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Chordomas: A retrospective clinical immunohistochemical study

Abstract

Chordomas are very rare, low to intermediate-grade malignant tumours, which behave locally aggressive and destructive. They develop from remnants of the notochord in the axial skeleton. Notochordal cells are ectodermally originated. During the embryologic development, when bone and cartilage formation starts, these primitive ectodermal cells become enmeshed by the endochondral ossification, and remanin as remnants in the nucleus pulposus of the intervertebral disk.
Usually, this notochordal tissue regresses between the sixth fetal month and second decade of life. If it still remains as asymptomatic, nonneoplastic rest it is denoted as "ecchordosis physaliphora". However, the option of development of a classic chordoma out of this precursor lesion exists.

The aims of this study are:
*Analysis of the factors predicting survival
*Analysis of immunohistochemical features

Keywords

general pathology

cancer research

oncology

ear, nose and throat illnesses

orthopaedics

neurosurgery

chordom

Immunohistochemie

Project Leader:

Leithner Andreas

Duration:

15.06.2007-14.06.2008

Type of Research

other

Staff

Leithner, Andreas, Project Leader

Radl, Roman, Co-worker

Bodo, Koppány Bonifác, Co-worker

Schmid, Christoph Michael, Co-worker

Barth, Alain, Co-worker

Windhager, Reinhard, Co-worker

Stammberger, Heinz, Co-worker

Beham, Alfred, Co-worker

MUG Research Units

Department of Neurosurgery

Department of Orthopaedics and Trauma

Diagnostic and Research Institute of Pathology

Division of General Otorhinolaryngology

Funded by

Hans und Blanca Moser-Stiftung, Spitalgasse 23; Ebene 01, 1090 Wien, Austria