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Kratky Dagmar |

Publications

** = Publications listed in SCI/SSCI/Pubmed

2025

Full paper/article (Journal)

** Akhmetshina, A; Schooltink, L; Amor, M; Kuentzel, KB; Rainer, S; Nandy, A; Habisch, H; Madl, T; Rendina-Ruedy, E; Leithner, K; Vujić, N; Kratky, D Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function.
BBA Adv. 2025; 7: 100135 Doi: 10.1016/j.bbadva.2024.100135 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Bradić, I; Kuentzel, KB; Pirchheim, A; Rainer, S; Schwarz, B; Trauner, M; Larsen, MR; Vujić, N; Kratky, D From LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism.
Biochim Biophys Acta Mol Cell Biol Lipids. 2024; 159575 Doi: 10.1016/j.bbalip.2024.159575
Web of Science PubMed FullText FullText_MUG

** Dixon, ED; Claudel, T; Nardo, AD; Riva, A; Fuchs, CD; Mlitz, V; Busslinger, G; Scharnagl, H; Stojakovic, T; Senéca, J; Hinteregger, H; Grabner, GF; Kratky, D; Verkade, H; Zimmermann, R; Haemmerle, G; Trauner, M Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice.
J Hepatol. 2024; Doi: 10.1016/j.jhep.2024.09.037
Web of Science PubMed FullText FullText_MUG

** Laurent, M; Harb, R; Jenny, C; Oustelandt, J; Jimenez, S; Cosette, J; Landini, F; Ferrante, A; Corre, G; Vujic, N; Piccoli, C; Brassier, A; Van Wittenberghe, L; Ronzitti, G; Kratky, D; Pacelli, C; Amendola, M Rescue of lysosomal acid lipase deficiency in mice by rAAV8 liver gene transfer
COMMUN MED-LONDON. 2025; 5(1): 110 Doi: 10.1038/s43856-025-00816-8 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Peña, de, la, Sancha, P; Wieser, BI; Schauer, S; Reicher, H; Sattler, W; Breinbauer, R; Schweiger, M; Lechleitner, M; Frank, S; Zechner, R; Kratky, D; Espenshade, PJ; Hoefler, G; Vesely, PW Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis.
Commun Biol. 2025; 8(1):588 Doi: 10.1038/s42003-025-08002-1 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Yeh, YS; Evans, TD; Iwase, M; Jeong, SJ; Zhang, X; Liu, Z; Park, A; Ghasemian, A; Dianati, B; Javaheri, A; Kratky, D; Kawarasaki, S; Goto, T; Zhang, H; Dutta, P; Schopfer, FJ; Straub, AC; Cho, J; Lodhi, IJ; Razani, B Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis.
J Clin Invest. 2025; 135(6): Doi: 10.1172/JCI185340 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2024

Full paper/article (Journal)

** Akhmetshina, A; Bianco, V; Bradić, I; Korbelius, M; Pirchheim, A; Kuentzel, KB; Eichmann, TO; Hinteregger, H; Kolb, D; Habisch, H; Liesinger, L; Madl, T; Sattler, W; Radović, B; Sedej, S; Birner-Gruenberger, R; Vujić, N; Kratky, D Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice.
Mol Metab. 2024; 79:101869 Doi: 10.1016/j.molmet.2023.101869 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Amor, M; Diaz, M; Bianco, V; Svecla, M; Schwarz, B; Rainer, S; Pirchheim, A; Schooltink, L; Mukherjee, S; Grabner, GF; Beretta, G; Lamina, C; Norata, GD; Hackl, H; Kratky, D Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model.
Cardiovasc Diabetol. 2024; 23(1): 298 Doi: 10.1186/s12933-024-02397-7 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Bianco, V; Svecla, M; Vingiani, GB; Kolb, D; Schwarz, B; Buerger, M; Beretta, G; Norata, GD; Kratky, D Regional Differences in the Small Intestinal Proteome of Control Mice and of Mice Lacking Lysosomal Acid Lipase.
J Proteome Res. 2024; 23(4): 1506-1518. Doi: 10.1021/acs.jproteome.4c00082 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Bradić, I; Vujić, N; Kuentzel, KB; Habisch, H; Pirchheim, A; Akhmetshina, A; Henderson, JD; Madl, T; Deshmukh, AS; Kratky, D Lanifibranor Reduces Inflammation and Improves Dyslipidemia in Lysosomal Acid Lipase-Deficient Mice.
Gastro Hep Adv. 2024; 3(6): 711-723. Doi: 10.1016/j.gastha.2024.05.006 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Breithofer, J; Bulfon, D; Fawzy, N; Tischitz, M; Zitta, C; Hartig, L; Grabner, GF; Pirchheim, A; Hackl, H; Taschler, U; Lass, A; Tam-Amersdorfer, C; Strobl, H; Kratky, D; Zimmermann, R Phospholipase A2 group IVD mediates the transacylation of glycerophospholipids and acylglycerols.
J Lipid Res. 2024; 65(12):100685 Doi: 10.1016/j.jlr.2024.100685 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Buerger, M; Amor, M; Akhmetshina, A; Bianco, V; Perfler, B; Zebisch, A; Weichhart, T; Kratky, D Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12.
Int J Mol Sci. 2024; 25(20): 11001 Doi: 10.3390/ijms252011001 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Bulfon, D; Breithofer, J; Grabner, GF; Fawzy, N; Pirchheim, A; Wolinski, H; Kolb, D; Hartig, L; Tischitz, M; Zitta, C; Bramerdorfer, G; Lass, A; Taschler, U; Kratky, D; Greimel, P; Zimmermann, R Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells.
Nat Commun. 2024; 15(1): 9937 Doi: 10.1038/s41467-024-54213-1 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Reinisch, I; Michenthaler, H; Sulaj, A; Moyschewitz, E; Krstic, J; Galhuber, M; Xu, R; Riahi, Z; Wang, T; Vujic, N; Amor, M; Zenezini, Chiozzi, R; Wabitsch, M; Kolb, D; Georgiadi, A; Glawitsch, L; Heitzer, E; Schulz, TJ; Schupp, M; Sun, W; Dong, H; Ghosh, A; Hoffmann, A; Kratky, D; Hinte, LC; von, Meyenn, F; Heck, AJR; Blüher, M; Herzig, S; Wolfrum, C; Prokesch, A Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape.
Nat Commun. 2024; 15(1): 1391 Doi: 10.1038/s41467-024-45724-y [OPEN ACCESS]
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** Tehlivets, O; Almer, G; Brunner, MS; Lechleitner, M; Sommer, G; Kolb, D; Leitinger, G; Diwoky, C; Wolinski, H; Habisch, H; Opriessnig, P; Bogoni, F; Pernitsch, D; Kavertseva, M; Bourgeois, B; Kukilo, J; Tehlivets, YG; Schwarz, AN; Züllig, T; Bubalo, V; Schauer, S; Groselj-Strele, A; Hoefler, G; Rechberger, GN; Herrmann, M; Eller, K; Rosenkranz, AR; Madl, T; Frank, S; Holzapfel, GA; Kratky, D; Mangge, H; Hörl, G Homocysteine contributes to atherogenic transformation of the aorta in rabbits in the absence of hypercholesterolemia.
BIOMED PHARMACOTHER. 2024; 178: 117244 Doi: 10.1016/j.biopha.2024.117244
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Review

** Xu, R; Vujić, N; Bianco, V; Reinisch, I; Kratky, D; Krstic, J; Prokesch, A Lipid-associated macrophages between aggravation and alleviation of metabolic diseases.
Trends Endocrinol Metab. 2024; Doi: 10.1016/j.tem.2024.04.009
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Laurent, M; Harb, R; Jenny, C; Oustelandt, J; Landini, F; Core, G; Brassier, A; Van Wittenberghe, L; Kratky, D; Ronzitti, G; Amendola, M Rescue of Lysosomal Acid Lipase Deficiency in Mice by AAV Liver Gene Transfer
MOL THER. 2024; 32(4):27-27. [Oral Communication]
Web of Science

2023

Full paper/article (Journal)

** Amor, M; Bianco, V; Buerger, M; Lechleitner, M; Vujić, N; Dobrijević, A; Akhmetshina, A; Pirchheim, A; Schwarz, B; Pessentheiner, AR; Baumgartner, F; Rampitsch, K; Schauer, S; Klobučar, I; Degoricija, V; Pregartner, G; Kummer, D; Svecla, M; Sommer, G; Kolb, D; Holzapfel, GA; Hoefler, G; Frank, S; Norata, GD; Kratky, D Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice.
Cardiovasc Diabetol. 2023; 22(1): 327 Doi: 10.1186/s12933-023-02064-3 [OPEN ACCESS]
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** Bianco, V; Korbelius, M; Vujic, N; Akhmetshina, A; Amor, M; Kolb, D; Pirchheim, A; Bradic, I; Kuentzel, KB; Buerger, M; Schauer, S; Phan, HTT; Bulfon, D; Hoefler, G; Zimmermann, R; Kratky, D Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration.
Mol Metab. 2023; 73: 101737 Doi: 10.1016/j.molmet.2023.101737 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Bradić, I; Liesinger, L; Kuentzel, KB; Vujić, N; Trauner, M; Birner-Gruenberger, R; Kratky, D Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase.
J Lipid Res. 2023; 64(9):100427 Doi: 10.1016/j.jlr.2023.100427 [OPEN ACCESS]
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** Goeritzer, M; Kuentzel, KB; Beck, S; Korbelius, M; Rainer, S; Bradić, I; Kolb, D; Mussbacher, M; Schrottmaier, WC; Assinger, A; Schlagenhauf, A; Rost, R; Gottschalk, B; Eichmann, TO; Züllig, T; Graier, WF; Vujić, N; Kratky, D Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice.
Int J Mol Sci. 2023; 24(4): 3116 Doi: 10.3390/ijms24043116 [OPEN ACCESS]
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** Liebscher, G; Vujic, N; Schreiber, R; Heine, M; Krebiehl, C; Duta-Mare, M; Lamberti, G; de, Smet, CH; Hess, MW; Eichmann, TO; Hölzl, S; Scheja, L; Heeren, J; Kratky, D; Huber, LA The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue.
Mol Metab. 2023; 71: 101705 Doi: 10.1016/j.molmet.2023.101705 [OPEN ACCESS]
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Review

** Akhmetshina, A; Kratky, D; Rendina-Ruedy, E Influence of Cholesterol on the Regulation of Osteoblast Function.
Metabolites. 2023; 13(4): Doi: 10.3390/metabo13040578 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Bianco, V; Kratky, D Glycoprotein Non-Metastatic Protein B (GPNMB): The Missing Link Between Lysosomes and Obesity.
Exp Clin Endocrinol Diabetes. 2023; 131(12): 639-645. Doi: 10.1055/a-2192-0101 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Korbelius, M; Kuentzel, KB; Bradić, I; Vujić, N; Kratky, D Recent insights into lysosomal acid lipase deficiency.
Trends Mol Med. 2023; 29(6):425-438 Doi: 10.1016/j.molmed.2023.03.001 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Bianco, V; Svecla, M; Buerger, M; Gorkiewicz, G; Norata, G; Kratky, D MULTI-OMICS APPROACH TO INVESTIGATE GUT DYSBIOSIS IMPLICATIONS IN LYSOSOMAL ACID LIPASE DEFICIENT MICE
ATHEROSCLEROSIS. 2023; 379: S136-S137.-91st Annual Meeting of the European-Atherosclerosis-Society (EAS); MAY 21-24, 2023; Mannheim, GERMANY. [Poster]
Web of Science

2022

Full paper/article (Journal)

** Almer, G; Opriessnig, P; Wolinski, H; Sommer, G; Diwoky, C; Lechleitner, M; Kolb, D; Bubalo, V; Brunner, MS; Schwarz, AN; Leitinger, G; Schoiswohl, G; Marsche, G; Niedrist, T; Schauer, S; Oswald, W; Groselj-Strele, A; Paar, M; Cvirn, G; Hoefler, G; Rechberger, GN; Herrmann, M; Frank, S; Holzapfel, GA; Kratky, D; Mangge, H; Hörl, G; Tehlivets, O Deficiency of B vitamins leads to cholesterol-independent atherogenic transformation of the aorta.
Biomed Pharmacother. 2022; 154:113640 Doi: 10.1016/j.biopha.2022.113640 [OPEN ACCESS]
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** Bradić, I; Kuentzel, KB; Honeder, S; Grabner, GF; Vujić, N; Zimmermann, R; Birner-Gruenberger, R; Kratky, D Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases.
Mol Metab. 2022; 61:101510 Doi: 10.1016/j.molmet.2022.101510 [OPEN ACCESS]
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** Goeritzer, M; Schlager, S; Kuentzel, KB; Vujić, N; Korbelius, M; Rainer, S; Kolb, D; Mussbacher, M; Salzmann, M; Schrottmaier, WC; Assinger, A; Schlagenhauf, A; Madreiter-Sokolowski, CT; Blass, S; Eichmann, TO; Graier, WF; Kratky, D Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo.
Cells. 2022; 11(5): Doi: 10.3390/cells11050850 [OPEN ACCESS]
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** Joshi, L; Plastira, I; Bernhart, E; Reicher, H; Koshenov, Z; Graier, WF; Vujic, N; Kratky, D; Rivera, R; Chun, J; Sattler, W Lysophosphatidic Acid Receptor 5 (LPA₅) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro.
Cells. 2022; 11(7): Doi: 10.3390/cells11071071 [OPEN ACCESS]
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** Korbelius, M; Vujić, N; Kuentzel, KB; Obrowsky, S; Rainer, S; Haemmerle, G; Rülicke, T; Kratky, D Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis.
Biochim Biophys Acta Mol Cell Biol Lipids. 2022; 1867(4): 159121 Doi: 10.1016/j.bbalip.2022.159121 [OPEN ACCESS]
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** Kuentzel, KB; Bradić, I; Mihalič, ZN; Korbelius, M; Rainer, S; Pirchheim, A; Kargl, J; Kratky, D Dysregulation of Placental Lipid Hydrolysis by High-Fat/High-Cholesterol Feeding and Gestational Diabetes Mellitus in Mice.
Int J Mol Sci. 2022; 23(20): 12286 Doi: 10.3390/ijms232012286 [OPEN ACCESS]
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** Reinisch, I; Klymiuk, I; Michenthaler, H; Moyschewitz, E; Galhuber, M; Krstic, J; Domingo, M; Zhang, F; Karbiener, M; Vujić, N; Kratky, D; Schreiber, R; Schupp, M; Lenihan-Geels, G; Schulz, TJ; Malli, R; Madl, T; Prokesch, A p53 Regulates a miRNA-Fructose Transporter Axis in Brown Adipose Tissue Under Fasting.
Front Genet. 2022; 13: 913030 Doi: 10.3389/fgene.2022.913030 [OPEN ACCESS]
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** Zhou, Q; Kerbl-Knapp, J; Zhang, F; Korbelius, M; Kuentzel, KB; Vujić, N; Akhmetshina, A; Hörl, G; Paar, M; Steyrer, E; Kratky, D; Madl, T Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism.
Metabolites. 2021; 12(1): Doi: 10.3390/metabo12010017 [OPEN ACCESS]
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** Zhou, Q; Zhang, F; Kerbl-Knapp, J; Korbelius, M; Kuentzel, KB; Vujić, N; Akhmetshina, A; Hörl, G; Paar, M; Steyrer, E; Kratky, D; Madl, T Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice.
BIOMOLECULES. 2022; 12(9): Doi: 10.3390/biom12091270 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Bellini, R; Bonacina, F; Kratky, D; Gomaraschi, M; Norata, GD LYSOSOMAL ACID LIPASE (LAL) DEFICIENCY ALTERS IMMUNE CELLS DISTRIBUTION IN MICE AND HUMANS
ATHEROSCLEROSIS. 2022; 355: E5-E6.-EAS Congress 2022; May 22-25, 2022; Milan. [Oral Communication]
Web of Science

** Bianco, V; Korbelius, M; Vujic, N; Akhmetshina, A; Kolb, D; Kratky, D CONSEQUENCES OF (INTESTINAL) LAL DEFICIENCY ON WHOLE BODY LIPID METABOLISM
ATHEROSCLEROSIS. 2022; 355: E42-E42.-EAS Congress 2022; May 22-25, 2022; Milan. [Oral Communication]
Web of Science

** Vos, DY; Heida, A; Koster, M; Tissink, J; Kuentzel, KB; Kloosterhuis, NJ; Smit, M; Huijkman, N; Reggiori, F; Mari, M; Scheja, L; Heeren, J; Kratky, D; Kuivenhoven, J; Van De Sluis, B THE ENDOSOMAL SORTING PROTEIN VPS35 CONTROLS LIPID HOMEOSTASIS THROUGH REGULATING HEPATIC LYSOSOMAL FUNCTION
ATHEROSCLEROSIS. 2022; 355: E50-E51.-EAS Congress 2022; May 22-25, 2022; Milan. [Oral Communication]
Web of Science

2021

Full paper/article (Journal)

** Galhuber, M; Kupper, N; Dohr, G; Gauster, M; Kwapiszewska, G; Olschewski, A; Jandl, K; Gschwandtner, E; Schweiger, M; Kratky, D; Leitinger, G; Prokesch, A; Kolb, D Simple method of thawing cryo-stored samples preserves ultrastructural features in electron microscopy.
Histochem Cell Biol. 2021; 155(5):593-603 Doi: 10.1007/s00418-020-01952-z [OPEN ACCESS]
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** Helderman, RC; Whitney, DG; Duta-Mare, M; Akhmetshina, A; Vujic, N; Jayapalan, S; Nyman, JS; Misra, BB; Rosen, CJ; Czech, MP; Kratky, D; Rendina-Ruedy, E Loss of function of lysosomal acid lipase (LAL) profoundly impacts osteoblastogenesis and increases fracture risk in humans.
Bone. 2021; 148:115946 Doi: 10.1016/j.bone.2021.115946 [OPEN ACCESS]
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** Kuentzel, KB; Bradić, I; Akhmetshina, A; Korbelius, M; Rainer, S; Kolb, D; Gauster, M; Vujić, N; Kratky, D Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth.
Int J Mol Sci. 2021; 22(19): Doi: 10.3390/ijms221910416 [OPEN ACCESS]
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** Sachdev, V; Duta-Mare, M; Korbelius, M; Vujić, N; Leopold, C; Freark, de, Boer, J; Rainer, S; Fickert, P; Kolb, D; Kuipers, F; Radovic, B; Gorkiewicz, G; Kratky, D Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase.
Cells. 2021; 10(10): Doi: 10.3390/cells10102619 [OPEN ACCESS]
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** Schilcher, I; Stadler, JT; Lechleitner, M; Hrzenjak, A; Berghold, A; Pregartner, G; Lhomme, M; Holzer, M; Korbelius, M; Reichmann, F; Springer, A; Wadsack, C; Madl, T; Kratky, D; Kontush, A; Marsche, G; Frank, S Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL.
Int J Mol Sci. 2021; 22(2): Doi: 10.3390/ijms22020719 [OPEN ACCESS]
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** Vujić, N; Bradić, I; Goeritzer, M; Kuentzel, KB; Rainer, S; Kratky, D; Radović, B ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.
Autophagy. 2021; 17(11):3402-3407 Doi: 10.1080/15548627.2021.1874132 [OPEN ACCESS]
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** Wunderling, K; Leopold, C; Jamitzky, I; Yaghmour, M; Zink, F; Kratky, D; Thiele, C Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir.
Mol Metab. 2020; 45: 101150-101150. Doi: 10.1016/j.molmet.2020.101150 [OPEN ACCESS]
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** Zhang, F; Kerbl-Knapp, J; Akhmetshina, A; Korbelius, M; Kuentzel, KB; Vujić, N; Hörl, G; Paar, M; Kratky, D; Steyrer, E; Madl, T Tissue-Specific Landscape of Metabolic Dysregulation during Ageing.
Biomolecules. 2021; 11(2): Doi: 10.3390/biom11020235 [OPEN ACCESS]
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** Zhang, F; Kerbl-Knapp, J; Rodriguez Colman, MJ; Meinitzer, A; Macher, T; Vujic, N; Fasching, S; Jany-Luig, E; Korbelius, M; Kuentzel, KB; Mack, M; Akhmetshina, A; Pirchheim, A; Paar, M; Rinner, B; Hörl, G; Steyrer, E; Stelzl, U; Burgering, B; Eisenberg, T; Pertschy, B; Kratky, D; Madl, T. Global analysis of protein arginine methylation.
Cell reports methods. 2021; 1(2): Doi: 10.1016/j.crmeth.2021.100016 [OPEN ACCESS]
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Abstract (Journal)

** Almer, G; Brunner, M; Schwarz, A; Diwoky, C; Lechleitner, M; Sommer, G; Kolb, D; Wolinski, H; Oswald, WK; Opriessnig, P; Horl, G; Groselj-Strele, A; Hofler, G; Rechberger, GN; Frank, S; Holzapfel, GA; Kratky, D; Mangge, H; Tehlivets, O Hypercholesterolemia “masks” defects in homocysteine degradation in a rabbit model of atherosclerosis
ATHEROSCLEROSIS. 2021; 331: E208-E208.-Austrian Atherosclerosis Society ONLINE-KONGRESS; 07.05.2021; [Oral Communication]
Web of Science

** Kuentzel, KB; Korbelius, M; Bradic, I; Vujic, N; Gauster, M; Wadsack, C; Kratky, D HOW DOES THE LOSS OF INTRACELLULAR LIPASES AFFECT MOUSE PLACENTA AND FETUS?
PLACENTA. 2021; 112: E73-E73.-IFPA 2021; AUG 30 - SEP 2, 2021; Amsterdam, Netherlands. [Onlinepräsentation]
Web of Science

2020

Full paper/article (Journal)

** Goeritzer, M; Bernhart, E; Plastira, I; Reicher, H; Leopold, C; Eichmann, TO; Rechberger, G; Madreiter-Sokolowski, CT; Prasch, J; Eller, P; Graier, WF; Kratky, D; Malle, E; Sattler, W Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro.
Int J Mol Sci. 2020; 21(3): Doi: 10.3390/ijms21031143 [OPEN ACCESS]
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** Radulović, S; Gottschalk, B; Hörl, G; Zardoya-Laguardia, P; Schilcher, I; Hallström, S; Vujić, N; Schmidt, K; Trieb, M; Graier, WF; Malli, R; Kratky, D; Marsche, G; Frank, S Endothelial lipase increases eNOS activating capacity of high-density lipoprotein.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(4):158612 Doi: 10.1016/j.bbalip.2020.158612 [OPEN ACCESS]
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** Schittmayer, M; Vujic, N; Darnhofer, B; Korbelius, M; Honeder, S; Kratky, D; Birner-Gruenberger, R Spatially Resolved Activity-based Proteomic Profiles of the Murine Small Intestinal Lipases.
Mol Cell Proteomics. 2020; 19(12):2104-2114 Doi: 10.1074/mcp.RA120.002171 [OPEN ACCESS]
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** Vujić, N; Korbelius, M; Sachdev, V; Rainer, S; Zimmer, A; Huber, A; Radović, B; Kratky, D Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden.
Atherosclerosis. 2020; 310:26-36 Doi: 10.1016/j.atherosclerosis.2020.07.030 [OPEN ACCESS]
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2019

Full paper/article (Journal)

** Bischof, H; Burgstaller, S; Vujic, N; Madl, T; Kratky, D; Graier, WF; Malli, R Purification and Application of Genetically Encoded Potassium Ion Indicators for Quantification of Potassium Ion Concentrations within Biological Samples.
Curr Protoc Chem Biol. 2019; 11(3): e71-e71. Doi: 10.1002/cpch.71 [OPEN ACCESS]
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** Gali, CC; Fanaee-Danesh, E; Zandl-Lang, M; Albrecher, NM; Tam-Amersdorfer, C; Stracke, A; Sachdev, V; Reichmann, F; Sun, Y; Avdili, A; Reiter, M; Kratky, D; Holzer, P; Lass, A; Kandimalla, KK; Panzenboeck, U Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice.
Mol Cell Neurosci. 2019; 99: 103390-103390. Doi: 10.1016/j.mcn.2019.103390 [OPEN ACCESS]
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** Hofer, DC; Zirkovits, G; Pelzmann, HJ; Huber, K; Pessentheiner, AR; Xia, W; Uno, K; Miyazaki, T; Kon, K; Tsuneki, H; Pendl, T; Al Zoughbi, W; Madreiter-Sokolowski, CT; Trausinger, G; Abdellatif, M; Schoiswohl, G; Schreiber, R; Eisenberg, T; Magnes, C; Sedej, S; Eckhardt, M; Sasahara, M; Sasaoka, T; Nitta, A; Hoefler, G; Graier, WF; Kratky, D; Auwerx, J; Bogner-Strauss, JG N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.
FASEB J. 2019; 33(12):13808-13824 Doi: 10.1096/fj.201801323R [OPEN ACCESS]
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** Huber, K; Hofer, DC; Trefely, S; Pelzmann, HJ; Madreiter-Sokolowski, C; Duta-Mare, M; Schlager, S; Trausinger, G; Stryeck, S; Graier, WF; Kolb, D; Magnes, C; Snyder, NW; Prokesch, A; Kratky, D; Madl, T; Wellen, KE; Bogner-Strauss, JG N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.
Biochim Biophys Acta Mol Cell Res. 2019; 1866(3): 337-348. Doi: 10.1016/j.bbamcr.2018.08.017 [OPEN ACCESS]
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** Klec, C; Madreiter-Sokolowski, CT; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WF Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells.
Cell Physiol Biochem. 2019; 52(1): 57-75. Doi: 10.33594/000000005 [OPEN ACCESS]
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** Klec, C; Madreiter-Sokolowski, CT; Ziomek, G; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WF Presenilin-1 Established ER-Ca²⁺ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose.
Cell Physiol Biochem. 2019; 53(3): 573-586. Doi: 10.33594/000000158 [OPEN ACCESS]
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** Korbelius, M; Vujic, N; Sachdev, V; Obrowsky, S; Rainer, S; Gottschalk, B; Graier, WF; Kratky, D ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes.
Cell Rep. 2019; 28(7): 1923-1934. Doi: 10.1016/j.celrep.2019.07.030 [OPEN ACCESS]
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** Leopold, C; Duta-Mare, M; Sachdev, V; Goeritzer, M; Maresch, LK; Kolb, D; Reicher, H; Wagner, B; Stojakovic, T; Ruelicke, T; Haemmerle, G; Hoefler, G; Sattler, W; Kratky, D Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019; 1864(4):500-511 Doi: 10.1016/j.bbalip.2019.01.007 [OPEN ACCESS]
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** Maresch, LK; Benedikt, P; Feiler, U; Eder, S; Zierler, KA; Taschler, U; Kolleritsch, S; Eichmann, TO; Schoiswohl, G; Leopold, C; Wieser, BI; Lackner, C; Rülicke, T; van, Klinken, J; Kratky, D; Moustafa, T; Hoefler, G; Haemmerle, G Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity.
Hepatol Commun. 2019; 3(2):227-245 Doi: 10.1002/hep4.1292 [OPEN ACCESS]
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** Schilcher, I; Ledinski, G; Radulović, S; Hallström, S; Eichmann, T; Madl, T; Zhang, F; Leitinger, G; Kolb-Lenz, D; Darnhofer, B; Birner-Gruenberger, R; Wadsack, C; Kratky, D; Marsche, G; Frank, S; Cvirn, G Endothelial lipase increases antioxidative capacity of high-density lipoprotein.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019; 1864(10):1363-1374 Doi: 10.1016/j.bbalip.2019.06.011 [OPEN ACCESS]
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Abstract (Journal)

** Goeritzer, M; Schlager, S; Vujic, N; Kolb, D; Schuligoi, R; Heinemann, A; Radovic, B; Kratky, D LOSS OF ADIPOSE TRIGLYCERIDE LIPASE AFFECTS PLATELET FUNCTION
ATHEROSCLEROSIS. 2019; 287: E60-E60.-87th Congress of the European-Atherosclerosis-Society (EAS); MAY 26-29, 2019; Maastricht, NETHERLANDS. Doi: 10.1016/j.atherosclerosis.2019.06.171 [Poster]
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** Helderman, R; Rosen, C; Rendina-Ruedy, E; Whitney, D; Duta-Mare, M; Kratky, D; Czech, M Loss of Function in Lysosomal Acid Lipase (LAL) Impairs Osteoblastogenesis and Increases Fracture Risk
J BONE MINER RES. 2019; 34: 176-176.
Web of Science

** Ivanov, S; Viaud, M; Vujic, N; Duta-Mare, M; Dugail, I; Hainault, I; Stehlik, C; Marchetti, S; Boyer, L; Guinamard, R; Foufelle, F; Bochem, A; Hovingh, KG; Thorp, EB; Gautier, EL; Kratky, D; Yvan-Charvet, L LYSOSOMAL CHOLESTEROL HYDROLYSIS COUPLES EFFEROCYTOSIS TO ANTI-INFLAMMATORY OXYSTEROL PRODUCTION
ATHEROSCLEROSIS. 2019; 287: E77-E77. Doi: 10.1016/j.atherosclerosis.2019.06.223 [Poster]
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** Kostner, G; Vujic, N; Kratky, D MIR-206 DEFICIENCY RESULTS IN A FAVORABLE PHENOTYPE: RELEVANCE FOR TYPE-2 DIABETES MELLITUS AND METABOLIC SYNDROME
ATHEROSCLEROSIS. 2019; 287: E129-E130.-87th Congress of the European-Atherosclerosis-Society (EAS); MAY 26-29, 2019; Maastricht, NETHERLANDS. Doi: 10.1016/j.atherosclerosis.2019.06.381 [Poster]
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** Vujic, N; Korbelius, M; Rainer, S; Sachdev, V; Radovic, B; Kratky, D EFFECTS OF INTESTINAL DGAT1 DEFICIENCY ON ATHEROSCLEROSIS IN APOE-KNOCKOUT MICE
ATHEROSCLEROSIS. 2019; 287: E28-E28.-87th Congress of the European-Atherosclerosis-Society (EAS); MAY 26-29, 2019; Maastricht, NETHERLANDS. Doi: 10.1016/j.atherosclerosis.2019.06.082 [Poster]
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2018

Full paper/article (Journal)

** Duta-Mare, M; Sachdev, V; Leopold, C; Kolb, D; Vujic, N; Korbelius, M; Hofer, DC; Xia, W; Huber, K; Auer, M; Gottschalk, B; Magnes, C; Graier, WF; Prokesch, A; Radovic, B; Bogner-Strauss, JG; Kratky, D Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis.
Biochim Biophys Acta. 2018; 1863(4):467-478 Doi: 10.1016/j.bbalip.2018.01.011 [OPEN ACCESS]
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** Nikam, A; Patankar, JV; Somlapura, M; Lahiri, P; Sachdev, V; Kratky, D; Denk, H; Zatloukal, K; Abuja, PM The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity.
Sci Rep. 2018; 8(1): 12964-12964. Doi: 10.1038/s41598-018-31389-3 [OPEN ACCESS]
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** Speziali, G; Liesinger, L; Gindlhuber, J; Leopold, C; Pucher, B; Brandi, J; Castagna, A; Tomin, T; Krenn, P; Thallinger, GG; Olivieri, O; Martinelli, N; Kratky, D; Schittmayer, M; Birner-Gruenberger, R; Cecconi, D Myristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cells.
J Proteomics. 2018; 181(7):118-130 Doi: 10.1016/j.jprot.2018.04.008
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** Viaud, M; Ivanov, S; Vujic, N; Duta-Mare, M; Aira, LE; Barouillet, T; Garcia, E; Orange, F; Dugail, I; Hainault, I; Stehlik, C; Marchetti, S; Boyer, L; Guinamard, R; Foufelle, F; Bochem, A; Hovingh, KG; Thorp, EB; Gautier, EL; Kratky, D; Dasilva-Jardine, P; Yvan-Charvet, L Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.
Circ Res. 2018; 122(10):1369-1384 Doi: 10.1161/CIRCRESAHA.117.312333 [OPEN ACCESS]
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** Xia, W; Pessentheiner, AR; Hofer, DC; Amor, M; Schreiber, R; Schoiswohl, G; Eichmann, TO; Walenta, E; Itariu, B; Prager, G; Hackl, H; Stulnig, T; Kratky, D; Rülicke, T; Bogner-Strauss, JG Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.
Cell Rep. 2018; 23(7):1948-1961 Doi: 10.1016/j.celrep.2018.04.055 [OPEN ACCESS]
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Abstract (Journal)

** Duta-Mare, M; Sachdev, V; Leopold, C; Kolb, D; Vujic, N; Korbelius, M; Hofer, D; Xia, W; Huber, K; Magnes, C; Radovic, B; Bogner-Strauss, J; Kratky, D LYSOSOMAL ACID LIPASE REGULATES FATTY ACID CHANNELING IN BROWN ADIPOSE TISSUE TO MAINTAIN THERMOGENESIS
ATHEROSCLEROSIS. 2018; 275: E15-E15.-86th Congress of the European-Atherosclerosis-Society (EAS); MAY 05-08, 2018; Lisbon, PORTUGAL. Doi: 10.1016/j.atherosclerosis.2018.06.927 [Oral Communication]
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** Rendina-Ruedy, E; Duta-Mare, MC; Kratky, D; Rosen, C Lysosomal Acid Lipase and Its Role in Osteoblast Differentiation
J BONE MINER RES. 2018; 33: 346-346.-Annual Meeting of the American-Society-for-Bone-and-Mineral-Research; SEP 28-OCT 01, 2018; Montreal, CANADA. [Poster]
Web of Science

** Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Doktorova, M; Scheicher, B; Goeritzer, M; Kolb, D; Turnbull, AV; Zimmer, A; Hoefler, G; Hussain, MM; Groen, AK; Kratky, D NOVEL ROLE OF A TRIGLYCERIDE-SYNTHESIZING ENZYME: DGAT1 AT THE CROSSROAD BETWEEN TRIGLYCERIDE AND CHOLESTEROL METABOLISM
ATHEROSCLEROSIS. 2018; 275: E10-E11.-86th Congress of the European-Atherosclerosis-Society (EAS); MAY 05-08, 2018; Lisbon, PORTUGAL. Doi: 10.1016/j.atherosclerosis.2018.06.915 [Oral Communication]
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2017

Full paper/article (Journal)

** Bischof, H; Rehberg, M; Stryeck, S; Artinger, K; Eroglu, E; Waldeck-Weiermair, M; Gottschalk, B; Rost, R; Deak, AT; Niedrist, T; Vujic, N; Lindermuth, H; Prassl, R; Pelzmann, B; Groschner, K; Kratky, D; Eller, K; Rosenkranz, AR; Madl, T; Plesnila, N; Graier, WF; Malli, R Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo.
Nat Commun. 2017; 8(1):1422-1422 Doi: 10.1038/s41467-017-01615-z [OPEN ACCESS]
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** Hofer, DC; Pessentheiner, AR; Pelzmann, HJ; Schlager, S; Madreiter-Sokolowski, CT; Kolb, D; Eichmann, TO; Rechberger, G; Bilban, M; Graier, WF; Kratky, D; Bogner-Strauss, JG Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis.
Biochim Biophys Acta Mol Cell Biol Lipids. 2017; 1862(3):358-368 Doi: 10.1016/j.bbalip.2016.12.009 [OPEN ACCESS]
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** Plastira, I; Bernhart, E; Goeritzer, M; DeVaney, T; Reicher, H; Hammer, A; Lohberger, B; Wintersperger, A; Zucol, B; Graier, WF; Kratky, D; Malle, E; Sattler, W Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.
J Neuroinflammation. 2017; 14(1):253-253 Doi: 10.1186/s12974-017-1024-1 [OPEN ACCESS]
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** Schilcher, I; Kern, S; Hrzenjak, A; Eichmann, TO; Stojakovic, T; Scharnagl, H; Duta-Mare, M; Kratky, D; Marsche, G; Frank, S Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein.
Sci Rep. 2017; 7(1):12485-12485 Doi: 10.1038/s41598-017-12882-7 [OPEN ACCESS]
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** Schlager, S; Vujic, N; Korbelius, M; Duta-Mare, M; Dorow, J; Leopold, C; Rainer, S; Wegscheider, M; Reicher, H; Ceglarek, U; Sattler, W; Radovic, B; Kratky, D Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages.
Oncotarget. 2017; 8(25):40037-40051 Doi: 10.18632/oncotarget.16673 [OPEN ACCESS]
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** Vujic, N; Korbelius, M; Leopold, C; Duta-Mare, M; Rainer, S; Schlager, S; Goeritzer, M; Kolb, D; Eichmann, TO; Diwoky, C; Zimmer, A; Zimmermann, R; Lass, A; Radovic, B; Kratky, D Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
Oncotarget. 2017; 8(20):33122-33136 Doi: 10.18632/oncotarget.16529 [OPEN ACCESS]
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Review

** Zechner, R; Madeo, F; Kratky, D Cytosolic lipolysis and lipophagy: two sides of the same coin.
Nat Rev Mol Cell Biol. 2017; 18(11):671-684 Doi: 10.1038/nrm.2017.76
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Abstract (Journal)

** Duta-Mare, M; Sachdev, V; Vujic, N; Huber, K; Xia, WM; Korbelius, M; Kratky, D LYSOSOMAL ACID LIPASE AND THERMOREGULATION DURING COLD EXPOSURE
ATHEROSCLEROSIS. 2017; 263: E71-E72.-85th Congress of the European-Atherosclerosis-Society (EAS); APR 23-26, 2017; Prague, CZECH REPUBLIC. Doi: 10.1016/j.atherosclerosis.2017.06.237 [Poster]
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** Korbelius, M; Obrowsky, S; Rainer, S; Vujic, N; Kratky, D ATGL/CGI-58-DEPENDENT HYDROLYSIS OF A LIPID STORAGE POOL IN ENTEROCYTES
ATHEROSCLEROSIS. 2017; 263: E85-E85.-85th Congress of the European-Atherosclerosis-Society (EAS); APR 23-26, 2017; Prague, CZECH REPUBLIC. Doi: 10.1016/j.atherosclerosis.2017.06.276 [Oral Communication]
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** Leopold, C; Mashek, D; Kratky, D THE ROLE OF LIPOPHAGY IN HEPATIC ENERGY METABOLISM
ATHEROSCLEROSIS. 2017; 263: E13-E14.-85th Congress of the European-Atherosclerosis-Society (EAS); APR 23-26, 2017; Prague, CZECH REPUBLIC. Doi: 10.1016/j.atherosclerosis.2017.06.071 [Oral Communication]
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** Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Boverhof, R; Doktorova, M; Scheicher, B; Kolb, D; Turnbull, AV; Zimmer, A; Hoefler, G; Hussain, MM; Groen, AK; Kratky, D NOVEL ROLE OF A TRIGLYCERIDE-SYNTHESIZING ENZYME: DGAT1 AT THE CROSSROAD BETWEEN TRIGLYCERIDE AND CHOLESTEROL METABOLISM
ATHEROSCLEROSIS. 2017; 263: E7-E7.-85th Congress of the European-Atherosclerosis-Society (EAS); APR 23-26, 2017; Prague, CZECH REPUBLIC. Doi: 10.1016/j.atherosclerosis.2017.06.048 [Oral Communication]
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2016

Full paper/article (Journal)

** Grumet, L; Eichmann, TO; Taschler, U; Zierler, KA; Leopold, C; Moustafa, T; Radovic, B; Romauch, M; Yan, C; Du, H; Haemmerle, G; Zechner, R; Fickert, P; Kratky, D; Zimmermann, R; Lass, A Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover.
J Biol Chem. 2016; 291(34):17977-87 Doi: 10.1074/jbc.M116.724054 [OPEN ACCESS]
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** Huang, J; Li, L; Lian, J; Schauer, S; Vesely, PW; Kratky, D; Hoefler, G; Lehner, R Tumor-Induced Hyperlipidemia Contributes to Tumor Growth.
Cell Rep. 2016; 15(2): 336-348. Doi: 10.1016/j.celrep.2016.03.020 [OPEN ACCESS]
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** Jandl, K; Stacher, E; Bálint, Z; Sturm, EM; Maric, J; Peinhaupt, M; Luschnig, P; Aringer, I; Fauland, A; Konya, V; Dahlen, SE; Wheelock, CE; Kratky, D; Olschewski, A; Marsche, G; Schuligoi, R; Heinemann, A Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung.
J Allergy Clin Immunol. 2016; 137(3):833-843 Doi: 10.1016/j.jaci.2015.11.012 [OPEN ACCESS]
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** Plastira, I; Bernhart, E; Goeritzer, M; Reicher, H; Kumble, VB; Kogelnik, N; Wintersperger, A; Hammer, A; Schlager, S; Jandl, K; Heinemann, A; Kratky, D; Malle, E; Sattler, W 1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype.
J Neuroinflammation. 2016; 13(1): 205-205. Doi: 10.1186/s12974-016-0701-9 [OPEN ACCESS]
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** Radović, B; Vujić, N; Leopold, C; Schlager, S; Goeritzer, M; Patankar, JV; Korbelius, M; Kolb, D; Reindl, J; Wegscheider, M; Tomin, T; Birner-Gruenberger, R; Schittmayer, M; Groschner, L; Magnes, C; Diwoky, C; Frank, S; Steyrer, E; Du, H; Graier, WF; Madl, T; Kratky, D Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.
Diabetologia. 2016; 59(8):1743-1752 Doi: 10.1007/s00125-016-3968-6 [OPEN ACCESS]
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** Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Boverhof, R; Doktorova, M; Scheicher, B; Goeritzer, M; Kolb, D; Turnbull, AV; Zimmer, A; Hoefler, G; Hussain, MM; Groen, AK; Kratky, D Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Biochim Biophys Acta. 2016; 1861(9 Pt A):1132-1141 Doi: 10.1016/j.bbalip.2016.06.014 [OPEN ACCESS]
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** Vinod, M; Patankar, JV; Sachdev, V; Frank, S; Graier, WF; Kratky, D; Kostner, GM MiR-206 is expressed in pancreatic islets and regulates glucokinase activity.
Am J Physiol Endocrinol Metab. 2016; 311(1):E175-E185 Doi: 10.1152/ajpendo.00510.2015 [OPEN ACCESS]
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** Vujic, N; Porter Abate, J; Schlager, S; David, T; Kratky, D; Koliwad, SK Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice.
PLoS One. 2016; 11(5):e0156364-e0156364 Doi: 10.1371/journal.pone.0156364 [OPEN ACCESS]
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** Vujic, N; Schlager, S; Eichmann, TO; Madreiter-Sokolowski, CT; Goeritzer, M; Rainer, S; Schauer, S; Rosenberger, A; Woelfler, A; Doddapattar, P; Zimmermann, R; Hoefler, G; Lass, A; Graier, WF; Radovic, B; Kratky, D Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.
Atherosclerosis. 2016; 244:9-21 Doi: 10.1016/j.atherosclerosis.2015.10.109 [OPEN ACCESS]
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Abstract (Journal)

** Duta-Mare, MC; Radovic, B; Schlager, S; Wegscheider, M; Kolb-Lenz, D; Madl, T; Stryeck, S; Kratky, D CONSEQUENCES OF LYSOSOMAL ACID LIPASE DEFICIENCY IN MACROPHAGES
ATHEROSCLEROSIS. 2016; 252: E226-E226.-Congress of the European-Atherosclerosis-Society (EAS); MAY 29-JUN 01, 2016; Innsbruck, AUSTRIA. Doi: 10.1016/j.atherosclerosis.2016.07.201 [Oral Communication]
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** Korbelius, M; Obrowsky, S; Rainer, S; Vujic, N; Kratky, D LIPIDS AND LIPOPROTEINS. CONSEQUENCES OF DEFECTIVE LIPOLYSIS IN THE SMALL INTESTINE ON LIPID METABOLISM
ATHEROSCLEROSIS. 2016; 252: E197-E197.-Congress of the European-Atherosclerosis-Society (EAS); MAY 29-JUN 01, 2016; Innsbruck, AUSTRIA. Doi: 10.1016/j.atherosclerosis.2016.07.105 [Oral Communication]
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** Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Doktorova, M; Goeritzer, M; Scheicher, B; Kolb, D; Hoefler, G; Turnbull, AV; Zimmer, A; Hussain, MM; Groen, AK; Kratky, D LIPOPROTEINS AND LIPID METABOLISM: APOB CONTAINING LIPOPROTEINS. NOVEL ROLE OF A TRIGLYCERIDE-SYNTHESIZING ENZYME: DGAT1 AT THE CROSSROAD BETWEEN TRIGLYCERIDE AND CHOLESTEROL METABOLISM
ATHEROSCLEROSIS. 2016; 252: E98-E99.-Congress of the European-Atherosclerosis-Society (EAS); MAY 29-JUN 01, 2016; Innsbruck, AUSTRIA. Doi: 10.1016/j.atherosclerosis.2016.07.564
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** Vujic, N; Schlager, S; Eichmann, TO; Goeritzer, M; Madreiter-Sokolowski, CT; Schauer, S; Lass, A; Zimmermann, R; Hoefler, G; Graier, WF; Radovic, B; Kratky, D MONOGLYCERIDE LIPASE REGULATES ENDOCANNABINOID TONE AND ATHEROSCLEROTIC PLAQUE STRUCTURE IN APOLIPOPROTEIN E-DEFICIENT MICE
ATHEROSCLEROSIS. 2016; 252: E259-E259.-Congress of the European-Atherosclerosis-Society (EAS); MAY 29-JUN 01, 2016; Innsbruck, AUSTRIA. Doi: 10.1016/j.atherosclerosis.2016.07.086 [Oral Communication]
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2015

Full paper/article (Journal)

** Dražić, T; Sachdev, V; Leopold, C; Patankar, JV; Malnar, M; Hećimović, S; Levak-Frank, S; Habuš, I; Kratky, D Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors.
Bioorg Med Chem. 2015; 23(10):2353-2359 Doi: 10.1016/j.bmc.2015.03.067 [OPEN ACCESS]
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** Goeritzer, M; Vujic, N; Schlager, S; Chandak, PG; Korbelius, M; Gottschalk, B; Leopold, C; Obrowsky, S; Rainer, S; Doddapattar, P; Aflaki, E; Wegscheider, M; Sachdev, V; Graier, WF; Kolb, D; Radovic, B; Kratky, D Active autophagy but not lipophagy in macrophages with defective lipolysis.
Biochim Biophys Acta. 2015; 1851(10):1304-1316 Doi: 10.1016/j.bbalip.2015.06.005 [OPEN ACCESS]
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** Out, C; Patankar, JV; Doktorova, M; Boesjes, M; Bos, T; de Boer, S; Havinga, R; Wolters, H; Boverhof, R; van Dijk, TH; Smoczek, A; Bleich, A; Sachdev, V; Kratky, D; Kuipers, F; Verkade, HJ; Groen, AK Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.
J Hepatol. 2015; 63(3):697-704 Doi: 10.1016/j.jhep.2015.04.030 [OPEN ACCESS]
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** Schlager, S; Goeritzer, M; Jandl, K; Frei, R; Vujic, N; Kolb, D; Strohmaier, H; Dorow, J; Eichmann, TO; Rosenberger, A; Wölfler, A; Lass, A; Kershaw, EE; Ceglarek, U; Dichlberger, A; Heinemann, A; Kratky, D Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis.
J Leukoc Biol. 2015; 98(5):837-50 Doi: 10.1189/jlb.3A0515-206R [OPEN ACCESS]
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Abstract (Journal)

** Vinod, M; Patankar, JV; Sachdev, V; Al-Zoughbi, WAEL; Hofler, G; Frank, SASA; Graier, WF; Kratky, D; Kostner, GM MICRO-RNA 206 AFFECTS GLUCOSE INDUCED INSULIN SECRETION UNDER HIGH-FAT DIET
ATHEROSCLEROSIS. 2015; 241(1):E83-E83.-83rd Congress of the European-Atherosclerosis-Society (EAS); MAR 22-25, 2015; Glasgow, SCOTLAND. Doi: 10.1016/j.atherosclerosis.2015.04.292 [Poster]
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** Vinod, M; Patankar, JV; Sachdev, V; Kostner, GM; Kratky, D; Graier, WF; Frank, S MIR-206, A NOVEL POST-TRANSCRIPTIONAL REGULATOR OF GLUCOKINASE.
ATHEROSCLEROSIS. 2015; 241(1):E85-E85.-83rd Congress of the European-Atherosclerosis-Society (EAS); MAR 22-25, 2015; Glasgow, SCOTLAND. Doi: 10.1016/j.atherosclerosis.2015.04.297 [Poster]
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2014

Full paper/article (Journal)

** Chirackal Manavalan, AP; Kober, A; Metso, J; Lang, I; Becker, T; Hasslitzer, K; Zandl, M; Fanaee-Danesh, E; Pippal, JB; Sachdev, V; Kratky, D; Stefulj, J; Jauhiainen, M; Panzenboeck, U Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in high density lipoprotein biogenesis and remodeling at the blood-brain barrier.
J Biol Chem. 2014; 289(8):4683-4698 Doi: 10.1074/jbc.M113.499129 [OPEN ACCESS]
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** Dražić, T; Molčanov, K; Sachdev, V; Malnar, M; Hećimović, S; Patankar, JV; Obrowsky, S; Levak-Frank, S; Habuš, I; Kratky, D Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors.
Eur J Med Chem. 2014; 87(9):722-734 Doi: 10.1016/j.ejmech.2014.10.014 [OPEN ACCESS]
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** Goeritzer, M; Schlager, S; Radovic, B; Madreiter, CT; Rainer, S; Thomas, G; Lord, CC; Sacks, J; Brown, AL; Vujic, N; Obrowsky, S; Sachdev, V; Kolb, D; Chandak, PG; Graier, WF; Sattler, W; Brown, JM; Kratky, D Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.
J Lipid Res. 2014; 55(12):2562-2575 Doi: 10.1194/jlr.M052613 [OPEN ACCESS]
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** Röhrl, C; Eigner, K; Winter, K; Korbelius, M; Obrowsky, S; Kratky, D; Kovacs, WJ; Stangl, H Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells.
J Lipid Res. 2014; 55(1):94-103 Doi: 10.1194/jlr.M043299 [OPEN ACCESS]
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** Rossmann, C; Windpassinger, C; Brunner, D; Kovacevic, A; Schweighofer, N; Malli, R; Schuligoi, R; Prokesch, A; Kluve-Beckerman, B; Graier, WF; Kratky, D; Sattler, W; Malle, E Characterization of rat serum amyloid A4 (SAA4): a novel member of the SAA superfamily.
Biochem Biophys Res Commun. 2014; 450(4):1643-1649 Doi: 10.1016/j.bbrc.2014.07.054 [OPEN ACCESS]
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** Vinod, M; Chennamsetty, I; Colin, S; Belloy, L; De Paoli, F; Schaider, H; Graier, WF; Frank, S; Kratky, D; Staels, B; Chinetti-Gbaguidi, G; Kostner, GM miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages.
Biochim Biophys Acta. 2014; 1841(6):827-835 Doi: 10.1016/j.bbalip.2014.02.006 [OPEN ACCESS]
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Review

** Kratky, D; Obrowsky, S; Kolb, D; Radovic, B Pleiotropic regulation of mitochondrial function by adipose triglyceride lipase-mediated lipolysis
BIOCHIMIE. 2014; 96C: 106-112. Doi: 10.1016/j.biochi.2013.06.023 [OPEN ACCESS]
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Abstract (Journal)

** Panzenboeck, U; Manavalan, APC; Kober, A; Schweinzer, C; Metso, J; Zandl, M; Fanaee-Danesh, E; Pippal, J; Lang, I; Sachdev, V; Kratky, D; Sattler, W; Jauhiainen, M LIVER-X RECEPTOR AGONISTS MODULATE HDL AND AMYLOID-BETA METABOLISM IN BRAIN CAPILLARY ENDOTHELIAL CELLS FORMING THE BLOOD-BRAIN BARRIER.
ATHEROSCLEROSIS. 2014; 235(2):E175-E175.-82nd Congress of the European-Atherosclerosis-Society (EAS); MAY 31-JUN 03, 2014; Madrid, SPAIN. Doi: 10.1016/j.atherosclerosis.2014.05.509 [Poster]
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** Vinod, M; Chennamsetty, I; Colin, S; Belloy, L; De Paoli, F; Schaider, H; Graier, W; Frank, S; Kratky, D; Staels, B; Chinetti-Gbaguidi, G; Kostner, G MIR-206 CONTROLS LXR-ALPHA EXPRESSION AND PROMOTES LXR-MEDIATED CHOLESTEROL EFFLUX IN MACROPHAGES
ATHEROSCLEROSIS. 2014; 235(2):E39-E39.-82nd Congress of the European-Atherosclerosis-Society (EAS); MAY 31-JUN 03, 2014; Madrid, SPAIN. Doi: 10.1016/j.atherosclerosis.2014.05.084 [Poster]
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** Vujic, N; Goeritzer, M; Schlager, S; Radovic, B; Kratky, D INCREASED ATHEROSCLEROTIC PLAQUE FORMATION IN APOLIPOPROTEIN E - DEFICIENT MICE LACKING MONOACYLGLYCEROL LIPASE
ATHEROSCLEROSIS. 2014; 235(2):E180-E181.-82nd Congress of the European-Atherosclerosis-Society (EAS); MAY 31-JUN 03, 2014; Madrid, SPAIN. Doi: 10.1016/j.atherosclerosis.2014.05.525 [Poster]
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2013

Full paper/article (Journal)

** Doddapattar, P; Radović, B; Patankar, JV; Obrowsky, S; Jandl, K; Nusshold, C; Kolb, D; Vujić, N; Doshi, L; Chandak, PG; Goeritzer, M; Ahammer, H; Hoefler, G; Sattler, W; Kratky, D Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Mol Nutr Food Res. 2013; 57(10):1718-1728 Doi: 10.1002/mnfr.201200794 [OPEN ACCESS]
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** Huang, J; Das, SK; Jha, P; Al Zoughbi, W; Schauer, S; Claudel, T; Sexl, V; Vesely, P; Birner-Gruenberger, R; Kratky, D; Trauner, M; Hoefler, G The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism.
Biochim Biophys Acta. 2013; 1831(10):1555-1565 Doi: 10.1016/j.bbalip.2013.04.012 [OPEN ACCESS]
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** Nikam, A; Patankar, JV; Lackner, C; Schöck, E; Kratky, D; Zatloukal, K; Abuja, PM Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1.
PLoS One. 2013; 8(6):e66094-e66094 Doi: 10.1371/journal.pone.0066094 [OPEN ACCESS]
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** Obrowsky, S; Chandak, PG; Patankar, JV; Povoden, S; Schlager, S; Kershaw, EE; Bogner-Strauss, JG; Hoefler, G; Levak-Frank, S; Kratky, D Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling.
J Lipid Res. 2013; 54(2):425-435 Doi: 10.1194/jlr.M031716 [OPEN ACCESS]
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** Üllen, A; Singewald, E; Konya, V; Fauler, G; Reicher, H; Nusshold, C; Hammer, A; Kratky, D; Heinemann, A; Holzer, P; Malle, E; Sattler, W Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo.
PLoS One. 2013; 8(5):e64034-e64034 Doi: 10.1371/journal.pone.0064034 [OPEN ACCESS]
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** Walenta, E; Pessentheiner, AR; Pelzmann, HJ; Deutsch, A; Goeritzer, M; Kratky, D; Hackl, H; Oh, DY; Prokesch, A; Bogner-Strauss, JG α/β-hydrolase domain containing protein 15 (ABHD15)--an adipogenic protein protecting from apoptosis.
PLoS One. 2013; 8(11):e79134-e79134 Doi: 10.1371/journal.pone.0079134 [OPEN ACCESS]
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** Waltl-Patankar, S; Patankar, J; Fauler, G; Nusshold, C; Ullen, A; Eibinger, G; Wintersperger, A; Kratky, D; Malle, E; Sattler, W 25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line.
Neurosci Lett. 2013; 539(4):16-21 Doi: 10.1016/j.neulet.2013.01.014 [OPEN ACCESS]
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Short report/Letter

** Patankar, JV; Sachdev, V; Obrowsky, S; Levak-Frank, S; Kratky, D Intestinal GATA4 deficiency induces proximal fibroblast growth factor 15 expression and represses hepatic gluconeogenesis.
J Hepatol. 2013; 59(5):1147-1149 Doi: 10.1016/j.jhep.2013.07.003 [OPEN ACCESS]
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Correction

** Aflaki, E; Balenga, NAB; Luschnig-Schratl, P; Wolinski, H; Povoden, S; Chandak, PG; Bogner-Strauss, JG; Eder, S; Konya, V; Kohlwein, SD; Heinemann, A; Kratky, D; Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis (vol 68, pg 3933, 2011).
CELL MOL LIFE SCI. 2013; 70(14): 2621-2621. Doi: 10.1007/s00018-013-1371-8 [OPEN ACCESS]
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2012

Full paper/article (Journal)

** Aflaki, E; Doddapattar, P; Radovic, B; Povoden, S; Kolb, D; Vujic, N; Wegscheider, M; Koefeler, H; Hornemann, T; Graier, WF; Malli, R; Madeo, F; Kratky, D C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages.
Cell Death Dis. 2012; 3(6):e280-e280 Doi: 10.1038/cddis.2012.17 [OPEN ACCESS]
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** Moustafa, T; Fickert, P; Magnes, C; Guelly, C; Thueringer, A; Frank, S; Kratky, D; Sattler, W; Reicher, H; Sinner, F; Gumhold, J; Silbert, D; Fauler, G; Höfler, G; Lass, A; Zechner, R; Trauner, M Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
Gastroenterology. 2012; 142(1):140-151 Doi: 10.1053/j.gastro.2011.09.051
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** Obrowsky, S; Chandak, PG; Patankar, JV; Pfeifer, T; Povoden, S; Schreiber, R; Haemmerle, G; Levak-Frank, S; Kratky, D Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice.
Biochim Biophys Acta. 2012; 1821(11):1406-1414 Doi: 10.1016/j.bbalip.2012.07.013 [OPEN ACCESS]
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** Patankar, JV; Obrowsky, S; Doddapattar, P; Hoefler, G; Battle, M; Levak-Frank, S; Kratky, D Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis.
J Hepatol. 2012; 57(5):1061-1068 Doi: 10.1016/j.jhep.2012.06.028 [OPEN ACCESS]
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** Stemmer, U; Dunai, ZA; Koller, D; Pürstinger, G; Zenzmaier, E; Deigner, HP; Aflaki, E; Kratky, D; Hermetter, A Toxicity of oxidized phospholipids in cultured macrophages.
Lipids Health Dis. 2012; 11(12):110-110 Doi: 10.1186/1476-511X-11-110 [OPEN ACCESS]
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Review

** Radovic, B; Aflaki, E; Kratky, D Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis.
Biol Chem. 2012; 393(9):1005-1011 Doi: 10.1515/hsz-2012-0192 [OPEN ACCESS]
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Abstract (Journal)

** Patankar, J; Obrowsky, S; Hoefler, G; Battle, M; Kratky, D; Levak-Frank, S INTESTINAL DEFICIENCY OF GATA4 PROTECTS FROM DIET-INDUCED HEPATIC STEATOSIS BY SUPPRESSING DE NOVO LIPOGENESIS AND GLUCONEOGENESIS IN MICE
J HEPATOL. 2012; 56: S496-S496.-47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL); APR 18-22, 2012; Barcelona, SPAIN. Doi: 10.1016/S0168-8278(12)61265-3 [Poster]
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2011

Full paper/article (Journal)

** Aflaki, E; Balenga, NA; Luschnig-Schratl, P; Wolinski, H; Povoden, S; Chandak, PG; Bogner-Strauss, JG; Eder, S; Konya, V; Kohlwein, SD; Heinemann, A; Kratky, D Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis.
Cell Mol Life Sci. 2011; 68(23): 3933-3947. Doi: 10.1007/s00018-011-0688-4 [OPEN ACCESS]
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** Aflaki, E; Radovic, B; Chandak, PG; Kolb, D; Eisenberg, T; Ring, J; Fertschai, I; Uellen, A; Wolinski, H; Kohlwein, SD; Zechner, R; Levak-Frank, S; Sattler, W; Graier, WF; Malli, R; Madeo, F; Kratky, D Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages.
J Biol Chem. 2011; 286(9): 7418-7428. Doi: 10.1074/jbc.M110.175703 [OPEN ACCESS]
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** Chandak, PG; Obrowsky, S; Radovic, B; Doddapattar, P; Aflaki, E; Kratzer, A; Doshi, LS; Povoden, S; Ahammer, H; Hoefler, G; Levak-Frank, S; Kratky, D Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.
Biochim Biophys Acta. 2011; 1811(12): 1011-1020. Doi: 10.1016/j.bbalip.2011.08.010 [OPEN ACCESS]
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** Chennamsetty, I; Claudel, T; Kostner, KM; Baghdasaryan, A; Kratky, D; Levak-Frank, S; Frank, S; Gonzalez, FJ; Trauner, M; Kostner, GM Farnesoid X receptor represses hepatic human APOA gene expression.
J Clin Invest. 2011; 121(9):3724-3734 Doi: 10.1172/JCI45277 [OPEN ACCESS]
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** Grunert, T; Leitner, NR; Marchetti-Deschmann, M; Miller, I; Wallner, B; Radwan, M; Vogl, C; Kolbe, T; Kratky, D; Gemeiner, M; Allmaier, G; Müller, M; Strobl, B A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).
J Proteomics. 2011; 74(12): 2866-2880. Doi: 10.1016/j.jprot.2011.07.006 [OPEN ACCESS]
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** Kratky, D Neutral cholesterol ester hydrolases in macrophages: still a matter of debate.
CIRC RES. 2011; 108(10): e13-e13. Doi: 10.1161/CIRCRESAHA.111.245829 [OPEN ACCESS]
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** Lammers, B; Chandak, PG; Aflaki, E; Van Puijvelde, GH; Radovic, B; Hildebrand, RB; Meurs, I; Out, R; Kuiper, J; Van Berkel, TJ; Kolb, D; Haemmerle, G; Zechner, R; Levak-Frank, S; Van Eck, M; Kratky, D Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice.
Arterioscler Thromb Vasc Biol. 2011; 31(1): 67-73. Doi: 10.1161/ATVBAHA.110.215814 [OPEN ACCESS]
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** Mueller, KM; Kornfeld, JW; Friedbichler, K; Blaas, L; Egger, G; Esterbauer, H; Hasselblatt, P; Schlederer, M; Haindl, S; Wagner, KU; Engblom, D; Haemmerle, G; Kratky, D; Sexl, V; Kenner, L; Kozlov, AV; Terracciano, L; Zechner, R; Schuetz, G; Casanova, E; Pospisilik, JA; Heim, MH; Moriggl, R Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.
Hepatology. 2011; 54(4):1398-1409 Doi: 10.1002/hep.24509 [OPEN ACCESS]
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** Patankar, JV; Chandak, PG; Obrowsky, S; Pfeifer, T; Diwoky, C; Uellen, A; Sattler, W; Stollberger, R; Hoefler, G; Heinemann, A; Battle, M; Duncan, S; Kratky, D; Levak-Frank, S Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.
Am J Physiol Endocrinol Metab. 2011; 300(3): E478-E488. Doi: 10.1152/ajpendo.00457.2010 [OPEN ACCESS]
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** Pfeifer, T; Buchebner, M; Chandak, PG; Patankar, J; Kratzer, A; Obrowsky, S; Rechberger, GN; Kadam, RS; Kompella, UB; Kostner, GM; Kratky, D; Levak-Frank, S Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol.
Curr Pharm Biotechnol. 2011; 12(2):285-292 Doi: 10.2174/138920111794295774 [OPEN ACCESS]
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** Rohde, E; Schallmoser, K; Reinisch, A; Hofmann, NA; Pfeifer, T; Fröhlich, E; Rechberger, G; Lanzer, G; Kratky, D; Strunk, D Pro-angiogenic induction of myeloid cells for therapeutic angiogenesis can induce mitogen-activated protein kinase p38-dependent foam cell formation.
Cytotherapy. 2011; 13(4):503-512 Doi: 10.3109/14653249.2010.536214 [OPEN ACCESS]
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Abstract (Journal)

** Doddapattar, PK; Aflaki, E; Radovic, B; Rathke, N; Gruenberger, RB; Kratky, D REDUCED ATHEROSCLEROTIC PLAQUE FORMATION IN APOE-/- MICE LACKING PERILIPIN
ATHEROSCLEROSIS SUPP. 2011; 12(1): 31-31. Doi: 10.1016/S1567-5688(11)70137-4
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2010

Full paper/article (Journal)

** Buchebner, M; Pfeifer, T; Rathke, N; Chandak, PG; Lass, A; Schreiber, R; Kratzer, A; Zimmermann, R; Sattler, W; Koefeler, H; Froehlich, E; Kostner, GM; Birner-Gruenberger, R; Chiang, KP; Haemmerle, G; Zechner, R; Levak-Frank, S; Cravatt, BF; Kratky, D Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363.
J Lipid Res. 2010; 51(10): 2896-2908. Doi: 10.1194/jlr.M004259 [OPEN ACCESS]
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** Chandak, PG; Radovic, B; Aflaki, E; Kolb, D; Buchebner, M; Fröhlich, E; Magnes, C; Sinner, F; Haemmerle, G; Zechner, R; Tabas, I; Levak-Frank, S; Kratky, D Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase.
J Biol Chem. 2010; 285(26):20192-20201 Doi: 10.1074/jbc.M110.107854 [OPEN ACCESS]
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Abstract (Journal)

** Aflaki, E; Malli, R; Radovic, B; Eisenberg, T; Ring, J; Chandak, PG; Graier, W; Madeo, F; Kratky, D ADIPOSE TRIGLYCERIDE LIPASE DEFICIENCY RESULTS IN MACROPHAGE APOPTOSIS
ATHEROSCLER SUPPL. 2010; 11(2):211--Gordon Research Conference; August 2010; MA, USA. Doi: 10.1016/S1567-5688(10)70278-6 [Oral Communication]
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** Chandak, P; Lammers, B; Radovic, B; Aflaki, E; Buchebner, M; Haemmerle, G; Zechner, R; van Eck, M; Kratky, D ADIPOSE TRIGLYCERIDE LIPASE DEFICIENCY AFFECTS MACROPHAGE MORPHOLOGY AND FUNCTION AND SIGNIFICANTLY REDUCES ATHEROSCLEROSIS IN LDLR-/- MICE
ATHEROSCLER SUPPL. 2010; 11(2):W4-Banff, Alberta. Doi: 10.1016/S1567-5688(10)70005-2 [Oral Communication]
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** Moustafa, T; Fickert, P; Magnes, C; Frank, S; Kratky, D; Sinner, F; Gumhold, J; Silbert, D; Halsegger, S; Trauner M METABOLIC REPROGRAMMING OF LIPID METABOLISM BY THE SIDE-CHAIN MODIFIED BILE ACID, 24-NORURSODEOXYCHOLIC ACID, RESTORES INFLAMMATION-DRIVEN LIVER INJURY AND ABERRANT PROLIFERATION IN ABCB4-/- MICE
J HEPATOL. 2010; 52: S20-S21.-45th Annual Meeting of the European Association for the Study of the Liver; APR 14 - 18,2010; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(10)60049-9 [Oral Communication]
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** Rohde, E; Schallmoser, K; Reinisch, A; Hofmann, N; Pfeifer, T; Rechberger, G; Lanzer, G; Kratky, D; Strunk, D BLOOD AND MARROW-DERIVED PROGENITORS ARE SUSCEPTIBLE TO MAPK P38-DEPENDENT FOAM CELL INDUCTION
HAEMATOL-HEMATOL J. 2010; 95: 1059- [Poster]
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** Rohde, E; Schallmoser, K; Reinisch, A; Hofmann, NA; Pfeifer, T; Rechberger, G; Lanzer, G; Linkesch, W; Kratky, D; Strunk, D MAPK p38-dependent foam cell formation of myeloid cells after pro-angiogenic induction as a risk factor of therapeutic angiogenesis
BONE MARROW TRANSPLANT. 2010; 45: S283-S283. -36th Annual Meeting of the European Group for Blood and Marrow Transplantation; MAR 21-24, 2010; Vienna, AUSTRIA. [Poster]
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2009

Full paper/article (Journal)

** Gürtl, B; Kratky, D; Guelly, C; Zhang, L; Gorkiewicz, G; Das, SK; Tamilarasan, KP; Hoefler, G Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy.
Int J Exp Pathol. 2009; 90(3): 338-46. Doi: 10.1111/j.1365-2613.2009.00647.x [OPEN ACCESS]
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** Gurtl, B; Kratky, D; Guelly, C; Zhang, LF; Gorkiewicz, G; Das, SK; Tamilarasan, KP; Hoefler, G Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy
INT J EXP PATHOL. 2009; 90(3): 338-346. Doi: 10.1111/j.1365-2613.2009.00647.x [OPEN ACCESS]
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** Kratzer, A; Buchebner, M; Pfeifer, T; Becker, TM; Uray, G; Miyazaki, M; Miyazaki-Anzai, S; Ebner, B; Chandak, PG; Kadam, RS; Calayir, E; Rathke, N; Ahammer, H; Radovic, B; Trauner, M; Hoefler, G; Kompella, UB; Fauler, G; Levi, M; Levak-Frank, S; Kostner, GM; Kratky, D Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia.
J Lipid Res. 2009; 50(2): 312-326. Doi: 10.1194/jlr.M800376-JLR200 [OPEN ACCESS]
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Abstract (Journal)

** Rohde, E; Pfeifer, T; Schallmoser, K; Reinisch, A; Hofmann, NA; Froehlich, E; Rechberger, G; Lanzer, G; Kratky, D; Strunk, D Pro-atherogenic risk of cellular therapy for vascular regeneration?
BONE MARROW TRANSPLANT. 35th Annual Meeting of the European Group for Blood and Marrow Transplantation2009; 43(1):S203-S204.-35th Annual Meeting of the European Group for Blood and Marrow Transplantation; MAR 29-APR 01, 2009; Goteborg, SWEDEN. [Poster]
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Full paper/article (Proceedings)

** Trauner, M; Fickert, P; Moustafa, T; Fuchsbichler, A; Claudel, T; Halilbasic, E; Kratky, D; Denk, H Potential role of ursodeoxycholic acid and its side-chain modified derivatives in the treatment of non-alcoholic fatty liver disease and associated atherosclerosis
FALK SYMP. 2009; 165: 151-156. [Oral Communication]
Web of Science

2008

Abstract (Journal)

** Rohde, E; Aflaki, E; Froehlich, E; Lanzer, G; Kratky, D; Strunk, D Combating Cardiovascular Disease: Is there a Risk of Foam Cell Formation in Transplanted Angiocompetent Cells Compromising Intended Beneficial Effects of Vascular Regenerative Therapy?
Fiftieth annual meeting abstracts2008; 112(11):665-666.-American Society of Hematology 50th Annual Meeting and Exposition; DEC 6-9, 2008; San Francisco, USA. [Oral Communication]
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2006

Full paper/article (Journal)

** Haemmerle, G; Lass, A; Zimmermann, R; Gorkiewicz, G; Meyer, C; Rozman, J; Heldmaier, G; Maier, R; Theussl, C; Eder, S; Kratky, D; Wagner, EF; Klingenspor, M; Hoefler, G; Zechner, R Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase.
SCIENCE. 2006; 312: 734-737. Doi: 10.1126/science.1123965 [OPEN ACCESS]
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Abstract (Journal)

** Becker, TM; Ebner, B; Kratzer, A; Calayir, E; Buchebner, M; Birner-Gruenberger, R; Hermetter, A; Levak-Frank, S; Kostner, GM; Kratky, D Identification of lipolytic enzymes and their potential role in the cholesterol homeostasis of murine macrophages
CHEM PHYS LIPIDS. 143: 58-59. Doi: 10.1016/j.chemphyslip.2006.06.006 [Oral Communication]
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** Kratzer, A; Ebner, B; Becker, T; Calayir, E; Levak-Frank, S; Uray, G; Kostner, GM; Kratky, D Regulatory effects of a novel liver X receptor agonist
CHEM PHYS LIPIDS. 143: 88-88. [Poster]
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2005

Full paper/article (Journal)

** Kratky, D; Zimmermann, R; Wagner, EM; Strauss, JG; Jin, W; Kostner, GM; Haemmerle, G; Rader, DJ; Zechner, R Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue.
J CLIN INVEST. 2005; 115(1): 161-167. Doi: 10.1172/JCI15972 [OPEN ACCESS]
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** Lindegaard, ML; Olivecrona, G; Christoffersen, C; Kratky, D; Hannibal, J; Petersen, BL; Zechner, R; Damm, P; Nielsen, LB Endothelial and lipoprotein lipases in human and mouse placenta.
J LIPID RES. 2005; 46: 2339-2346. Doi: 10.1194/jlr.M500277-JLR200 [OPEN ACCESS]
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2004

Full paper/article (Journal)

** Wagner, EM; Kratky, D; Haemmerle, G; Hrzenjak, A; Kostner, GM; Steyrer, E; Zechner, R Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis.
J LIPID RES. 2004; 45(2): 356-365. Doi: 10.1194/jlr.M300293-JLR200 [OPEN ACCESS]
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Abstract (Journal)

** Ebner, B; Becker, T; Schittl, J; Kratzer, A; Levak-Frank, S; Kostner, G; Kratky, D Identification of novel genes in murine peritoneal macrophages and foam cells involved in cholesterol homeostasis
FASEB J 2004 18: C262-C262.
Web of Science

** Kratzer, A; Ebner, B; Schittl, J; Becker, T; Levak-Frank, S; Kostner, G; Kratky, D Influence of nuclear receptor ligands on the cholesterol metabolism in RAW264.7 mouse macrophages and foam cells
FASEB J 2004 18: C262-C262.
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2003

Full paper/article (Journal)

** Zimmermann, R; Haemmerle, G; Wagner, EM; Strauss, JG; Kratky, D; Zechner, R Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue.
J Lipid Res. 2003; 44(11):2089-2099 Doi: 10.1194/jlr.M300190-JLR200 [OPEN ACCESS]
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2002

Full paper/article (Journal)

** Haemmerle, G; Zimmermann, R; Strauss, JG; Kratky, D; Riederer, M; Knipping, G; Zechner, R Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle.
J BIOL CHEM 2002 277: 12946-12952. Doi: 10.1074/jbc.M108640200 [OPEN ACCESS]
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** Strauss, JG; Zimmermann, R; Hrzenjak, A; Zhou, Y; Kratky, D; Levak-Frank, S; Kostner, GM; Zechner, R; Frank, S Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity.
Biochem J. 2002; 368(Pt 1):69-79 Doi: 10.1042/BJ20020306 [OPEN ACCESS]
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2001

Full paper/article (Journal)

** Kratky, D; Strauss, JG; Zechner, R Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models.
Biochem J. 2001; 355(Pt 3):647-652 Doi: 10.1042/bj3550647 [OPEN ACCESS]
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** Strauss, JG; Frank, S; Kratky, D; Hämmerle, G; Hrzenjak, A; Knipping, G; von Eckardstein, A; Kostner, GM; Zechner, R Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice.
J Biol Chem. 2001; 276(39):36083-36090 Doi: 10.1074/jbc.M104430200 [OPEN ACCESS]
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** Voshol, PJ; Jong, MC; Dahlmans, VE; Kratky, D; Levak-Frank, S; Zechner, R; Romijn, JA; Havekes, LM In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake.
Diabetes. 2001; 50(11):2585-2590 Doi: 10.2337/diabetes.50.11.2585 [OPEN ACCESS]
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2000

Full paper/article (Journal)

** Zechner, R; Strauss, J; Frank, S; Wagner, E; Hofmann, W; Kratky, D; Hiden, M; Levak-Frank, S The role of lipoprotein lipase in adipose tissue development and metabolism.
Int J Obes Relat Metab Disord. 2000; 24 Suppl 4:S53-S56 Doi: 10.1038/sj.ijo.0801506 [OPEN ACCESS]
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Abstract (Journal)

** Guertl, B; Noehammer, C; Kratky, D; Tessaro, B; Zechner, R; Hoefler, G New genes involved in the development of metabolic cardiomyopathies
J PATHOL 2000 192: 11A-11A.
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1999

Full paper/article (Journal)

** Kratky, D; Lass, A; Abuja, PM; Esterbauer, H; Kühn, H A sensitive chemiluminescence method to measure the lipoxygenase catalyzed oxygenation of complex substrates.
Biochim Biophys Acta. 1999; 1437(1): 13-22. Doi: 10.1016/S0005-2760(98)00176-3
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1997

Abstract (Journal)

** Kratky, D; Hayn, M; Kuhn, H; Esterbauer, H A novel method to measure the oxygenation of low-density lipoprotein by 15-lipoxygenase
ATHEROSCLEROSIS 1997 134: 214-214. Doi: 10.1016/S0021-9150(97)89150-2
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