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NANO-HEALTH: Nano-Plaque
- Abstract
- Introduction, Background and Aims:
Nano-Plaque is part of the Nano-Health project, which consists of 13 research projects aiming to develop new generations of nanoparticles (NPs) for diagnosis, imaging and drug delivery.
The main objective of Nano Plaque is to address more in depth prospects of improved diagnosis of atherosclerosis complementary to the clinical studies STYJOBS/EDECTA by means of basic science. An animal model for atherosclerotic lesions, the ApoE deficient mouse, is used. Biomarkers which play an important role in the atherosclerotic plaque scenario, and binding domain fragments of antibodies against such biomarkers, will be coupled with NPs to investigate the potential of nanotechnology for an improved diagnosis of atherosclerotic plaques. These NP-biomarker, or NP-antibody fragment complexes will be investigated towards their potency to characterise critical scenarios within plaque lesions of the vascular wall. New imaging methods such as 3Tesla NMRI will be used for the visualisation.
- Keywords
- pathophysiology
- magnetic resonance tomography
- Vascular biology
- medical diagnostics
- circulatory diseases
- Biotechnology
- Local Subprojectlead:
- Mangge Harald
- Duration:
- 01.03.2007-28.02.2009
- Subprogramme
- FWF: Nano Initiative
- Type of Research
- basic research
- MUG Research Units
- Clinical Institute of Medical and Chemical Laboratory Diagnostics
- Department of Radiology
- Funded by
- FWF, Fonds zur Förderung der Wissenschaftlichen Forschung, Wien, Austria
FWF-Grant-DOI: 10.55776/N212
- Project results published
- > High risk vs. "metabolically healthy" ph... Exp Clin Endocrinol Diabetes. 2013; 121(7):384-390
- > Interleukin-10: an anti-inflammatory marker to tar... Mol Pharm. 2013; 10(1):175-186
- > Uric acid best predicts metabolically unhealthy ob... Obesity (Silver Spring). 2013; 21(1):E71-E77
- > Ultrasmall superparamagnetic iron oxide (USPIO)-ba... Int J Nanomedicine. 2012; 7(1):2349-2359
- > N-terminal pro-B-type natriuretic peptide in early... Clin Chem Lab Med. 2011; 49(9):1539-1545
- > High density lipoprotein cholesterol level is a ro... Clin Chim Acta. 2011; 412(15-16):1345-1349
- > Nuchal thickness of subcutaneous adipose tissue is... Atherosclerosis. 2009; 203(1):277-283