, Gabriele Maria, Co-worker
- Mautner, Selma, Co-worker
- Ehall, Barbara, Co-worker
- Bounab, Kaddour, Co-worker
- Karacay, Ceren, Co-worker
- Skofler, Christina, Co-worker
- Hois-Zelinka, Victoria, Co-worker
- MUG Research Units
- Diagnostic and Research Institute of Pathology
- Division of Endocrinology and Diabetology
- Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging)
- Project partners
-
Graz University of Technology, Austria
Contact person: Thomas Pock; -
Institute for Molecular Biosciences, Austria
Contact person: Gabriele Schoiswohl;