Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Holzer Herwig |
** = Publikationen gelistet in SCI/SSCI/Pubmed
2010
Originalarbeit (Zeitschrift)
** Krisper, P; Tiran, B; Fliser, D; Haditsch, B; Stadlbauer, V; Otto, R; Ernst, T; Kretschmer, U; Stauber, RE; Haller, H; Holzer, H; Manns, MP; Rifai, K
Efficacy and safety of anticoagulation with heparin versus heparin plus epoprostenol in patients undergoing extracorporeal liver support with prometheus.
Artif Organs. 2010; 34(1): 84-88.
Doi: 10.1111/j.1525-1594.2009.00793.x
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** Schneditz, D; Hafner-Giessauf, H; Holzer, H; Thomaseth, K
Intracorporeal glucose disposal during hemodialysis after a standardized glucose load.
ASAIO J. 2010; 56(3): 204-209.
Doi: 10.1097/MAT.0b013e3181ce1c9b
[OPEN ACCESS]
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** Schneditz, D; Hafner-Giessauf, H; Thomaseth, K; Bachler, I; Obermayer-Pietsch, B; Holzer, H
Insulinogenic index in non-diabetics during haemodialysis.
Nephrol Dial Transplant. 2010; 25(10): 3365-3372.
Doi: 10.1093/ndt/gfq204
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** van Gelder, T; Silva, HT; de Fijter, JW; Budde, K; Kuypers, D; Arns, W; Soulillou, JP; Kanellis, J; Zelvys, A; Ekberg, H; Holzer, H; Rostaing, L; Mamelok, RD
Renal Transplant Patients at High Risk of Acute Rejection Benefit From Adequate Exposure to Mycophenolic Acid
TRANSPLANTATION. 2010; 89(5): 595-599.
Doi: 10.1097/TP.0b013e3181ca7d84
[OPEN ACCESS]
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Originalarbeit (Konferenzband)
** Salvadori, M; Bertoni, E; Budde, K; Holzer, H; Civati, G; Lien, B; Arns, W
Superior efficacy of enteric-coated mycophenolate vs mycophenolate mofetil in de novo transplant recipients: pooled analysis.
Transplant Proc. 2010; 42(4):1325-1328
Doi: 10.1016/j.transproceed.2010.03.044
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2009
Originalarbeit (Zeitschrift)
** Fahrleitner-Pammer, A; Dobnig, H; Dimai, HP; Holzer, H; Benesch, T; Borchhardt, K; Cejka, D; Haas, M
The effect of RANKL and OPG on bone mineral density in pre-dialysis chronic renal failure.
Clin Nephrol. 2009; Volume 71(June): 652-659.
Doi: 10.5414/CNP71652
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** Sundl, I; Roob, JM; Meinitzer, A; Tiran, B; Khoschsorur, G; Haditsch, B; Holzer, H; Winklhofer-Roob, BM
Antioxidant status of patients on peritoneal dialysis: associations with inflammation and glycoxidative stress.
Perit Dial Int. 2009; 29(1): 89-101.
Doi: 10.1177/089686080902900113
[OPEN ACCESS]
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Fallbericht
** Kleinert, J; Kotanko, P; Spada, M; Pagliardini, S; Paschke, E; Paul, K; Voigtländer, T; Wallner, M; Kramar, R; Stummvoll, HK; Schwarz, C; Horn, S; Holzer, H; Födinger, M; Sunder-Plassmann, G
Anderson-Fabry disease: a case-finding study among male kidney transplant recipients in Austria.
Transpl Int. 2009; 22(3):287-292
Doi: 10.1111/j.1432-2277.2008.00791.x
(- Case Report)
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Abstract (Zeitschrift)
** Salvadori, M; Budde, K; Holzer, H; Arns, W; Civati, G; Lien, B
EC-MPS Is Associated with Superior Efficacy Outcomes Compared to MMF in De Novo Kidney Transplant Patients: A Pooled Analysis.
AM J TRANSPLANT. 2009; 9: 220-220.-9th Joint Meeting of the American-Society-of-Transplant-Surgeon/American-Society-of-Transplantation; MAY 30-JUN 03, 2009; Boston, MA.
[Oral Communication]
Web of Science
** Salvadori, M; Budde, K; Holzer, H; Civati, G; Lien, B; Arns, W
EC-MPS IS ASSOCIATED WITH SUPERIOR EFFICACY OUTCOMES COMPARED TO MMF IN DE NOVO KIDNEY TRANSPLANT PATIENTS: A POOLED ANALYSIS
TRANSPLANT INT. 2009; 22: 80-80.-14th Congress of the European Society for Organ Transplantation; AUG 30 - SEP 2, 2009; Paris, FRANCE.
[Poster]
Web of Science
2008
Originalarbeit (Zeitschrift)
** Wolf, IH; Wolf, P; Cerroni, L; Holzer, H; Kerl, H
Drug reactions - new observations.
J Dtsch Dermatol Ges. 2008; 6(6):508-509
Doi: 10.1111/j.1610-0387.2008.06634.x
(- Case Report)
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Abstract (Zeitschrift)
** Giessauf, H; Schneditz, D; Bachler, I; Obermayer-Pietsch, B; Holzer, H
Characteristics of glucose metabolism measured by an intra-dialytic glucose tolerance test.
WIEN KLIN WOCHENSCHR. 2008; 120(15-16):A55-A56.-39. Jahrestagung der Österreichischen Gesellschaft für Innere Medizin - ÖGIM; SEP 17-21, 2008; Graz, AUSTRIA.
[Poster]
Web of Science
Originalarbeit (Konferenzband)
** Fahrleitner-Pammer, A; Herberth, J; Browning, SR; Obermayer-Pietsch, B; Wirnsberger, G; Holzer, H; Dobnig, H; Malluche, HH
Bone Markers Predict Cardiovascular Events in Chronic Kidney Disease
J BONE MINER RES. 2008; 23(11): 1850-1858.
Doi: 10.1359/jbmr.080610
[Poster]
[OPEN ACCESS]
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Kommentar
** Zitta, S; Holzer, H; Reibnegger, G; Estelberger, W
Comment on 'Comparison between creatinine and cystatin C-based GFR equations in renal transplantation'.
Nephrol Dial Transplant. 2008; 23(5):1764; author reply 1765-1764; author reply 1765
Doi: 10.1093/ndt/gfm927
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2007
Originalarbeit (Zeitschrift)
** Stadlbauer, V; Krisper, P; Beuers, U; Haditsch, B; Schneditz, D; Jung, A; Putz-Bankuti, C; Holzer, H; Trauner, M; Stauber, RE
Removal of bile acids by two different extracorporeal liver support systems in acute-on-chronic liver failure.
ASAIO J. 2007; 53(2): 187-193.
Doi: 10.1097/01.mat.0000249852.71634.6c
[OPEN ACCESS]
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Abstract (Zeitschrift)
** Giessauf, H; Holzer, H; Obermayer-Pietsch, B; Bachler, I; Schneditz, D
Glucose uptake and elimination following an intradialytic glucose load.
NEPHROL DIALYSIS TRANSPLANT. 2007; 22: 365-365.-XLIV ERA-EDTA Congress; JUN 21-24, 2007; Barcelona, SPAIN.
[Poster]
Web of Science
** Haditsch, B; Krisper, P; Stauber, R; Mekaroonkamol, P; Holzer, H; Schneditz, D
Measurement of indocyanine green concentration and elimination in the extracorporeal circulation during hemodialysis and extracorpotreal liver support therapy.
NEPHROL DIALYSIS TRANSPLANT. 2007; 22: 122-122.-XLIV ERA-EDTA Congress; JUN 21-24, 2007; Barcelona, SPAIN.
[Poster]
Web of Science
** Wirnsberger, GH; Mauric, A; Worm, H; Roller-Wirnsberger, RE; Holzer, H
Improvement of renal graft function after conversion to everolimus in long-term transplanted patients
TRANSPLANT INT. 2007; 20: 255-255.
[Poster]
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Kommentar
** Zitta, S; Holzer, H; Reibnegger, G; Estelberger, W
Recalibration of population-based GFR formulae by pharmacokinetic methods.
Nephrol Dial Transplant. 2007; 22(2):665-665
Doi: 10.1093/ndt/gfl537
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2006
Originalarbeit (Zeitschrift)
** Herberth, J; Fahrleitner-Pammer, A; Obermayer-Pietsch, B; Krisper, P; Holzer, H; Malluche, HH; Dobnig, H
Changes in total parathyroid hormone (PTH), PTH-(1-84) and large C-PTH fragments in different stages of chronic kidney disease.
Clin Nephrol. 2006; 65(5):328-334
Doi: 10.5414/CNP65328
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** Jung, A; Krisper, P; Haditsch, B; Stauber, RE; Trauner, M; Holzer, H; Schneditz, D
Bilirubin kinetic modeling for quantification of extracorporeal liver support.
Blood Purif. 2006; 24(4):413-422
Doi: 10.1159/000094575
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** Salvadori, M; Holzer, H; Civati, G; Sollinger, H; Lien, B; Tomlanovich, S; Bertoni, E; Seifu, Y; Marrast, AC; ERL B301 Study Group
Long-term administration of enteric-coated mycophenolate sodium (EC-MPS; myfortic) is safe in kidney transplant patients.
Clin Nephrol. 2006; 66(2):112-119
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** Wimmer, J; Bachler, I; Haditsch, B; Stadlbauer, V; Holzer, H; Schneditz, D
Device and technique for extracorporeal blood volume sequestration during hemodialysis.
ASAIO J. 2006; 52(6): 662-669.
Doi: 10.1097/01.mat.0000235812.55055.5b
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Abstract (Zeitschrift)
** Haditsch, B; Wimmer, J; Bachler, I; Holzer, H; Schneditz, D
A sequestration test to examine individual blood pressure regulation during hemodialysis (HD).
INT J ARTIF ORGANS. 29: 528-528.-XXXIII Congress of the European Society for Artificial Organs (ESAO); JUNE 20-21, 2006; Umeå, SWEDEN.
[Poster]
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** Locatelli, F; Macario, F; Brink, HS; Dhaene, M; Pai, P; Holzer, H; Zani, V; Carter, D; Molemans, B; Reichel, H
The OPTIMA study: Efficacy of a cinacalcet (MIMPARA (R)/SENSIPAR (R)) treatment algorithm to treat dialysis patients with elevated PTH and calcium-phosphorus product (Ca x P)
NEPHROL DIALYSIS TRANSPLANT. 21: 133-134.
[Poster]
Web of Science
** Sundl, I; Roob, JM; Gruber, HJ; Khoschsorur, G; Holzer, H; Winklhofer-Roob, BM
Nuclear factor-kappa B activation in continuous ambulatory peritoneal dialysis compared to hemodialysis and hemodiafiltration
NEPHROL DIALYSIS TRANSPLANT. 2006; 21: 209-209.
[Poster]
Web of Science
** Sundl, I; Roob, JM; Tiran, B; Meinitzer, A; Khoschsorur, G; Haditsch, B; Holzer, H; Winklhofer-Roob, BM
Inverse relation between circulating interleukin 6 and plasma concentrations of the dietary carotenoid beta-cryptoxanthin in patients on continuous ambulatory peritoneal dialysis (CAPD)
NEPHROL DIALYSIS TRANSPLANT. 2006; 21: 503-503.
[Poster]
Web of Science
** Wimmer, J; Bachler, I; Haditsch, B; Stadlbauer, V; Holzer, H; Schneditz, D
Device and technique for extracorporeal blood volume sequestration during hemodialysis (HD)
INT J ARTIF ORGANS. 29: 525-525.-XXXIII Congress of the European Society for Artificial Organs (ESAO); JUNE 20-21, 2006; Umeå, SWEDEN.
[Oral Communication]
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** Winklhofer-Roob, BM; Sundl, I; Meinitzer, A; Khoschsorur, G; Haditsch, B; Tiran, B; Maritschnegg, M; Holzer, H; Roob, JM
Antioxidants, glycoxidation and lipid peroxidation in continuous ambulatory peritoneal dialysis (CAPD) compared to hemodialysis
FREE RADICAL RES. 2006; 40: S62-S62.
[Poster]
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** Winklhofer-Roob, BM; Sundl, I; Meinitzer, A; Khoschsorur, G; Haditsch, B; Tiran, B; Maritschnegg, M; Holzer, H; Roob, JM
Biomarkers of antioxidant status, glycoxidation and lipid peroxidation in patients on hemodialysis and continuous ambulatory peritoneal dialysis
NEPHROL DIALYSIS TRANSPLANT. 2006; 21: 206-207.
[Poster]
Web of Science
2005
Originalarbeit (Zeitschrift)
** Asmus, HG; Braun, J; Krause, R; Brunkhorst, R; Holzer, H; Schulz, W; Neumayer, HH; Raggi, P; Bommer, J
Two year comparison of sevelamer and calcium carbonate effects on cardiovascular calcification and bone density.
Nephrol Dial Transplant. 2005; 20(8):1653-1661
Doi: 10.1093/ndt/gfh894
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** Krisper, P; Haditsch, B; Stauber, R; Jung, A; Stadlbauer, V; Trauner, M; Holzer, H; Schneditz, D
In vivo quantification of liver dialysis: comparison of albumin dialysis and fractionated plasma separation.
J Hepatol. 2005; 43(3):451-457
Doi: 10.1016/j.jhep.2005.02.038
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** Raggi, P; James, G; Burke, SK; Bommer, J; Chasan-Taber, S; Holzer, H; Braun, J; Chertow, GM
Decrease in thoracic vertebral bone attenuation with calcium-based phosphate binders in hemodialysis.
J Bone Miner Res. 2005; 20(5):764-772
Doi: 10.1359/JBMR.041221
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Abstract (Zeitschrift)
** Cunningham, J; Urena, P; Reichel, H; Holzer, H; Drueke, T; Zani, V; Hutton, S; Turner, S; Braun, J
Long term efficacy of cinacalcet in secondary hyperparathyroidism (HPT) of end stage renal disease (ESRD)
NEPHROL DIALYSIS TRANSPLANT 2005 20: V89-V90.
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** Frazao, JM; Holzer, H; Stummvoll, HK; Bahner, U; Wilkie, M; Zani, V; Hutton, H; Motellon, JL; Braun, J
Cinacalcet (MIMPARA (R)/SENSIPAR (R)) maintains achievement of NKF-K/DOQI treatment targets for secondary hyperparathyroidism (HPT) in patients on dialysis
NEPHROL DIALYSIS TRANSPLANT 2005 20: V89-V89.
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** Haditsch, B; Roessler, A; Krisper, P; Holzer, H; Frisch, H; Waldhauser, F; Hinghofer-Szalkay, H
Adrenomedullin might be involved in the regulation of the hypoxic diuretic response
NEPHROL DIALYSIS TRANSPLANT. 2005; 20: V25-V26.-42nd Annual Meeting of the European-Renal-Association/European-Dialysis-and-Transplant-Association (ERA-EDTA); JUN 04-07, 2005; Istanbul, TURKEY.
[Poster]
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** Jung, A; Krisper, P; Haditsch, B; Trauner, M; Holzer, H; Schneditz, D
Two-compartment model for kinetics of conjugated bilirubin during extracorporeal liver support therapy
NEPHROL DIALYSIS TRANSPLANT. 2005; 20: -42nd Annual Meeting of the European-Renal-Association/European-Dialysis-and-Transplant-Association (ERA-EDTA); JUN 04-07, 2005; Istanbul, TURKEY.
Web of Science
** Krisper, P; Stadlbauer, V; Haditsch, B; Holzer, H; Trauner, M; Stauber, RE; Schneditz, D
The bilirubin/albumin ratio does not influence the clearance of conjugated bilirubin in extracorporeal liver support (ELS)
NEPHROL DIALYSIS TRANSPLANT. 2005; 20: V117-V117.-42nd Annual Meeting of the European-Renal-Association/European-Dialysis-and-Transplant-Association (ERA-EDTA); JUN 04-07, 2005; Istanbul, TURKEY.
Web of Science
2004
Originalarbeit (Zeitschrift)
** Braun, J; Asmus, HG; Holzer, H; Brunkhorst, R; Krause, R; Schulz, W; Neumayer, HH; Raggi, P; Bommer, J
Long-term comparison of a calcium-free phosphate binder and calcium carbonate--phosphorus metabolism and cardiovascular calcification.
Clin Nephrol. 2004; 62(2):104-115
Doi: 10.5414/CNP62104
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** Chertow, GM; Raggi, P; Chasan-Taber, S; Bommer, J; Holzer, H; Burke, SK
Determinants of progressive vascular calcification in haemodialysis patients.
Nephrol Dial Transplant. 2004; 19(6):1489-1496
Doi: 10.1093/ndt/gfh125
[OPEN ACCESS]
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** Salvadori, M; Holzer, H; de Mattos, A; Sollinger, H; Arns, W; Oppenheimer, F; Maca, J; Hall, M; The ERL B301 Study Groups
Enteric-coated mycophenolate sodium is therapeutically equivalent to mycophenolate mofetil in de novo renal transplant patients.
Am J Transplant. 2004; 4(2):231-236
Doi: 10.1046%2Fj.1600-6143.2003.00337.x
[OPEN ACCESS]
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** Worm, HC; Wirnsberger, GH; Mauric, A; Holzer, H
High prevalence of Chlamydia pneumoniae infection in cyclosporin A-induced post-transplant gingival overgrowth tissue and evidence for the possibility of persistent infection despite short-term treatment with azithromycin.
Nephrol Dial Transplant. 2004; 19(7):1890-1894
Doi: 10.1093/ndt/gfh095
[OPEN ACCESS]
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Abstract (Zeitschrift)
** Krisper, P; Stauber, R; Haditsch, B; Trauner, M; Holzer, H; Schneditz, D
Mars versus prometheus: Comparison of reduction ratios (RR) as a measure of treatment dose in two different liver detoxification devices
J HEPATOL. 2004; 40: 69-70.-39th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 14-18, 2004; Berlin, GERMANY.
Doi: 10.1016/S0168-8278(04)90216-4
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** Krisper, P; Stauber, R; Haditsch, B; Trauner, M; Holzer, H; Schneditz, D
MARS versus Prometheus: Comparison of clearances as a measure of efficiency in two different liver detoxification devices
GASTROENTEROLOGY. 2004; 126: A706 -A706 .
Web of Science
2003
Originalarbeit (Zeitschrift)
** Hessinger, M; Zitta, S; Holzer, H; Tiesenhausen, K
Dialock--an alternative to Permcath and access graft
Zentralbl Chir. 2003; 128(9):753-756
Doi: 10.1055/s-2003-42754
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** Krisper, P; Quehenberger, F; Schneditz, D; Holzer, H; Polaschegg, HD
Prediction of time-averaged concentration of haemoglobin in haemodialysis patients.
Nephrol Dial Transplant. 2003; 18(10):2082-2087
Doi: 10.1093/ndt/gfg355
[OPEN ACCESS]
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** Mayer, B; Zitta, S; Greilberger, J; Holzer, H; Reibnegger, G; Hermetter, A; Oettl, K
Effect of hemodialysis on the antioxidative properties of serum.
Biochim Biophys Acta. 2003; 1638(3):267-272
Doi: 10.1016/S0925-4439(03)00093-0
[OPEN ACCESS]
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Abstract (Zeitschrift)
** Bommer, J; Asmus, HG; Holzer, H; Brunkhorst, R; Krause, R; Schulz, W; Neumayer, HH; Raggi, P; Burke, S; Braun, J
Biochemical factors related to progressive vascular calcification in hemodialysis patients.
J AMER SOC NEPHROL 2003 14: 692A-692A.
Web of Science
** de Francisco, ALM; Suranyi, M; Cunningham, J; Messa, P; Locatelli, F; Evenepoel, P; Fournier, A; Gonzalez, MT; Urena, P; Holzer, H; Brink, HS; Johnson, D; Zani, V; Baker, N; Turner, SA; Drueke, T
Oral cinacalcet HCI (AMG 073) for the treatment of hemodialysis patients with secondary hyperparathyroidism (HPT): Results of a European/Australian-Phase 3 study.
J AMER SOC NEPHROL 2003 14: 461A-461A.
Web of Science
** Haditsch, B; Wabel, P; Krisper, P; Holzer, H; Schneditz, D
Cardiac output during hemodialysis.
J AMER SOC NEPHROL 2003 14: 487A-487A.
Web of Science
** Horina, JH; Roob, JM; Holzer, H; Horn, S; Krause, R
Combined therapy with amphotericin and caspofungin for aspergillus oryzae peritonitis in a continuous peritoneal dialysis patient.
J AMER SOC NEPHROL 2003 14: 863A-863A.
Web of Science
** Raggi, P; Burke, SK; Chasan-Taber, S; Blair, AT; Chertow, GM; Holzer, H; Bommer, J
The severity of coronary and aortic calcification is inversely related to trabecular bone density.
J AMER SOC NEPHROL 2003 14: 694A-694A.
Web of Science
** Raggi, P; Burke, SK; Chasan-Taber, S; Chertow, GM; Holzer, H; Bommer, J
Sevelamer preserves and calcium reduces trabecular bone mineral density.
J AMER SOC NEPHROL 2003 14: 502A-502A.
Web of Science
** Schneditz, D; Wimmer, J; Haditsch, B; Holzer, H
Measurement of systemic blood flow by slow infusion of ultra-pure dialysate during hemodialysis.
J AMER SOC NEPHROL 2003 14: 213A-213A.
Web of Science
** Wimmer, J; Haditsch, B; Holzer, H; Schneditz, D
Measurement of central blood volume by slow infusion of ultra-pure dialysate during hemodialysis.
J AMER SOC NEPHROL 2003 14: 851A-851A.
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Kommentar
** Zitta, S; Holzer, H; Estelberger, W; Reibnegger, G
Assessment of experimentally induced acute changes of renal haemodynamics.
Nephrol Dial Transplant. 2003; 18(5):1030; author reply 1030-1030; author reply 1031
Doi: 10.1093/ndt/gfg060
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2002
Originalarbeit (Zeitschrift)
** Domej, W; Tilz, GP; Földes-Papp, Z; Demel, U; Rabold, T; Holzer, H
Cystatin C of pleural effusion as a novel diagnostic aid in pleural diseases of different aetiologies.
Clin Sci (Lond). 2002; 102(3):373-380
Doi: 10.1042%2FCS20010168
[OPEN ACCESS]
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** Haas, M; Mayer, G; Wirnsberger, G; Holzer, H; Ratschek, M; Neyer, U; Neuweiler, J; Kramar, R; Schneider, B; Breiteneder-Geleff, S; Regele, HM; Hörl, WH; Kerjaschki, D
Antioxidant treatment of therapy-resistant idiopathic membranous nephropathy with probucol: a pilot study.
Wien Klin Wochenschr. 2002; 114(4):143-147
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** Hörl, WH; Holzer, H; Mayer, GJ; Osterreichische Aranesp Studiengruppe
Treatment of renal anemia with darbepoetin alfa: results of an Austrian multicenter study
Wien Klin Wochenschr. 2002; 114(23-24):967-971
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** Zitta, S; Estelberger, W; Holzer, H; Lipp, RW; Oettl, K; Reibnegger, G
Pitfalls of single-sample determination of renal clearance.
Nephrol Dial Transplant. 2002; 17(12):2239-2243
Doi: 10.1093/ndt/17.12.2239
[OPEN ACCESS]
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2001
Originalarbeit (Zeitschrift)
** Roob, JM; Rabold, T; Hayn, M; Khoschsorur, G; Resch, U; Holzer, H; Winklhofer-Roob, BM
Ex vivo low-density lipoprotein oxidizability and in vivo lipid peroxidation in patients on CAPD.
Kidney Int Suppl. 2001; 78(1):S128-S136
Doi: 10.1046/j.1523-1755.2001.59780128.x
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** Shipkova, M; Armstrong, VW; Kuypers, D; Perner, F; Fabrizi, V; Holzer, H; Wieland, E; Oellerich, M; MMF Creeping Creatinine Study Group
Effect of cyclosporine withdrawal on mycophenolic acid pharmacokinetics in kidney transplant recipients with deteriorating renal function: preliminary report.
Ther Drug Monit. 2001; 23(6):717-721
Doi: 10.1097%2F00007691-200112000-00020
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Abstract (Zeitschrift)
** Maier, R; Leitner, G; Zitta, S; Estelberger, W; Holzer, H; Klein, W
Good medicines for bad genes.
EUR HEART J. 2001; 22(7):523-525.- ;
Doi: 10.1053/euhj.2000.2448
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** Winklhofer-Roob, BM; Sitzwohl, B; Bergmann, AR; Waeg, G; Malle, E; Holzer, H; Roob, JM
Oxidative protein modifications in chronic peritoneal dialysis (CAPD) are induced by both 4-hydroxy-2,3-transnonenal and hypochlorite.
FREE RADICAL BIOL MED 2001 31: 275-275.
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Kommentar
** Zitta, S; Auprich, M; Holzer, H; Reibnegger, G
Cystatin C concentration and glomerular filtration rate.
Lancet. 2001; 357(9256):635-635
Doi: 10.1016/S0140-6736(05)71424-0
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2000
Originalarbeit (Zeitschrift)
** Krisper, P; Aschauer, M; Tiesenhausen, K; Leitner, G; Holzer, H; Schneditz, D
Access recirculation in a native fistula in spite of a seemingly adequate access flow.
Am J Kidney Dis. 2000; 35(3):529-532
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(- Case Report)
Web of Science
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** Roob, JM; Khoschsorur, G; Tiran, A; Horina, JH; Holzer, H; Winklhofer-Roob, BM
Vitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis.
J Am Soc Nephrol. 2000; 11(3):539-549
Doi: 10.1681/ASN.V113539
[OPEN ACCESS]
Web of Science
PubMed
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** Zitta, S; Stoschitzky, K; Zweiker, R; Lang, T; Holzer, H; Mayer, F; Reibnegger, G; Estelberger, W
Determination of renal reserve capacity by identification of kinetic systems
MATH COMPUT MODEL DYNAM SYST. 2000; 6: 190-207.
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Web of Science
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** Zitta, S; Stoschitzky, K; Zweiker, R; Oettl, K; Reibnegger, G; Holzer, H; Estelberger, W
Dynamic renal function testing by compartmental analysis: assessment of renal functional reserve in essential hypertension.
Nephrol Dial Transplant. 2000; 15(8):1162-1169
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[OPEN ACCESS]
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Abstract (Zeitschrift)
** Maier, R; Leitner, G; Lang, T; Holzer, H; Klein, W
Cardiac troponin T levels predict mortality in chronic haemodialysis patients
EUR HEART J 2000 21: 524-524.
Web of Science
** Maier, RM; Leitner, GC; Zitta, S; Holzer, H; Klein, WW
Cardiac troponin T: A diagnostic tool with prognostic implications in chronic hemodialysis patients
CIRCULATION 2000 102: 612-612.
Web of Science
** Roob, JM; Tiran, A; Khoschsorur, G; Holzer, H; Winklhofer-Roob, BM
Induction of interleukin-6 by IV iron during hemodialysis (HD) and attenuation by vitamin E and C.
FASEB J 2000 14: A485-A485.
Web of Science
** Zitta, S; Zweiker, R; Stoschitzky, K; Oettl, K; Reibnegger, G; Estelberger, W; Holzer, H
Effects of carvedilol and fosinopril on renal functional reserve and renal vascular resistance in essential hypertension
J HYPERTENSION 2000 18: S59-S59.
Doi: 10.1097/00004872-200006001-00198
Web of Science
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1999
Originalarbeit (Zeitschrift)
** Kostner, GM; Ibovnik, A; Holzer, H; Grillhofer, H
Preparation of a stable fresh frozen primary lipoproteina (Lpa) standard.
J Lipid Res. 1999; 40(12):2255-2263
Doi: 10.1016/S0022-2275(20)32100-3
[OPEN ACCESS]
Web of Science
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Kurzbericht/Letter
** Wirnsberger, GH; Bogiatzis, A; Holzer, H
Clinical impact of stained urine cytology for UTI diagnosis.
Clin Nephrol. 1999; 51(1):60-61
Web of Science
PubMed
** Wirnsberger, GH; Mauric, A; Holzer, H
Hyperimmune globulin prophylaxis for cytomegalovirus infection in renal transplantation.
Nephron. 1999; 81(3):368-369
Doi: 10.1159/000045315
Web of Science
PubMed
FullText
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** Wirnsberger, GH; Pfragner, R; Holzer, H
Chronic bacterial inflammation of the gum: the main risk factor for posttransplant gingival hyperplasia?
Clin Nephrol. 1999; 51(1):63-64
Web of Science
PubMed
Abstract (Zeitschrift)
** Roob, JM; Khoschsorur, G; Tiran, A; Holzer, H; Winklhofer-Roob, BM
Vitamin E plus vitamin C attenuate oxidant stress induced by IV iron in chronic hemodialysis (HD).
FASEB J 1999 13: A702-A702.
Web of Science
Kommentar
** Zitta, S; Holzer, H; Reibnegger, G; Estelberger, W
Renal haemodynamic responses to a chicken or beef meal in normal individuals.
Nephrol Dial Transplant. 1999; 14(3):794-795
Doi: 10.1093/ndt/14.3.794c
[OPEN ACCESS]
Web of Science
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1998
Originalarbeit (Zeitschrift)
** Horn, S; Holzer, H; Horina, J
Losartan and renal transplantation.
Lancet. 1998; 351(9096):111-111
Doi: 10.1016/S0140-6736(05)78150-2
(- Case Report)
Web of Science
PubMed
FullText
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** Khoschsorur, G; Auer, T; Lanzer, G; Petritsch, P; Holzer, H; Tscheliessnigg, KH
The determination of metabolite M17 and its meaning for immunosuppressive cyclosporin therapy.
Angiology. 1998; 49(4):307-314
Doi: 10.1177/000331979804900409
Web of Science
PubMed
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** Resch, B; Mache, CJ; Windhager, T; Holzer, H; Leitner, G; Müller, W
FK 506 and successful pregnancy in a patient after renal transplantation.
TRANSPLANT PROC 1998 30: 163-164.
Doi: 10.1016%2FS0041-1345%2897%2901220-7
(- Case Report)
Web of Science
PubMed
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** Wirnsberger, GH; Pfragner, R; Mauric, A; Zach, R; Bogiatzis, A; Holzer, H
Effect of antibiotic treatment with azithromycin on cyclosporine A-induced gingival hyperplasia among renal transplant recipients.
TRANSPLANT PROC. 1998; 30(5): 2117-2119.
Doi: 10.1016%2FS0041-1345%2898%2900558-2
Web of Science
PubMed
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** Wirnsberger, GH; Ratschek, M; Dimai, HP; Holzer, H; Mandal, AK
Post-transplantation lymphoproliferative disorder of the T-cell/B-cell type: an unusual manifestation in a renal allograft.
ONCOL REP. 1998; 6(1): 29-32.
(- Case Report)
Web of Science
PubMed
Abstract (Zeitschrift)
** Roob, JM; Rabold, T; Khoschsorur, G; Resch, U; Holzer, H; Winklhofer-Roob, BM
Lipid peroxidation and LDL oxidizability in patients on continuous ambulatory peritoneal dialysis (CAPD)
FASEB J 1998 12: A253-A253.
Web of Science
** Zitta, S; Holzer, H; Stoschitzky, K; Zweiker, R; Lang, T; Reibnegger, G; Estelbeger, W
Changes in dynamic renal function due to antihypertensive and antioxidative drugs.
CLIN PHARMACOL THER 1998 63: 237-237.
Web of Science
1997
Originalarbeit (Zeitschrift)
** Scharfetter, H; Wirnsberger, GH; Holzer, H; Hutten, H
Influence of ionic shifts during dialysis on volume estimations with multifrequency impedance analysis.
Med Biol Eng Comput. 1997; 35(2):96-102
Doi: 10.1007/BF02534137
Web of Science
PubMed
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Übersichtsarbeit
** Horn, S; Horina, JH; Krejs, GJ; Holzer, H; Ratschek, M
End-stage renal failure from mushroom poisoning with Cortinarius orellanus: report of four cases and review of the literature.
Am J Kidney Dis. 1997; 30(2):282-286
Doi: 10.1016/S0272-6386(97)90066-4
(- Case Report)
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Abstract (Zeitschrift)
** Horn, S; Gasser, R; Horn, E; Koppel, H; Klein, W; Holzer, H
Hypoxia induced vasodilation of renal and coronary arteries: The effect of K+-ATP-channel blockers.
J AMER SOC NEPHROL 1997 8: A1598-A1598.
Web of Science
** Krachler, M; Scharfetter, H; Wirnsberger, GH; Maxlmoser, W; Mandal, AK; Holzer, H; Irgolic, KJ
Kinetics of trace elements during hemodialysis.
J AMER SOC NEPHROL 1997 8: A1117-A1117.
Web of Science
** Wirnsberger, GH; Mandal, AK; Bogiatzis, A; Mauric, A; Holzer, H
Clinical impact of stained urine cytology for the diagnosis of urinary tract infections.
J AMER SOC NEPHROL 1997 8: A0712-A0712.
Web of Science
1996
Originalarbeit (Zeitschrift)
** Horn, S; Holzer, H; Horina, JH
Spontaneous bacterial peritonitis in a patient with nephrogenic ascites during an episode of acute renal transplant rejection.
Am J Kidney Dis. 1996; 27(3):441-443
Doi: 10.1016/S0272-6386(96)90371-6
(- Case Report)
Web of Science
PubMed
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** Lipp, RW; Wirnsberger, GH; Ratschek, M; Stepan, V; Holzer, H; Leb, G
The influence of vascular diathesis on the localization of inflammatory foci in renal allografts with a specific antigranulocyte antibody.
Eur J Nucl Med. 1996; 23(4):395-400
Doi: 10.1007/BF01247367
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** Preidler, KW; Szolar, D; Schreyer, H; Ebner, F; Kern, R; Holzer, H; Horina, JH
Differentiation of delayed kidney graft function with gadolinium-DTPA-enhanced magnetic resonance imaging and Doppler ultrasound.
Invest Radiol. 1996; 31(6):364-371
Doi: 10.1097%2F00004424-199606000-00009
Web of Science
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** Schneditz, D; Roob, JM; Vaclavik, M; Holzer, H; Kenner, T
Noninvasive measurement of blood volume in hemodialysis patients.
J Am Soc Nephrol. 1996; 7(8):1241-1244
Doi: 10.1681/ASN.V781241
[OPEN ACCESS]
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Kurzbericht/Letter
** Horina, JH; Horn, S; Holzer, H; Langmann, G
OKT3 monoclonal antibody therapy and visual loss.
Nephrol Dial Transplant. 1996; 11(7):1497-1498
Doi: 10.1093/ndt/11.7.1497a
[OPEN ACCESS]
Web of Science
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** Horn, S; Holzer, H; Horina, JH
Renal transplantation despite systemic viral infections.
Lancet. 1996; 347(9011):1341-1342
Doi: 10.1016/S0140-6736(96)90995-2
(- Case Report)
Web of Science
PubMed
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** Horn, S; Holzer, H; Horina, JH; Krejs, GJ
Allocation of kidneys for renal transplantation - Reply.
LANCET . 1996; 348(9021): 194-195.
Doi: 10.1016/S0140-6736(05)66138-7
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Abstract (Zeitschrift)
** Horina, JH; Preidler, K; Ebner, F; Horn, S; Holzer, H; Szolar, DH
Functional magnetic resonance imaging (MRI) of human renal allografts during the post-transplant period: Preliminary observations.
J AMER SOC NEPHROL 1996 7: A3326-A3326.
Web of Science
** Wirnsberger, GH; Mauric, A; BaumannHalwachs, G; Hasch, H; Holzer, H
Hyperimmune globulin prophylaxis for cytomegalovirus infection in renal transplantation: A randomized, controlled trial.
J AMER SOC NEPHROL 1996 7: A3399-A3399.
Web of Science
** Wirnsberger, GH; Mauric, A; Holzer, H
Is urine (immuno) cytochemistry a useful tool in the differential diagnosis of renal graft dysfunction?
J AMER SOC NEPHROL 1996 7: A3400-A3400.
Web of Science
1995
Originalarbeit (Zeitschrift)
** Estelberger, W; Petek, W; Zitta, S; Mauric, A; Horn, S; Holzer, H; Pogglitsch, H
Determination of the glomerular filtration rate by identification of sinistrin kinetics.
Eur J Clin Chem Clin Biochem. 1995; 33(4):201-209
Doi: 10.1515/cclm.1995.33.4.201
Web of Science
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** Estelberger, W; Zitta, S; Lang, T; Mayer, F; Mauric, A; Horn, S; Holzer, H; Petek, W; Riebnegger, G
System identification of the low-dose kinetics of p-aminohippuric acid.
Eur J Clin Chem Clin Biochem. 1995; 33(11):847-853
Doi: 10.1515/cclm.1995.33.11.847
Web of Science
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** Scharfetter, H; Wirnsberger, G; Hutten, H; Holzer, H
Development and critical evaluation of an improved comprehensive multicompartment model for the exchange processes during hemodialysis.
Biomed Tech (Berl). 1995; 40(3):54-63
Doi: 10.1515/bmte.1995.40.3.54
Web of Science
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** Smolle, KH; Kaufmann, P; Holzer, H; Druml, W
Intradialytic parenteral nutrition in malnourished patients on chronic haemodialysis therapy.
Nephrol Dial Transplant. 1995; 10(8):1411-1416
[OPEN ACCESS]
Web of Science
PubMed
Kurzbericht/Letter
** Horina, JH; Müllegger, RR; Horn, S; Holzer, H; Halwachs, G; Kerl, H; Wolf, P
Photopheresis for renal allograft rejection.
LANCET . 1995; 346(8966): 61-61.
Doi: 10.1016/S0140-6736(95)92696-8
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** Horn, S; Holzer, H; Gasser, R; Horina, JH
Severe rhabdomyolysis in a kidney-transplant recipient receiving intravenous nifedipine.
LANCET . 1995; 346(8978): 848-849.
Doi: 10.1016%2FS0140-6736%2895%2991668-7
(- Case Report)
Web of Science
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Abstract (Zeitschrift)
** HORINA, JH; BACHERNEGG, M; HORN, S; HOLZER, H; PILGER, E; STARK, G
DIRECT VASOPRESSOR EFFECT OF RECOMBINANT-HUMAN-ERYTHROPOIETIN (RH-EPO) ON THE CORONARY CIRCULATORY BED OF ISOLATED-PERFUSED GUINEA-PIG HEARTS
J AMER SOC NEPHROL 1995 6: 737-737.
Web of Science
** WIRNSBERGER, GH; MAURIC, A; HOLZER, H
TECHNICAL IMPROVEMENTS IN DIAGNOSTIC IMMUNOCYTOCHEMISTRY OF THE URINE SEDIMENT
J AMER SOC NEPHROL 1995 6: 1122-1122.
Web of Science
1994
Originalarbeit (Zeitschrift)
** Halwachs, G; Tiran, A; Reisinger, EC; Zach, R; Sabin, K; Fölsch, B; Lanzer, H; Holzer, H; Wilders-Truschnig, M
Serum levels of the soluble receptor for tumor necrosis factor in patients with renal disease.
Clin Investig. 1994; 72(6):473-476
Doi: 10.1007/BF00180527
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Abstract (Zeitschrift)
** DIMAI, HP; WIMSBERGER, GH; PORTA, S; HOLZER, H; LEB, G
A PHYSIOLOGICAL ORAL MAGNESIUM SUPPLEMENTATION AFFECTS SERUM LEVELS OF IONIZED MAGNESIUM AND INTACT PARATHYROID-HORMONE IN HEALTHY HUMANS
J AMER SOC NEPHROL. 1994; 5(3): 878-878.
Web of Science
1993
Originalarbeit (Zeitschrift)
** Halwachs, G; Zach, R; Pogglitsch, H; Holzer, H; Tiran, A; Iberer, F; Wasler, A; Tscheliessnigg, HP; Lanzer, G; Fölsch, B
A rapid immunocytochemical assay for CMV detection in peripheral blood of organ-transplanted patients in clinical practice.
Transplantation. 1993; 56(2):338-342
Doi: 10.1097/00007890-199308000-00016
Web of Science
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** Horina, JH; Hammer, HF; Reisinger, EC; Enzinger, GF; Holzer, H; Krejs, GJ
Spontaneous bacterial peritonitis in a hemodialysis patient with systemic lupus erythematosus.
Nephron. 1993; 65(4):633-635
Doi: 10.1159/000187577
(- Case Report)
Web of Science
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** Horina, JH; Schwaberger, G; Brussee, H; Sauseng-Fellegger, G; Holzer, H; Krejs, GJ
Increased red cell 2,3-diphosphoglycerate levels in haemodialysis patients treated with erythropoietin.
Nephrol Dial Transplant. 1993; 8(11):1219-1222
[OPEN ACCESS]
Web of Science
PubMed
** Horina, JH; Wirnsberger, G; Horn, S; Roob, JM; Ratschek, M; Holzer, H; Pogglitsch, H; Krejs, GJ
Long-term follow-up of a patient with lecithin cholesterol acyltransferase deficiency syndrome after kidney transplantation.
Transplantation. 1993; 56(1):233-236
Doi: 10.1097/00007890-199307000-00048
(- Case Report)
Web of Science
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** Horina, JH; Wirnsberger, GH; Kenner, L; Holzer, H; Krejs, GJ
Increased susceptibility for CsA-induced hepatotoxicity in kidney graft recipients with chronic viral hepatitis C.
Transplantation. 1993; 56(5):1091-1094
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Web of Science
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1992
Kurzbericht/Letter
** Horina, JH; Holzer, H; Reisinger, EC; Krejs, GJ; Neugebauer, JS
Elderly patients and chronic haemodialysis.
Lancet. 1992; 339(8786):183-183
Doi: 10.1016/0140-6736(92)90251-W
(- Case Report)
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1991
Originalarbeit (Zeitschrift)
** Zach, R; Roob, JM; Horn, S; Kaufmann, P; Winkler, HM; Holzer, H; Tilz, GP; Pogglitsch, H
Clinical experiences with Wegener's granulomatosis from the nephrologic viewpoint
WIEN KLIN WOCHENSCHR. 1991; 103(17): 528-532.
Web of Science
PubMed
Kurzbericht/Letter
** Horina, JH; Horn, S; Holzer, H; Petritsch, P; Pogglitsch, H
Transient glycosuria and aminoaciduria in successful transplantation of infant kidneys to adults.
LANCET . 1991; 338(8771): 894-894.
Doi: 10.1016/0140-6736(91)91559-D
(- Case Report)
Web of Science
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Übersichtsarbeit
** Kaufmann, P; Smolle, K; Winkler, H; Zach, R; Holzer, H; Mausser, G
Special problems of nutrition therapy in patients with terminal kidney insufficiency with chronic ambulatory hemodialysis
Wien Med Wochenschr. 1991; 141(4): 86-88.
Web of Science
PubMed
1990
Kurzbericht/Note
** Zitta, S; Holzer, H; Zech, K; Thieme, G; Wurst, W; Dietzel, K; Taucher, J
Pharmacokinetics of urapidil in patients with impaired renal function.
Drugs. 1990; 40 Suppl 4(8822):67-68
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1988
Originalarbeit (Zeitschrift)
** POGGLITSCH, H; PETEK, W; ESTELBERGER, W; ZIAK, E; WINKLER, HM; HOLZER, H
INTESTINAL PHOSPHATE BINDING BY CALCIUM LACTATE IN DIALYSIS PATIENTS
NIEREN HOCHDRUCK. 1988; 17: 66-71.
Web of Science
1986
Originalarbeit (Zeitschrift)
** Smolle, KH; Holzer, H
Acute management of poisonings
WIEN MED WOCHENSCHR. 1986; 136(5-6): 137-142.
(- Case Report)
Web of Science
PubMed
1985
Originalarbeit (Zeitschrift)
** Pogglitsch, H; Petek, W; Ziak, E; Sterz, F; Holzer, H
Phosphorus kinetics during haemodialysis and haemofiltration.
Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985; 21(3-4):461-468
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1982
Originalarbeit (Zeitschrift)
** KATSCHNIG, H; SIXL, B; GELL, G; POGGLITSCH, H; HOLZER, H; KORTHALS, C; SMOLLE, H
BACTERIOLOGIC SPECTRUM AND RESISTANCE OF URINARY BACTERIA ISOLATED FROM PATIENTS OF THE MEDICAL-UNIVERSITY-CLINIC-GRAZ IN THE PERIOD BETWEEN 1976 AND 1980
NIEREN HOCHDRUCK. 1982; 11: 166-172.
Web of Science
** Ladurner, G; Wawschinek, O; Pogglitsch, H; Petek, W; Urlesberger, H; Holzer, H
Neurophysiological findings and serum aluminium in dialysis encephalopathy.
EUR NEUROL. 1982; 21(5): 335-339.
Doi: 10.1159/000115500
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** WAWSCHINEK, O; PETEK, W; LANG, J; POGGLITSCH, H; HOLZER, H
THE DETERMINATION OF ALUMINUM IN HUMAN-PLASMA
MIKROCHIM ACTA 1982 1: 335-339.
Doi: 10.1007/BF01197113
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1981
Originalarbeit (Zeitschrift)
** BRANDT, D; POGGLISCH, H; HARPF, H; HOLZER, H; KLEIN, W
ULTRAFILTRATION IN THE THERAPY OF SEVERE CONGESTIVE HEART-FAILURE
HERZ KREISLAUF. 1981; 13: 30-32.
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** Holzer, H; Marguc, K; Pogglitsch, H; Ott, E; Katschnig, H
The effects of haemodialysis on cerebral blood flow.
Proc Eur Dial Transplant Assoc. 1981; 18(6):126-132
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** HOLZER, H; POGGLITSCH, H; KATSCHNIG, H; KORTHALS, C
TREATMENT OF HYPERTENSION CRISES USING A SINGLE SUBSTANCE WITH ALPHA-BLOCKING AND BETA-BLOCKING PROPERTIES (LABETALOL)
WIEN MED WOCHENSCHR. 1981; 131: 10-13.
Web of Science
** Ladurner, G; Holzer, H; Wawschinek, O; Pogglitsch, H; Petek, W
The importance of aluminiun in dialyseencephalopathie (author's transl)
FORTSCHR NEUROL PSYCHIAT. 1981; 49(5): 211-213.
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1980
Originalarbeit (Zeitschrift)
** Hinghofer-Szalkay, H; Leopold, H; Kenner, T; Holzer, H
On the coefficient of thermal expansion of blood and its constituents (author's transl)
Biomed Tech (Berl). 1980; 25(6):151-157
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** Jaske, R; Holzer, H; Popper, H
Fatty neck. Symmetrical lipomatosis with Madelung's symptom (author's transl)
LARYNGOL RHINOL OTOL VER MONA. 1980; 59(11): 749-758.
Doi: 10.1055/s-2007-1008924
(- Case Report)
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PubMed
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** Moser, M; Hinghofer-Szalkay, H; Kenner, T; Holzer, H
Measurement of the colloid osmotic pressure from plasma density by means of the mechanical oscillator technique (author's transl)
J Clin Chem Clin Biochem. 1980; 18(4):233-236
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** Pogglitsch, H; Katschnigg, H; Holzer, H; Pristautz, H; Korthals, C
Differentiation of primary acute and primary chronic interstitial nephritis according to etiological aspects (author's transl)
WIEN MED WOCHENSCHR. 1980; 130(24): 794-798.
Web of Science
PubMed
1979
Originalarbeit (Zeitschrift)
** Hinghofer-Szalkay, H; Kenner, T; Leopold, H; Holzer, H
Application of the mechanical oscillator technique for the measurement of blood density and hematocrit (author's transl)
Klin Wochenschr. 1979; 57(21):1163-1167
Doi: 10.1007/BF01491756
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** Holzer, H; Pogglitsch, H; Hinghofer-Szalkay, H; Kenner, T; Leopold, H; Passath, A
Continuous determination of the blood density during haemodialysis (author's transl)
Wien Klin Wochenschr. 1979; 91(22):762-765
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Abstract (Zeitschrift)
** HINGHOFERSZALKAY, H; KENNER, T; MOSER, M; HOLZER, H; LEOPOLD, H
USE OF THE MECHANICAL OSCILLATOR TECHNIQUE FOR THE ASSESSMENT OF THE CORRELATION BETWEEN DENSITY AND PHYSICOCHEMICAL PROPERTIES OF BLOOD-CONSTITUENTS
MICROVASCULAR RES. 1979; 17(3): S112-S112.
Web of Science
1978
Originalarbeit (Zeitschrift)
** Leopold, H; Hinghofer-Szalkay, H; Kenner, T; Holzer, H
Rapid determination of the sedimentation rate of blood free from the influence of gravity (author's transl)
Biomed Tech (Berl). 1978; 23(5): 99-103.
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Abstract (Zeitschrift)
** HINGHOFERSZALKAY, H; KENNER, T; LEOPOLD, H; HOLZER, H
OBSERVATION OF BLOOD SEDIMENTATION IN A MECHANICAL OSCILLATOR
PFLUGERS ARCH-EUR J PHYSIOL. 1978; R41-R41.
Web of Science
** MOSER, M; KENNER, T; HINGHOFERSZALKAY, H; HOLZER, H; LEOPOLD, H
RELATION BETWEEN COLLOID OSMOTIC-PRESSURE (COP), PLASMA-DENSITY (PD) AND CAPILLARY FLUID EXCHANGE
PFLUGERS ARCH-EUR J PHYSIOL. 1978; 377: R12-R12.
Web of Science