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GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells
- Abstract
- Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.
The general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.
The proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.
- Local Subprojectlead:
- Kratky Dagmar
- Duration:
- 01.02.2009-30.04.2012
- Programme:
- GENAU
- Type of Research
- basic research
- MUG Research Units
- Center for Medical Research (ZMF)
- Division of Molecular Biology and Biochemistry
- Project partners
- Department for Social Studies of Science, University of Vienna, Austria
- Division of Genetic Epidemiology, Medical University Innsbruck, Austria
- Institut für Biochemie/Technische Universität Graz, Austria
- Institut für Chemie, Universität Graz, Austria
- Institute for Molecular Biosciences, Austria
- Institute of Medical Biochemistry, Medical University of Vienna, Austria
- Technische Universität Graz, Institut für Genomik und Bioinformatik , Austria
- Project results published
- > C16 ceramide is crucial for triacylglycerol-induce... Cell Death Dis. 2012; 3(6):e280-e280
- > Adipose triglyceride lipase deficiency in murine m... Lipidology: Lipidomics in Health and Disease; May 10-13, 2009; Göteborg, Schweden. 2009.
- > Synthetic LXR agonist attenuates plaque formation ... J Lipid Res. 2009; 50(2): 312-326.
- > Comparison of HSL and KIAA1363: two potential chol... Frontier Lipidology:Lipidomics in Health and Disease; May 10-13, ; Gothenburg, Sweden. 2009.