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GENINCA - Genomic instability and genomic alterations in pre-cancerous lesions and/or cancer
- Abstract
- GENINCA will address two tumor entities, for which we have good access to pre-malignant lesions and in which genomic instability is a common feature: colorectal and liver cancer.
GENINCA represents a collaborative study of 8 academic and 3 industrial partners from 5 European countries. GENINCA will focus on exploring pre-cancerous and cancer lesions of the two aforementioned tumor entities and their respective microenvironment. As the recent identification of human colon-cancer initiating cells by one of our academic consortium members paves the way for completely new strategies for studying mechanisms of tumorgenesis, a particular focus of this grant proposal will be the detailed characterization of these cancer initiating stem cells. At present, it is still a matter of debate which genomic changes are already present in precursor lesions and whether these lesions already show genetic instability. We will therefore address the occurrence of genomic instability and explore their underlying mechanisms especially in pre-cancerous and early cancer lesions. This will be greatly facilitated by in vivo endomicroscopy approaches, sophisticated animal models and large-scale genomic and proteomic analyses. Furthermore, we ill include an in-depth analysis of the corresponding microenvironment. As this represents a translational research effort, we expect to identify markers for novel therapeutic and/or preventative strategies, as well as facilitating tumor diagnosis, prognosis, and monitoring.
- Project Leader:
- Speicher Michael
- Duration:
- 01.01.2008-30.06.2011
- Programme:
- EU (FP-7)
- Subprogramme
- HEALTH-2007-2.4.1-3
- EU-Project Instruments
- Collaborative Project (Small or Medium-Scale focused research Project)
- Type of Research
- applied research
- Staff
- Speicher, Michael, Project Leader
- MUG Research Units
- Diagnostic and Research Institute of Human Genetics
- Project partners
- Biolution Grünert & co keg, Austria
- Cancer Research UK, United Kingdom
- Cordeliers Research Center, France
- IFOM Foundation - The FIRC Institute of Molecular Oncology Foundation, Italy
- Institut National de Sante et Recherche Medicale, France
- Instituto Superiore di Sanità, Italy
- Mosaiques Diagnostics & Therapeutics AG, Germany
- Oridis Biomed, Forschungs- und Entwicklungs-GmbH, Austria
- Universität Ulm, Germany
- Universitätsklinikum Hamburg-Eppendorf, Germany
- University of Mainz, Germany
- , Germany