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Analysis of the genetic basis of multiple chemical sensitivity (MCS) by exome sequencing
- Abstract
- Multiple chemical sensitivity (MCS) is an environmental illness of unkown aetiology. Since evidence for an involvement of xenobiotic-metabolizing enzymes is lacking, the current proposal will test the hypotheses that (1) genetic risk factors for MCS can be identified by exome sequencing and (2) MCS is related to polymorphisms in genes relevant to chemosensation. First applied to MCS patients, exome sequencing will break new ground in the elucidation of the genetic basis of this illness. This cost-efficient technology will identify not only target genes associated with MCS but also complex genetic patterns underlying MCS. Exome sequencing will also be used to examine whether MCS is due to exaggerated chemosensation, because
polymorphisms in genes relevant to chemosensation are likely to predispose for hypersensitivity to chemicals. In these goals, the project has great potential in identifying a possibly genetic cause of MCS and providing leads for the diagnosis and therapy
of MCS.
- Keywords
- Genomics
- psychopathology
- gene technology
- Chemosensorgene
- Gesamtexomsequenzierung
- Lebensqualität
- Multiple Chemikaliensensitivität
- Psychopathologie
- Project Leader:
- Holzer Peter
- Duration:
- 01.02.2012-30.11.2014
- Programme:
- Bund
- Type of Research
- basic research
- MUG Research Units
- Center for Medical Research (ZMF)
- Division of Pharmacology
- Project partners
-
Hospital Hall, Department of Psychiatry and Psychotherapy A, Austria
Contact person: Mag. Dr. Evelin Singewald; -
Karl-Franzens-Universität Graz, Austria
Contact person: Univ.-Prof. DDr. Elisabeth Weiss;
- Project results published
- > Differences in psychological and somatic symptom c... Psychiatry Res. 2017; 249(8):187-194