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Abstract: Regenerative stem cell therapy is a novel therapeutic concept aiming to support organ regeneration after ischemic, metabolic or toxic injury by stem cell transplantation. Target diseases include cardiovascular and metabolic disorders, neurodegenerative conditions as well as immunological diseases being only the most common examples. Based on a growing amount of experimental data and early clinical observations regenerative stem cell therapy is currently translated into a growing number of groundbreaking clinical trials. One of the major limitations for understanding and consecutive optimization of regenerative stem cell therapy is a definitive lack of technology that allows monitoring the fate of the transplated stem cells after application.
The main objective of the proposed project is to utilize nanoparticles with high signalling capacity in magnetic resonance imaging to target human stem cells for high resolution molecular imaging. To accomplish this goal this project will access readily established leading technology for clinical scale propagation of human stem cells under good manufacturing practice resulting in immediate availability of reasonable quantities of billions of stem cells at highest quality.

Funded by: FWF, Fonds zur Förderung der Wissenschaftlichen Forschung, Wien, Austria

Project results published: > Pro-angiogenic induction of myeloid cells for ther... Cytotherapy. 2011; 13(4):503-512; > Endothelial progenitor cells: quod erat demonstran... CURR PHARM DESIGN. 2011; 17(30): 3245-3251.; > Immunomodulative efficacy of bone marrow-derived m... J Clin Immunol. 2011; 31(6):1143-1156; > Behaviour of multipotent maxillary bone-derived ce... Clin Oral Implants Res. 2010; 21(7):699-708; > How to track cellular aging of mesenchymal stromal... AGING-US. 2010; 2(4): 224-230.