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Neue Methode zur Beschleunigung der Knochenbruchheilung unter Zuhilfenahme von bioaktivem Glas, das mit Protein/Lipid-Peroxidationsprodukten beschichtet ist

Abstract

Fractures of long bones or large joints are followed by long lasting and often incomplete recovery in particular in elderly people and patients with multifragmentary fractures. Hoping to solve this difficult medical and social problem various experimental treatments are being developed using bioactive materials or substances that may stimulate bone growth.

On the contrary, patients with traumatic brain injury exert very short period of bone healing. Our clinical studies and the use of genuine model of human bone tissue cultures indicated that such enhanced osteogenesis is associated with the complex stress response involving lipid peroxidation. Studying molecular mechanisms of this phenomenon we found that the product of lipid peroxidation 4-hydroxynonenal (HNE) may regulate the growth of cultured human bone cells.

Therefore, the aim of this project is to study in vitro possible use of HNE applied on bioactive glass for promotion of osteogenesis.

Project Leader:

Wildburger Renate

Duration:

01.09.2007-31.08.2009

Programme:

Jubiläumsfonds (ÖNB)

Type of Research

applied research

Staff

Wildburger, Renate, Project Leader

MUG Research Units

Department of Orthopaedics and Trauma

Funded by

Österreichische Nationalbank (Jubiläumsfonds), Otto Wagner Platz 3, A-1090 Wien, Austria