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Denk Helmut |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2024

Originalarbeit (Zeitschrift)

** Denk, H; Abuja, PM; Zatloukal, K Mallory-Denk bodies and hepatocellular senescence: a causal relationship?
Virchows Arch. 2024; Doi: 10.1007/s00428-024-03748-1 [OPEN ACCESS]
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** Fromme, M; Hamesch, K; Schneider, CV; Mandorfer, M; Pons, M; Thorhauge, KH; Pereira, V; Sperl, J; Frankova, S; Reichert, MC; Benini, F; Burbaum, B; Kleinjans, M; Amzou, S; Rademacher, L; Bewersdorf, L; Verbeek, J; Nevens, F; Genesca, J; Miravitlles, M; Nuñez, A; Schaefer, B; Zoller, H; Janciauskiene, S; Waern, J; Oliveira, A; Maia, L; Simões, C; Mahadeva, R; Fraughen, DD; Trauner, M; Krag, A; Lammert, F; Bals, R; Gaisa, NT; Aigner, E; Griffiths, WJ; Denk, H; Teumer, A; McElvaney, NG; Turner, AM; Trautwein, C; Strnad, P Alpha-1 Antitrypsin Augmentation and the Liver Phenotype of Adults With Alpha-1 Antitrypsin Deficiency (Genotype Pi∗ZZ).
Clin Gastroenterol Hepatol. 2024; 22(2):283-294.e5 Doi: 10.1016/j.cgh.2023.08.038
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2023

Kurzbericht/Letter

** Fickert, P; Lin, AC; Ritschl, H; Hammer, N; Denk, H Portal venous branches as an anatomic railroad for a gut-bile duct-axis.
J Hepatol. 2023; 79(2):e82-e84 Doi: 10.1016/j.jhep.2023.03.043
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2022

Originalarbeit (Zeitschrift)

** Denk, H; Pabst, D; Abuja, PM; Reihs, R; Tessaro, B; Zatloukal, K; Lackner, C Senescence markers in focal nodular hyperplasia of the liver: pathogenic considerations on the basis of immunohistochemical results.
Mod Pathol. 2022; 35(1):87-95 Doi: 10.1038/s41379-021-00940-5
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** Langford, CR; Goldinger, MH; Treanor, D; McGenity, C; Dillman, JR; Allende, DS; Goldin, R; Brunt, EM; Zatloukal, K; Denk, H; Fleming, KA Improved pathology reporting in NAFLD/NASH for clinical trials.
J Clin Pathol. 2022; 75(2):73-75 Doi: 10.1136/jclinpath-2021-207967 [OPEN ACCESS]
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2021

Originalarbeit (Zeitschrift)

** Abuja, PM; Zatloukal, K; Denk, H Priming, Triggering, Adaptation and Senescence (PTAS): A Hypothesis for a Common Damage Mechanism of Steatohepatitis.
Int J Mol Sci. 2021; 22(22): Doi: 10.3390/ijms222212545 [OPEN ACCESS]
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** Geier, A; Tiniakos, D; Denk, H; Trauner, M From the origin of NASH to the future of metabolic fatty liver disease
GUT. 2021; 70(8): 1570-1579. Doi: 10.1136/gutjnl-2020-323202 [OPEN ACCESS]
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** Lackner, C; Stauber, RE; Davies, S; Denk, H; Dienes, HP; Gnemmi, V; Guido, M; Miquel, R; Paradis, V; Schirmacher, P; Terracciano, L; Berghold, A; Pregartner, G; Binder, L; Douschan, P; Rainer, F; Sygulla, S; Jager, M; Rautou, PE; Bumbu, A; Horhat, A; Rusu, I; Stefanescu, H; Detlefsen, S; Krag, A; Thiele, M; Cortez-Pinto, H; Moreno, C; Gouw, ASH; Tiniakos, DG Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease.
J Hepatol. 2021; 75(4):810-819 Doi: 10.1016/j.jhep.2021.05.029
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** Somlapura, M; Gottschalk, B; Lahiri, P; Kufferath, I; Pabst, D; Rülicke, T; Graier, WF; Denk, H; Zatloukal, K Different Roles of p62 (SQSTM1) Isoforms in Keratin-Related Protein Aggregation.
Int J Mol Sci. 2021; 22(12): Doi: 10.3390/ijms22126227 [OPEN ACCESS]
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** Torbenson, M; Desmet, V; Denk, H; Callea, F; Burt, AD; Hübscher, SG; Terracciano, L; Dienes, HP; Goodman, ZD; Bedossa, P; Wanless, IR; Roberts, EA; Brunt, EM; Clouston, AD; Gouw, ASH; Kleiner, D; Schirmacher, P; Tiniakos, D Fifty years of impact on liver pathology: a history of the Gnomes.
Virchows Arch. 2021; 478(2):191-200 Doi: 10.1007/s00428-020-02879-5 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Stefanescu, H; Jager, M; Pe, R; Horhat, A; Susan, D; Denk, H; Dienes, HP; Gnemmi, V; Guido, M; Miquel, R; Paradis, V; Rusu, I; Schirmacher, P; Terracciano, LM; Stauber, RE; Gouw, A; Tiniakos, D; Lackner, C Histological lesions can predict response to corticosteroids in patients with severe alcohol-related steatohepatitis
J HEPATOL. 2021; 75: S318-S318. [Poster]
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2020

Originalarbeit (Zeitschrift)

** Schneider, CV; Hamesch, K; Gross, A; Mandorfer, M; Moeller, LS; Pereira, V; Pons, M; Kuca, P; Reichert, MC; Benini, F; Burbaum, B; Voss, J; Gutberlet, M; Woditsch, V; Lindhauer, C; Fromme, M; Kümpers, J; Bewersdorf, L; Schaefer, B; Eslam, M; Bals, R; Janciauskiene, S; Carvão, J; Neureiter, D; Zhou, B; Wöran, K; Bantel, H; Geier, A; Dirrichs, T; Stickel, F; Teumer, A; Verbeek, J; Nevens, F; Govaere, O; Krawczyk, M; Roskams, T; Haybaeck, J; Lurje, G; Chorostowska-Wynimko, J; Genesca, J; Reiberger, T; Lammert, F; Krag, A; George, J; Anstee, QM; Trauner, M; Datz, C; Gaisa, NT; Denk, H; Trautwein, C; Aigner, E; Strnad, P; European Alpha-1 Liver Study Group Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers.
Gastroenterology. 2020; 159(2):534-548 Doi: 10.1053/j.gastro.2020.04.058 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Burbaum, B; Schneider, C; Hamesch, K; Fromme, M; Mandorfer, M; Reichert, M; Arslanow, A; Woditsch, V; Bals, R; Pereira, V; Carvao, J; Lammert, F; Trauner, M; Krag, A; Denk, H; Trautwein, C; Strnad, P European Study: Heterozygous Alpha-1-Antitrypsin Deficiency (Pi*MZ) genetic Risk Factor for Hepatopathy.
INTERNIST. Abstracts zum 126. Kongress der Deutschen Gesellschaft für Innere Medizin e.V.. 2020; 61(SUPPL 1):S5-S6.-126. Kongress der Deutschen Gesellschaft für Innere Medizin e.V.; APR 25-28, 2020; Wiesbaden, GERMANY. [Poster]
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2019

Übersichtsarbeit

** Denk, H; Abuja, PM; Zatloukal, K Animal models of NAFLD from the pathologist's point of view.
Biochim Biophys Acta Mol Basis Dis. 2019; 1865(5):929-942 Doi: 10.1016/j.bbadis.2018.04.024 [OPEN ACCESS]
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** Denk, H; Stumptner, C; Abuja, PM; Zatloukal, K Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma.
Expert Opin Ther Targets. 2019; 23(5):393-406 Doi: 10.1080/14728222.2019.1601703
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** Holzinger, A; Langs, G; Denk, H; Zatloukal, K; Muller, H Causability and explainability of artificial intelligence in medicine
WIRES DATA MIN KNOWL. 2019; 9(4): e1312 Doi: 10.1002/widm.1312 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Schneider, CV; Hamesch, K; Fromme, M; Mandorfer, M; Reichert, M; Arslanow, A; Woditsch, V; Gutberlet, M; Neureiter, D; Bals, R; Pereira, V; Carvao, J; Lammert, F; Trauner, MH; Aigner, E; Denk, H; Trautwein, C; Strnad, P PATIENTS WITH HETEROZYGOUS alpha1-ANTITRYPSIN DEFICIENCY (PI*MZ) DISPLAY INCREASED LIVER STIFFNESS, ELEVATED LIVER ENZYMES AND OCCASIONALLY INCLUSION BODIES (EUROPEAN MULTI-CENTER STUDY)
HEPATOLOGY. 2019; 70: 101A-102A.-Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting; NOV 08-12, 2019; Boston, MA. [Oral Communication]
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Kommentar

** Kümpers, J; Fromme, M; Schneider, CV; Trautwein, C; Denk, H; Hamesch, K; Strnad, P Assessment of liver phenotype in adults with severe alpha-1 antitrypsin deficiency (Pi*ZZ genotype).
J Hepatol. 2019; 71(6):1272-1274 Doi: 10.1016/j.jhep.2019.08.011 [OPEN ACCESS]
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2018

Originalarbeit (Zeitschrift)

** Nikam, A; Patankar, JV; Somlapura, M; Lahiri, P; Sachdev, V; Kratky, D; Denk, H; Zatloukal, K; Abuja, PM The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity.
Sci Rep. 2018; 8(1): 12964-12964. Doi: 10.1038/s41598-018-31389-3 [OPEN ACCESS]
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News-Item

** Denk, H [Gerhard Korb : 9 February 1929-24 December 2017].
Pathologe. 2018; 39(Suppl 2):352-352 Doi: 10.1007/s00292-018-0556-1 [OPEN ACCESS]
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2017

Originalarbeit (Zeitschrift)

** Aigelsreiter, A; Neumann, J; Pichler, M; Halasz, J; Zatloukal, K; Berghold, A; Douschan, P; Rainer, F; Stauber, R; Haybaeck, J; Denk, H; Lackner, C Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis.
Liver Int. 2017; 37(4):600-610 Doi: 10.1111/liv.13325
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2014

Originalarbeit (Zeitschrift)

** Kucukoglu, O; Guldiken, N; Chen, Y; Usachov, V; El-Heliebi, A; Haybaeck, J; Denk, H; Trautwein, C; Strnad, P High-fat diet triggers Mallory-Denk body formation through misfolding and crosslinking of excess keratin 8.
Hepatology. 2014; 60(1):169-178 Doi: 10.1002/hep.27068 [OPEN ACCESS]
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** Quan, P; Moinfar, F; Kufferath, I; Absenger, M; Kueznik, T; Denk, H; Zatloukal, K; Haybaeck, J Effects of targeting endometrial stromal sarcoma cells via histone deacetylase and PI3K/AKT/mTOR signaling.
Anticancer Res. 2014; 34(6):2883-2897
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Abstract (Zeitschrift)

** Quan, P; Moinfar, F; Kufferath, I; Absenger, M; Kueznik, T; Denk, H; Zatloukal, K; Haybaeck, J Targeting Endometrial Stromal Sarcoma Cells Via Histone Deacetylase and the PI3K/AKT/mTOR Pathway
Anticancer Research. 2014; 34(10):5943-5943.-9th International Conference of Anticancer Research; OCT 6-10, 2014; Sithonia, Greece. [Poster]
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2013

Originalarbeit (Zeitschrift)

** Fickert, P; Krones, E; Pollheimer, MJ; Thueringer, A; Moustafa, T; Silbert, D; Halilbasic, E; Yang, M; Jaeschke, H; Stokman, G; Wells, RG; Eller, K; Rosenkranz, AR; Eggertsen, G; Wagner, CA; Langner, C; Denk, H; Trauner, M Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice.
Hepatology. 2013; 58(6):2056-2069 Doi: 10.1002/hep.26599 [OPEN ACCESS]
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** Fickert, P; Pollheimer, MJ; Silbert, D; Moustafa, T; Halilbasic, E; Krones, E; Durchschein, F; Thüringer, A; Zollner, G; Denk, H; Trauner, M Differential effects of norUDCA and UDCA in obstructive cholestasis in mice.
J Hepatol. 2013; 58(6):1201-1208 Doi: 10.1016/j.jhep.2013.01.026 [OPEN ACCESS]
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Übersichtsarbeit

** Strnad, P; Nuraldeen, R; Guldiken, N; Hartmann, D; Mahajan, V; Denk, H; Haybaeck, J Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models.
Compr Physiol. 2013; 3(4):1393-1436 Doi: 10.1002/cphy.c120032
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2012

Originalarbeit (Zeitschrift)

** Haybaeck, J; Stumptner, C; Thueringer, A; Kolbe, T; Magin, TM; Hesse, M; Fickert, P; Tsybrovskyy, O; Müller, H; Trauner, M; Zatloukal, K; Denk, H Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.
Lab Invest. 2012; 92(6):857-867 Doi: 10.1038/labinvest.2012.49 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Aigelsreiter, A; Neumann, J; Pichler, M; Halasz, J; Zatloukal, K; Berghold, A; Lederer, E; Hayback, J; Denk, H; Lackner, C Prognostic relevance of Mallory-Denk and intracytoplasmic hyaline bodies in hepatocellular carcinoma
HEPATOLOGY. 2012; 56: 474A-475A.-63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); NOV 09-13, 2012; Boston, MA. [Poster]
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** Aigelsreiter, A; Neumann, J; Pichler, M; Halasz, J; Zatloukal, K; Berghold, A; Lederer, E; Haybaeck, J; Denk, H; Lackner, C PROGNOSTIC RELEVANCE OF MALLORY-DENK BODIES AND INTRACELLULAR HYALINE BODIES IN HEPATOCELLULAR CARCINOMA
J HEPATOL. 2012; 56: S287-S287. Doi: 10.1016/S0168-8278(12)60741-7 [Oral Communication]
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** Bettermann, K; Mehta, AK; Lederer, E; Diwoky, C; Thuringer, A; Muller, H; Mahajan, VS; Stumptner, C; Kolbe, T; Magin, TM; Denk, H; Lackner, C; Zatloukal, K; Haybaeck, J; Steatohepatitis-driven hepatocellular carcinoma.
INT J MOL MED. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE30: S6-S6. ATHENS: SPANDIDOS PUBL LTD; [Oral Communication]
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** Quan, P; Lederer, E; Halbwedl, I; Denk, H; Zatloukal, K; Haybaeck, J; Targeting endometrial stromal sarcoma: Histone deacetylase and PI3K/Akt/mTOR signaling.
VIRCHOWS ARCHIV. VIRCHOWS ARCHIV461: S31-S31. NEW YORK: SPRINGER; [Oral Communication]
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2011

Originalarbeit (Zeitschrift)

** Denk, H What is expected from the pathologist in the diagnosis of viral hepatitis?
Virchows Arch. 2011; 458(4):377-392 Doi: 10.1007/s00428-011-1057-2
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** Kireva, T; Erhardt, A; Tiegs, G; Tilg, H; Denk, H; Haybaeck, J; Aigner, E; Moschen, A; Distler, JH; Schett, G; Zwerina, J Transcription factor Fra-1 induces cholangitis and liver fibrosis.
Hepatology. 2011; 53(4):1259-1269 Doi: 10.1002/hep.24175 [OPEN ACCESS]
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** Mahajan, V; Klingstedt, T; Simon, R; Nilsson, KP; Thueringer, A; Kashofer, K; Haybaeck, J; Denk, H; Abuja, PM; Zatloukal, K Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions.
Gastroenterology. 2011; 141(3):1080-1090.e1-1080-1090.e7 Doi: 10.1053/j.gastro.2011.05.039
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Übersichtsarbeit

** Tannapfel, A; Denk, H; Dienes, HP; Langner, C; Schirmacher, P; Trauner, M; Flott-Rahmel, B Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease.
Virchows Arch. 2011; 458(5): 511-523. Doi: 10.1007/s00428-011-1066-1 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Fickert, P; Silbert, D; Moustafa, T; Halilbasic, E; Krones, E; Durchschein, F; Thueringer, A; Pollheimer, MJ; Zollner, G; Denk, H; Trauner, M DIFFERENTIAL EFFECTS OF NORUDCA AND UDCA IN OBSTRUCTIVE CHOLESTASIS IN MICE
HEPATOLOGY. 2011; 54: 775A-775A.-62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); NOV 04-08, 2011; San Francisco, CA. [Poster]
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** Fickert, P; Thueringer, A; Moustafa, T; Silbert, D; Yang, M; Jaeschke, H; Stokman, G; Wells, R; Eller, K; Rosenkranz, AR; Eggertsen, G; Denk, H; Trauner, M TUBULOINTERSTITIAL KIDNEY FIBROSIS AND CHRONIC RENAL FAILURE IN LONG-TERM COMMON BILE-DUCT-LIGATED MICE AS A RESULT OF COLLECTING DUCT INJURY: THE ROLE OF OSTEOPONTIN, FXR, AND CYP8B1
HEPATOLOGY. 2011; 54: 1250A-1251A.-62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); NOV 04-08, 2011; San Francisco, CA.
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** Fickert, P; Thueringer, A; Moustafa, T; Yang, M; Jaeschke, H; Wells, RG; Stokman, G; Denk, H; Trauner, M LONG-TERM COMMON BILE DUCT-LIGATION IN MICE INDUCES TUBULOINTERSTITIAL KIDNEY FIBROSIS AND CHRONIC RENAL FAILURE: ROLE OF BILE ACID NUCLEAR RECEPTOR FXR AND OSTEOPONTIN
J HEPATOL. 2011; 54: S244-S244.-46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL); 2011; Berlin, GERMANY. Doi: 10.1016/S0168-8278(11)60602-8
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2010

Originalarbeit (Zeitschrift)

** Fickert, P; Thueringer, A; Moustafa, T; Silbert, D; Gumhold, J; Tsybrovskyy, O; Lebofsky, M; Jaeschke, H; Denk, H; Trauner, M The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice.
Lab Invest. 2010; 90(6):844-852 Doi: 10.1038/labinvest.2010.61 [OPEN ACCESS]
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** Hrzenjak, A; Moinfar, F; Kremser, ML; Strohmeier, B; Petru, E; Zatloukal, K; Denk, H Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo.
Mol Cancer. 2010; 9(10): 49-49. Doi: 10.1186/1476-4598-9-49 [OPEN ACCESS]
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** Tannapfel, A; Denk, H; Dienes, HP; Langner, C; Schirmacher, P; Trauner, M; Flott-Rahmel, B Histopathological diagnose of non-alcoholic and alcoholic fatty liver disease.
Z Gastroenterol. 2010; 48(4): 486-498. Doi: 10.1055/s-0029-1245278
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Übersichtsarbeit

** Tannapfel, A; Denk, H; Dienes, HP; Langner, C; Schirmacher, P; Trauner, M; Flott-Rahmel, B Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease. Grade 2 consensus-based guidelines.
Pathologe. 2010; 31(3): 225-237. Doi: 10.1007/s00292-010-1274-5
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Abstract (Zeitschrift)

** Hrzenjak, A; Moinfar, F; Kremser, ML; Strohmeier, B; Petru, E; Zatloukal, K; Denk, H Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
EJC SUPPL. 2010; 8(5): 248 Doi: 10.1016/S1359-6349(10)71055-7
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2009

Originalarbeit (Zeitschrift)

** Aigelsreiter, A; Janig, E; Sostaric, J; Pichler, M; Unterthor, D; Halasz, J; Lackner, C; Zatloukal, K; Denk, H Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosis.
Histopathology. 2009; 54(5): 561-570. Doi: 10.1111/j.1365-2559.2009.03258.x
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** Fickert, P; Fuchsbichler, A; Moustafa, T; Wagner, M; Zollner, G; Halilbasic, E; Stöger, U; Arrese, M; Pizarro, M; Solís, N; Carrasco, G; Caligiuri, A; Sombetzki, M; Reisinger, E; Tsybrovskyy, O; Zatloukal, K; Denk, H; Jaeschke, H; Pinzani, M; Trauner, M Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.
Am J Pathol. 2009; 175(6):2392-2405 Doi: 10.2353/ajpath.2009.090114 [OPEN ACCESS]
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** Fickert, P; Fuchsbichler, A; Wagner, M; Silbert, D; Zatloukal, K; Denk, H; Trauner, M The role of the hepatocyte cytokeratin network in bile formation and resistance to bile acid challenge and cholestasis in mice.
Hepatology. 2009; 50(3):893-899 Doi: 10.1002/hep.23068 [OPEN ACCESS]
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** Halilbasic, E; Fiorotto, R; Fickert, P; Marschall, HU; Moustafa, T; Spirli, C; Fuchsbichler, A; Gumhold, J; Silbert, D; Zatloukal, K; Langner, C; Maitra, U; Denk, H; Hofmann, AF; Strazzabosco, M; Trauner, M Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice.
Hepatology. 2009; 49(6):1972-1981 Doi: 10.1002/hep.22891 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Aigelsreiter, A; Pixner, T; Denk, H; Lackner, C Mallory-Denk-Body-like cytoplasmic inclusions in the cholangiocarcinoma component of a case of combined hepatocellular and cholangiocarcinoma
VIRCHOWS ARCHIV. 2009; 455: 201-201.-22nd Congress of Pathology, European Society of Pathology; SEP 4 - 9, 2009; Florenz, ITALY. [Poster]
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Originalarbeit (Konferenzband)

** Halilbasic, E; Fickert, P; Fiorotto, R; Marschall, HU; Moustafa, T; Fuchsbichler, A; Gumhold, J; Silbert, D; Langner, C; Maitra, U; Denk, H; Strazzabosco, M; Trauner, M Side-chain modification as critical determinant of the therapeutic properties of 24-norursodeoxycholic acid in Mdr2 (Abcb4) knockout mice
FALK SYMP. 2009; 165: 157-162. [Oral Communication]
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** Trauner, M; Fickert, P; Moustafa, T; Fuchsbichler, A; Claudel, T; Halilbasic, E; Kratky, D; Denk, H Potential role of ursodeoxycholic acid and its side-chain modified derivatives in the treatment of non-alcoholic fatty liver disease and associated atherosclerosis
FALK SYMP. 2009; 165: 151-156. [Oral Communication]
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2008

Originalarbeit (Zeitschrift)

** Hrzenjak, A; Kremser, ML; Strohmeier, B; Moinfar, F; Zatloukal, K; Denk, H SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway.
J Pathol. 2008; 216(4):495-504 Doi: 10.1002/path.2434
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** Lackner, C; Gogg-Kamerer, M; Zatloukal, K; Stumptner, C; Brunt, EM; Denk, H Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis.
J Hepatol. 2008; 48(5):821-828 Doi: 10.1016/j.jhep.2008.01.026
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Übersichtsarbeit

** Strnad, P; Stumptner, C; Zatloukal, K; Denk, H Intermediate filament cytoskeleton of the liver in health and disease.
HISTOCHEMISTRY CELL BIOL. 2008; 129(6): 735-749. Doi: 10.1007/s00418-008-0431-x [OPEN ACCESS]
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** Strnad, P; Zatloukal, K; Stumptner, C; Kulaksiz, H; Denk, H Mallory-Denk-bodies: lessons from keratin-containing hepatic inclusion bodies.
Biochim Biophys Acta. 2008; 1782(12): 764-774. Doi: 10.1016/j.bbadis.2008.08.008 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Denk, H Non-alcoholic fatty liver disease (steatohepatitis) in children.
ACTA CLIN CROAT. 2008; 47(1): 47:47.
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** Fickert, P; Moustafa, T; Fuchsbichler, A; Claudel, T; Halilbasic, E; Zatloukal, K; Denk, H; Trauner, M Differential effects of nor UDCA and UDCA in the treatment of fatty liver and arteriosclerosis in western chow-fed ApoE knock out mice
J HEPATOL. 2008; 48: S42-S42.-Annual Meeting, EASL; April 2008; Milann, Italy. Doi: 10.1016/S0168-8278(08)60100-2 [Oral Communication]
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** Moustafa, T; Halilbasic, E; Fickert, P; Fuchsbichler, A; Gumhold, J; Silbert, D; Denk, H; Trauner, M Side chain modified bile acids modulate endoplasmic reticulum stress in Mdr2(-/-) mice in vivo and bile duct epithelial cells in vitro
J HEPATOL. 2008; 48: S54-S55.-EASL Annula Meeting; April 2008; Milan Italy. Doi: 10.1016/S0168-8278(08)60127-0 [Oral Communication]
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2007

Originalarbeit (Zeitschrift)

** Asslaber, M; Abuja, PM; Stark, K; Eder, J; Gottweis, H; Trauner, M; Samonigg, H; Mischinger, HJ; Schippinger, W; Berghold, A; Denk, H; Zatloukal, K The Genome Austria Tissue Bank (GATiB).
Pathobiology. 2007; 74(4):251-258 Doi: 10.1159/000104453 [OPEN ACCESS]
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** Fickert, P; Stöger, U; Fuchsbichler, A; Moustafa, T; Marschall, HU; Weiglein, AH; Tsybrovskyy, O; Jaeschke, H; Zatloukal, K; Denk, H; Trauner, M A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.
Am J Pathol. 2007; 171(2):525-536 Doi: 10.2353/ajpath.2007.061133 [OPEN ACCESS]
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** Janig, E; Haslbeck, M; Aigelsreiter, A; Braun, N; Unterthor, D; Wolf, P; Khaskhely, NM; Buchner, J; Denk, H; Zatloukal, K Clusterin associates with altered elastic fibers in human photoaged skin and prevents elastin from ultraviolet-induced aggregation in vitro.
Am J Pathol. 2007; 171(5):1474-1482 Doi: 10.2353/ajpath.2007.061064 [OPEN ACCESS]
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** Panzitt, K; Tschernatsch, MM; Guelly, C; Moustafa, T; Stradner, M; Strohmaier, HM; Buck, CR; Denk, H; Schroeder, R; Trauner, M; Zatloukal, K Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA.
Gastroenterology. 2007; 132(1):330-342 Doi: 10.1053/j.gastro.2006.08.026
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** Richtig, E; Berghold, A; Schwantzer, G; Ott, A; Wölfelmaier, F; Karner, B; Ludwig, R; Denk, H; Stering, R; Leitner, G; Lax, S; Okcu, M; Gerger, A; Kerl, H; Smolle, J Clinical epidemiology of invasive cutaneous malignant melanoma in the Austrian province Styria in the years 2001-2003 and its relationship with local geographical, meteorological and economic data.
Dermatology. 2007; 214(3):246-252 Doi: 10.1159/000099590
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** Stumptner, C; Fuchsbichler, A; Zatloukal, K; Denk, H In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62.
Hepatology. 2007; 46(3): 851-860. Doi: 10.1002/hep.21744 [OPEN ACCESS]
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** Wagner, M; Zollner, G; Fickert, P; Gumhold, J; Silbert, D; Fuchsbichler, A; Gujral, JS; Zatloukal, K; Denk, H; Jaeschke, H; Trauner, M Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress.
Drug Metab Dispos. 2007; 35(9):1694-1699 Doi: 10.1124/dmd.107.015610 [OPEN ACCESS]
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** Zollner, G; Wagner, M; Fickert, P; Silbert, D; Gumhold, J; Zatloukal, K; Denk, H; Trauner, M Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis.
Liver Int. 2007; 27(7):920-929 Doi: 10.1111/j.1478-3231.2007.01506.x
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Übersichtsarbeit

** Aigelsreiter, A; Janig, E; Stumptner, C; Fuchsbichler, A; Zatloukal, K; Denk, H How a cell deals with abnormal proteins. Pathogenetic mechanisms in protein aggregation diseases.
Pathobiology. 2007; 74(3): 145-158. Doi: 10.1159/000103374 [OPEN ACCESS]
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Editorial

** Denk, H Tissue banking: its significance in modern medicine.
Pathobiology. 2007; 74(4): 197-197. Doi: 10.1159/000104444 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Aigelsreiter, A; Halasz, J; Lackner, C; Sostaric, J; Reihs, R; Stark, K; Kufferath, I; Pichler, M; Stumptner, C; Zatloukal, K; Denk, H Hepatocellular carcinomas with Mallory bodies and/or Intracellular hyaline bodies: Correlation with steatohepatitic features
Virchows Archive . 2007; 451(2):370-370.-21th European Congress of Pathology; SEPT 8-13, 2007; Istanbul, TURKEY. [Poster]
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** Aigelsreiter, A; Janig, E; Halasz,, J; Lackner, C; Sostaric, J; Pichler, M; Stumptner,, C; Unterthor, D; Kufferath,, I; Zatloukal, K; Denk, H Clusterin expression in cholestasis and liver fibrosis
Virchows Archive. 2007; 451(2):132-132.-21th European Congress of Pathology; SEPT 8-13; Istanbul, TURKEY. [Oral Communication]
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** Halilbasic, E; Fickert, P; Fuchbichler, A; Langner, C; Gumhold, J; Silbert, D; Maitra, U; Zatloukal, K; Denk, H; Trauner, M Taurine-conjugation critically determines the therapeutic effectiveness of 24-nor-ursodeoxycholic acid (norUDCA) in the treatment of sclerosing cholangitis in Mdr2 (ABCB4) knockout mice
J HEPATOL. 2007; 46: S51-S51.-EASL; April 11-15, 2007; Doi: 10.1016/S0168-8278(07)61714-0 [Oral Communication]
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** Halilbasic, E; Fickert, P; Fuchsbichler, A; Moustafa, T; Stoeger, U; Ueno, Y; Denk, H; Trauner, M TNF alpha and LPS but not bile acids play a key role in the induction of reactive phenotype in bile duct epithelial cells in vitro
J HEPATOL. 2007; 46: S121-S121.-EASL; April 11-15, 2007; Barcelona/Spain. Doi: 10.1016/S0168-8278(07)61905-9 [Poster]
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** Hrzenjak, A; Moinfar, F; Kremser, ML; Strohmeier, B; Zatloukal, K; Denk, H Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, selectively induces growth suppression and cell death of endometrial stromal sarcoma cells in vitro
VIRCHOWS ARCHIV. 2007; 451(2):401-401.-21th European Congress of Pathology; SEPT 8-13, 2007; Istanbul, Turkey. [Oral Communication]
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** Jahnel, J; Wagner, M; Langner, C; Hoegenauer, C; Fickert, P; Silbert, D; Gumhold, J; Fuchsbichler, A; Denk, H; Trauner, M Impact of colitis on bile secretion and hepatobiliary transporter expression in mice possible implications for pathogenesis of sclerosing cholangitis
J HEPATOL. 2007; 46: S122-S122. Doi: 10.1016/S0168-8278(07)61907-2 [Poster]
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** Janig, E; Haslbeck, M; Buchner, J; Aigelsreiter, A; Denk, H; Zatloukal, K; Wolf, P Association of the extracellular chaperone clusterin with altered elastic fibers in vivo and in vitro
J INVEST DERMATOL. 2007; 127: S45-S45. [Poster]
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** Lackner, C; Zatloukal, K; Stumptner, C; Denk, H Keratin immunostaining as objective marker of hepatocyte ballooning in steatohepatitis.
J HEPATOL. 2007; 46: S266-S266. Doi: 10.1016/S0168-8278(07)62303-4 [Poster]
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** Maitz, S; Wimmer, R; Rust, C; Denk, H; Invernizzi, P; Ferdinandusse, S; Wanders, RJ; Fuchsbichler, A; Fickert, P; Trauner, M; Hofmann, AF; Beuers, U Taurine conjugation is essential for anticholestatic action of norursodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver
HEPATOLOGY. 2007; 46(4):338A-339A.-AASLD; NOV 2-6, 2007; Boston, USA. [Poster]
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** Moustafa, T; Fickert, P; Vesely, P; Silbert, D; Gumhold, J; Fuchsbichler, A; Denk, H; Guelly, C; Trauner, M Retention of toxic bile acids activate the mTOR, p70S6k/rps6 signaling pathway in mouse models of cholestatic liver injury
J HEPATOL. 2007; 46: S23-S23. Doi: 10.1016/S0168-8278(07)61646-8 [Oral Communication]
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** Pichler, M; Abuja, P; Aigelsreiter, A; Mischinger, HJ; Denk, H; Zatloukal, K Overexpression of glutathione synthesizing enzymes in a mouse model fur drug-induced steatohepatitis
Virchows Archive . 2007; 451(2):567-567.-21th European Congress of Pathology ; SEPT 8-13, 2007; Istanbul, TURKEY. [Poster]
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** Pichler, M; Hatz, M; Aigelsreiter, A; Mischinger HJ; Denk, H; Zatloukal, K Altered S-Adenosylmethionine metabolism in a Mallory body mouse model
Virchows Archive . 2007; 451(2):377-378.-21th European Congress of Pathology; SEPT 8-13, 2007; Istanbul, Turkey. [Poster]
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** Wagner, M; Moustafa, T; Fickert, P; Zollner, G; Gumhold, J; Silbert, D; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M Absence of FXR protects mice from bile-infarcts in biliary obstruction by reduction of bile acid-independent bile flow: Implications for targeting FXR in treatment of cholestasis?
J HEPATOL. 2007; 46: S5-S5.-42th Annual Meeting, European Association for the Study of the Liver; April, 11-15, 2007; Barcelona, Spain. Doi: 10.1016/S0168-8278(07)61603-1 [Oral Communication]
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2006

Originalarbeit (Zeitschrift)

** Denk, H; Stumptner, C; Fuchsbichler, A; Müller, T; Farr, G; Müller, W; Terracciano, L; Zatloukal, K Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related?
J PATHOL. 2006; 208: 653-661. Doi: 10.1002/path.1946
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** Fickert, P; Fuchsbichler, A; Marschall, HU; Wagner, M; Zollner, G; Krause, R; Zatloukal, K; Jaeschke, H; Denk, H; Trauner, M Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.
Am J Pathol. 2006; 168(2):410-422 Doi: 10.2353/ajpath.2006.050404 [OPEN ACCESS]
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** Fickert, P; Wagner, M; Marschall, HU; Fuchsbichler, A; Zollner, G; Tsybrovskyy, O; Zatloukal, K; Liu, J; Waalkes, MP; Cover, C; Denk, H; Hofmann, AF; Jaeschke, H; Trauner, M 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.
Gastroenterology. 2006; 130(2):465-481 Doi: 10.1053/j.gastro.2005.10.018
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** Hrzenjak, A; Moinfar, F; Kremser, ML; Strohmeier, B; Staber, PB; Zatloukal, K; Denk, H Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells.
Mol Cancer Ther. 2006; 5(9):2203-2210 Doi: 10.1158/1535-7163.MCT-05-0480 [OPEN ACCESS]
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** Leibl, S; Bodo, K; Gogg-Kammerer, M; Hrzenjak, A; Petru, E; Winter, R; Denk, H; Moinfar, F Ovarian granulosa cell tumors frequently express EGFR (Her-1), Her-3, and Her-4: An immunohistochemical study.
Gynecol Oncol. 2006; 101(1): 18-23. Doi: 10.1016/j.ygyno.2005.10.009
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** Zollner, G; Wagner, M; Moustafa, T; Fickert, P; Silbert, D; Gumhold, J; Fuchsbichler, A; Halilbasic, E; Denk, H; Marschall, HU; Trauner, M Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.
Am J Physiol Gastrointest Liver Physiol. 2006; 290(5):G923-G932 Doi: 10.1152/ajpgi.00490.2005 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Froehlich, E; Gutmann, B; Hermetter, A; Wightman, L; Stumptner, C; Hecht, P; Denk, H; Zatloukal, K Mitochondria-targeted antioxidants prevent liver injury in animal models of steatohepatitis and CCl4 intoxication
J HEPATOL. 44: S267-S267.-41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 26-30, 2006; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(06)80726-9 [Poster]
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** Moustafa, T; Fickert, P; Guelly, C; Silbert, D; Gumhold, J; Fuchsbichler, A; Denk, H; Trauner, M Transcriptional profiling of Mdr2 knockout (Mdr2-/-) mice treated with nor-UDCA reveals global anti-inflammatory and anti-fibrotic effects
J HEPATOL. 2006; 44: S42-S42.-41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 26-30, 2006; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(06)80095-4 [Poster]
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** Moustafa, T; Fickert, P; Prokesch, A; Wagner, M; Fuchsbichler, A; Silbert, D; Gumhold, J; Denk, H; Trajanoski, Z; Trauner, M Common bile-duct-ligation of FXR knockout mice results in severe hepatic steatosis due to enhancement in lipogenic gene expression
J HEPATOL. 44: S28-S28.-41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 26-30, 2006; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(06)80063-2 [Poster]
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** Stoger, U; Fickert, P; Fuchsbichler, A; Moustafa, T; Gumhold, J; Silbert, D; Zatlouka, K; Denk, H; Trauner, M 3.5-diethoxycarbonyl-1.4-dihydrocollidine (DDC) feeding induces cholestasis, chronic inflammatory bile duct damage and biliary fibrosis in mice
J HEPATOL. 44: S123-S124.-41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 26-30, 2006; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(06)80321-1 [Poster]
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** Stumptner, C; Fuchsbichler, A; Zatloukal, K; Denk, H In vitro production of mallory bodies and intracellular hyaline bodies: Clues to their pathogenesis and significance
J HEPATOL. ; 44: S264-S264.-41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 26-30, 2006; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(06)80719-1 [Poster]
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2005

Originalarbeit (Zeitschrift)

** Fickert, P; Trauner, M; Fuchsbichler, A; Zollner, G; Wagner, M; Marschall, HU; Zatloukal, K; Denk, H Oncosis represents the main type of cell death in mouse models of cholestasis.
J Hepatol. 2005; 42(3):378-385 Doi: 10.1016/j.jhep.2004.10.016
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** Geier, A; Zollner, G; Dietrich, CG; Wagner, M; Fickert, P; Denk, H; van Rooijen, N; Matern, S; Gartung, C; Trauner, M Cytokine-independent repression of rodent Ntcp in obstructive cholestasis.
Hepatology. 2005; 41(3):470-477 Doi: 10.1002/hep.20594 [OPEN ACCESS]
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** Halbwedl, I; Ullmann, R; Kremser, ML; Man, YG; Isadi-Moud, N; Lax, S; Denk, H; Popper, HH; Tavassoli, FA; Moinfar, F Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization.
GYNECOL ONCOL. 2005; 97: 582-587. Doi: 10.1016/j.ygyno.2005.01.002
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** Janig, E; Stumptner, C; Fuchsbichler, A; Denk, H; Zatloukal, K Interaction of stress proteins with misfolded keratins.
EUR J CELL BIOL. 2005; 84(2-3): 329-339. Doi: 10.1016/j.ejcb.2004.12.019
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** Lackner, C; Dlaska, D; Fuchsbichler, A; Stumptner, C; Gogg-Kamerer, M; Zatloukal, K; Denk, H p62 protein is expressed in pancreatic beta cells.
J PATHOL. 2005; 206(4): 402-408. Doi: 10.1002/path.1786
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** Leibl, S; Gogg-Kammerer, M; Sommersacher, A; Denk, H; Moinfar, F Metaplastic breast carcinomas: are they of myoepithelial differentiation?: immunohistochemical profile of the sarcomatoid subtype using novel myoepithelial markers.
Am J Surg Pathol. 2005; 29(3):347-353 Doi: 10.1097/01.pas.0000152133.60278.d2
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** Moinfar, F; Gogg-Kamerer, M; Sommersacher, A; Regitnig, P; Man, YG; Zatloukal, K; Denk, H; Tavassoli, FA Endometrial stromal sarcomas frequently express epidermal growth factor receptor (EGFR, HER-1): potential basis for a new therapeutic approach.
AMER J SURG PATHOL. 2005; 29(4): 485-489. Doi: 10.1097%2F01.pas.0000155149.83541.24
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** Wagner, M; Halilbasic, E; Marschall, HU; Zollner, G; Fickert, P; Langner, C; Zatloukal, K; Denk, H; Trauner, M CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.
Hepatology. 2005; 42(2):420-430 Doi: 10.1002/hep.20784 [OPEN ACCESS]
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** Zollner, G; Wagner, M; Fickert, P; Geier, A; Fuchsbichler, A; Silbert, D; Gumhold, J; Zatloukal, K; Kaser, A; Tilg, H; Denk, H; Trauner, M Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.
Am J Physiol Gastrointest Liver Physiol. 2005; 289(5):G798-G805 Doi: 10.1152/ajpgi.00319.2004 [OPEN ACCESS]
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** Zollner, G; Wagner, M; Fickert, P; Silbert, D; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M Hepatobiliary transporter expression in human hepatocellular carcinoma.
Liver Int. 2005; 25(2):367-379 Doi: 10.1111/j.1478-3231.2005.01033.x
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Übersichtsarbeit

** Hrzenjak, A; Moinfar, F; Tavassoli, FA; Strohmeier, B; Kremser, ML; Zatloukal, K; Denk, H JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue.
J MOL DIAGN. 2005; 7(3): 388-395. Doi: 10.1016/S1525-1578(10)60568-5 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Fickert, P; Fuchsbichler, A; Wagner, M; Zollner, G; Krause, R; Zatloukal, K; Marschall, HU; Jaeschke, H; Denk, H; Trauner, M Lithocholic acid feeding induces biliary obstruction and destructive cholangitis in mice
J HEPATOL. 2005; 42: 113-113.-40th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 13-17, 2005; Paris, FRANCE.
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** Fickert, P; Wagner, M; Marshall, HU; Fuchsbichler, A; Zollner, G; Zatloukal, K; Liu, J; Waalkes, MP; Cover, C; Denk, H; Hofmann, AF; Jaeschke, H; Trauner, M 24-norursodeoxycholic acid as novel therapeutic approach to sclerosing cholangitis in Mdr2 (ABCB4) knockout mice
HEPATOLOGY. 2005; 42: -56th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases; NOV 11-15, 2005; San Francisco, CA.
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** Geier, A; Zollner, G; Dietrich, CG; Wagner, M; Fickert, P; Denk, H; van Rooijen, N; Matern, S; Gartung, C; Trauner, M Cytokine-independent repression of rodent Ntcp in obstructive cholestasis
J HEPATOL. 2005; 42: 114-114.-40th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 13-17, 2005; Paris, FRANCE.
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** Janig, E; Fuchsbichler, A; Fickert, P; Trauner, M; Denk, H; Zatloukal, K Clusterin: A novel stress marker in biliary disease models
HEPATOLOGY. 2005; 42 (4): 413-414.-56th Annual Meeting of the American Association for the Study of Liver Diseases; NOV 11-15, 2005; San Francisco, CA.
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** Stumptner, C; Muller, T; Fuchsbichler, A; Zatloukal, K; Denk, H Pathogenesis and relationship of mallory bodies and intracellular hyaline bodies: In vitro studies
HEPATOLOGY 2005 42: -.
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** Wagner, M; Zollner, G; Fickert, P; Gumhold, J; Silbert, D; Fuchsbichler, A; Gujral, JS; Zatloukal, K; Denk, H; Jaeschke, H; Trauner, M Alterations of hepatobiliary transporter expression in response to common bile duct ligation in mice are independent of ICAM-1 and FAS-receptor expression
J HEPATOL. 2005; 42: 115-115.-40th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 13-17, 2005; Paris, FRANCE.
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** Zollner, G; Wagner, M; Fickert, P; Gumhold, J; Silbert, D; Marschall, HU; Denk, H; Trauner, M Expression of key bile acid detoxification enzymes and the alternative bile acid export pump MRP4 in primary biliary cirrhosis
J HEPATOL. 2005; 42: 240-240.-40th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 13-17, 2005; Paris, FRANCE.
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** Zollner, G; Wagner, M; Fickert, P; Gumhold, J; Silbert, D; Marschall, HU; Denk, H; Trauner, M Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
GASTROENTEROLOGY. 2005; 128: A691-A691.
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2004

Originalarbeit (Zeitschrift)

** Fickert, P; Fuchsbichler, A; Wagner, M; Zollner, G; Kaser, A; Tilg, H; Krause, R; Lammert, F; Langner, C; Zatloukal, K; Marschall, HU; Denk, H; Trauner, M Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.
Gastroenterology. 2004; 127(1):261-274 Doi: 10.1053/j.gastro.2004.04.009
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** Hrzenjak, A; Tippl, M; Kremser, ML; Strohmeier, B; Guelly, C; Neumeister, D; Lax, S; Moinfar, F; Tabrizi, AD; Isadi-Moud, N; Zatloukal, K; Denk, H Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas.
J PATHOL. 2004; 204(1): 19-27. Doi: 10.1002/path.1616
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** Lackner, C; Jukic, Z; Tsybrovskyy, O; Jatzko, G; Wette, V; Hoefler, G; Klimpfinger, M; Denk, H; Zatloukal, K Prognostic relevance of tumour-associated macrophages and von Willebrand factor-positive microvessels in colorectal cancer.
VIRCHOWS ARCHIV. 2004; 445(2): 160-167. Doi: 10.1007/s00428-004-1051-z
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** Moinfar, F; Kremser, ML; Man, YG; Zatloukal, K; Tavassoli, FA; Denk, H Allelic imbalances in endometrial stromal neoplasms: frequent genetic alterations in the nontumorous normal-appearing endometrial and myometrial tissues.
GYNECOL ONCOL. 2004; 95(3): 662-671. Doi: 10.1016/j.ygyno.2004.08.016
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** Moinfar, F; Regitnig, P; Tabrizi, AD; Denk, H; Tavassoli, FA Expression of androgen receptors in benign and malignant endometrial stromal neoplasms.
VIRCHOWS ARCHIV. 2004; 444(5): 410-414. Doi: 10.1007/s00428-004-0981-9
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** Müller, T; Langner, C; Fuchsbichler, A; Heinz-Erian, P; Ellemunter, H; Schlenck, B; Bavdekar, AR; Pradhan, AM; Pandit, A; Müller-Höcker, J; Melter, M; Kobayashi, K; Nagasaka, H; Kikuta, H; Müller, W; Tanner, MS; Sternlieb, I; Zatloukal, K; Denk, H Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis.
HEPATOLOGY. 2004; 39(4): 963-969. Doi: 10.1002/hep.20108 [OPEN ACCESS]
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Übersichtsarbeit

** Langner, C; Denk, H Wilson disease.
VIRCHOWS ARCHIV. 2004; 445(2): 111-118. Doi: 10.1007/s00428-004-1047-8
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** Schirmacher, P; Fleig, WE; Tannapfel, A; Langner, C; Dries, V; Terracciano, L; Denk, H; Dienes, HP; German Society for Digestive and Metabolic Diseases Bioptic diagnosis of chronic hepatitis. Results of an evidence-based consensus conference of the German Society of Pathology, of the German Society for Digestive and Metabolic Diseases and of Compensated Hepatitis (HepNet)
PATHOLOGE. 2004; 25(5): 337-348. Doi: 10.1007/s00292-004-0692-7
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** Zatloukal, K; Stumptner, C; Fuchsbichler, A; Fickert, P; Lackner, C; Trauner, M; Denk, H The keratin cytoskeleton in liver diseases.
J Pathol. 2004; 204(4):367-376 Doi: 10.1002/path.1649 [OPEN ACCESS]
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** Zatloukal, K; Stumptner, C; Fuchsbichler, A; Janig, E; Denk, H Intermediate filament protein inclusions.
METHOD CELL BIOL. 2004; 78(1-2): 205-228. Doi: 10.1016/S0091-679X(04)78008-5
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Abstract (Zeitschrift)

** Fickert, P; Fuchsbichler, A; Wagner, M; Zollner, G; Kaser, A; Tilg, H; Krause, R; Langner, C; Zatloukal, K; Marschall, HU; Denk, H; Trauner, M Biliary leakage of fluorescent bile acids in MDR2 knockout mice: Evidence for a critical role of bile duct leakage in the pathogenesis of sclerosing cholangitis
J HEPATOL. 2004; 40: 91-91.-39th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 14-18, 2004; Berlin, GERMANY. Doi: 10.1016/S0168-8278(04)90295-4
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** Fickert, P; Fuchsbichler, A; Wagner, M; Zollner, G; Kaser, A; Tilg, H; Krause, R; Langner, C; Zatloukal, K; Marschall, HU; Denk, H; Trauner, M Bile acids regurgitation from leaky bile ducts causes sclerosing cholangitis in Mdr2 knockout mice
GASTROENTEROLOGY. 2004; 126: A663-A663.
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** Fickert, P; Trauner, M; Fuchsbichler, A; Zollner, G; Wagner, M; Marschall, HU; Zartloukal, K; Denk, H; Zsengeller, Z; Szabo, C Oncosis represents the main type of cell death in mouse models of cholestasis: evidence for a critical role of poly(ADP-ribose) polymerase (PARP) activation in bile acid-induced hepatocytes death
FASEB J. 2004; 18: A558-A558.-Experimental Biology 2004 Meeting; APR 17-21, 2004; Washington, DC.
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** Panzitt, K; Strohmaier, HM; Moustafa, T; Stradner, M; Gully, C; Buck, CR; Denk, H; Zatloukal, K A non-protein-coding RNA is a major deregulated gene in hepatocellular carcinoma and may act as a general modulator of gene expression
HEPATOLOGY 2004 40: 253A-253A.
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** Wagner, M; Fickert, P; Marschall, HU; Zollner, G; Silbert, D; Fuchsbichler, A; Gumhold, J; Schuetz, JD; Gonzalez, FJ; Zatloukal, K; Denk, H; Trauner, M Alternative exretory routes for accumulating bile acids via adaptive renal ABC transporter expression in common bile duct-ligated (CBDL) mice
GASTROENTEROLOGY. 2004; 126: A129-A130.
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** Wagner, M; Fickert, P; Zollner, G; Fuchsbichler, A; Gumhold, J; Silbert, D; Zatloukal, K; Gu, GL; Marschall, HU; Denk, H; Trauner, M Role of adaptive hepatobiliary transporter expression and regulation of bile acid synthetic enzymes in MDR2-/- mice: A model for chronic cholestatic liver disease due to sclerosing cholangitis
J HEPATOL. 2004; 40: 163-163.-39th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 14-18, 2004; Berlin, GERMANY. Doi: 10.1016/S0168-8278(04)90557-0
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** Wagner, M; Fickert, P; Zollner, G; Silbert, D; Fuchsbichler, A; Gumhold, J; Schuetz, JD; Gonzalez, FJ; Zatloukal, K; Marschall, HU; Denk, H; Trauner, M Adaptive renal ABC transporter expression in common bile duct-ligated mice
J HEPATOL. 2004; 40: 26-26.-39th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 14-18, 2004; Berlin, GERMANY. Doi: 10.1016/S0168-8278(04)90073-6
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** Wagner, M; Fickert, P; Zollner, G; Silbert, D; Gumhold, J; Fuchsbichler, A; Zatloukal, K; Marschall, HU; Denk, H; Trauner, M Gender and pregnancy affect hepatic and renal ABC transporter expression in mice
J HEPATOL. 2004; 40: 94-94.-39th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 14-18, 2004; Berlin, GERMANY. Doi: 10.1016/S0168-8278(04)90307-8
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** Wagner, M; Fickert, P; Zollner, G; Silbert, D; Gumhold, J; Fuchsbichler, A; Zatloukal, K; Marschall, HU; Denk, H; Trauner, M Hepatic and renal ABC transporter expression in mice depends on gender and changes in pregnancy
GASTROENTEROLOGY. 2004; 126: A130-A130.
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** Wagner, M; Halilbasic, E; Fickert, P; Zollner, G; Fuchsbichler, A; Gumhold, J; Silbert, D; Zatloukal, K; Denk, H; Trauner, M Nuclear receptor (PXR, CAR) agonists induce adaptive hepatic transporter and enzyme expression in mouse liver
J HEPATOL. 2004; 40: 25-25.-39th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 14-18, 2004; Berlin, GERMANY. Doi: 10.1016/S0168-8278(04)90069-4
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** Wagner, M; Halilbasic, E; Zollner, G; Fickert, P; Gumhold, J; Silbert, D; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M Xenobiotic nuclear receptor (PXR, CAR) agonists coordinately stimulate a spectrum of detoxification enzymes and transport systems involved in the adaptive response to cholestasis in vivo.
HEPATOLOGY. 2004; 40: 489A-489A.-55th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); OCT 29-NOV 02, 2004; Boston, MA.
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** Zollner, G; Halilbasic, E; Wagner, M; Fickert, P; Silbert, D; Gumhold, J; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M Cholic acid (CA) and ursodeoxycholic acid (UDCA) exert different effects on hepatic and renal expression of Mrp4 and Mrp6, two novel ABC transporters
GASTROENTEROLOGY. 2004; 126: A16-A16.
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** Zollner, G; Halilbasic, E; Wagner, M; Fickert, P; Silbert, D; Gumhold, J; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M Differential effects of ursodeoxycholic acid (UDCA) and cholic acid (CA) on hepatic and renal expression of MRP4 and MRP6, two novel abc transporters, in mice
J HEPATOL. 2004; 40: 25-25. Doi: 10.1016/S0168-8278(04)90070-0
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** Zollner, G; Wagner, M; Fickert, P; Fuchsbichler, A; Gumhold, J; Silbert, D; Zatloukal, K; Guo, GL; Marschall, HU; Denk, H; Trauner, M Mdr2(-/-) mice with sclerosing cholangitis: A model of chronic cholestasis to study the role of the adaptive response of hepatobiliary transport systems and bile acid synthetic enzymes
GASTROENTEROLOGY. 2004; 126: A751-A751.
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2003

Originalarbeit (Zeitschrift)

** Fickert, P; Trauner, M; Fuchsbichler, A; Stumptner, C; Zatloukal, K; Denk, H Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins.
J Hepatol. 2003; 38(4):387-394 Doi: 10.1016/S0168-8278(02)00439-7
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** Leibl, S; Tsybrovskyy, O; Denk, H How many lymph nodes are necessary to stage early and advanced adenocarcinoma of the sigmoid colon and upper rectum?
Virchows Arch. 2003; 443(2):133-138 Doi: 10.1007/s00428-003-0858-3
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** Moinfar, F; Okcu, M; Tsybrovskyy, O; Regitnig, P; Lax, SF; Weybora, W; Ratschek, M; Tavassoli, FA; Denk, H Androgen receptors frequently are expressed in breast carcinomas: potential relevance to new therapeutic strategies.
Cancer. 2003; 98(4):703-711 Doi: 10.1002/cncr.11532 [OPEN ACCESS]
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** Müller, T; van de Sluis, B; Zhernakova, A; van Binsbergen, E; Janecke, AR; Bavdekar, A; Pandit, A; Weirich-Schwaiger, H; Witt, H; Ellemunter, H; Deutsch, J; Denk, H; Müller, W; Sternlieb, I; Tanner, MS; Wijmenga, C The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis.
J Hepatol. 2003; 38(2):164-168 Doi: 10.1016%2FS0168-8278%2802%2900356-2
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** Wagner, M; Fickert, P; Zollner, G; Fuchsbichler, A; Silbert, D; Tsybrovskyy, O; Zatloukal, K; Guo, GL; Schuetz, JD; Gonzalez, FJ; Marschall, HU; Denk, H; Trauner, M Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice.
Gastroenterology. 2003; 125(3):825-838 Doi: 10.1016/S0016-5085(03)01068-0
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** Zollner, G; Fickert, P; Fuchsbichler, A; Silbert, D; Wagner, M; Arbeiter, S; Gonzalez, FJ; Marschall, HU; Zatloukal, K; Denk, H; Trauner, M Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine.
J Hepatol. 2003; 39(4):480-488 Doi: 10.1016/S0168-8278(03)00228-9
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** Zollner, G; Fickert, P; Silbert, D; Fuchsbichler, A; Marschall, HU; Zatloukal, K; Denk, H; Trauner, M Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.
J Hepatol. 2003; 38(6):717-727 Doi: 10.1016/S0168-8278(03)00096-5
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Abstract (Zeitschrift)

** Fickert, P; Trauner, M; Fuchsbichler, A; Zollner, G; Wagner, M; Zenz, R; Zsengeller, Z; Szabo, C; Denk, H Inhibition of poly(ADP-ribose) polymerase (PARP) protects mice from cholestatic liver injury.
HEPATOLOGY 2003 38: 576A-576A.
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** Moinfar, F; Okcu, M; Tsybrovskyy, O; Regitnig, P; Lax, SF; Weybora, W; Ratschek, M; Tavassoli, FA; Denk, H Androgen receptors are frequently expressed in breast carcinomas
MODERN PATHOL 2003 16: 41A-41A.
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** Moinfar, F; Okcu, M; Tsybrovskyy, O; Regitnig, P; Lax, SF; Weybora, W; Ratschek, M; Tavassoli, FA; Denk, H Androgen receptors are frequently expressed in breast carcinomas
LAB INVEST 2003 83: 41A-41A.
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** Stumptner, C; Wagner, K; Denk, H; Zatloukal, K Molecular evidence for a toxic memory effect in steatohepatitis.
HEPATOLOGY 2003 38: 500A-500A.
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** Wagner, M; Fickert, P; Fuchsbichler, A; Silbert, D; Gumhold, J; Zollner, G; Zatloukal, K; Marschall, HU; Schuetz, JD; Gonzalez, FJ; Denk, H; Trauner, M Hepatic and renal ABC transporter expression as critical determinants of ursodeoxycholic acid-induced bile infarcts in bile duct-ligated mice.
HEPATOLOGY 2003 38: 688A-689A.
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** Wagner, M; Fickert, P; Zollner, G; Fuchsbichler, A; Silbert, D; Marschall, HU; Gonzalez, FJ; Zatloukal, K; Denk, H; Trauner, M The role of the bile acid receptor FXR in determining ATP-binding cassette (ABC) transporter expression and liver injury in common bile duct ligated (CBDL) mice
J HEPATOL 2003 38: 190-190. Doi: 10.1016/S0168-8278(03)80031-4
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** Zatloukal, K; Stumptner, C; Fuchsbichler, A; Fickert, P; Trauner, M; Denk, H The role of keratin in steatohepatitis.
HEPATOLOGY 2003 38: 501A-501A.
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** Zollner, G; Fickert, P; Silbert, D; Fuchsbichler, A; Wagner, M; Zatloukal, K; Denk, H; Trauner, M Role of short heterodimer partner (SHP) -dependent and -independent pathways for regulation of Na+/taurocholate cotransporter (NTCP) expression in cholestatic mouse models.
J HEPATOL. 2003; 38(2):9-10.-38th Annual Meeting of the European-Association-for-the-Study-of-the-Liver; MAR 29-APR 01, 2003; ISTANBUL, TURKEY. Doi: 10.1016/S0168-8278(03)80442-7
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** Zollner, G; Fickert, P; Wagner, M; Fuchsbichler, A; Silbert, D; Gumhold, J; Zatloukal, K; Denk, H; Trauner, M Induction of intestinal multidrug resistance-associated proteins 2 and 3 (Mrp2, Mrp3) by cholic acid (CA) and ursodeoxycholic acid (UDCA) in mice.
HEPATOLOGY 2003 38: 689A-689A.
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2002

Originalarbeit (Zeitschrift)

** Fickert, P; Trauner, M; Fuchsbichler, A; Stumptner, C; Zatloukal, K; Denk, H Bile acid-induced Mallory body formation in drug-primed mouse liver.
Am J Pathol. 2002; 161(6):2019-2026 Doi: 10.1016/S0002-9440(10)64480-X [OPEN ACCESS]
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** Fickert, P; Trauner, M; Fuchsbichler, A; Stumptner, C; Zatloukal, K; Denk, H Cytokeratins as targets for bile acid-induced toxicity.
Am J Pathol. 2002; 160(2):491-499 Doi: 10.1016/S0002-9440(10)64868-7 [OPEN ACCESS]
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** Fickert, P; Zollner, G; Fuchsbichler, A; Stumptner, C; Weiglein, AH; Lammert, F; Marschall, HU; Tsybrovskyy, O; Zatloukal, K; Denk, H; Trauner, M Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles.
Gastroenterology. 2002; 123(4):1238-1251 Doi: 10.1053/gast.2002.35948
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** Stumptner, C; Fuchsbichler, A; Heid, H; Zatloukal, K; Denk, H Mallory body--a disease-associated type of sequestosome.
HEPATOLOGY. 2002; 35(5): 1053-1062. Doi: 10.1053/jhep.2002.32674 [OPEN ACCESS]
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** Zatloukal, K; Stumptner, C; Fuchsbichler, A; Heid, H; Schnoelzer, M; Kenner, L; Kleinert, R; Prinz, M; Aguzzi, A; Denk, H p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases.
Am J Pathol. 2002; 160(1):255-263 Doi: 10.1016/S0002-9440(10)64369-6 [OPEN ACCESS]
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** Zollner, G; Fickert, P; Silbert, D; Fuchsbichler, A; Stumptner, C; Zatloukal, K; Denk, H; Trauner, M Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice.
Am J Physiol Gastrointest Liver Physiol. 2002; 282(1):G184-G191 Doi: 10.1152/ajpgi.00215.2001 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Fickert, P; Trauner, M; Fuchsbichler, A; Stumptner, C; Neuberger, J; Zatloukal, K; Denk, H Abnormal expression and phosphorylation of cytokeratins in primary biliary cirrhosis (PBC).
J HEPATOL. 2002; 36(S1):141-141. Doi: 10.1016/S0168-8278(02)80506-2
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** Fickert, P; Zollner, G; Silbert, D; Fuchsbichler, A; Arbeiter, S; Gonzalez, F; Denk, H; Trauner, M Adaptive hepatic and renal transporter regulation in cholic acid (CA)-fed mice: Role of nuclear bile acid receptor (FXR).
HEPATOLOGY 2002 36: 454A-454A.
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** Zollner, G; Fickert, P; Arbeiter, S; Silbert, D; Fuchsbichler, A; Gonzalez, F; Zatloukal, K; Denk, H; Trauner, M Ursodeoxycholic acid (UDCA) feeding induces adaptive hepatic and renal ABC-transporter expression in mice.
HEPATOLOGY 2002 36: 454A-454A.
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** Zollner, G; Fickert, P; Silbert, D; Fuchsbichler, A; Stumptner, C; Neuberger, J; Zatloukal, K; Denk, H; Trauner, M Alterations of hepatobiliary transporter expression in primary biliary cirrhosis (PBC)
J HEPATOL 2002 36: 28-29. Doi: 10.1016/S0168-8278(02)80086-1
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** Zollner, G; Fickert, P; Silbert, D; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M Messenger RNA expression of nuclear, orphan receptors and hepatocyte nuclear factor 1 alpha (HNF-1 alpha) in inflammation-associated cholestasis (IC) and primary biliary cirrhosis
HEPATOLOGY 2002 36: 454A-454A.
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2001

Originalarbeit (Zeitschrift)

** Denk, H; Stumptner, C; Fuchsbichler, A; Zatloukal, K Alcoholic and nonalcoholic steatohepatitis. Histopathologic and pathogenetic considerations
Pathologe. 2001; 22(6):388-398 Doi: 10.1007/s002920100489
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** Fickert, P; Zollner, G; Fuchsbichler, A; Stumptner, C; Pojer, C; Zenz, R; Lammert, F; Stieger, B; Meier, PJ; Zatloukal, K; Denk, H; Trauner, M Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver.
Gastroenterology. 2001; 121(1):170-183 Doi: 10.1053/gast.2001.25542
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** Jagoditsch, M; Pertl, A; Jatzko, GR; Denk, H; Stettner, HM Long-term outcome of stomach carcinoma achieved in an Austrian standard hospital with an oncologic focus
Chirurg. 2001; 72(7):822-831 Doi: 10.1007/s001040170111
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** Regitnig, P; Spuller, E; Denk, H Insulinoma of the pancreas with insular-ductular differentiation in its liver metastasis--indication of a common stem-cell origin of the exocrine and endocrine components.
Virchows Arch. 2001; 438(6):624-628 Doi: 10.1007%2Fs004280100406 (- Case Report)
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** Stumptner, C; Fuchsbichler, A; Lehner, M; Zatloukal, K; Denk, H Sequence of events in the assembly of Mallory body components in mouse liver: clues to the pathogenesis and significance of Mallory body formation.
J Hepatol. 2001; 34(5):665-675 Doi: 10.1016%2FS0168-8278%2800%2900099-4
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** Zollner, G; Fickert, P; Zenz, R; Fuchsbichler, A; Stumptner, C; Kenner, L; Ferenci, P; Stauber, RE; Krejs, GJ; Denk, H; Zatloukal, K; Trauner, M Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.
Hepatology. 2001; 33(3):633-646 Doi: 10.1053/jhep.2001.22646 [OPEN ACCESS]
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Übersichtsarbeit

** Langner, C; Denk, H Chronic cholangitis
Pathologe. 2001; 22(6):375-387 Doi: 10.1007/s002920100488
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Editorial

** Denk, H Hepatology, a main topic in DER PATHOLOGE
PATHOLOGE 2001 22: 361-361. Doi: 10.1007/s00292-001-0495-z
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Abstract (Zeitschrift)

** Fickert, P; Fuchsbichler, A; Zollner, G; Stumptner, C; Weiglein, A; Zatloukal, K; Denk, H; Trauner, M Mdr2-p-glycoprotein-deficient (Mdr2-/-) mouse - A new model for primary sclerosing cholangitis (PSC)?
HEPATOLOGY 2001 34: 509A-509A.
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** Fickert, P; Zollner, G; Fuchsbichler, A; Stumptner, C; Lammert, F; Zatloukal, K; Denk, H; Trauner, M Ursodeoxycholic acid feeding aggravates liver injury in bile duct-ligated mice
GASTROENTEROLOGY 2001 120: A1-A1.
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** Zollner, G; Fickert, P; Fuchsbichler, A; Stumptner, C; Denk, H; Zatloukal, K; Ferenci, P; Trauner, M Expression of multidrug resistance P-glycoproteins (MDRs) and multidrug resistance-associated proteins (MRPs) in Wilson disease (WD)
J HEPATOL 2001 34: 188-188.
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** Zollner, G; Fickert, P; Fuchsbichler, A; Stumptner, C; Denk, H; Zatloukal, K; Trauner, M Multidrug resistance P-glycoproteins (MDR) and multidrug resistance-associated proteins (MRP) are not overexpressed in human hepatocellular carcinomas (HCC).
J HEPATOL 2001 34: 189-189.
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** Zollner, G; Fickert, P; Silbert, D; Fuchsbichler, A; Stumptner, C; Ott, P; Zatloukal, K; Denk, H; Trauner, M Expression of multidrug resistance p-glycoproteins (MDR), multidrug resistance-associated proteins (MRP) and bile acid transporters in human hepatocellular carcinomas (HCC).
HEPATOLOGY 2001 34: 665A-665A.
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** Zollner, G; Fickert, P; Silbert, D; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M; Franzens, K Induction of the transcriptional repressor short heterodimer partner 1 precedes down-regulation of the Na+/taurocholate cotransporter in bile duct-ligated mice.
HEPATOLOGY 2001 34: 469A-469A.
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2000

Originalarbeit (Zeitschrift)

** Jagoditsch, M; Lisborg, PH; Jatzko, GR; Wette, V; Kropfitsch, G; Denk, H; Klimpfinger, M; Stettner, HM Long-term prognosis for colon cancer related to consistent radical surgery: multivariate analysis of clinical, surgical, and pathologic variables.
World J Surg. 2000; 24(10):1264-1270 Doi: 10.1007%2Fs002680010252
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** Regitnig, P; Denk, H Lack of Pseudomelanosis coli in colonic adenomas suggests different pathways of apoptotic bodies in normal and neoplastic colonic mucosa.
Virchows Arch. 2000; 436(6):588-594 Doi: 10.1007%2Fs004289900178
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** Stumptner, C; Omary, MB; Fickert, P; Denk, H; Zatloukal, K Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model.
Am J Pathol. 2000; 156(1):77-90 Doi: 10.1016/S0002-9440(10)64708-6 [OPEN ACCESS]
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** Zatloukal, K; Stumptner, C; Lehner, M; Denk, H; Baribault, H; Eshkind, LG; Franke, WW Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies.
Am J Pathol. 2000; 156(4):1263-1274 Doi: 10.1016/S0002-9440(10)64997-8 [OPEN ACCESS]
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Übersichtsarbeit

** Denk, H; Stumptner, C; Zatloukal, K Mallory bodies revisited.
J Hepatol. 2000; 32(4):689-702 Doi: 10.1016%2FS0168-8278%2800%2980233-0
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Abstract (Zeitschrift)

** Fickert, P; Trauner, M; Fuchsbichler, A; Zatloukal, K; Denk, H Toxic bile acids induce cytokeratin 8/18 overexpression and hyperphosphorylation in mouse liver.
GASTROENTEROLOGY 2000 118: 3726-3726. Doi: 10.1016/S0016-5085(00)86223-X
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** Fickert, P; Trauner, M; Fuchsbichler, A; Zatloukal, K; Denk, H Cytokeratin 8/18 overexpression and hyperphosphorylation induced by toxic bile acids in mouse liver
J HEPATOL 2000 32: 76-76. Doi: 10.1016/S0168-8278(00)80623-6
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** Fickert, P; Zenz, R; Zoliner, G; Pojer, C; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M Role of bile acid hydrophobicity in regulation of hepatocellular transporter expression in mice
J HEPATOL. 2000; 32(1 Su):39-39. Doi: 10.1016/S0168-8278(00)80479-1
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** Fickert, P; Zenz, R; Zollner, G; Pojer, C; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M Regulation of hepatocellular transporter expression depends on bile acid hydrophobicity in mice.
GASTROENTEROLOGY 2000 118: 168-168. Doi: 10.1016/S0016-5085(00)85876-X
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** Mueller, T; Fuchsbichler, A; Müller, W; Bavdekar, AR; Pradhan, AM; Knisely, AS; Rodeck, B; Kobayashi, K; Nagasaka, H; Sternlieb, I; Zatloukal, K; Denk, H Characterization of Mallory bodies in non-Wilsonian hepatic copper toxicosis and alcoholic hepatitis.
HEPATOLOGY 2000 32: 1213-1213.
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1999

Originalarbeit (Zeitschrift)

** D'Adda, T; Candidus, S; Denk, H; Bordi, C; Höfler, H Gastric neuroendocrine neoplasms: tumour clonality and malignancy-associated large X-chromosomal deletions.
J Pathol. 1999; 189(3):394-401 Doi: 10.1002/(SICI)1096-9896(199911)189:3<394::AID-PATH444>3.0.CO;2-P
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** Jatzko, G; Siebert, F; Wolf, B; Karner-Hanusch, J; Kleinert, R; Denk, H Combined restorative proctocolectomy and pancreaticoduodenectomy for familial adenomatous polyposis.
Z Gastroenterol. 1999; 37(11):1109-1113 (- Case Report)
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** Kenner, L; Zatloukal, K; Stumptner, C; Eferl, R; Denk, H Altered microtubule-associated tau messenger RNA isoform expression in livers of griseofulvin- and 3,5-diethoxycarbonyl-1, 4-dihydrocollidine-treated mice.
Hepatology. 1999; 29(3):793-800 Doi: 10.1002/hep.510290325 [OPEN ACCESS]
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** Preisegger, KH; Factor, VM; Fuchsbichler, A; Stumptner, C; Denk, H; Thorgeirsson, SS Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease.
Lab Invest. 1999; 79(2):103-109
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** Stumptner, C; Heid, H; Fuchsbichler, A; Hauser, H; Mischinger, HJ; Zatloukal, K; Denk, H Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent.
Am J Pathol. 1999; 154(6):1701-1710 Doi: 10.1016/S0002-9440(10)65426-0 (- Case Report) [OPEN ACCESS]
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Abstract (Zeitschrift)

** Fickert, P; Trauner, M; Fuchsbichler, A; Kenner, L; Zatloukal, K; Denk, H Role of Kupffer cells in hepatocellular cytokeratin 8/18 expression in lipopoly-saccharide or DDC-induced hepatic injury.
HEPATOLOGY 1999 30: 552A-552A.
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** Fickert, P; Trauner, M; Fuchsbichler, A; Zatloukal, K; Denk, H Cholestasis and bile acid feeding induce cytokeratin 8/18 expression and mallory body formation in mice.
HEPATOLOGY 1999 30: 464A-464A.
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** Lackner, C; Stadlbauer, V; Stindl, G; Mischinger, HJ; Denk, H; Zatloukal, K Overexpression of keratin 8- and 18 mRNA in hepatocellular carcinoma.
HEPATOLOGY 1999 30: 324A-324A.
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** Stumptner, C; Zatloukal, K; Fickert, P; Denk, H p62/A170 - A novel component of mallory bodies associated with alcoholic hepatitis.
HEPATOLOGY 1999 30: 412A-412A.
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** Stumptner, C; Zatloukal, K; Fickert, P; Denk, H P62/A170 - A novel component of Mallory Bodies associated with alcoholic hepatitis.
HEPATOLOGY 1999 30: 551A-551A.
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** Trauner, M; Fickert, F; Zenz, R; Pojer, C; Fuchsbichler, A; Zollner, G; Denk, H; Zatloukal, K Role of Kupffer cells in regulation of multidrug resistance (mdr) P-glycoprotein expression in intrahepatic and obstructive cholestasis.
HEPATOLOGY 1999 30: 463A-463A.
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** Trauner, M; Zenz, R; Fickert, P; Kenner, L; Stauber, RE; Denk, H; Zatloukal, K Quantification of hepatobiliary transporter expression in liver biopsies from patients with cholestasis.
HEPATOLOGY 1999 30: 467A-467A.
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1998

Abstract (Zeitschrift)

** Guertl, B; Stumptner, C; Zatloukal, K; Denk, H Role of protein kinases and phosphatases in the pathogenesis of liver disease and related animal models.
HEPATOLOGY 1998 28: 638A-638A.
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** Kenner, L; Stumptner, C; Trauner, M; Fickert, P; Stauber, RE; Eferl, R; Denk, H; Zatloukal, K Tau overexpression in human alcoholic liver disease.
HEPATOLOGY 1998 28: 512A-512A.
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** Kenner, L; Trauner, M; Fickert, P; Stauber, RE; Eferl, R; Denk, H; Zatloukal, K Overexpression of keratin-8 and -18 RNA associated with mallory body formation in patients with alcoholic hepatitis.
HEPATOLOGY 1998 28: 303A-303A.
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** Magin, TM; Hesse, M; Zatloukal, K; Stumptner, C; Denk, H; Mayer, FJ Age-dependent formation of intermediate filament inclusion bodies in keratin 18-deficient mice.
MOL BIOL CELL 1998 9: 166A-166A.
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** Stumptner, C; Heid, H; Zatloukal, K; Fuchsbichler, A; Hauser, H; Denk, H Identification of p62, a phosphotyrosine-independent ligand of p56(lck), as a main component of intracytoplasmic hyaline bodies in hepatocellular carcinoma.
HEPATOLOGY 1998 28: 416A-416A.
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** Stumptner, C; Omary, MB; Denk, H; Zatloukal, K Changes in the phosphorylation of the hepatocytic keratins 8/18 in human alcoholic hepatitis and in experimentally intoxicated mouse liver.
HEPATOLOGY 1998 28: 512A-512A.
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** Stumptner, C; Omary, MB; Denk, H; Zatloukal, K Hepatocyte keratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a Mallory body mouse model.
MOL BIOL CELL 1998 9: 165A-165A.
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** Stumptner, C; Zatloukal, K; Magin, TM; Fuchsbichler, A; Franke, WW; Baribault, H; Denk, H Pronounced liver pathology in aged keratin 8 and keratin 18 knockout mice.
MOL BIOL CELL 1998 9: 165A-165A.
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** Stumptner, C; Zatloukal, K; Magin, TM; Fuchsbichler, A; Franke, WW; Baribault, H; Denk, H Different pathologic changes in livers of aged keratin 8 and keratin 18 knockout mice.
HEPATOLOGY 1998 28: 500A-500A.
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1997

Originalarbeit (Zeitschrift)

** Jatzko, G; Lisborg, P; Siebert, F; Denk, H; Klimpfinger, M A first report of familial visceral myopathy with additional chylous ascites in two siblings.
Scand J Gastroenterol. 1997; 32(2):187-190 Doi: 10.3109/00365529709000191 (- Case Report)
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** Lisborg, PH; Jatzko, GR; Denk, H; Klimpfinger, MH; Stettner, HM Long-term survival analysis of gastric cancer limited to the subserosa.
Z Gastroenterol. 1997; 35(9):663-668
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Übersichtsarbeit

** Jatzko, G; Kleinert, R; Denk, H Intestinal schistosomiasis, a facultative precancerous condition? Review of the literature with reference to Schistosoma japonicum associated rectum carcinoma
Chirurg. 1997; 68(7):727-731 Doi: 10.1007/s001040050261 (- Case Report)
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Abstract (Zeitschrift)

** Eferl, R; Kenner, L; Fickert, P; Stauber, R; Denk, H; Zatloukal, K Validation of quantitative reverse transcription polymerase chain reaction for analysis of gene expression in liver biopsies.
HEPATOLOGY 1997 26: 1496-1496.
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** Stumptner, C; Zatloukal, K; Hauser, H; Mischinger, HJ; Fuchsbichler, A; Denk, H Common antigens in intracytoplasmatic hyaline bodies in hepatocellular carcinoma, mallory bodies and neurofibrillary tangles.
HEPATOLOGY 1997 26: 265-265.
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** Stumptner, C; Zatloukal, K; Magin, TM; Franke, WW; Denk, H Keratin 8 and keratin is knockout mice as models for alcoholic hepatitis - Evidence for different functions of keratin 8 and 18.
MOL BIOL CELL 1997 8: 360-360.
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** Stumptner, C; Zatloukal, K; Magin, TM; Fuchsbichler, A; Franke, WW; Denk, H Keratin 8 and keratin 18 knockout mice as models for alcoholic hepatitis - Evidence for a different role of keratin 8 and 18 in MB formation.
HEPATOLOGY 1997 26: 264-264.
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** Zatloukal, K; Stumptner, C; Lehner, M; Fuchsbichler, A; Eshkind, LG; Baribault, H; Denk, H; Franke, WW Cytokeratin protects hepatocytes from intoxication: A possible new function of intermediate filaments revealed by cytokeratin 8 knock-out mice.
HEPATOLOGY 1997 26: 213-213.
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** Zatloukal, K; Stumptner, C; Lehner, M; Fuchsbichler, A; Eshkind, LG; Baribault, H; Denk, H; Franke, WW Keratin protects hepatocytes from intoxication: A possible new function of intermediate filaments as revealed by keratin 8 knock-out mice.
MOL BIOL CELL 1997 8: 361-361.
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1996

Originalarbeit (Zeitschrift)

** Petritsch, W; Hinterleitner, TA; Aichbichler, B; Denk, H; Hammer, HF; Krejs, GJ Endosonography in colitis cystica profunda and solitary rectal ulcer syndrome.
Gastrointest Endosc. 1996; 44(6):746-751 Doi: 10.1016/S0016-5107(96)70067-6 (- Case Report)
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** Preisegger, KH; Stumptner, C; Riegelnegg, D; Brown, PC; Silverman, JA; Thorgeirsson, SS; Denk, H Experimental Mallory body formation is accompanied by modulation of the expression of multidrug-resistance genes and their products.
Hepatology. 1996; 24(1):248-252 Doi: 10.1002/hep.510240139 [OPEN ACCESS]
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** Stupnicki, T; Taufer, M; Denk, H; Ratschek, M; Spath, P; Graf, K Triple therapy with sucralfate, amoxycillin and metronidazole for healing duodenal ulcer and eradicating Helicobacter pylori infection.
Aliment Pharmacol Ther. 1996; 10(2):193-197 Doi: 10.1046/j.1365-2036.1996.720100000.x
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Abstract (Zeitschrift)

** Eferl, R; Sibilia, M; Gurtl, B; Hilberg, F; Fuchsbichler, A; Kapfer, I; Stumptner, C; Denk, H; Wagner, EF; Zatloukal, K Role of c-jun in embryonic mouse liver development.
HEPATOLOGY 1996 24: 506-506.
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** Kenner, L; Zatloukal, K; Eferl, R; Stumptner, C; Denk, H Griseofulvin and DDC intoxication causes overexpression and changes in the alternative splicing of tau mRNA in murine liver.
HEPATOLOGY 1996 24: 911-911.
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** Preisegger, KH; Factor, V; Stumptner, C; Denk, H; Thorgeirsson, SS TGF-beta inhibits the proliferation of the potential liver stem cell compartment in the mouse
HEPATOLOGY 1996 24: 518-518.
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** Stumptner, C; Fuchsbichler, A; Denk, H; Zatloukal, K Overexpression of cytokeratin induces accumulation of the Mallory body-specific component M(M)120-1 in vitro.
HEPATOLOGY 1996 24: 10-10.
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** Stumptner, C; Fuchsbichler, A; Lehner, M; Denk, H; Zatloukal, K Overexpression of cytokeratin induces accumulation of the Mallory body-specific component M(M)120-1.
MOL BIOL CELL 1996 7: 300-300.
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** Zatloukal, K; Stumptner, C; Fuchsbichler, A; Lehner, M; Denk, H Induction of mallory bodies reflects a toxic memory response and is linked to overexpression of cytokeratin mRNA in hepatocytes.
HEPATOLOGY 1996 24: 1900-1900.
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1995

Originalarbeit (Zeitschrift)

** Jatzko, GR; Lisborg, PH; Denk, H; Klimpfinger, M; Stettner, HM A 10-year experience with Japanese-type radical lymph node dissection for gastric cancer outside of Japan.
Cancer. 1995; 76(8):1302-1312 Doi: 10.1002/1097-0142(19951015)76:8<1302::AID-CNCR2820760803>3.0.CO;2-8 [OPEN ACCESS]
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Editorial

** Ishak, K; Baptista, A; Bianchi, L; Callea, F; De Groote, J; Gudat, F; Denk, H; Desmet, V; Korb, G; MacSween, RN Histological grading and staging of chronic hepatitis.
J Hepatol. 1995; 22(6):696-699 Doi: 10.1016%2F0168-8278%2895%2980226-6
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Abstract (Zeitschrift)

** PETRITSCH, W; HINTERLEITNER, TA; AICHBICHLER, B; DENK, H; HAMMER, HF; KREJS, GJ ENDOSONOGRAPHIC FINDINGS IN COLITIS CYSTICA PROFUNDA AND SOLITARY RECTAL ULCER SYNDROME
GASTROINTEST ENDOSCOP 1995 41: 383-383. Doi: 10.1016/S0016-5107(05)80387-6
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1994

Originalarbeit (Zeitschrift)

** Lisborg, P; Jatzko, G; Horn, M; Neumann, HJ; Müller, M; Stettner, H; Denk, H Radical surgery (R2 resection) for gastric cancer. A multivariate analysis.
Scand J Gastroenterol. 1994; 29(11):1024-1028 Doi: 10.3109/00365529409094880
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** Salmhofer, H; Rainer, I; Zatloukal, K; Denk, H Posttranslational events involved in griseofulvin-induced keratin cytoskeleton alterations.
Hepatology. 1994; 20(3):731-740 Doi: 10.1016%2F0270-9139%2894%2990111-2
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Übersichtsarbeit

** Denk, H; Scheuer, PJ; Baptista, A; Bianchi, L; Callea, F; De Groote, J; Desmet, VJ; Gudat, F; Ishak, KG; Korb, G Guidelines for the diagnosis and interpretation of hepatic granulomas.
Histopathology. 1994; 25(3):209-218 Doi: 10.1111/j.1365-2559.1994.tb01320.x
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Kurzbericht/Note

** Kenner, L; el-Shabrawi, Y; Hutter, H; Forstner, M; Zatloukal, K; Hoefler, G; Preisegger, KH; Kurzbauer, R; Denk, H Expression of three- and four-repeat tau isoforms in mouse liver.
Hepatology. 1994; 20(4 Pt 1):1086-1089 Doi: 10.1002/hep.1840200442
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** Lax, SF; Beham, A; Kronberger-Schönecker, D; Langsteger, W; Denk, H Coexistence of papillary and medullary carcinoma of the thyroid gland-mixed or collision tumour? Clinicopathological analysis of three cases.
VIRCHOWS ARCHIV. 1994; 424(4): 441-447. Doi: 10.1007/BF00190568 (- Case Report)
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** Mandak, M; Kerbl, U; Kleinert, R; Höfler, G; Zeichen, R; Denk, H Miliary tuberculosis of the liver as a cause of septic shock with multi-organ failure
Wien Klin Wochenschr. 1994; 106(4):111-114 (- Case Report)
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1993

Originalarbeit (Zeitschrift)

** Hutter, H; Zatloukal, K; Winter, G; Stumptner, C; Denk, H Disturbance of keratin homeostasis in griseofulvin-intoxicated mouse liver.
Lab Invest. 1993; 69(5):576-582
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** Ohlinger, W; Dinges, HP; Zatloukal, K; Mair, S; Gollowitsch, F; Denk, H Immunohistochemical detection of tumor necrosis factor-alpha, other cytokines and adhesion molecules in human livers with alcoholic hepatitis.
Virchows Arch A Pathol Anat Histopathol. 1993; 423(3):169-176 Doi: 10.1007/BF01614767
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** Schmid, C; Zatloukal, K; Beham, A; Denk, H Involucrin expression in breast carcinomas: an immunohistochemical study.
VIRCHOWS ARCH A PATH ANAT HIS. 1993; 423(3): 161-167. Doi: 10.1007/BF01614766
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Kurzbericht/Letter

** Denk, H Osteoclastical Giant-Cell Tumor of the Pancreas - Critical Commentary
PATHOL RES PRACT . 1993; 189: 233-234. Doi: 10.1016/S0344-0338(11)80103-2
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1992

Originalarbeit (Zeitschrift)

** Beham, A; Ratschek, M; Zatloukal, K; Schmid, C; Denk, H Distribution of cytokeratins, vimentin and desmoplakins in normal renal tissue, renal cell carcinomas and oncocytoma as revealed by immunofluorescence microscopy.
Virchows Arch A Pathol Anat Histopathol. 1992; 421(3):209-215 Doi: 10.1007/BF01611177
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** Dinges, HP; Zatloukal, K; Denk, H; Smolle, J; Mair, S Alcoholic liver disease. Parenchyma to stroma relationship in fibrosis and cirrhosis as revealed by three-dimensional reconstruction and immunohistochemistry.
Am J Pathol. 1992; 141(1):69-83 [OPEN ACCESS]
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** Preisegger, KH; Zatloukal, K; Spurej, G; Riegelnegg, D; Denk, H Common epitopes of human and murine Mallory bodies and Lewy bodies as revealed by a neurofilament antibody.
Lab Invest. 1992; 66(2):193-199
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** Zatloukal, K; Denk, H; Spurej, G; Hutter, H Modulation of protein composition of nuclear lamina. Reduction of lamins B1 and B2 in livers of griseofulvin-treated mice.
Lab Invest. 1992; 66(5):589-597
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1991

Originalarbeit (Zeitschrift)

** Schmitt-Gräff, A; Krüger, S; Bochard, F; Gabbiani, G; Denk, H Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers.
Am J Pathol. 1991; 138(5):1233-1242 [OPEN ACCESS]
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** Zatloukal, K; Böck, G; Rainer, I; Denk, H; Weber, K High molecular weight components are main constituents of Mallory bodies isolated with a fluorescence activated cell sorter.
Lab Invest. 1991; 64(2):200-206
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1990

Originalarbeit (Zeitschrift)

** Ferenci, P; Vogel, W; Pristautz, H; Deimer, J; Denk, H; Judmaier, G; Maier, KP; Krejs, GJ; Gangl, A One-year treatment of chronic non-A, non-B hepatitis with interferon alfa-2b.
J Hepatol. 1990; 11 Suppl 1:S50-S53 Doi: 10.1016/0168-8278(90)90163-L
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** Radner, H; Kleinert, R; Vennigerholz, F; Denk, H Peculiar changes in Rosenthal fibres in an atypical astrocytoma.
Neuropathol Appl Neurobiol. 1990; 16(2):171-177 Doi: 10.1111/j.1365-2990.1990.tb00945.x (- Case Report)
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** Zatloukal, K; Denk, H; Spurej, G; Lackinger, E; Preisegger, KH; Franke, WW High molecular weight component of Mallory bodies detected by a monoclonal antibody.
Lab Invest. 1990; 62(4):427-434
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** Zatloukal, K; Spurej, G; Rainer, I; Lackinger, E; Denk, H Fate of Mallory body-containing hepatocytes: disappearance of Mallory bodies and restoration of the hepatocytic intermediate filament cytoskeleton after drug withdrawal in the griseofulvin-treated mouse.
Hepatology. 1990; 11(4):652-661 Doi: 10.1002/hep.1840110419
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1989

Originalarbeit (Zeitschrift)

** Judmaier, G; Prior, C; Klimpfinger, M; Bernklau, E; Vogel, W; Dietze, O; Denk, H Is percutaneous liver biopsy using the Trucut (Travenol) needle superior to Menghini puncture?
Z Gastroenterol. 1989; 27(11):657-661
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** Preisegger, KH; Denk, H Hepatitis delta virus infection: an immunohistochemical study
Wien Klin Wochenschr. 1989; 101(16):544-547
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** Zatloukal, K; Denk, H; Lackinger, E; Rainer, I Hepatocellular cytokeratins as substrates of transglutaminases.
Lab Invest. 1989; 61(6):603-608
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1988

Originalarbeit (Zeitschrift)

** Beham, A; Denk, H; Desoye, G The distribution of intermediate filament proteins, actin and desmoplakins in human placental tissue as revealed by polyclonal and monoclonal antibodies.
PLACENTA 1988 9: 479-492. Doi: 10.1016/0143-4004(88)90020-3
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** Denk, H Immunohistologic heterogeneity of malignant tumors.
Pathol Res Pract. 1988; 183(6):693-697 Doi: 10.1016/S0344-0338(88)80054-2
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** Denk, H; Klimpfinger, M Colorectal cancer: classification and aspects of the proliferation kinetics
Wien Med Wochenschr. 1988; 138(11-12):288-292
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** Klimpfinger, M; Hauser, H; Beham, A; Denk, H Classification of colorectal cancers: current results from the catchment area of the Graz Institute of Pathology
Wien Med Wochenschr. 1988; 138(11-12):267-270
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** Zatloukal, K; Sohar, R; Lackinger, E; Denk, H Induction of heat shock proteins in short-term cultured hepatocytes derived from normal and chronically griseofulvin-treated mice.
Hepatology. 1988; 8(3):607-612 Doi: 10.1002/hep.1840080328
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1987

Originalarbeit (Zeitschrift)

** Denk, H; Lackinger, E; Zatloukal, K; Franke, WW Turnover of cytokeratin polypeptides in mouse hepatocytes.
Exp Cell Res. 1987; 173(1):137-143 Doi: 10.1016/0014-4827(87)90339-9
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** Denk, H; Moll, R; Weybora, W; Lackinger, E; Vennigerholz, F; Beham, A; Franke, WW Intermediate filaments and desmosomal plaque proteins in testicular seminomas and non-seminomatous germ cell tumours as revealed by immunohistochemistry.
Virchows Arch A Pathol Anat Histopathol. 1987; 410(4):295-307 Doi: 10.1007/BF00711286
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** Dragosics, B; Ferenci, P; Hitchman, E; Denk, H Long-term follow-up study of asymptomatic HBsAg-positive voluntary blood donors in Austria: a clinical and histologic evaluation of 242 cases.
Hepatology. 1987; 7(2):302-306 Doi: 10.1002/hep.1840070215
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** Klimpfinger, M; Beham, A; Denk, H Pathologic findings in colorectal cancers and discussion of their significance for tumor therapy according to stage
Wien Klin Wochenschr. 1987; 99(14):488-493
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** Popper, H; Wirnsberger, G; Hoefler, H; Denk, H Immunohistochemical and histochemical markers of primary lung cancer, lung metastases, and pleural mesotheliomas.
Cancer Detect Prev. 1987; 10(3-4):167-174
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1986

Originalarbeit (Zeitschrift)

** Beham, A; Weybora, W; Lackinger, E; Denk, H; Björklund, V; Björklund, B Distribution of TPA and cytokeratins in gastrointestinal carcinomas as revealed by immunohistochemistry.
Virchows Arch A Pathol Anat Histopathol. 1986; 409(5):641-655 Doi: 10.1007/BF00713430
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** Hazan, R; Denk, H; Franke, WW; Lackinger, E; Schiller, DL Change of cytokeratin organization during development of Mallory bodies as revealed by a monoclonal antibody.
Lab Invest. 1986; 54(5):543-553
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** Hoefler, H; Denk, H; Lackinger, E; Helleis, G; Polak, JM; Heitz, PU Immunocytochemical demonstration of intermediate filament cytoskeleton proteins in human endocrine tissues and (neuro-) endocrine tumours.
Virchows Arch A Pathol Anat Histopathol. 1986; 409(5):609-626 Doi: 10.1007/BF00713428
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Übersichtsarbeit

** Denk, H; Lackinger, E Cytoskeleton in liver diseases.
Semin Liver Dis. 1986; 6(3):199-211 Doi: 10.1055/s-2008-1040603
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** Denk, H; Lackinger, E; Vennigerholz, F Pathology of the cytoskeleton of hepatocytes.
Prog Liver Dis. 1986; 8(1):237-251
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1985

Originalarbeit (Zeitschrift)

** Denk, H; Lackinger, E; Cowin, P; Franke, WW Maintenance of desmosomes in mouse hepatocytes after drug-induced rearrangement of cytokeratin filament material. Demonstration of independence of desmosomes and intermediate-sized filaments.
Exp Cell Res. 1985; 161(1):161-171 Doi: 10.1016/0014-4827(85)90500-2
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** Denk, H; Weybora, W; Ratschek, M; Sohar, R; Franke, WW Distribution of vimentin, cytokeratins, and desmosomal-plaque proteins in human nephroblastoma as revealed by specific antibodies: co-existence of cell groups of different degrees of epithelial differentiation.
Differentiation. 1985; 29(1):88-97 Doi: 10.1111/j.1432-0436.1985.tb00297.x
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** Höfler, H; Kerl, H; Lackinger, E; Helleis, G; Denk, H The intermediate filament cytoskeleton of cutaneous neuroendocrine carcinoma (Merkel cell tumour). Immunohistochemical and biochemical analyses.
Virchows Arch A Pathol Anat Histopathol. 1985; 406(3):339-350 Doi: 10.1007/BF00704303
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Übersichtsarbeit

** Denk, H; Lackinger, E Changes in the intermediate filament cytoskeleton of liver cells in alcoholic liver injury
WIEN KLIN WOCHENSCHR. 1985; 97(8): 354-358.
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1984

Originalarbeit (Zeitschrift)

** DENK, H THE INTERMEDIATE FILAMENT CYTOSKELETON IN NEOPLASTIC AND NON-NEOPLASTIC LIVER DISORDERS
J SUBMICROSC CYTOL PATHOL 1984 16: 141-145.
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** Denk, H; Bernklau, G; Krepler, R Effect of griseofulvin treatment and neoplastic transformation on transglutaminase activity in mouse liver.
Liver. 1984; 4(3):208-213 Doi: 10.1111/j.1600-0676.1984.tb00929.x
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** Fritsch, A; Denk, H; Jakesz, R; Wunderlich, M; Schiessel, R The role of the pathologist in reinterventions in surgery
CHIRURG. 1984; 55(7): 438-443.
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** Hoefler, H; Kerl, H; Rauch, HJ; Denk, H New immunocytochemical observations with diagnostic significance in cutaneous neuroendocrine carcinoma.
Am J Dermatopathol. 1984; 6(6):525-530 Doi: 10.1097/00000372-198412000-00002
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** Höfler, H; Denk, H Immunocytochemical demonstration of cytokeratin in gastrointestinal carcinoids and their probable precursor cells.
Virchows Arch A Pathol Anat Histopathol. 1984; 403(3):235-240 Doi: 10.1007/BF00694899
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** Höfler, H; Denk, H; Walter, GF Immunohistochemical demonstration of cytokeratins in endocrine cells of the human pituitary gland and in pituitary adenomas.
Virchows Arch A Pathol Anat Histopathol. 1984; 404(4):359-368 Doi: 10.1007/BF00695220
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** Höfler, H; Walter, GF; Denk, H Immunohistochemistry of folliculo-stellate cells in normal human adenohypophyses and in pituitary adenomas.
Acta Neuropathol (Berl). 1984; 65(1):35-40 Doi: 10.1007/BF00689825
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** Seifert, G; Denk, H; Klein, PJ; Stein, H; Otto, HF Use of immunocytochemistry in practical diagnosis by the pathologist. Areas of use--methods--cost planning
PATHOLOGE. 1984; 5(4): 187-199.
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