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Vergleich der Expression des GLUT4 Gens (Insulinabhängiges transmembranäres Glukose-Transportmolekül) in humanem Myocard unter maximaler Oxygenierung bzw. kürzerer und längerer experimenteller Ischämie in vitro bei Patienten mit diabetes mellitus Typ II
- Abstract
- Ischemic heart disease is still the main cause of death in the western hemisphere despite considerable improvement of primary and secondary prevention, diagnostic techniques and treatment during the recent years. Like hypertension and dyslipidemia, dysfunctional glucose metabolism contributes largely to cardiovascular disease morbidity and mortality. Ample epidemiologic and clincal evidence suggests that these cardiovascular disease risk factors tend to cluster within individuals with even mild disturbances in glucose metabolism (glucose tolerance, insulin resistance, insulin secretion). In this context, comparatively little is known about insulin-dependent trans-membrane glucose transport in human heart. However, the latter may play a decisive role both in the outcome of CHD and myocardial tolerance towards ischemia. However, the topic has recently received considerable attention. The investigation of insulin-dependent trans-membrane glucose transport (via GLUT4) and its implications in diabetes mellitus during ischemia, hence, appears to be of high priority in fighting coronary death.
The present project is designed to study GLUT4-gene expression in diabetic patients under ischemic conditions using an appropriate experimental chamber various degrees of experimental ischemia and real-time-GLUT4-PCR. We wish to see whether or not there is a difference in GLUT4-gene expression in patients with and without coronary heart disease under ischemic conditions.
From our experiments, we expect to learn about insulin dependent myocardial transmembrane glucose transport both in ischemic heart disease and diabetes mellitus. In the long run, our results may provide new approaches in primary prevention as well as in direct myocardial tissue protection in diabetic patients.
- Project Leader:
- Gasser Robert
- Duration:
- 01.10.2007-30.09.2008
- Type of Research
- basic research
- MUG Research Units
- Division of Cardiology