Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Kretschmer Nadine |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2024

Originalarbeit (Zeitschrift)

** Kobetitsch, S; Gierlikowska, B; Kunert, O; Mazen, AMA; Raab, P; Kretschmer, N; Donolo, C; Pirker, T; Bauer, R; Kiss, AK; Pferschy-Wenzig, EM Salvadora persica leaves: phytochemical profile and in vitro-inhibitory activity on inflammatory mediators implicated in periodontal disease.
Pharm Biol. 2024; 62(1): 563-576. Doi: 10.1080/13880209.2024.2374801 [OPEN ACCESS]
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2023

Originalarbeit (Zeitschrift)

** Lohberger, B; Kaltenegger, H; Eck, N; Glänzer, D; Leithner, A; Kretschmer, N The Biological Assessment of Shikonin and β,β-dimethylacrylshikonin Using a Cellular Myxofibrosarcoma Tumor Heterogeneity Model.
Int J Mol Sci. 2023; 24(21): Doi: 10.3390/ijms242115910 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Lohberger, B; Sadoghi, P; Leithner, A; Kretschmer, N; Steinecker-Frohnwieser, B NEXT GENERATION SEQUENCING AND SHIKONIN EFFECTS ON HUMAN PRIMARY ARTICULAR OSTEOARTHRITIS CHONDROCYTES
ANN RHEUM DIS. 2023; 82: 1196-1196. Doi: 10.1136/annrheumdis-2023-eular.3578 [Poster]
Web of Science FullText FullText_MUG

 

2022

Originalarbeit (Zeitschrift)

** Kretschmer, N; Durchschein, C; Hufner, A; Rinner, B; Lohberger, B; Bauer, R SK119, a Novel Shikonin Derivative, Leads to Apoptosis in Melanoma Cell Lines and Exhibits Synergistic Effects with Vemurafenib and Cobimetinib
INT J MOL SCI. 2022; 23(10): 5684 Doi: 10.3390/ijms23105684 [OPEN ACCESS]
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** Lohberger, B; Glänzer, D; Kaltenegger, H; Eck, N; Leithner, A; Bauer, R; Kretschmer, N; Steinecker-Frohnwieser, B Shikonin derivatives cause apoptosis and cell cycle arrest in human chondrosarcoma cells via death receptors and MAPK regulation.
BMC Cancer. 2022; 22(1):758 Doi: 10.1186/s12885-022-09857-x [OPEN ACCESS]
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** Lohberger, B; Kaltenegger, H; Eck, N; Glänzer, D; Sadoghi, P; Leithner, A; Bauer, R; Kretschmer, N; Steinecker-Frohnwieser, B Shikonin Derivatives Inhibit Inflammation Processes and Modulate MAPK Signaling in Human Healthy and Osteoarthritis Chondrocytes.
Int J Mol Sci. 2022; 23(6): Doi: 10.3390/ijms23063396 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Lohberger, B; Kaltenegger, H; Eck, N; Glanzer, D; Leithner, A; Bauer, R; Kretschmer, N; Steinecker-Frohnwieser, B THE SUPPRESSION OF INFLAMMATORY PROCESSES AND MODULATION OF MAPK SIGNALING BY SHIKONIN DERIVATIVES IN PRIMARY OA CHONDROCYTES
ANN RHEUM DIS. 2022; 81: 1159-1159. Doi: 10.1136/annrheumdis-2022-eular.1544 [Poster]
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2021

Originalarbeit (Zeitschrift)

** Kretschmer, N; Hufner, A; Durchschein, C; Popodi, K; Rinner, B; Lohberger, B; Bauer, R Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives.
Int J Mol Sci. 2021; 22(5): Doi: 10.3390/ijms22052774 [OPEN ACCESS]
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** Schrom, S; Hebesberger, T; Wallner, SA; Anders, I; Richtig, E; Brandl, W; Hirschmugl, B; Garofalo, M; Bernecker, C; Schlenke, P; Kashofer, K; Wadsack, C; Aigelsreiter, A; Heitzer, E; Riedl, S; Zweytick, D; Kretschmer, N; Richtig, G; Rinner, B MUG Mel3 Cell Lines Reflect Heterogeneity in Melanoma and Represent a Robust Model for Melanoma in Pregnancy.
Int J Mol Sci. 2021; 22(21): Doi: 10.3390/ijms222111318 [OPEN ACCESS]
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2020

Originalarbeit (Zeitschrift)

** Lohberger, B; Bernhart, E; Stuendl, N; Glaenzer, D; Leithner, A; Rinner, B; Bauer, R; Kretschmer, N Periplocin mediates TRAIL-induced apoptosis and cell cycle arrest in human myxofibrosarcoma cells via the ERK/p38/JNK pathway.
Phytomedicine. 2020; 76: 153262-153262. Doi: 10.1016/j.phymed.2020.153262 [OPEN ACCESS]
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** Stallinger, A; Kretschmer, N; Kleinegger, F; Brvar, L; Liegl-Atzwanger, B; Prokesch, A; Durchschein, C; Bauer, R; Deutsch, A; Rinner, B β,β-Dimethylacrylshikonin Induces Apoptosis in Melanoma Cell Lines by NOXA Upregulation.
J Nat Prod. 2020; 83(2):305-315 Doi: 10.1021/acs.jnatprod.9b00719
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2019

Originalarbeit (Zeitschrift)

** Tran, HT; Gao, X; Kretschmer, N; Pferschy-Wenzig, EM; Raab, P; Pirker, T; Temml, V; Schuster, D; Kunert, O; Huynh, L; Bauer, R Anti-inflammatory and antiproliferative compounds from Sphaeranthus africanus.
Phytomedicine. 2019; 62: 152951 Doi: 10.1016/j.phymed.2019.152951
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2018

Originalarbeit (Zeitschrift)

** Durchschein, C; Hufner, A; Rinner, B; Stallinger, A; Deutsch, A; Lohberger, B; Bauer, R; Kretschmer, N Synthesis of Novel Shikonin Derivatives and Pharmacological Effects of Cyclopropylacetylshikonin on Melanoma Cells.
Molecules. 2018; 23(11): Doi: 10.3390/molecules23112820 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Jahanafrooz, Z; Stallinger, A; Anders, I; Kleinegger, F; Lohberger, B; Durchschein, C; Bauer, R; Deutsch, A; Rinner, B; Kretschmer, N Influence of silibinin and β-β-dimethylacrylshikonin on chordoma cells.
Phytomedicine. 2018; 49(11):32-40 Doi: 10.1016/j.phymed.2018.06.005
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** Katanić, J; Pferschy-Wenzig, EM; Mihailović, V; Boroja, T; Pan, SP; Nikles, S; Kretschmer, N; Rosić, G; Selaković, D; Joksimović, J; Bauer, R Phytochemical analysis and anti-inflammatory effects of Filipendula vulgaris Moench extracts.
Food Chem Toxicol. 2018; 122(11):151-162 Doi: 10.1016/j.fct.2018.10.001
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** Kretschmer, N; Deutsch, A; Durchschein, C; Rinner, B; Stallinger, A; Higareda-Almaraz, JC; Scheideler, M; Lohberger, B; Bauer, R Comparative Gene Expression Analysis in WM164 Melanoma Cells Revealed That β-β-Dimethylacrylshikonin Leads to ROS Generation, Loss of Mitochondrial Membrane Potential, and Autophagy Induction.
Molecules. 2018; 23(11): Doi: 10.3390/molecules23112823 [OPEN ACCESS]
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** Lohberger, B; Wagner, S; Wohlmuther, J; Kaltenegger, H; Stuendl, N; Leithner, A; Rinner, B; Kunert, O; Bauer, R; Kretschmer, N Periplocin, the most anti-proliferative constituent of Periploca sepium, specifically kills liposarcoma cells by death receptor mediated apoptosis.
Phytomedicine. 2018; 51:162-170 Doi: 10.1016/j.phymed.2018.10.008
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** Mohsin, NU; Seebacher, W; Faist, J; Hochegger, P; Kaiser, M; Mäser, P; Belaj, F; Saf, R; Kretschmer, N; Alajlani, M; Turek, I; Brantner, A; Bauer, R; Bucar, F; Weis, R Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
Eur J Med Chem. 2018; 143(8):97-106 Doi: 10.1016/j.ejmech.2017.11.025
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** Presser, A; Lainer, G; Kretschmer, N; Schuehly, W; Saf, R; Kaiser, M; Kalt, MM Synthesis of Jacaranone-Derived Nitrogenous Cyclohexadienones and Their Antiproliferative and Antiprotozoal Activities.
Molecules. 2018; 23(11): Doi: 10.3390/molecules23112902 [OPEN ACCESS]
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** Tran, HT; Pferschy-Wenzig, EM; Kretschmer, N; Kunert, O; Huynh, L; Bauer, R Antiproliferative Carvotacetones from Sphaeranthus africanus.
J Nat Prod. 2018; 81(8):1829-1834 Doi: 10.1021/acs.jnatprod.8b00309
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2017

Originalarbeit (Zeitschrift)

** Hasenoehrl, C; Schwach, G; Ghaffari-Tabrizi-Wizsy, N; Fuchs, R; Kretschmer, N; Bauer, R; Pfragner, R Anti-tumor effects of shikonin derivatives on human medullary thyroid carcinoma cells.
Endocr Connect. 2017; 6(2):53-62 Doi: 10.1530/EC-16-0105 [OPEN ACCESS]
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** Katanić, J; Matić, S; Pferschy-Wenzig, EM; Kretschmer, N; Boroja, T; Mihailović, V; Stanković, V; Stanković, N; Mladenović, M; Stanić, S; Mihailović, M; Bauer, R Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
Food Chem Toxicol. 2017; 99(2):86-102 Doi: 10.1016/j.fct.2016.11.018
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2016

Originalarbeit (Zeitschrift)

** Pacifico, S; Piccolella, S; Galasso, S; Fiorentino, A; Kretschmer, N; Pan, SP; Bauer, R; Monaco, P Influence of harvest season on chemical composition and bioactivity of wild rue plant hydroalcoholic extracts.
Food Chem Toxicol. 2016; 90(2):102-111 Doi: 10.1016/j.fct.2016.02.009
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2015

Originalarbeit (Zeitschrift)

** Lohberger, B; Kretschmer, N; Bernhart, E; Rinner, B; Stuendl, N; Kaltenegger, H; Kahl, S; Bauer, R; Leithner, A 25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.
J Ethnopharmacol. 2015; 164(36):265-272 Doi: 10.1016/j.jep.2015.02.023
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** Zhao, Q; Assimopoulou, AN; Klauck, SM; Damianakos, H; Chinou, I; Kretschmer, N; Rios, JL; Papageorgiou, VP; Bauer, R; Efferth, T Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.
Oncotarget. 2015; 6(36):38934-38951 Doi: 10.18632/oncotarget.5380 [OPEN ACCESS]
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** Zhao, Q; Kretschmer, N; Bauer, R; Efferth, T Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib.
Int J Cancer. 2015; 137(6):1446-1456 Doi: 10.1002/ijc.29483 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Kretschmer, N; Heubl, G; Bauer, R Discrimination of Zi Cao species based on genomic analysis, TLC and HPLC
PLANTA MED. . 2015; 81(16):1542-1542.-63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA); AUG 23-27, 2015; Budapest, HUNGARY. [Oral Communication]
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** Kretschmer, N; Lohberger, B; Bernhart, E; Rinner, B; Stuendl, N; Kaltenegger, H; Kahl, S; Bauer, R; Leithner, A Effects of 25-O-acetyl-23,24-dihydro-cucurbitacin F on cell viability, cell cycle distribution and apoptosis induction in human soft tissue sarcoma cells
PLANTA MED. . 2015; 81(16):1482-1482.-63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA); AUG 23-27, 2015; Budapest, HUNGARY. [Oral Communication]
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2014

Originalarbeit (Zeitschrift)

** Alza, NP; Pferschy-Wenzig, EM; Ortmann, S; Kretschmer, N; Kunert, O; Rechberger, GN; Bauer, R; Murray, AP Inhibition of NO production by Grindelia argentina and isolation of three new cytotoxic saponins.
Chem Biodivers. 2014; 11(2):311-322 Doi: 10.1002/cbdv.201300193
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** Bernaskova, M; Kretschmer, N; Schuehly, W; Huefner, A; Weis, R; Bauer, R Synthesis of tetrahydrohonokiol derivates and their evaluation for cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma and HCT-116 colon cancer cells.
Molecules. 2014; 19(1):1223-1237 Doi: 10.3390/molecules19011223 [OPEN ACCESS]
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** Galasso, S; Pacifico, S; Kretschmer, N; Pan, SP; Marciano, S; Piccolella, S; Monaco, P; Bauer, R Influence of seasonal variation on Thymus longicaulis C. Presl chemical composition and its antioxidant and anti-inflammatory properties.
Phytochemistry. 2014; 107(6):80-90 Doi: 10.1016/j.phytochem.2014.08.015
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** Schinkovitz, A; Kaur, A; Urban, E; Zehl, M; Páchniková, G; Wang, Y; Kretschmer, N; Slaninová, I; Pauli, GF; Franzblau, SG; Krupitza, G; Bauer, R; Kopp, B Cytotoxic constituents from Lobaria scrobiculata and a comparison of two bioassays for their evaluation.
J Nat Prod. 2014; 77(4):1069-1073 Doi: 10.1021/np4008574
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2013

Originalarbeit (Zeitschrift)

** Lohberger, B; Rinner, B; Stuendl, N; Kaltenegger, H; Steinecker-Frohnwieser, B; Bernhart, E; Bonyadi Rad, E; Weinberg, AM; Leithner, A; Bauer, R; Kretschmer, N Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells.
PLoS One. 2013; 8(6):e66300-e66300 Doi: 10.1371/journal.pone.0066300 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Kretschmer, N; Rinner, B; Deutsch, A; Lohberger, B; Schaider, H; Bauer, R In vitro effects of dimethylacrylshikonin on melanoma cells
J DTSCH DERMATOL GES. . 2013; 11: 92-92. [Poster]
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2012

Originalarbeit (Zeitschrift)

** Damianakos, H; Kretschmer, N; Sykłowska-Baranek, K; Pietrosiuk, A; Bauer, R; Chinou, I Antimicrobial and cytotoxic isohexenylnaphthazarins from Arnebia euchroma (Royle) Jonst. (Boraginaceae) callus and cell suspension culture.
Molecules. 2012; 17(12):14310-14322 Doi: 10.3390/molecules171214310 [OPEN ACCESS]
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** Gregori, A; Kretschmer, N; Wagner, S; Boechzelt, H; Klinar, D; Bauer, R; Pohleven, F Influence of olive oil press cakes on Shiitake culinary-medicinal mushroom, lentinus edodes (Berk.) singer (higher basidiomycetes) fruiting bodies production and effect of their crude polysaccharides on CCRF-CEM cell proliferation.
Int J Med Mushrooms. 2012; 14(4):419-424 Doi: 10.1615/IntJMedMushr.v14.i4.100
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** Kretschmer, N; Rinner, B; Deutsch, AJ; Lohberger, B; Knausz, H; Kunert, O; Blunder, M; Boechzelt, H; Schaider, H; Bauer, R Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma Cells.
J Nat Prod. 2012; 75(5):865-869 Doi: 10.1021/np2006499 [OPEN ACCESS]
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** Kretschmer, N; Rinner, B; Stuendl, N; Kaltenegger, H; Wolf, E; Kunert, O; Boechzelt, H; Leithner, A; Bauer, R; Lohberger, B Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells.
Planta Med. 2012; 78(16):1749-1756 Doi: 10.1055/s-0032-1315385 [OPEN ACCESS]
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2011

Originalarbeit (Zeitschrift)

** Kretschmer, N; Blunder, M; Kunert, O; Rechberger, GN; Bauer, R; Schuehly, W Cytotoxic furanogermacranolides from the flowers of Helianthus angustifolius.
Planta Med. 2011; 77(17):1912-1915 Doi: 10.1055/s-0031-1279994
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2010

Originalarbeit (Zeitschrift)

** Rinner, B; Kretschmer, N; Knausz, H; Mayer, A; Boechzelt, H; Hao, XJ; Heubl, G; Efferth, T; Schaider, H; Bauer, R A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner.
J Ethnopharmacol. 2010; 129(2):182-188 Doi: 10.1016/j.jep.2010.02.006
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Abstract (Zeitschrift)

** Kretschmer, N; Rinner, B; Deutsch, A; Knausz, H; Blunder, M; Kunert, O; Efferth, T; Schaider, H; Boechzelt, H; Bauer, R Effects of dimethylacrylshikonin and epoxyshikonin on melanoma cell lines
PLANTA MED. 2010; 76(12):1281-1281. [Poster]
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** Rinner, B; Kretschmer, N; Deutsch, A; Knausz, H; Novak, A; Boechzelt, H; Schaider, H; Bauer, R ANTI-CANCER ACTIVITY OF A PETROL ETHER EXTRACT OF ONOSMA PANICULATUM
CYTOMETRY PART B-CLIN CYTOM. 2010; 78B(6):458-459. [Poster]
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2009

Abstract (Zeitschrift)

** Kretschmer, N; Rinner, B; Knausz, H; Efferth, T; Boechzelt, H; Schaider, H; Bauer, R A petrol ether extract of Onosma paniculatum Bur. & Franch. shows strong anti-proliferative activity and induces apoptosis in human cancer cell lines
PLANTA MED. 2009; 75(9):969-969.-57th international congress and annual meeting of the socitey for medicinal plant and natural product reserach; 16th-20th August; Geneva. [Poster]
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