Medizinische Universität Graz - Research portal
Byrne Nikole |
** = Publications listed in SCI/SSCI/Pubmed
2025
Full paper/article (Journal)
** Byrne, NJ; Koentges, C; Khan, E; Pfeil, K; Sandulescu, R; Bakshi, S; Költgen, C; Vosko, I; Gollmer, J; Rathner, T; Rothf, G; Hoffmann, MM; Odening, KE; Orstmann, H; Potter, LA; Boded, C; Wolf, D; Sourij, H; Ljubojevic-Holzera, S; Wallnera, M; Rainer, PP; Sedej, S; Scherr, D; von Lewinski, D; Wende, AR; Zirlik, A; Bugger, H
Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
J MOL CELL CARD PLUS. 2025; 12: 100299
Doi: 10.1016/j.jmccpl.2025.100299
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2024
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** Hofmann, C; Serafin, A; Schwerdt, OM; Fischer, J; Sicklinger, F; Younesi, FS; Byrne, NJ; Meyer, IS; Malovrh, E; Sandmann, C; Jürgensen, L; Kamuf-Schenk, V; Stroh, C; Löwenthal, Z; Finke, D; Boileau, E; Beisaw, A; Bugger, H; Rettel, M; Stein, F; Katus, HA; Jakobi, T; Frey, N; Leuschner, F; Völkers, M
Transient Inhibition of Translation Improves Cardiac Function After Ischemia/Reperfusion by Attenuating the Inflammatory Response.
Circulation. 2024;
Doi: 10.1161/CIRCULATIONAHA.123.067479
[OPEN ACCESS]
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2023
Abstract (Journal)
** Byrne, N; Koentges, C; Khan, E; Pfeil, K; Sandulescu, R; Bakshi, S; Koltgen, C; Vosko, I; Gollmer, J; Hoffmann, M; Wolf, D; Ljubojevic-Holzer, S; Wallner, M; Rainer, P; Sedej, S; Scherr, D; von Lewinski, D; Wende, A; Zirlik, A; Bugger, H
Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
WIEN KLIN WOCHENSCHR. 2023; 135: S398-S398.-Österreichische Kardiologische Gesellschaft (ÖKG); Salzburg, AUSTRIA.
[Poster]
Web of Science
** Vosko, I; Holscher, ME; Koentges, C; Tarkhnishvili, A; Byrne, NJ; Pfeil, K; Tang, S; Gollmer, J; Hoffmann, MM; von Lewinski, D; Wallner, M; Bode, C; Zirlik, A; Bugger, H
SIRT4 deficiency modifies fatty acid utilization in the normal and diabetic heart
WIEN KLIN WOCHENSCHR. 2023; 135: S454-S454.
[Poster]
Web of Science
2022
Full paper/article (Journal)
** Lorenzana-Carrillo, MA; Gopal, K; Byrne, NJ; Tejay, S; Saleme, B; Das, SK; Zhang, Y; Haromy, A; Eaton, F; Mendiola, Pla, M; Bowles, DE; Dyck, JRB; Ussher, JR; Michelakis, ED; Sutendra, G
TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.
Sci Transl Med. 2022; 14(669): eabm3565
Doi: 10.1126/scitranslmed.abm3565
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** Tarkhnishvili, A; Koentges, C; Pfeil, K; Gollmer, J; Byrne, NJ; Vosko, I; Lueg, J; Vogelbacher, L; Birkle, S; Tang, S; Bon-Nawul, Mwinyella, T; Hoffmann, MM; Odening, KE; Michel, NA; Wolf, D; Stachon, P; Hilgendorf, I; Wallner, M; Ljubojevic-Holzer, S; von, Lewinski, D; Rainer, P; Sedej, S; Sourij, H; Bode, C; Zirlik, A; Bugger, H
Effects of Short Term Adiponectin Receptor Agonism on Cardiac Function and Energetics in Diabetic db/db Mice.
J Lipid Atheroscler. 2022; 11(2):161-177
Doi: 10.12997/jla.2022.11.2.161
[OPEN ACCESS]
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Review
** Bugger, H; Byrne, NJ; Abel, ED
Animal Models of Dysregulated Cardiac Metabolism.
Circ Res. 2022; 130(12):1965-1993
Doi: 10.1161/CIRCRESAHA.122.320334
[OPEN ACCESS]
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Abstract (Journal)
** Byrne, NJ; Witt, CN; Koentges, C; Pfeil, K; Pusdrowski, T; Gollmer, J; Vosko, I; Bode, C; Zirlik, A; Bugger, H
SIRT5 is necessary for recovery from myocardial ischemia reperfusion injury
J MOL CELL CARDIOL. 2022; 173: S67-S67.Berlin, GERMANY.
Doi: 10.1016/j.yjmcc.2022.08.136
[Poster]
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2021
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** Philippaert, K; Kalyaanamoorthy, S; Fatehi, M; Long, W; Soni, S; Byrne, NJ; Barr, A; Singh, J; Wong, J; Palechuk, T; Schneider, C; Darwesh, AM; Maayah, ZH; Seubert, JM; Barakat, K; Dyck, JRB; Light, PE
Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin.
Circulation. 2021; 143(22): 2188-2204.
Doi: 10.1161/CIRCULATIONAHA.121.053350
[OPEN ACCESS]
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Review
** Byrne, NJ; Rajasekaran, NS; Abel, ED; Bugger, H
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy.
Free Radic Biol Med. 2021; 169:317-342
Doi: 10.1016/j.freeradbiomed.2021.03.046
[OPEN ACCESS]
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Abstract (Journal)
** Tarkhnishvili, A; Gollmer, J; Koentges, C; Byrne, NJ; Pfeil, K; Mwinyella, TB; Wolf, D; Bode, C; Zirlik, A; Bugger, H
Effects of short term adiponectin receptor agonism on cardiac function and energetics in diabetic db/db mice
WIEN KLIN WOCHENSCHR. 2021; 133(SUPPL 3):S49-S50.
[Oral Communication]
Web of Science
2020
Full paper/article (Journal)
** Byrne, NJ; Matsumura, N; Maayah, ZH; Ferdaoussi, M; Takahara, S; Darwesh, AM; Levasseur, JL; Jahng, JWS; Vos, D; Parajuli, N; El-Kadi, AOS; Braam, B; Young, ME; Verma, S; Light, PE; Sweeney, G; Seubert, JM; Dyck, JRB
Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure.
Circ Heart Fail. 2020; 13(1): e006277
Doi: 10.1161/CIRCHEARTFAILURE.119.006277
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** Byrne, NJ; Soni, S; Takahara, S; Ferdaoussi, M; Al, Batran, R; Darwesh, AM; Levasseur, JL; Beker, D; Vos, DY; Schmidt, MA; Alam, AS; Maayah, ZH; Schertzer, JD; Seubert, JM; Ussher, JR; Dyck, JRB
Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure.
Circ Heart Fail. 2020; 13(6): e006573
Doi: 10.1161/CIRCHEARTFAILURE.119.006573
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2019
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** Wang, W; Zhang, L; Battiprolu, PK; Fukushima, A; Nguyen, K; Milner, K; Gupta, A; Altamimi, T; Byrne, N; Mori, J; Alrob, OA; Wagg, C; Fillmore, N; Wang, SH; Liu, DM; Fu, A; Lu, JY; Chaves, M; Motani, A; Ussher, JR; Reagan, JD; Dyck, JRB; Lopaschuk, GD
Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction.
JACC Basic Transl Sci. 2019; 4(3):385-400
Doi: 10.1016/j.jacbts.2019.02.003
[OPEN ACCESS]
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2018
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** Matsumura, N; Takahara, S; Maayah, ZH; Parajuli, N; Byrne, NJ; Shoieb, SM; Soltys, CM; Beker, DL; Masson, G; El-Kadi, AOS; Dyck, JRB
Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites.
J Mol Cell Cardiol. 2018; 125: 162-173.
Doi: 10.1016/j.yjmcc.2018.10.023
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2017
Full paper/article (Journal)
** Byrne, NJ; Parajuli, N; Levasseur, JL; Boisvenue, J; Beker, DL; Masson, G; Fedak, PWM; Verma, S; Dyck, JRB
Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure.
JACC Basic Transl Sci. 2017; 2(4): 347-354.
Doi: 10.1016/j.jacbts.2017.07.003
[OPEN ACCESS]
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** Sung, MM; Byrne, NJ; Kim, TT; Levasseur, J; Masson, G; Boisvenue, JJ; Febbraio, M; Dyck, JR
Cardiomyocyte-specific ablation of CD36 accelerates the progression from compensated cardiac hypertrophy to heart failure.
Am J Physiol Heart Circ Physiol. 2017; 312(3): H552-H560.
Doi: 10.1152/ajpheart.00626.2016
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** Sung, MM; Byrne, NJ; Robertson, IM; Kim, TT; Samokhvalov, V; Levasseur, J; Soltys, CL; Fung, D; Tyreman, N; Denou, E; Jones, KE; Seubert, JM; Schertzer, JD; Dyck, JR
Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure.
Am J Physiol Heart Circ Physiol. 2017; 312(4): H842-H853.
Doi: 10.1152/ajpheart.00455.2016
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2016
Full paper/article (Journal)
** Byrne, NJ; Levasseur, J; Sung, MM; Masson, G; Boisvenue, J; Young, ME; Dyck, JR
Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression.
Cardiovasc Res. 2016; 110(2): 249-57.
Doi: 10.1093/cvr/cvw051
[OPEN ACCESS]
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2015
Full paper/article (Journal)
** Sung, MM; Das, SK; Levasseur, J; Byrne, NJ; Fung, D; Kim, TT; Masson, G; Boisvenue, J; Soltys, CL; Oudit, GY; Dyck, JR
Resveratrol treatment of mice with pressure-overload-induced heart failure improves diastolic function and cardiac energy metabolism.
Circ Heart Fail. 2015; 8(1): 128-37.
Doi: 10.1161/CIRCHEARTFAILURE.114.001677
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