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In vivo aging as regenerative defect. Effects of adrenergic and oxidative stress on stem cell functions
- Abstract
- We plan to study stem cell biology in the context of the aging process. Besides a gross characterization of stem cells with regard to tissue regeneration, we will also investigate, if and how oxidative stress and catecholamines influence the growth and regenartive capcity of adult stem cells in the bone marrow, and, by the same token, affect aging, age-associated disease and life span. Experimentally, this will be tested in the Senescence-Accelerated-Mouse-Prone/Resistant Model. Several substrains with differing in age-associated pathology are available.
In particular, we will determine *the regenerative capacity of b one marrow stem cells in the context of aging and age-associated pathology, *if stem cell survival and functions can be affected by catecholamines and/or oxidative stress, *if aging and age associated pathology can be reduced by transplantation of bone marrow cells from young but not old donors.
- Local Subprojectlead:
- Liebmann-Holzmann Peter
- Duration:
- 01.01.2005-31.12.2007
- Programme:
- Einzelprojekt
- Type of Research
- basic research
- Staff
- Liebmann-Holzmann, Peter, Project Leader
- Preisegger, Karl Heinz, Co-worker
- Schwarzenberger, Elke, Co-worker
- Supanz, Sabine, Co-worker
- MUG Research Units
- Diagnostic and Research Institute of Pathology
- Division of Immunology
- Project partners
-
Eccocell Biotechnologie GmbH, Austria
Contact person: Mag. Clemens Kittinger; -
Institute of Biomedical Aging Research, Austria
Contact person: B. Grubeck-Lobenstein and Günter Lepperdinger; -
Institute of Pharmaceutical Chemistry & Pharmaceutical Technology/Karl-Franzens-University Graz, Austria
Contact person: Prof. Andreas Kungl; -
Technische Universität Graz, Institut für Genomik und Bioinformatik
, Austria
Contact person: Prof. Zlatko Trajanoski;