Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
SHR
Neuro
Krebs
Kardio
Stoffw
Microb
Lipid
Am Übergang vom Feten zum Neugeborenen: Neonatale Immunologie.
- Abstract
- During pregnancy TH1 immunity is downregulated favouring a TH2 driven immunresponse so that preeclampsia, premature delivery or even placental detachment and fetal soll are preventet. Furthermore, B cells express primarily IgM, but have not completed their maturation process in order to perform Ig switching. In addition to that, reduction in the available bone marrow reserve of granulocyte precursors, recuction in serum complement activity and deficient phagocytic cell function contribute to a physiologically immaturity of the neonate's immune system. An adult form of immune response is developed after live birth during the first yeaars of childhood by interaction with environmental stimuli (antigens). The reduced ability of the neonat's immune system to respond to bacterial, viral or fungal organisms is reflected by a higher rate of infections and septic events. The incidence of neonatal sepsis is still high, it varies from 1 to 8, 1 casses per 1.000 live births. The factor associated most significantly with development of septicaemia is low birth weight, therefore, preterm infants are essentially higher risk. Inflaamation and sepsis do not only contribute to a high mortality rate, but also to high morbidity. For example, neurological outcome, expecially occurrence of cerebral palsy, is strongly associated with neionatal infection. In order to reuce the resulting high mortality and morbidity, but also in order to study a model of primary immune response diverse studies have been performed by using umbilical cord blood. However, few investigations have been made with peripheral blood mononuclear cells of neonates, especially of lower gestational age. Peripheral blood represents another environment; so blood cells are exposed to other stimuli, resulting in other messages for B and T cells triggering activation and subsequent proliferation, differentntiation or even cell-death. Therefore, we want to examine absolute count of diverse lymphcyte subsets for different gestational ages in order to get reliable reference values, expression patterns of costimulatory molecules like CD40/CD40L, CD80, CD86, CD28, CD152, Interleukinsecretion of T cells, functional abilities conerning activation, proliferation and cell-death as read-out systems for activation and interactions of B and T cells immediately after life-birth.
- Schlagworte
- Kinderheilkunde
- Projektleitung:
- Marschitz Ingrid Christine
- Laufzeit:
- 01.03.2005-28.02.2008
- Programm:
- Jubiläumsfonds (ÖNB)
- Art der Forschung
- Angewandte Forschung
- Mitarbeiter*innen
- Marschitz, Ingrid Christine, Projektleiter*in
- Müller, Wilhelm, Sub-Projektleiter*in
- Urlesberger, Berndt, Sub-Projektleiter*in
- Resch, Bernhard, Projektmitarbeiter*in
- Beteiligte MUG-Organisationseinheiten
- Abteilung Zentrum für Medizinische Forschung (ZMF)
- Klinische Abteilung für Neonatologie
- Gefördert durch
- Österreichische Nationalbank (Jubiläumsfonds), Otto Wagner Platz 3, A-1090 Wien, Österreich
- Publizierte Projektergebnisse
- > CD28 expression and early-onset sepsis in term and... Pediatric Critical Care Medicine2007; 8(3):A1145-A1145.-World Congress on Pediatric Critical Care; JUN 24 28, 2007; Geneve.
- > Anstieg der CD40-Expression bei der RSV-Bronchioli... Z Geburtshilfe Neonatol 20072007; 211(S1):-33. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin ; JUN 14.-16.2007; Hamburg, Deutschland.
- > CD4- und CD45RA-Expression bei Early-onset Sepsis ... Jahrestagung der Deutschen Gesellschaft für Kinder- und Jugendmedizin; SEPT 13-16, 2007; Nürnberg, GERMANY. 2007.
- > CD28 expression in term and preterm neonates with ... Abstractband2007; 42-42.-ZMF-Tag; NOV 21, 2007; Graz, AUSTRIA.
- > Interleukin-6 und Interleukin-8 als Parameter für ... Jahrestagung der Deutschen Gesellschaft für Kinder- und Jugendmedizin; SEPT 13-16, 2007; Nürnberg. 2007.
- > Reduktion der Anzahl an CD4+ Lymphozyten sowie der... Zeitschrift für Geburtshilfe und Neonatologie; S 1, 2007 (Infektiologie und Immunologie) 2007; 211(S1):-33. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin ; JUN 14-16, 2007; Hamburg, Deutschland.