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EMBIC:The Control of Embryo Implantation

Abstract

We aim to build an European virtual laboratory on major mechanism of implantation by thoroughly exploring what knock out mice have recently established as cellular - cytokine networks/ key pathways promoting the development of 2 de novo organs: the decidua basalis and the mature placenta. At present, fragmentation of experimental capacity and disparate approaches result in lack of a comprehensive skills base, and lack of access to very specialised approaches and technological platforms such as animal experimentation in very strict conditions, genomics and proteomics facilities or multicentric clinical evaluation. These require to be used in a coordinated fashion to maximise their effect in this area.
We will thus: 1.) Assemble critical talents and approaches, to develop an integrative, evaluative, capacity to set up EMBIC; 2.) Integrate EMBIC laboratories using crucial models and coordination of the joint programme of activities; 3.) Constitute a European cohort of infertile women with creation of RT generated DNA, sera and micro-biopsy tissue samples banks; 4.) Establish guidelines for management of infertile women combined with diagnosis procedures and ultimately recombinant technologies therapies for selected pathologies; 5.) Open the network of validated platforms for education and cooperative experimentation.
EMBIC will contribute and benefit from the creation of integrated platforms based on animal models, genomic and proteomic facilities, protein intra-net database set-up, integrated clinical set-up. EMBIC will spread excellence by facilitaing the exchange of scientists within the laboratories, promote recruitment/training of out network post-docs, organise workshops and satellite meetings in pan European or regional Immunology/Fertility meetings and an annual summer school.

Local Subprojectlead:

Sedlmayr Peter

Duration:

01.10.2004-30.09.2008

Programme:

EU (FP-6)

EU-Project Instruments

Network of Excellence (NoE)

Type of Research

basic research

Staff

Sedlmayr, Peter, Project Leader

Helige, Christine, Co-worker

Daxboeck, Christine, Co-worker

Blaschitz, Astrid, Co-worker

Schmied, Rudolf, Co-worker

Walcher, Wolfgang, Co-worker

Dohr, Gottfried, Co-worker

Hutter, Heinz, Co-worker

Hammer, Astrid, Co-worker

Lang-Olip, Ingrid, Co-worker

Juch, Herbert, Co-worker

MUG Research Units

Department of Obstetrics and Gynaecology

Division of Cell Biology, Histology and Embryology

Project partners

INRA, France
Contact person: Lean-Paul Renard;

INSERM, France
Contact person: Gèrard Chaouat;

Inserm-Transfert, France
Contact person: Emmanuelle Benhamou;

Istituto di Ricerche Farmacologiche "Mario Negri", Italy
Contact person: Alberto Mantovani;

Universidad autonoma de Barcelona, United Kingdom
Contact person: Paz Martinez;

Universität Friedrich Schiller Jena, Germany
Contact person: Udo Markert;

Universität Humboldt, Germany
Contact person: Petra Arck;

Université de Bordeaux, France
Contact person: Jean-Francois Moreau;

Université de Liege, Belgium
Contact person: Jean-Michel Foidart;

University of Florence, Italy
Contact person: Marie-Pierre Piccinni;

University of Oxford, United Kingdom
Contact person: Ian Sargent;

University of Pecs, Hungary
Contact person: Julia Szekeres Bartho;

University of Rijeka, Croatia
Contact person: Daniel Rukavina;

University of Rome "La Sapienza", Italy
Contact person: Angela Santoni;

University of Trieste, Italy
Contact person: Francesco Tedesco;

University of Warwick, United Kingdom
Contact person: Colin Ockleford;

Funded by

Europäische Kommission, Rue de la Loi, Brussels, Belgium

Project results published

> Neuroendocrine circuitry and endometriosis: proges... J Mol Med. 2010; 88(3): 267-278.

> A new method of morphometric analysis of tissue ti... International Immunology 2010; 22 suppl. 1: ii65-ii65.-14th International Congress of Immunology; AUG 22-27; Kobe, JAPAN.

> Role of indoleamine 2,3-dioxygenase in materno-fet... XVIth Symposium of Czech Reproductive Immunologists with International Participation; MAY 28-30, 2010; Zdar nad Sazavou, CZECH REPUBLIC. 2010.

> Measurement of cell death by oxidative stress in t... J REPROD IMMUNOL. 2010; 85(1): 63-70.

> Morphometric analysis: applications in placenta im... Abstracts of the 7th European Congress on Reproductive Immunology2009; 81(2):126-126.-7th European Congress on Reproductive Immunology; Sept. 17-20, 2009; Marathon, GREECE.

> Progesterone-induced blocking factor is expressed ... Am. J. Reprod. Immunol.2007; 58(3):223-223.-5th European Congress of Reproductive Immunology; AUG 30 - SEPT 2, 2007; Berlin, GERMANY.