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Abstract: Osteoarthritis (OA) is the most prevalent disorder of the musculoskeletal system and has a very high socioeconomic impact. Current treatments for Osteoarthritis are only symptomatic, because they do not act on the causes of Arthritis and do not stop the progression of the disease. This study is designed to investigate the effect of Resveratrol, Quercetin, and Selenium on special inflammation enzymes and factors in human synovial fluid.
Especially Resveratrol is known as a potent specific inhibitor of inflammation, but its potency has not been tested on human synovial fluid. If the protective potency on Osteoarthritis is similar to the results of animal experiments, it would be an enormous effort. Previous studies indicate that elevated levels of matrix metalloproteinases (MMPs) and receptor activator of nuclear factor NFkB ligand (RANKL) play an important role in cartilage degeneration in OA Rheumatic Arthritis (RA) and Psoriatic Arthritis (PsA) [1, 2].
This study should be undertaken to define a possible influence of Resveratrol compared to other antioxidants like Quercetin and Selenium on synovial fluid and these factors. A close interaction between clinicians and basic scientists is necessary because of the combination of analytical, functional and molecular methods.

Staff: Glehr, Mathias, Project Leader; Gruber, Gerald, Co-worker; Rinner, Beate, Co-worker; Lohberger, Birgit, Co-worker; Moazedi-Fürst, Florentine, Co-worker; Walzer, Sonja, Co-worker; Windhager, Reinhard, Co-worker

MUG Research Units: Center for Medical Research (ZMF); Department of Orthopaedics and Trauma; Division of Rheumatology and Immunology

Funded by: AFOR-Stiftung, Association for Orthopaedic Research, CH-2545 Selzach, Switzerland