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Effect of environmental enrichment on emotional behaviour and the gut-brain axis in mice: refinement and indirect reduction of animal experiments

Abstract

In summary, this project sets out to investigate the impact of environmental enrichment on the emotional behaviour of the animals, the activity of the hypothalamic-pituitary-adrenal axis, the expression of gastrointestinal inflammation and the activity of the gut-brain axis under conditions of gastrointestinal inflammation. The overall aim of the work is to optimize the housing conditions both for the sake of animal welfare and experimental standardization. This goal represents an important way to refine animal experimentation and thereby to reduce the number of animal experiments.

Project Leader:

Holzer Peter

Duration:

01.11.2007-30.06.2010

Type of Research

basic research

Staff

Holzer, Peter, Project Leader

Singewald, Evelin, Co-worker

Eichholzer, Margit, Co-worker

MUG Research Units

Division of Pharmacology

Funded by

Bundesministerium für Wissenschaft und Forschung (bmwf), Minoritenplatz 5, 1014 Wien, Austria

Project results published

> Environmental enrichment induces behavioural distu... Sci Rep. 2016; 6(2):28182-28182

> A potential role of neuropeptide Y for the benefic... Program & Abstracts, RegPep 2016. 2016; 85-85.-RegPep 2016; JUL 12-14, 2016; Rouen, FRANCE.

> A novel unbiased counting method for the quantific... J Neurosci Methods. 2015; 240(6):13-21

> ANXIOLYTIC EFFECTS OF ENVIRONMENTAL ENRICHMENT ARE... Abstract Book of the 1st joint meeting of the European Brain and Behaviour Society and the European Behavioural Pharmacological Society. 2015; -1st joint meeting of the European Brain and Behaviour Society and the European Behavioural Pharmacological Society ; SEP 12-15, 2015; Verona, ITALY.

> Neuropeptide Y knockout alters behavioural effects... Intrinsic Activity. 2015; 3(Suppl. 2): -21st Scientific Symposium of the Austrian Pharmacological Society: Joint Meeting with the British Pharmacological Society and the Pharmacological Societies of Croatia, Serbia and Slovenia; SEP 16-18, 2015; Graz, AUSTRIA.

> Environmental Enrichment and Gut Inflammation Modi... PLoS One. 2013; 8(1):e54811-e54811

> Gastrointestinal inflammation and environmental en... NEUROGASTROENTEROL MOTIL. 2012; 24: 70-70.-2012 Joint International Neurogastroenterology and Motility Meeting; SEP 6-8, 2012; Bologna, ITALY.