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IMPACTS: ARCHIVE´S TISSUES: IMPROVING MOLECULAR MEDICINE RESEARCH AND CLINICAL PRACTICE
- Abstract
- Nowadays, emerging capabilities are being introduced to a more personalized molecular approach in medicine with individual risk assessment and best suited care. An important tool for translation research in this field is the large number of human archive's tissues, with any kind of disease, stored in hospitals all over Europe. Tissues from biopsies or surgical therapy are fixed and paraffin embedded to obtain a histopathology diagnosis, and then stored in archives for many decades. We developed already the technology that allows molecular research at DNA and RNA level in paraffin embedded tissues, so that the findings can be evaluated in the proper context. These methods were first designed by European scientists. In this way it is easy to study lesions with known therapy outcomes. There is the opportunity of this European Coordination Action ín advanced genomics to improve and speed up clinical applications for health and also for R&D of European biotechnology companies.
Expected results of the Action are integrating European molecular research with a faster dissemination and application of molecular methods in clinical practice, preparing the opportunity of new multicentric functional gemonics research projects, stimulating technology innovation with industrial collaboratiion in the fields of gene expression analysis and proteomics.
- Keywords
- Gewebeasservierung
- Lungenkarzinom
- Pathologie
- Local Subprojectlead:
- Popper Helmuth
- Duration:
- 01.03.2007-28.02.2010
- Programme:
- EU (FP-6)
- EU-Project Instruments
- Coordination Action (CA)
- Type of Research
- applied research
- Staff
- Popper, Helmuth, Project Leader
- Kothmaier, Hannelore, Co-worker
- Halbwedl, Iris, Co-worker
- MUG Research Units
- Diagnostic and Research Institute of Pathology
- Project partners
- Centre National de la Recherche Scientifique, France
- Charite-Universitätsmedizin Berlin, Germany
- Consorzio der l'AREA di Ricerca Scientifica e Tecnologica di Trieste, Italy
- Hospital Clinic i provincial de Barcelona, Spain
- Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Spain
- Instituto de Patologia e Imunologia Molecular da Universidade de Porto, Portugal
- International Centre for Genetic Engineering and Biotechnology, Italy
- Klinikum Bolnice "Sestre Milosrdnice", Croatia
- Ludwig-Maximilians-Universität München, Germany
- Medical University of Wroclaw, Poland
- Medizinische Universität Innsbruck, Austria
- Milestone S.r.l., Italy
- Stichting Katholieke Universiteit - the Radboud University Nijmegen Medical Centre, Netherlands
- Technische Universität München, Germany
- Universidad de Valencia, Spain
- Universita degli studi di Torino, Italy
- Universita degli studi di Verona, Italy
- Universite de Lausanne, Switzerland
- University of Pisa, Italy
- Univerza v Ljubljani, Slovenia
- Project results published
- > Laser Capture Microdissection (LCM).... In: Stanta, G; editors(s). Guidelines for Molecular Analysis in Archive Tissues. Berlin Heidelberg: Springer; 2011. p. pp27-pp29. (ISBN: 978-3-642-17889-4)
- > Multicentre validation study of nucleic acids extr... Virchows Arch. 2010; 457(3): 309-317.
- > Sarcoidosis Specific Biomarkers Detection in Bronc... http://www.wiley-vch.de/vch/journals/2120/not2wis/HUPO_abstracts/POS-WED-029-101.pdf2008; 2120: 101-101.-Human Proteome Organisation (HUPO) Worldcongress 2008 ; AUG 16-20,2008; Amsterdam, NETHERLANDS.
- > Pulmonary histiocytic sarcoma in a young adult mim... HISTOPATHOLOGY. 2008; 53: 833--27th International Congress of the International-Academy-of-Pathology; OCT 12-17, 2008; Athens, GREECE.
- > Measuring STAT1 activation in malignant pleural me... Annual meeting of the ANGT, ÖGBT, ÖGGGT, ÖGBM.2008; 61-61.-Life Sciences Graz 2008; SEP 22-24, 2008; Graz, AUSTRIA.
- > Proteomics-Tissue and Protein Microarrays and Anti... ARCH PATHOL LAB MED. 2008; 132(10):1570-1572.-21st European Congress of Pathology; SEP 08-13, 2007; Istanbul, TURKEY.
- > Comparison of three commercially, non-crosslinking... HISTOPATHOLOGY. Histopathology Suppl.12008; 53: 685-299.-27th International Congress of the International-Academy-of-Pathology; OCT 12-17, 2008; Athens, GREECE.
- > STAT1 activation in malignant pleural mesothelioma... HISTOPATHOLOGY. 2008; 53: 808--27th International Congress of the International-Academy-of-Pathology; OCT 12-17, 2008; Athens, GREECE.
- > Lymphohistiocytic tumors of the lung... 3rd Intercontinental Congress of Pathology; MAY 17-21,2008; Barcelona, SPAIN. 2008.
- > The VEGF-signalling pathway in vascular and periva... VIRCHOWS ARCHIV. 2008; 452: S55-S56.-3rd Intercontinental Congress of Pathology; MAY 17-21,2008; Barcelona, SPAIN.
- > Evidence of STAT1 Activation in Malignant Pleural ... The 9th International Conference of the International Mesothelioma Interest Group2008; 66-66.-The International conference of the International Mesothelioma Interest Group; SEP 25-27, 2008; Amsterdam; The Netherlands.