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PHANOS - PHysostigmine-enHAnced Opioid analgeSia

Abstract

Several studies have shown that cholinergic mechanisms play a pivotal role in the anti-nociceptive system by acting synergistically with morphine and reducing postoperative opioid consumption. In addition, the anti-cholinesterase drug physostigmine that increases synaptic acetylcholine concentrations has anti-inflammatory effects. In this randomised placebo-controlled trial including 110 patients undergoing nephrectomy, we evaluated the effects of intraoperative physostigmine 0.5 mg h-1 i.v. for 24 h on opioid consumption, hyperalgesia, pain scores, and satisfaction with pain control.

Project Leader:

Bornemann-Cimenti Helmar

Farzi Sylvia Ingrid

Duration:

01.11.2012-30.07.2013

Subprogramme

Land Steiermark unter 5.000,-

Type of Research

clinical trial

Staff

Bornemann-Cimenti, Helmar, Project Leader

Rumpold-Seitlinger, Gudrun, Co-worker

MUG Research Units

Division of Anaesthesiology and Intensive Care Medicine 1

Funded by

Land Steiermark, Graz, Austria

Project results published

> Perioperative use of physostigmine to reduce opioi... Br J Anaesth. 2021; 126(3):700-705