** = Publications listed in SCI/SSCI/Pubmed
** Dražić, T; Sachdev, V; Leopold, C; Patankar, JV; Malnar, M; Hećimović, S; Levak-Frank, S; Habuš, I; Kratky, D
Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors.
Bioorg Med Chem. 2015; 23(10):2353-2359
Doi: 10.1016/j.bmc.2015.03.067
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** Dražić, T; Molčanov, K; Sachdev, V; Malnar, M; Hećimović, S; Patankar, JV; Obrowsky, S; Levak-Frank, S; Habuš, I; Kratky, D
Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors.
Eur J Med Chem. 2014; 87(9):722-734
Doi: 10.1016/j.ejmech.2014.10.014
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** Obrowsky, S; Chandak, PG; Patankar, JV; Povoden, S; Schlager, S; Kershaw, EE; Bogner-Strauss, JG; Hoefler, G; Levak-Frank, S; Kratky, D
Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling.
J Lipid Res. 2013; 54(2):425-435
Doi: 10.1194/jlr.M031716
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** Patankar, JV; Sachdev, V; Obrowsky, S; Levak-Frank, S; Kratky, D
Intestinal GATA4 deficiency induces proximal fibroblast growth factor 15 expression and represses hepatic gluconeogenesis.
J Hepatol. 2013; 59(5):1147-1149
Doi: 10.1016/j.jhep.2013.07.003
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** Obrowsky, S; Chandak, PG; Patankar, JV; Pfeifer, T; Povoden, S; Schreiber, R; Haemmerle, G; Levak-Frank, S; Kratky, D
Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice.
Biochim Biophys Acta. 2012; 1821(11):1406-1414
Doi: 10.1016/j.bbalip.2012.07.013
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** Patankar, JV; Obrowsky, S; Doddapattar, P; Hoefler, G; Battle, M; Levak-Frank, S; Kratky, D
Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis.
J Hepatol. 2012; 57(5):1061-1068
Doi: 10.1016/j.jhep.2012.06.028
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** Patankar, J; Obrowsky, S; Hoefler, G; Battle, M; Kratky, D; Levak-Frank, S
INTESTINAL DEFICIENCY OF GATA4 PROTECTS FROM DIET-INDUCED HEPATIC STEATOSIS BY SUPPRESSING DE NOVO LIPOGENESIS AND GLUCONEOGENESIS IN MICE
J HEPATOL. 2012; 56: S496-S496.-47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL); APR 18-22, 2012; Barcelona, SPAIN.
Doi: 10.1016/S0168-8278(12)61265-3
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** Aflaki, E; Radovic, B; Chandak, PG; Kolb, D; Eisenberg, T; Ring, J; Fertschai, I; Uellen, A; Wolinski, H; Kohlwein, SD; Zechner, R; Levak-Frank, S; Sattler, W; Graier, WF; Malli, R; Madeo, F; Kratky, D
Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages.
J Biol Chem. 2011; 286(9): 7418-7428.
Doi: 10.1074/jbc.M110.175703
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** Chandak, PG; Obrowsky, S; Radovic, B; Doddapattar, P; Aflaki, E; Kratzer, A; Doshi, LS; Povoden, S; Ahammer, H; Hoefler, G; Levak-Frank, S; Kratky, D
Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.
Biochim Biophys Acta. 2011; 1811(12): 1011-1020.
Doi: 10.1016/j.bbalip.2011.08.010
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** Chennamsetty, I; Claudel, T; Kostner, KM; Baghdasaryan, A; Kratky, D; Levak-Frank, S; Frank, S; Gonzalez, FJ; Trauner, M; Kostner, GM
Farnesoid X receptor represses hepatic human APOA gene expression.
J Clin Invest. 2011; 121(9):3724-3734
Doi: 10.1172/JCI45277
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** Lammers, B; Chandak, PG; Aflaki, E; Van Puijvelde, GH; Radovic, B; Hildebrand, RB; Meurs, I; Out, R; Kuiper, J; Van Berkel, TJ; Kolb, D; Haemmerle, G; Zechner, R; Levak-Frank, S; Van Eck, M; Kratky, D
Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice.
Arterioscler Thromb Vasc Biol. 2011; 31(1): 67-73.
Doi: 10.1161/ATVBAHA.110.215814
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** Patankar, JV; Chandak, PG; Obrowsky, S; Pfeifer, T; Diwoky, C; Uellen, A; Sattler, W; Stollberger, R; Hoefler, G; Heinemann, A; Battle, M; Duncan, S; Kratky, D; Levak-Frank, S
Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.
Am J Physiol Endocrinol Metab. 2011; 300(3): E478-E488.
Doi: 10.1152/ajpendo.00457.2010
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** Pfeifer, T; Buchebner, M; Chandak, PG; Patankar, J; Kratzer, A; Obrowsky, S; Rechberger, GN; Kadam, RS; Kompella, UB; Kostner, GM; Kratky, D; Levak-Frank, S
Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol.
Curr Pharm Biotechnol. 2011; 12(2):285-292
Doi: 10.2174/138920111794295774
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** Buchebner, M; Pfeifer, T; Rathke, N; Chandak, PG; Lass, A; Schreiber, R; Kratzer, A; Zimmermann, R; Sattler, W; Koefeler, H; Froehlich, E; Kostner, GM; Birner-Gruenberger, R; Chiang, KP; Haemmerle, G; Zechner, R; Levak-Frank, S; Cravatt, BF; Kratky, D
Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363.
J Lipid Res. 2010; 51(10): 2896-2908.
Doi: 10.1194/jlr.M004259
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** Chandak, PG; Radovic, B; Aflaki, E; Kolb, D; Buchebner, M; Fröhlich, E; Magnes, C; Sinner, F; Haemmerle, G; Zechner, R; Tabas, I; Levak-Frank, S; Kratky, D
Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase.
J Biol Chem. 2010; 285(26):20192-20201
Doi: 10.1074/jbc.M110.107854
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** Kratzer, A; Buchebner, M; Pfeifer, T; Becker, TM; Uray, G; Miyazaki, M; Miyazaki-Anzai, S; Ebner, B; Chandak, PG; Kadam, RS; Calayir, E; Rathke, N; Ahammer, H; Radovic, B; Trauner, M; Hoefler, G; Kompella, UB; Fauler, G; Levi, M; Levak-Frank, S; Kostner, GM; Kratky, D
Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia.
J Lipid Res. 2009; 50(2): 312-326.
Doi: 10.1194/jlr.M800376-JLR200
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** Trenker, M; Malli, R; Fertschai, I; Levak-Frank, S; Graier, WF
Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport.
Nat Cell Biol. 2007; 9(4): 445-452.
Doi: 10.1038/ncb1556
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** Becker, TM; Ebner, B; Kratzer, A; Calayir, E; Buchebner, M; Birner-Gruenberger, R; Hermetter, A; Levak-Frank, S; Kostner, GM; Kratky, D
Identification of lipolytic enzymes and their potential role in the cholesterol homeostasis of murine macrophages
CHEM PHYS LIPIDS. 143: 58-59.
Doi: 10.1016/j.chemphyslip.2006.06.006
[Oral Communication]
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** Kratzer, A; Ebner, B; Becker, T; Calayir, E; Levak-Frank, S; Uray, G; Kostner, GM; Kratky, D
Regulatory effects of a novel liver X receptor agonist
CHEM PHYS LIPIDS. 143: 88-88.
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** Sovic, A; Panzenboeck, U; Wintersperger, A; Kratzer, I; Hammer, A; Levak-Frank, S; Frank, S; Rader, DJ; Malle, E; Sattler, W
Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood-brain barrier.
J NEUROCHEM. 2005; 94(1): 109-119.
Doi: 10.1111/j.1471-4159.2005.03175.x
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** Ebner, B; Becker, T; Schittl, J; Kratzer, A; Levak-Frank, S; Kostner, G; Kratky, D
Identification of novel genes in murine peritoneal macrophages and foam cells involved in cholesterol homeostasis
FASEB J 2004 18: C262-C262.
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** Kratzer, A; Ebner, B; Schittl, J; Becker, T; Levak-Frank, S; Kostner, G; Kratky, D
Influence of nuclear receptor ligands on the cholesterol metabolism in RAW264.7 mouse macrophages and foam cells
FASEB J 2004 18: C262-C262.
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** Schaeffer, G; Levak-Frank, S; Spitaler, MM; Fleischhacker, E; Esenabhalu, VE; Wagner, AH; Hecker, M; Graier, WF
Intercellular signalling within vascular cells under high D-glucose involves free radical-triggered tyrosine kinase activation.
Diabetologia. 2003; 46(6):773-783
Doi: 10.1007/s00125-003-1091-y
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** Strauss, JG; Hayn, M; Zechner, R; Levak-Frank, S; Frank, S
Fatty acids liberated from high-density lipoprotein phospholipids by endothelial-derived lipase are incorporated into lipids in HepG2 cells.
Biochem J. 2003; 371(Pt 3):981-988
Doi: 10.1042/BJ20021437
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** Wadsack, C; Hammer, A; Levak-Frank, S; Desoye, G; Kozarsky, KF; Hirschmugl, B; Sattler, W; Malle, E
Selective cholesteryl ester uptake from high density lipoprotein by human first trimester and term villous trophoblast cells.
Placenta. 2003; 24(2-3):131-143
Doi: 10.1053/plac.2002.0912
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** Wadsack, C; Hirschmugl, B; Hammer, A; Levak-Frank, S; Kozarsky, KF; Sattler, W; Malle, E
Scavenger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins.
Int J Biochem Cell Biol. 2003; 35(4):441-454
Doi: 10.1016/S1357-2725(02)00272-8
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** Wadsack, C; Hrzenjak, A; Hammer, A; Hirschmugl, B; Levak-Frank, S; Desoye, G; Sattler, W; Malle, E
Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins.
Eur J Biochem. 2003; 270(3):451-462
Doi: 10.1046%2Fj.1432-1033.2003.03394.x
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** Esenabhalu, VE; Cerimagic, M; Malli, R; Osibow, K; Levak-Frank, S; Frieden, M; Sattler, W; Kostner, GM; Zechner, R; Graier, WF
Tissue-specific expression of human lipoprotein lipase in the vascular system affects vascular reactivity in transgenic mice.
Br J Pharmacol. 2002; 135(1):143-154
Doi: 10.1038/sj.bjp.0704440
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** Panzenboeck, U; Balazs, Z; Sovic, A; Hrzenjak, A; Levak-Frank, S; Wintersperger, A; Malle, E; Sattler, W
ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells.
J Biol Chem. 2002; 277(45):42781-42789
Doi: 10.1074/jbc.M207601200
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** Strauss, JG; Zimmermann, R; Hrzenjak, A; Zhou, Y; Kratky, D; Levak-Frank, S; Kostner, GM; Zechner, R; Frank, S
Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity.
Biochem J. 2002; 368(Pt 1):69-79
Doi: 10.1042/BJ20020306
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** Wadsack, C; Hammer, A; Levak-Frank, S; Sattler, W; Desoye, G; Malle, E
Scavenger receptor class B type I represents an efficient route for supplying cholesterol esters from maternal lipoproteins to developing embryonic tissues
MOL BIOL CELL 2002 13: 640-640.
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** Goti, D; Hrzenjak, A; Levak-Frank, S; Frank, S; van der Westhuyzen, DR; Malle, E; Sattler, W
Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E.
J Neurochem. 2001; 76(2):498-508
Doi: 10.1046%2Fj.1471-4159.2001.00100.x
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** Marsche, G; Levak-Frank, S; Quehenberger, O; Heller, R; Sattler, W; Malle, E
Identification of the human analog of SR-BI and LOX-1 as receptors for hypochlorite-modified high density lipoprotein on human umbilical venous endothelial cells.
FASEB J. 2001; 15(6):1095-1097
Doi: 10.1096/fj.00-0532fje
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** Voshol, PJ; Jong, MC; Dahlmans, VE; Kratky, D; Levak-Frank, S; Zechner, R; Romijn, JA; Havekes, LM
In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake.
Diabetes. 2001; 50(11):2585-2590
Doi: 10.2337/diabetes.50.11.2585
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** Zimmermann, R; Panzenböck, U; Wintersperger, A; Levak-Frank, S; Graier, W; Glatter, O; Fritz, G; Kostner, GM; Zechner, R
Lipoprotein lipase mediates the uptake of glycated LDL in fibroblasts, endothelial cells, and macrophages.
DIABETES 2001 50: 1643-1653.
Doi: 10.2337/diabetes.50.7.1643
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** Zechner, R; Strauss, J; Frank, S; Wagner, E; Hofmann, W; Kratky, D; Hiden, M; Levak-Frank, S
The role of lipoprotein lipase in adipose tissue development and metabolism.
Int J Obes Relat Metab Disord. 2000; 24 Suppl 4:S53-S56
Doi: 10.1038/sj.ijo.0801506
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** Levak-Frank, S; Hofmann, W; Weinstock, PH; Radner, H; Sattler, W; Breslow, JL; Zechner, R
Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels.
Proc Natl Acad Sci U S A. 1999; 96(6):3165-3170
Doi: 10.1073%2Fpnas.96.6.3165
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** Wang, X; Greilberger, J; Levak-Frank, S; Zimmermann, R; Zechner, R; Jürgens, G
Endogenously produced lipoprotein lipase enhances the binding and cell association of native, mildly oxidized and moderately oxidized low-density lipoprotein in mouse peritoneal macrophages.
Biochem J. 1999; 343 Pt 2(2-3):347-353
Doi: 10.1042%2F0264-6021%3A3430347
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** Zimmermann, R; Kostner, GM; Wintersberger, A; Levak-Frank, S; Panzenbuck, U; Zechner, R
Endogenously expressed lipoprotein lipase can mediate the uptake of glycated LDL in macrophages
CIRCULATION 1998 98: 663-663.
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** Hoefler, G; Noehammer, C; Levak-Frank, S; el-Shabrawi, Y; Schauer, S; Zechner, R; Radner, H
Muscle-specific overexpression of human lipoprotein lipase in mice causes increased intracellular free fatty acids and induction of peroxisomal enzymes.
Biochimie. 1997; 79(2-3):163-168
Doi: 10.1016%2FS0300-9084%2897%2981509-X
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** Levak-Frank, S; Weinstock, PH; Hayek, T; Verdery, R; Hofmann, W; Ramakrishnan, R; Sattler, W; Breslow, JL; Zechner, R
Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma.
J Biol Chem. 1997; 272(27):17182-17190
Doi: 10.1074%2Fjbc.272.27.17182
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** Panzenboeck, U; Wintersberger, A; Levak-Frank, S; Zimmermann, R; Zechner, R; Kostner, GM; Malle, E; Sattler, W
Implications of endogenous and exogenous lipoprotein lipase for the selective uptake of HDL3-associated cholesteryl esters by mouse peritoneal macrophages.
J Lipid Res. 1997; 38(2):239-253
Doi: 10.1016/S0022-2275(20)37437-X
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** Weinstock, PH; Levak-Frank, S; Hudgins, LC; Radner, H; Friedman, JM; Zechner, R; Breslow, JL
Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase.
Proc Natl Acad Sci U S A. 1997; 94(19):10261-10266
Doi: 10.1073%2Fpnas.94.19.10261
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** Wang, X; Greilberger, J; LevakFrank, S; Zechner, R; Jurgens, G
Effect of oxidative modification of low density lipoprotein on its binding to mouse peritoneal macrophages mediated by endogenous and exogenous lipoprotein lipase
ATHEROSCLEROSIS 1997 134: 228-228.
Doi: 10.1016/S0021-9150(97)89217-9
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** Sattler, W; Levak-Frank, S; Radner, H; Kostner, GM; Zechner, R
Muscle-specific overexpression of lipoprotein lipase in transgenic mice results in increased alpha-tocopherol levels in skeletal muscle.
Biochem J. 1996; 318 ( Pt 1)(6):15-19
Doi: 10.1042/bj3180015
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** LevakFrank, S; Hofmann, W; Weinstock, PH; Sattler, W; Breslow, JL; Zechner, R
A genetic model of lipoprotein lipase deficiency in skeletal muscle and adipose tissue.
CIRCULATION 1996 94: 2321-2321.
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** Weinstock, PH; LevakFrank, S; Radner, H; Bisgaier, CL; Hayek, T; Sheiffele, PJ; Zechner, R; Breslow, JL
Studies of lipid and energy metabolism in induced-mutant mice deficient in adipose tissue lipoprotein lipase
CIRCULATION 1996 94: 2322-2322.
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** Levak-Frank, S; Radner, H; Walsh, A; Stollberger, R; Knipping, G; Hoefler, G; Sattler, W; Weinstock, PH; Breslow, JL; Zechner, R
Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.
J Clin Invest. 1995; 96(2):976-986
Doi: 10.1172/JCI118145
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** Weinstock, PH; Bisgaier, CL; Aalto-Setälä, K; Radner, H; Ramakrishnan, R; Levak-Frank, S; Essenburg, AD; Zechner, R; Breslow, JL
Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.
J Clin Invest. 1995; 96(6):2555-2568
Doi: 10.1172/JCI118319
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** HOFMANN, W; LEVAKFRANK, S; WALSH, AM; KNIPPING, G; BRESLOW, JL; ZECHNER, R
TRANSGENIC MICE EXPRESSING HUMAN LIPOPROTEIN-LIPASE DRIVEN BY THE MOUSE LIPOPROTEIN-LIPASE PROMOTER
CIRCULATION 1995 92: 3046-3046.
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** LEVAKFRANK, S; JURITSCH, B; HOEFLER, G; WALSH, AM; BRESLOW, JL; ZECHNER, R
MYOPATHY AND PROLIFERATION OF MITOCHONDRIA AND PEROXISOMES CAUSED BY OVEREXPRESSION OF LIPOPROTEIN-LIPASE IN MUSCLE
CIRCULATION 1995 92: 3045-3045.
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