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EuroSTEC: Soft tissue engineering for congenital birth defects in children: from "biomatrix - cell interaction - model system" to clinical trials

Abstract: IMPPACT will develop an intervention planning and monitoring application for Radiofrequency Ablation (RFA) of malignant liver tumours. RFA is a minimally invasive form to treat cancer without open surgery, by placing a needle inside the malignancy and destroying it through intensive heating. Though the advantages of this approach ale obvious, the intervention is currently hard to plan, almost impossible to monitor or assess, and therefore is not the first choice for treatment. IMPPACT will develop a physiological model of the liver and simulate the intervention's result, accounting for patient specific physiological factors. Gaps in the understanding of particular aspects of the RFA treatment will be closed by multi-scale studies on cells and animals. New findings will be evaluated microscopically and transformed into macroscopic equations. The long-established bio-heat equation will be extended to incorporate multiple scales. Validation will be performed at multiple levels. Images from ongoing patient treatment will be used to cross check validity for human physiology. Final validation will be performed at macroscopic level through visual comparison of simulation and treatment results gathered in animal studies and during patient treatment. This extensive validation together with a user-centered software design approach will guarantee suitability of the solution for clinical practice. The consortium consists of two Hospitals, three Universities, one Research Institute and one industrial SME. The final project deliverables will be the patient specific intervention planning system and an augmented reality training simulator for the RFA intervention.

Keywords: cancer research; Molecular pathology; radiology; medical diagnostics; Transplantation medicine; HCC; RFA; Tierexperiment

Local Subprojectlead:: Stiegler Philipp

Duration:: 01.09.2008-31.12.2011

Programme:: EU (FP-7)

EU-Project Instruments: Collaborative Project (Small or Medium-Scale focused research Project)

Type of Research: tech development

Staff: Stiegler, Philipp, Project Leader; Schweiger, Martin, Co-worker; Sereinigg, Michael, Co-worker; Iberer, Florian, Co-worker; Portugaller, Rupert, Co-worker; Lackner, Karoline, Co-worker

MUG Research Units: Diagnostic and Research Institute of Pathology; Division of General, Visceral and Transplant Surgery; Division of Neuroradiology, Vascular and Interventional Radiology

Project partners: Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V., Germany; Helsinki University of Technology, Finland; Medizinische Universität Leipzig, Germany; NUMA Engineering Services Ltd, Ireland; Technische Universität Graz, Austria; University of Oxford, United Kingdom

Funded by: Europäische Kommission, Rue de la Loi, Brussels, Belgium

Project results published: > Immunohistochemical and radiological characterizat... Histol Histopathol. 2016; 31(1):115-129; > PERICYTE ACTIVATION AND CEREBRAL SEQULAE OF CIRRHO... J HEPATOL. 2012; 56: S237-S237.-47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL); APR 18-22, 2012; Barcelona, SPAIN.; > Impact of temperature on cell death in a cell-cult... Anticancer Res. 2012; 32(3):915-921; > Augmented Environments for Computer-Assisted Inter... In: Linte, C, Moore, J, Chen, E, Holmes, d editors(s). Augmented Environments for Computer-Assisted Interventions. 2012(ISBN: 978-3-642-32629-5); > Cell to cell interactions influence sensitivity of... Anticancer Res. 2011; 31(11):3713-3717; > Effect of hyperthermia on liver cell lines: import... Anticancer Res. 2011; 31(5):1583-1588; > A three-state mathematical model of hyperthermic c... Ann Biomed Eng. 2011; 39(1):570-579; > Image-based multi-scale modelling and validation o... Philos Transact A Math Phys Eng Sci. 2011; 369(1954): 4233-4254.; > Vessel segmentation for ablation treatment plannin... Med Image Comput Comput Assist Interv. 2010; 13(Pt 1): 45-52.; > Computer oriented image acquisition of the liver: ... Conf Proc IEEE Eng Med Biol Soc. 2009; 1: 3755-3758.