Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
SHR
Neuro
Krebs
Kardio
Stoffw
Microb
Lipid
GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling
Teilprojekt zu: GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling
- Abstract
- Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.
The general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.
The proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.
- Lokale Teilprojektleitung:
- Birner-Grünberger Ruth
- Laufzeit:
- 01.02.2009-30.04.2012
- Programm:
- GENAU
- Art der Forschung
- Angewandte Forschung
- Mitarbeiter*innen
- Birner-Grünberger, Ruth, Projektleiter*in
- Beteiligte MUG-Organisationseinheiten
- Abteilung Zentrum für Medizinische Forschung (ZMF)
- Lehrstuhl für Molekularbiologie und Biochemie
- Projektpartner
- Department for Social Studies of Science, University of Vienna, Österreich
- Division of Genetic Epidemiology, Medical University Innsbruck, Österreich
- Institut für Biochemie/Technische Universität Graz, Österreich
- Institut für Chemie, Universität Graz, Österreich
- Institut für Genomik und Bioinformatik/Technische Universität Graz, Österreich
- Institut für Molekulare Biowissenschaften / Universität Graz, Österreich
- Institute of Medical Biochemistry, Medical University of Vienna, Österreich
- Publizierte Projektergebnisse
- > Conformational plasticity and ligand binding of ba... J Biol Chem. 2013; 288(43):31093-31104
- > Altered activity-based profiles of lipases in muri... Proceedings of the Keystone Symposium Cancer and Metabolism. 2012; -Keystone Symposium Cancer and Metabolism; Feb 12-17; Banff, Canada.
- > Adiponutrin functions as a nutritionally regulated... Cell Metab. 2012; 15(5):691-702
- > Lipolytic proteomics.... Mass Spectrom Rev. 2012; 31(5):570-582
- > Activity based subcellular resolution imaging of l... Bioorg Med Chem. 2012; 20(2):628-632
- > Functional mapping of CGI-58/ABHD5... Proccedings of the 10th Austrian Proteomic Research Symposium. 2012; -10th Austrian Proteomic Research Symposium, Special Focus on Functional Proteomics; SEP 24-26, 2012; Graz, AUSTRIA. (ISBN: 978-3-200-02789-3 )
- > In vivo profiling of lipases by CLICK-DABGE... 5th EU-Summer school "Proteomic Basics"; Jul 31 - Aug 6, 2011; Brixen, Italy. 2011.
- > Activity-based imaging of lipases... 5th EU-Summer school "Proteomic Basics"; Jul 31 - Aug 6, 2011; Brixen, Italy. 2011.
- > Lipo-proteomics: functional proteomics in lipid re... IMP Seminar Series; Mar 30, 2011; Vienna, AUSTRIA. 2011.
- > Highlights of the MUG Proteomics Core Facility... Dionex BioanalytiClub; Mar 29, 2011; Graz, Austria. 2011.
- > Activity-based imaging of lipases... 18th Annual Meeting of the Austrian Atherosclerosis Society; MAY 6-7, 2011; St. Gilgen, Austria. 2011.
- > Chemical tools in lipid metabolism functional prot... 3rd International Symposium on Lipid and Membrane Biology. 2010; -3rd International Symposium on Lipid and Membrane Biology; Mar 18-20, 2010; Graz, Austria.
- > Functional proteomic analysis of lipases and ester... J Proteome Res. 2010; 9(12): 6334-6344.
- > Activity-based profiling of lipases in living cell... Methods Mol Biol. 2009; 580: 251-266.
- > Functional proteomics in lipid research: lipases, ... J Proteomics. 2009; 72(6): 1006-1018.