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Modulation of sensorimotor cortex by sustained mechanical and peripheral magnetic stimulation - effectiveness and therapeutical potential

Abstract

The proposed research examines the hypothesis that sustained somatosensory stimulation induces post-stimulus adaptive changes in primary motor cortex of healthy subjects. As such changes are associated with increased corticospinal excitability and reorganization of cortical networks, non-invasive assessment tools like transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) are suited to evaluate the stimulation effects. Two types of sensory stimulation will be tested and compared here, repetitive peripheral magnetic stimulation (RPMS) of hand muscles and whole-hand mechanical stimulation (MSTIM). The research strategy employs a series of experiments to quantify the adaptive changes following stimulation protocols with different parameters. Specifically, we are interested into stimuli to effectively modulate the motor cortex, and into the reliability of the two assessment tools to quantify the post-stimulus effects. These experimental series will provide a fundamental scientific basis for better understanding how sustained sensory stimulation modulates central motor controlling structures and will help to evaluate the potential clinical benefit from the proposed stimulation techiques.

Keywords

brain research

neurophysiology

Magnetstimulation

Motorkortex

Neuromodulation

Somatosensorik

Project Leader:

Gallasch Eugen

Duration:

01.01.2009-30.06.2011

Programme:

Jubiläumsfonds (ÖNB)

Type of Research

basic research

Staff

Gallasch, Eugen, Project Leader

MUG Research Units

Division of Physiology and Pathophysiology

Project partners

Universitätsklinik für Neurologie, Paracelsus Medizinische Privatuniversität Salzburg, Austria
Contact person: ao. Univ.-Prof. Dr. med. Dipl.-Ing. Stefan Golaszewski;

Funded by

Österreichische Nationalbank (Jubiläumsfonds), Otto Wagner Platz 3, A-1090 Wien, Austria

Project results published

> Modulation of Sensorimotor Cortex by Afferent Stim... BIT`s 6th Annual World Congress of Neurotalk-2015; May 22-24, 2015; Hangzhou, CHINA. 2015.

> Modulation of sensorimotor cortex by repetitive pe... Front Hum Neurosci. 2015; 9(7):407-407

> Mechanical flutter stimulation induces a lasting r... Hum Brain Mapp. 2013; 34(11):2767-2774

> Outlasting corticomotor excitability changes induc... Eur J Appl Physiol. 2011; 111(12):3051-3059

> Modulation of sensorimotor cortex by repetitive pe... Clinical Neurophysiology. 2011; 122, Suppl 1: S187-S187.-4th International Conference on Transcranial Magnetic and Direct Current Stimulation ; June 25, 2011; Rome; ITALY.

> Cortical activation patterns following whole hand ... 10. Österreichisches fMRT Symposium ; Dez 04, 2010; Graz, Austria. 2010.

> Changes in motor cortex excitability following who... CD-Rom2010; -XVIII Congress of the International Socienty of Electrophysiology and Kinesiology; June 16-19, 2010; Aalbourg, DENMARK. (ISBN: 978-87-7094-047-4 )

> Vibration stimulation during non-fatiguing tonic c... J Electromyogr Kinesiol. 2010; 20(4): 627-635.

> Modulation der Erregbarkeit des Motorkortex infolg... 5. Arbeitstagung Motodiagnostik - Mototherapie; JUNE 4-6, 2010; Jena, GERMANY. 2010.

> Increased motor cortical excitability after whole-... EUR J NEUROLOGY. 2009; 16: 24-24.-13th Congress of the European Federation of Neurological Societies (EFNS); Sept 12-15, 2009; Florence, Italy.

> MODULATION OF CONTRALATERAL AND IPSILATERAL MOTOR ... J PHYSIOL SCI. Journal of the Physiological Sciences, Proceeedings of the IUPS2009. 2009; 59: 176-176.-XXXVI International Congress of Physiological Sciences (IUPS2009); July 27 - August 1, 2009; Kyoto, Japan.