Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Bugger Heiko Matthias |
** = Publikationen gelistet in SCI/SSCI/Pubmed
2025
Originalarbeit (Zeitschrift)
** Byrne, NJ; Koentges, C; Khan, E; Pfeil, K; Sandulescu, R; Bakshi, S; Költgen, C; Vosko, I; Gollmer, J; Rathner, T; Rothf, G; Hoffmann, MM; Odening, KE; Orstmann, H; Potter, LA; Boded, C; Wolf, D; Sourij, H; Ljubojevic-Holzera, S; Wallnera, M; Rainer, PP; Sedej, S; Scherr, D; von Lewinski, D; Wende, AR; Zirlik, A; Bugger, H
Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
J MOL CELL CARD PLUS. 2025; 12: 100299
Doi: 10.1016/j.jmccpl.2025.100299
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** Lindfors, S; Schmotz, C; Lewandowski, D; Hau, A; Saikko, L; Lehtonen, E; Majaniemi, V; Karhe, M; Naams, JB; Nisen, H; Tienari, J; Saleem, MA; Pfeil, K; Bugger, H; Pietiläinen, KH; Mirtti, T; Palczewski, K; Lehtonen, S
Integrin Trafficking, Fibronectin Architecture, and Glomerular Injury upon AdipoR1 Depletion.
J Am Soc Nephrol. 2025;
Doi: 10.1681/ASN.0000000611
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2024
Originalarbeit (Zeitschrift)
** Benedikt, M; Aziz, F; Fröschl, T; Strohhofer, C; Kolesnik, E; Tripolt, N; Pferschy, P; Wallner, M; Bugger, H; Zirlik, A; Scherr, D; Sourij, H; von, Lewinski, D
Impact of baseline ECG characteristics on changes in cardiac biomarkers and echocardiographic metrices after acute myocardial infarction treated with Empagliflozin.
Sci Rep. 2024; 14(1): 15083
Doi: 10.1038/s41598-024-64175-5
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** Bodi, I; Mettke, L; Michaelides, K; Hornyik, T; Meier, S; Nimani, S; Perez-Feliz, S; El-Battrawy, I; Bugger, H; Zehender, M; Brunner, M; Heijman, J; Odening, KE
Beneficial normalization of cardiac repolarization by carnitine in transgenic SQT1 rabbit models.
Cardiovasc Res. 2024;
Doi: 10.1093/cvr/cvae149
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** Hofmann, C; Serafin, A; Schwerdt, OM; Fischer, J; Sicklinger, F; Younesi, FS; Byrne, NJ; Meyer, IS; Malovrh, E; Sandmann, C; Jürgensen, L; Kamuf-Schenk, V; Stroh, C; Löwenthal, Z; Finke, D; Boileau, E; Beisaw, A; Bugger, H; Rettel, M; Stein, F; Katus, HA; Jakobi, T; Frey, N; Leuschner, F; Völkers, M
Transient Inhibition of Translation Improves Cardiac Function After Ischemia/Reperfusion by Attenuating the Inflammatory Response.
Circulation. 2024;
Doi: 10.1161/CIRCULATIONAHA.123.067479
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** Horstmann, H; Michel, NA; Sheng, X; Hansen, S; Lindau, A; Pfeil, K; Fernández, MC; Marchini, T; Winkels, H; Mitre, LS; Abogunloko, T; Li, X; Mwinyella, TB; Gissler, MC; Bugger, H; Heidt, T; Buscher, K; Hilgendorf, I; Stachon, P; Piepenburg, S; Verheyen, N; Rathner, T; Gerhardt, T; Siegel, PM; Oswald, WK; Cohnert, T; Zernecke, A; Madl, J; Kohl, P; Foks, AC; von, Zur, Muehlen, C; Westermann, D; Zirlik, A; Wolf, D
Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis.
Cardiovasc Res. 2024; 120(14): 1713-1726.
Doi: 10.1093/cvr/cvae154
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** Litwin, SE; Komtebedde, J; Borlaug, BA; Kaye, DM; Hasenfuβ, G; Kawash, R; Hoendermis, E; Hummel, SL; Cikes, M; Gustafsson, F; Chung, E; Mohan, R; Sverdlov, AL; Swarup, V; Winkler, S; Hayward, CS; Bergmann, MW; Bugger, H; McKenzie, S; Nair, A; Rieth, A; Burkhoff, D; Cutlip, DE; Solomon, SD; van, Veldhuisen, DJ; Leon, MB; Shah, SJ
Long term safety and outcomes after atrial shunting for heart failure with preserved or mildly reduced ejection fraction: 5-year and 3-year follow-up in the REDUCE LAP-HF I and II trials.
Am Heart J. 2024;
Doi: 10.1016/j.ahj.2024.08.014
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** Patel, RB; Silvestry, FE; Komtebedde, J; Solomon, SD; Hasenfuß, G; Litwin, SE; Borlaug, BA; Price, MJ; Kawash, R; Hummel, SL; Cutlip, DE; Leon, MB; van, Veldhuisen, DJ; Rieth, AJ; McKenzie, S; Bugger, H; Mazurek, JA; Kapadia, SR; Vanderheyden, M; Ky, B; Shah, SJ
Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial.
JAMA Cardiol. 2024;
Doi: 10.1001/jamacardio.2024.0520
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** Prunea, DM; Bachl, E; Herold, L; Kanoun, Schnur, SS; Pätzold, S; Altmanninger-Sock, S; Sommer, GA; Glantschnig, T; Kolesnik, E; Wallner, M; Ablasser, K; Bugger, H; Buschmann, E; Praschk, A; Fruhwald, FM; Schmidt, A; von, Lewinski, D; Toth, GG
Impact of the Timing of Mechanical Circulatory Support on the Outcomes in Myocardial Infarction-Related Cardiogenic Shock: Subanalysis of the PREPARE CS Registry.
J Clin Med. 2024; 13(6): 1552
Doi: 10.3390/jcm13061552
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Kurzbericht/Letter
** Sourij, C; Oulhaj, A; Aziz, F; Tripolt, NJ; Aberer, F; Pferschy, PN; Postula, M; Drexel, H; Benedikt, M; Kolesnik, E; Pieber, TR; Bugger, H; von, Lewinski, D; Sourij, H
Impact of glycaemic status on the cardiac effects of empagliflozin when initiated immediately after myocardial infarction: A post-hoc analysis of the EMMY trial.
Diabetes Obes Metab. 2024; 26(5): 1971-1975.
Doi: 10.1111/dom.15477
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Übersichtsarbeit
** Gollmer, J; Zirlik, A; Bugger, H
Updated guidelines for cardiac patients with diabetes: Pragmatic diagnostic and therapeutic algorithm
DEUT MED WOCHENSCHR. 2024; 149(08): 470-475.
Doi: 10.1055/a-2226-0683
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Editorial
** Verheyen, N; Bugger, H
ESC Cardiomyopathy Guidelines 2023 - An Overview
J KARDIOL. 2024; 31(9-10):
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Abstract (Zeitschrift)
** Andreka, J; Deharo, P; Adamaszek, MM; Regueiro, A; Pranevicius, R; Stark, C; Prunea, D; Schnur, SSK; Bugger, H; Wolf, A; Cuisset, T; Schmidt, A; Brugaletta, S; Toth, GG
Procedure-related radiation and contrast use during TAVI procedures with balloon-expandable versus self-expanding devices
EUR HEART J. 2024; 45: ehae6662443
Doi: 10.1093/eurheartj/ehae666.2443
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Guideline/Konsensuspapier
** Zweiker, D; Koppelstätter, C; Hohenstein, K; Lang, I; Perl, S; Bugger, H; Brandt, MC; Horn, S; Binder, RK; Watschinger, B; Frick, M; Niessner, A; Weber, T
Renal sympathetic denervation 2024 in Austria: recommendations from the Austrian Society of Hypertension : Endorsed by the Austrian Society of Nephrology and the Working Group of Interventional Cardiology of the Austrian Society of Cardiology.
Wien Klin Wochenschr. 2024; 136(Suppl 14):559-569
Doi: 10.1007/s00508-024-02440-3
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2023
Originalarbeit (Zeitschrift)
** Litwin, SE; Komtebedde, J; Seidler, T; Borlaug, BA; Winkler, S; Solomon, SD; Eicher, JC; Mazimba, S; Khawash, R; Sverdlov, AL; Hummel, SL; Bugger, H; Boenner, F; Hoendermis, E; Cikes, M; Demers, C; Silva, G; van, Empel, V; Starling, RC; Penicka, M; Cutlip, DE; Leon, MB; Kitzman, DW; van, Veldhuisen, DJ; Shah, SJ, , REDUCE, LAP-HF, Investigators, and, Research, Staff
Obesity in heart failure with preserved ejection fraction: Insights from the REDUCE LAP-HF II trial.
Eur J Heart Fail. 2023;
Doi: 10.1002/ejhf.3092
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** Patel, RB; Reddy, VY; Komtebedde, J; Wegerich, SW; Sekaric, J; Swarup, V; Walton, A; Laurent, G; Chetcuti, S; Rademann, M; Bergmann, M; McKenzie, S; Bugger, H; Bruno, RR; Herrmann, HC; Nair, A; Gupta, DK; Lim, S; Kapadia, S; Gordon, R; Vanderheyden, M; Noel, T; Bailey, S; Gertz, ZM; Trochu, JN; Cutlip, DE; Leon, MB; Solomon, SD; van Veldhuisen, DJ; Auricchio, A; Shah, SJ
Atrial Fibrillation Burden and Atrial Shunt Therapy in Heart Failure With Preserved Ejection Fraction
JACC-HEART FAIL. 2023; 11(10): 1351-1362.
Doi: 10.1016/j.jchf.2023.05.024
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** Pogran, E; Zweiker, D; Gargiulo, L; El-Razek, AA; Lechner, I; Vosko, I; Rechberger, S; Bugger, H; Christ, G; Bonderman, D; Kunschitz, E; Zirlik, A; Bauer, A; Metzler, B; Lambert, T; Steinwender, C; Huber, K
Takotsubo syndrome before and during the COVID-19 pandemic in Austria: a retrospective cohort study (TOSCA-19).
ESC Heart Fail. 2023; 10(6):3667-3676
Doi: 10.1002/ehf2.14536
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** Tripolt, NJ; Hofer, SJ; Pferschy, PN; Aziz, F; Durand, S; Aprahamian, F; Nirmalathasan, N; Waltenstorfer, M; Eisenberg, T; Obermayer, AMA; Riedl, R; Kojzar, H; Moser, O; Sourij, C; Bugger, H; Oulhaj, A; Pieber, TR; Zanker, M; Kroemer, G; Madeo, F; Sourij, H
Glucose Metabolism and Metabolomic Changes in Response to Prolonged Fasting in Individuals with Obesity, Type 2 Diabetes and Non-Obese People-A Cohort Trial.
Nutrients. 2023; 15(3):
Doi: 10.3390/nu15030511
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** von, Lewinski, D; Herold, L; Bachl, E; Bugger, H; Glantschnig, T; Kolesnik, E; Verheyen, N; Benedikt, M; Wallner, M; von, Lewinski, F; Schmidt, A; Harb, S; Ablasser, K; Sacherer, M; Scherr, D; Manninger-Wünscher, M; Pätzold, S; Gollmer, J; Zirlik, A; Toth, GG
Outcomes of ECLS-SHOCK Eligibility Criteria Applied to a Real-World Cohort.
J Clin Med. 2023; 12(22):
Doi: 10.3390/jcm12226988
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Übersichtsarbeit
** Vosko, I; Zirlik, A; Bugger, H
Impact of COVID-19 on Cardiovascular Disease.
Viruses. 2023; 15(2): 508
Doi: 10.3390/v15020508
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Abstract (Zeitschrift)
** Byrne, N; Koentges, C; Khan, E; Pfeil, K; Sandulescu, R; Bakshi, S; Koltgen, C; Vosko, I; Gollmer, J; Hoffmann, M; Wolf, D; Ljubojevic-Holzer, S; Wallner, M; Rainer, P; Sedej, S; Scherr, D; von Lewinski, D; Wende, A; Zirlik, A; Bugger, H
Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
WIEN KLIN WOCHENSCHR. 2023; 135: S398-S398.-Österreichische Kardiologische Gesellschaft (ÖKG); Salzburg, AUSTRIA.
[Poster]
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** Gollmer, J; Horstmann, H; Potter, L; Vosko, I; Tomin, T; Pfeil, K; Briner-Gruenberger, R; Von Lewinski, D; Sedej, S; Scherr, D; Wende, AR; Rainer, P; Zirlik, A; Wolf, D; Bugger, H
Molecular alterations of human diabetic heart disease revealed using single nucleus RNA sequencing
EUR HEART J. 2023; 44: -Annual Meeting of the European-Society-of-Cardiology (ESC); AUG 25-28, 2023; Amsterdam, NETHERLANDS.
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** Pogran, EE; Zweiker, DZ; Lechner, IL; Vosko, IV; Rechberger, SR; Bugger, HB; Christ, GC; Bonderman, DB; Kunschitz, EK; Zirlik, AZ; Bauer, AB; Metzler, BM; Lambert, TL; Steinwender, CS; Huber, KH
Takotsubo syndrome before and during Covid-19 pandemic in Austria. A retrospective cohort study (TOSCA-19)
EUR J HEART FAIL. 2023; 25: 281-282.
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** Vosko, I; Holscher, ME; Koentges, C; Tarkhnishvili, A; Byrne, NJ; Pfeil, K; Tang, S; Gollmer, J; Hoffmann, MM; von Lewinski, D; Wallner, M; Bode, C; Zirlik, A; Bugger, H
SIRT4 deficiency modifies fatty acid utilization in the normal and diabetic heart
WIEN KLIN WOCHENSCHR. 2023; 135: S454-S454.
[Poster]
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2022
Originalarbeit (Zeitschrift)
** Borlaug, BA; Blair, J; Bergmann, MW; Bugger, H; Burkhoff, D; Bruch, L; Celermajer, DS; Claggett, B; Cleland, JGF; Cutlip, DE; Dauber, I; Eicher, JC; Gao, Q; Gorter, TM; Gustafsson, F; Hayward, C; van der Heyden, J; Hasenfuss, G; Hummel, SL; Kaye, DM; Komtebedde, J; Massaro, JM; Mazurek, JA; McKenzie, S; Mehta, SR; Petrie, MC; Post, MC; Nair, A; Rieth, A; Silvestry, FE; Solomon, SD; Trochu, JN; Van Veldhuisen, DJ; Westenfeld, R; Leon, MB; Shah, SJJ
Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure
CIRCULATION. 2022; 145(21): 1592-1604.
Doi: 10.1161/CIRCULATIONAHA.122.059486
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** Marchini, T; Malchow, S; Caceres, L; El Rabih, AA; Hansen, S; Mwinyella, T; Spiga, L; Piepenburg, S; Horstmann, H; Olawale, T; Li, XW; Mitre, LS; Gissler, MC; Bugger, H; Zirlik, A; Heidt, T; Hilgendorf, I; Stachon, P; Muehlen, CV; Bode, C; Wolf, D
Circulating Autoantibodies Recognizing Immunodominant Epitopes From Human Apolipoprotein B Associate With Cardiometabolic Risk Factors, but Not With Atherosclerotic Disease
FRONT CARDIOVASC MED. 2022; 9: 826729
Doi: 10.3389/fcvm.2022.826729
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** Tarkhnishvili, A; Koentges, C; Pfeil, K; Gollmer, J; Byrne, NJ; Vosko, I; Lueg, J; Vogelbacher, L; Birkle, S; Tang, S; Bon-Nawul, Mwinyella, T; Hoffmann, MM; Odening, KE; Michel, NA; Wolf, D; Stachon, P; Hilgendorf, I; Wallner, M; Ljubojevic-Holzer, S; von, Lewinski, D; Rainer, P; Sedej, S; Sourij, H; Bode, C; Zirlik, A; Bugger, H
Effects of Short Term Adiponectin Receptor Agonism on Cardiac Function and Energetics in Diabetic db/db Mice.
J Lipid Atheroscler. 2022; 11(2):161-177
Doi: 10.12997/jla.2022.11.2.161
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** Voglhuber, J; Holzer, M; Radulović, S; Thai, PN; Djalinac, N; Matzer, I; Wallner, M; Bugger, H; Zirlik, A; Leitinger, G; Dedkova, EN; Bers, DM; Ljubojevic-Holzer, S
Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca2+ signalling in heart failure.
Philos Trans R Soc Lond B Biol Sci. 2022; 377(1864): 20210320
Doi: 10.1098/rstb.2021.0320
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** von, Lewinski, D; Herold, L; Stoffel, C; Pätzold, S; Fruhwald, F; Altmanninger-Sock, S; Kolesnik, E; Wallner, M; Rainer, P; Bugger, H; Verheyen, N; Rohrer, U; Manninger-Wünscher, M; Scherr, D; Renz, D; Yates, A; Zirlik, A; Toth, GG
PRospective REgistry of PAtients in REfractory cardiogenic shock-The PREPARE CardShock registry.
Catheter Cardiovasc Interv. 2022; 100(3):319-327
Doi: 10.1002/ccd.30327
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** Zweiker, D; Pogran, E; Gargiulo, L; Abd, El-Razek, A; Lechner, I; Vosko, I; Rechberger, S; Bugger, H; Christ, G; Bonderman, D; Kunschitz, E; Czedik-Eysenberg, C; Roithinger, A; Weihs, V; Kaufmann, CC; Zirlik, A; Bauer, A; Metzler, B; Lambert, T; Steinwender, C; Huber, K
Neutrophile-Lymphocyte Ratio and Outcome in Takotsubo Syndrome.
Biology (Basel). 2022; 11(8):
Doi: 10.3390/biology11081154
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Übersichtsarbeit
** Abdellatif, M; Bugger, H; Kroemer, G; Sedej, S
NAD+ and Vascular Dysfunction: From Mechanisms to Therapeutic Opportunities.
J Lipid Atheroscler. 2022; 11(2): 111-132.
Doi: 10.12997/jla.2022.11.2.111
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** Bugger, H; Byrne, NJ; Abel, ED
Animal Models of Dysregulated Cardiac Metabolism.
Circ Res. 2022; 130(12):1965-1993
Doi: 10.1161/CIRCRESAHA.122.320334
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** Michel, NA; Ljubojevic-Holzer, S; Bugger, H; Zirlik, A
Cellular Heterogeneity of the Heart
FRONT CARDIOVASC MED. 2022; 9: 868466
Doi: 10.3389/fcvm.2022.868466
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Abstract (Zeitschrift)
** Byrne, NJ; Witt, CN; Koentges, C; Pfeil, K; Pusdrowski, T; Gollmer, J; Vosko, I; Bode, C; Zirlik, A; Bugger, H
SIRT5 is necessary for recovery from myocardial ischemia reperfusion injury
J MOL CELL CARDIOL. 2022; 173: S67-S67.Berlin, GERMANY.
Doi: 10.1016/j.yjmcc.2022.08.136
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** Gollmer, J; Potter, L; Vosko, I; Tomin, T; Birner-Gruenberger, R; Von Lewinski, D; Sedej, S; Scherr, D; Wende, AR; Rainer, P; Zirlik, A; Bugger, H
Transcriptomic and proteomic profiling of human diabetic heart disease
EUR HEART J. 2022; 43: 2951-2951.
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** Herold, L; Toth-Gayor, G; Fruhwald, F; Patzold, S; Altmanninger-Sock, S; Harb, S; Schmidt, A; Buschmann, E; Bugger, H; Ablasser, K; Glantschnig, T; Bisping, E; Stoffel, C; Knopper, S; Weixler, R; Muckenauer, W; Zweiker, R; Gasser, R; Zirlik, A; von Lewinski, D
Influence of OFF-hours admission on outcome of CS-patients at a high-volume cardiology centre
WIEN KLIN WOCHENSCHR. Abstracts der Österreichische Kardiologische Gesellschaft Jahrestagung 2022. 2022; 134(SUPPL 2):190-191.-Österreichische Kardiologische Gesellschaft Jahrestagung 2022; MAI 25-28, 2022; Salzburg, AUSTRIA.
[Poster]
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** Voglhuber, J; Holzer, M; Radulovic, S; Thai, PN; Djalinac, N; Matzer, I; Wallner, M; Bugger, H; Zirlik, A; Leitinger, G; Dedkova, EN; Bers, DM; Ljubojevic, S
Functional remodeling of perinuclear mitochondria alters nucleoplasmic Ca2+ signaling in heart failure
BIOPHYS J. 2022; 121(3):509A-510A.
[Oral Communication]
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** Voglhuber, J; Holzer, M; Radulovic, S; Thai, PN; Djalinac, N; Matzer, I; Wallner, M; Bugger, H; Zirlik, A; Leitinger, G; Dedkova, EN; Bers, DM; Ljubojevic-Holzer, S
Functional remodeling of perinuclear mitochondria alters nucleoplasmic Ca2+signaling in heart failure
CARDIOVASC RES. 2022; 118(SUPPL 1):
Doi: 10.1093/cvr/cvac066.027
[Oral Communication]
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** Voglhuber, J; Holzer, M; Radulovic, S; Thai, PN; Djalinac, N; Matzer, I; Wallner, M; Bugger, H; Zirlik, A; Leitinger, G; Dedkova, EN; Bers, DM; Ljubojevic-Holzer, S
Perinuclear mitochondria are functionally affected in heart failure and alter nucleoplasmic Ca2+signaling
WIEN KLIN WOCHENSCHR. Abstracts der Österreichische Kardiologische Gesellschaft Jahrestagung 2022. 2022; 134(SUPPL 2):156-157.-Österreichische Kardiologische Gesellschaft Jahrestagung 2022; MAI 25-28, 2022; Salzburg, AUSTRIA.
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** Vosko, I; Gollmer, J; Hilvo, M; Jylha, A; Laaksonen, R; Marz, W; Zirlik, A; Bugger, H
Unsaturated ceramides as independent predictor for cardiovascular mortality in diabetic and non-diabetic subjects with coronary artery disease
WIEN KLIN WOCHENSCHR. 2022; 134(SUPPL 2):173-173.
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** Zweiker, D; Pogran, E; Gargiulo, L; El-Razek, A; Vosko, I; Rechberger, S; Bugger, H; Christ, G; Bonderman, D; Kunschitz, E; Zirlik, A; Bauer, A; Metzler, B; Steinwender, C; Huber, K
Neutrophile-lymphocyte ratio and outcome in takotsubo syndrome
EUR HEART J. 2022; 43: 1796-1796.
Web of Science
** Zweiker, D; Pogran, E; Gargiulo, L; El-Razek, AA; Lechner, I; Vosko, I; Rechberger, S; Bugger, H; Christ, G; Bonderman, D; Kunschitz, E; Zirlik, A; Bauer, A; Metzler, B; Lambert, T; Steinwender, C; Huber, K
Neutrophile-lymphocyte ratio and outcome in Takotsubo Syndrome
WIEN KLIN WOCHENSCHR. 2022; 134(SUPPL 2):128-128.
[Oral Communication]
Web of Science
2021
Originalarbeit (Zeitschrift)
** Bugger, H; Zirlik, A
Anti-inflammatory Strategies in Atherosclerosis.
Hamostaseologie. 2021; 41(6):433-442
Doi: 10.1055/a-1661-0020
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** Gissler, MC; Anto-Michel, N; Pennig, J; Scherrer, P; Li, X; Marchini, T; Pfeiffer, K; Härdtner, C; Abogunloko, T; Mwinyella, T; Sol, Mitre, L; Spiga, L; Koentges, C; Smolka, C; von, Elverfeldt, D; Hoppe, N; Stachon, P; Dufner, B; Heidt, T; Piepenburg, S; Hilgendorf, I; Bjune, JI; Dankel, SN; Mellgren, G; Seifert, G; Eisenhardt, SU; Bugger, H; von, Zur, Muhlen, C; Bode, C; Zirlik, A; Wolf, D; Willecke, F
Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice.
Arterioscler Thromb Vasc Biol. 2021; 41(10):2563-2574
Doi: 10.1161/ATVBAHA.121.316677
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** Smolka, C; Schlosser, D; Koentges, C; Tarkhnishvili, A; Gorka, O; Pfeifer, D; Bemtgen, X; Asmussen, A; Gross, O; Diehl, P; Moser, M; Bode, C; Bugger, H; Grundmann, S; Pankratz, F
Cardiomyocyte-specific miR-100 overexpression preserves heart function under pressure overload in mice and diminishes fatty acid uptake as well as ROS production by direct suppression of Nox4 and CD36
FASEB J. 2021; 35(11): e21956
Doi: 10.1096/fj.202100829RR
Web of Science
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** Tomin, T; Schittmayer, M; Sedej, S; Bugger, H; Gollmer, J; Honeder, S; Darnhofer, B; Liesinger, L; Zuckermann, A; Rainer, PP; Birner-Gruenberger, R
Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts.
Int J Mol Sci. 2021; 22(4):
Doi: 10.3390/ijms22041787
[OPEN ACCESS]
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Übersichtsarbeit
** Byrne, NJ; Rajasekaran, NS; Abel, ED; Bugger, H
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy.
Free Radic Biol Med. 2021; 169:317-342
Doi: 10.1016/j.freeradbiomed.2021.03.046
[OPEN ACCESS]
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Editorial
** Sedej, S; Bugger, H
Editorial of Special Issue "Sirtuins in Health and Disease".
Int J Mol Sci. 2021; 22(10):
Doi: 10.3390/ijms22105054
[OPEN ACCESS]
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Abstract (Zeitschrift)
** Tarkhnishvili, A; Gollmer, J; Koentges, C; Byrne, NJ; Pfeil, K; Mwinyella, TB; Wolf, D; Bode, C; Zirlik, A; Bugger, H
Effects of short term adiponectin receptor agonism on cardiac function and energetics in diabetic db/db mice
WIEN KLIN WOCHENSCHR. 2021; 133(SUPPL 3):S49-S50.
[Oral Communication]
Web of Science
2020
Originalarbeit (Zeitschrift)
** Bugger, H; Gollmer, J; Pregartner, G; Wünsch, G; Berghold, A; Zirlik, A; von Lewinski, D
Complications and mortality of cardiovascular emergency admissions during COVID-19 associated restrictive measures.
PLoS One. 2020; 15(9):e0239801-e0239801
Doi: 10.1371/journal.pone.0239801
[OPEN ACCESS]
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** Dangas, GD; Tijssen, JGP; Wöhrle, J; Søndergaard, L; Gilard, M; Möllmann, H; Makkar, RR; Herrmann, HC; Giustino, G; Baldus, S; De Backer, O; Guimarães, AHC; Gullestad, L; Kini, A; von Lewinski, D; Mack, M; Moreno, R; Schäfer, U; Seeger, J; Tchétché, D; Thomitzek, K; Valgimigli, M; Vranckx, P; Welsh, RC; Wildgoose, P; Volkl, AA; Zazula, A; van Amsterdam, RGM; Mehran, R; Windecker, S; GALILEO Investigators
A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement.
N Engl J Med. 2020; 382(2):120-129
Doi: 10.1056/NEJMoa1911425
[OPEN ACCESS]
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** Koyani, CN; Plastira, I; Sourij, H; Hallström, S; Schmidt, A; Rainer, PP; Bugger, H; Frank, S; Malle, E; von, Lewinski, D
Empagliflozin protects heart from inflammation and energy depletion via AMPK activation.
Pharmacol Res. 2020; 158:104870
Doi: 10.1016/j.phrs.2020.104870
Web of Science
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** Wallner, M; Eaton, DM; Berretta, RM; Liesinger, L; Schittmayer, M; Gindlhuber, J; Wu, J; Jeong, MY; Lin, YH; Borghetti, G; Baker, ST; Zhao, H; Pfleger, J; Blass, S; Rainer, PP; von Lewinski, D; Bugger, H; Mohsin, S; Graier, WF; Zirlik, A; McKinsey, TA; Birner-Gruenberger, R; Wolfson, MR; Houser, SR
HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction.
Sci Transl Med. 2020; 12(525):
Doi: 10.1126/scitranslmed.aay7205
[OPEN ACCESS]
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Übersichtsarbeit
** Bugger, H; Pfeil, K
Mitochondrial ROS in myocardial ischemia reperfusion and remodeling.
Biochim Biophys Acta Mol Basis Dis. 2020; 1866(7):165768-165768
Doi: 10.1016/j.bbadis.2020.165768
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** Gollmer, J; Zirlik, A; Bugger, H
Mitochondrial Mechanisms in Diabetic Cardiomyopathy.
Diabetes Metab J. 2020; 44(1):33-53
Doi: 10.4093/dmj.2019.0185
[OPEN ACCESS]
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Abstract (Zeitschrift)
** Bugger, H; Gollmer, J; Pregartner, G; Wunsch, G; Berghold, A; Zirlik, A; von Lewinski, D
Complications and mortality of cardiovascular emergency admissions during COVID-19 associated restrictive measures.
WIEN KLIN WOCHENSCHR. 2020; 132: S160-S160.
[Oral Communication]
Web of Science
** Daskalopoulos, E; Beauloye, C; Bertrand, L; Bugger, H; Dufeys, C; Horman, S; Koentges, C; Sakamoto, K
Myocardial glycogen genetic depletion does not affect function recovery following I/R or progression of left ventricular remodeling in chronic MI.
ACTA CARDIOL. Abstracts Belgian Society of Cardiology 39th Annual Congress. 2020; 75: 14-14.-39th Annual Congress of the Belgian Society of Cardiology; FEB 13-14, 2020; Brussels, BELGIUM.
[Poster]
Web of Science
** Glantschnig, T; Theiler-Schwetz, V; Pilz, S; Obermayer-Pietsch, B; Ablasser, K; Kolesnik, E; Patzold, S; Pieber, T; Zirlik, A; Bugger, H
NSTEMI as initial manifestation of pheochromocytoma induced multi organ failure.
WIEN KLIN WOCHENSCHR. 2020; 132: S197-S197.
[Poster]
Web of Science
** Gollmer, J; Achstetter, L; Tang, S; Pfeil, K; Koentges, C; Tarkhnishvili, A; Bode, C; Zirlik, A; Bugger, H
Overexpression of sirtuin 4 impairs systemic glucose homeostasis and promotes cardiac hypertrophy during high-fat diet.
WIEN KLIN WOCHENSCHR. 2020; 132: S255-S255.
[Poster]
Web of Science
** Koentges, C; Khan, E; Birkle, S; Hoelscher, M; Pfeil, K; Gollmer, J; Hoffmann, MM; Bode, C; Zirlik, A; Bugger, H
Sirtuin 4 contributes to heart failure development by increasing mitochondrial oxidative stress.
EUR HEART J. 2020; 41: 3602-3602.
[Poster]
Web of Science
** Koentges, C; Vogelbacher, L; Pfeil, K; Sandulescu, R; Bode, C; Zirlik, A; Bugger, H
SIRT4 deficiency protects the heart from ischemia reperfusion injury.
WIEN KLIN WOCHENSCHR. 2020; 132: S155-S155.
[Oral Communication]
Web of Science
2019
Originalarbeit (Zeitschrift)
** Bodi, I; Sorge, J; Castiglione, A; Glatz, SM; Wuelfers, EM; Franke, G; Perez-Feliz, S; Koren, G; Zehender, M; Bugger, H; Seemann, G; Brunner, M; Bode, C; Odening, KE
Postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2.
Europace. 2019; 21(7): 1126-1138.
Doi: 10.1093/europace/euz037
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** Koentges, C; Cimolai, MC; Pfeil, K; Wolf, D; Marchini, T; Tarkhnishvili, A; Hoffmann, MM; Odening, KE; Diehl, P; von Zur Mühlen, C; Alvarez, S; Bode, C; Zirlik, A; Bugger, H
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis.
J Mol Cell Cardiol. 2019; 133(1):138-147
Doi: 10.1016/j.yjmcc.2019.06.008
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** Mauler, M; Herr, N; Schoenichen, C; Witsch, T; Marchini, T; Härdtner, C; Koentges, C; Kienle, K; Ollivier, V; Schell, M; Dorner, L; Wippel, C; Stallmann, D; Normann, C; Bugger, H; Walther, P; Wolf, D; Ahrens, I; Lämmermann, T; Ho-Tin-Noé, B; Ley, K; Bode, C; Hilgendorf, I; Duerschmied, D
Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation.
Circulation. 2019; 139(7):918-931
Doi: 10.1161/CIRCULATIONAHA.118.033942
[OPEN ACCESS]
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** Odening, KE; Bodi, I; Franke, G; Rieke, R; Ryan de Medeiros, A; Perez-Feliz, S; Fürniss, H; Mettke, L; Michaelides, K; Lang, CN; Steinfurt, J; Pantulu, ND; Ziupa, D; Menza, M; Zehender, M; Bugger, H; Peyronnet, R; Behrends, JC; Doleschall, Z; Zur Hausen, A; Bode, C; Jolivet, G; Brunner, M
Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/action potential duration shortening in the atria and ventricles and increased ventricular tachycardia/ventricular fibrillation inducibility.
Eur Heart J. 2019; 40(10):842-853
Doi: 10.1093/eurheartj/ehy761
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** Pepin, ME; Koentges, C; Pfeil, K; Gollmer, J; Kersting, S; Wiese, S; Hoffmann, MM; Odening, KE; von Zur Mühlen, C; Diehl, P; Stachon, P; Wolf, D; Wende, AR; Bode, C; Zirlik, A; Bugger, H
Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.
Front Endocrinol (Lausanne). 2019; 10(1):872-872
Doi: 10.3389/fendo.2019.00872
[OPEN ACCESS]
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** Ramadani-Muja, J; Gottschalk, B; Pfeil, K; Burgstaller, S; Rauter, T; Bischof, H; Waldeck-Weiermair, M; Bugger, H; Graier, WF; Malli, R
Visualization of Sirtuin 4 Distribution between Mitochondria and the Nucleus, Based on Bimolecular Fluorescence Self-Complementation.
Cells. 2019; 8(12):
Doi: 10.3390/cells8121583
[OPEN ACCESS]
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** Wiviott, SD; Raz, I; Bonaca, MP; Mosenzon, O; Kato, ET; Cahn, A; Silverman, MG; Zelniker, TA; Kuder, JF; Murphy, SA; Bhatt, DL; Leiter, LA; McGuire, DK; Wilding, JPH; Ruff, CT; Gause-Nilsson, IAM; Fredriksson, M; Johansson, PA; Langkilde, AM; Sabatine, MS; DECLARE–TIMI 58 Investigators
Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes.
N Engl J Med. 2019; 380(4): 347-357.
Doi: 10.1056/NEJMoa1812389
[OPEN ACCESS]
Web of Science
PubMed
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** Ziupa, D; Menza, M; Koppermann, S; Moss, R; Beck, J; Franke, G; Perez Feliz, S; Brunner, M; Mayer, S; Bugger, H; Koren, G; Zehender, M; Jung, BA; Seemann, G; Foell, D; Bode, C; Odening, KE
Electro-mechanical (dys-)function in long QT syndrome type 1.
Int J Cardiol. 2019; 274(48): 144-151.
Doi: 10.1016/j.ijcard.2018.07.050
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Kurzbericht/Letter
** Ahlgrimm, B; Pottgiesser, T; Stachon, P; Zehender, M; Bugger, H; Helbing, T; Siepe, M; Grundmann, S; Bode, C; Diehl, P
The Cardia Ultraseal Left Atrial Appendage Occluder: A Case Series With Significant Device-Related Complications.
JACC Cardiovasc Interv. 2019; 12(19): 1987-1989.
Doi: 10.1016/j.jcin.2019.06.026
[OPEN ACCESS]
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Übersichtsarbeit
** Gollmer, J; Zirlik, A; Bugger, H
Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
J Lipid Atheroscler. 2019; 8(1):26-47
Doi: 10.12997/jla.2019.8.1.26
[OPEN ACCESS]
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Abstract (Zeitschrift)
** Ahmed, I; Merz, J; Dimanski, D; Rofa, K; Rog-Zielinska, EA; Koentges, C; Hoppe, N; Dufner, B; Kohl, P; Bugger, H; Hilgendorf, I; Bode, C; Zirlik, A; Stachon, P
Purinergic receptor Y6 (P2Y6) deficiency impairs left ventricular function
EUR HEART J. 2019; 40: 3948-3948.-ESC Congress / World Congress of Cardiology; AUG 31-SEP 04, 2019; Paris, FRANCE.
[Oral Communication]
Web of Science
** Gollmer, J; Koentges, C; Pepin, M; Pfeil, K; Wende, AR; Bode, C; Zirlik, A; Bugger, H
Tissue-specific regulation of the mitochondrial proteome by adiponectin receptor 1
EUR HEART J. 2019; 40: 2096-2096.-ESC Congress / World Congress of Cardiology; AUG 31-SEP 04, 2019; Paris, FRANCE.
[Poster]
Web of Science
** Koentges, C; Pfeil, K; Bode, C; Zirlik, A; Bugger, H
Overexpression of sirtuin 4 accelerates the development of heart failure
WIEN KLIN WOCHENSCHR. 2019; 131: 257-257.
[Poster]
Web of Science
** Witt, C; Koentges, C; Pfeil, K; Bode, C; Zirlik, A; Bugger, H
Sirtuin 5 deficiency exaggerates myocardial ischemia reperfusion injury
WIEN KLIN WOCHENSCHR. 2019; 131: 304-304.
[Poster]
Web of Science
** Witt, CN; Koentges, C; Pfeil, K; Vogelbacher, L; Pusdrowski, T; Bode, C; Zirlik, A; Bugger, H
Lack of sirtuin 5 aggravates myocardial ischemia reperfusion injury
EUR HEART J. 2019; 40: 3269-3269.-ESC Congress / World Congress of Cardiology; AUG 31-SEP 04, 2019; Paris, FRANCE.
[Poster]
Web of Science
2018
Originalarbeit (Zeitschrift)
** Diehl, P; Gaul, DS; Sogl, J; Flierl, U; Henstridge, D; Pahla, J; Bugger, H; Emmert, MY; Ruschitzka, F; Bode, C; Lüscher, TF; Moser, M; Matter, CM; Peter, K; Winnik, S
The effect of oxygen in Sirt3-mediated myocardial protection: a proof-of-concept study in cultured cardiomyoblasts.
J Thromb Thrombolysis. 2018; 46(1): 102-112.
Doi: 10.1007/s11239-018-1677-3
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** Koentges, C; Pepin, ME; Müsse, C; Pfeil, K; Alvarez, SVV; Hoppe, N; Hoffmann, MM; Odening, KE; Sossalla, S; Zirlik, A; Hein, L; Bode, C; Wende, AR; Bugger, H
Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.
Basic Res Cardiol. 2018; 113(1):8-8
Doi: 10.1007/s00395-017-0666-6
[OPEN ACCESS]
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** Maack, C; Lehrke, M; Backs, J; Heinzel, FR; Hulot, JS; Marx, N; Paulus, WJ; Rossignol, P; Taegtmeyer, H; Bauersachs, J; Bayes-Genis, A; Brutsaert, D; Bugger, H; Clarke, K; Cosentino, F; De Keulenaer, G; Dei Cas, A; González, A; Huelsmann, M; Iaccarino, G; Lunde, IG; Lyon, AR; Pollesello, P; Rena, G; Riksen, NP; Rosano, G; Staels, B; van Laake, LW; Wanner, C; Farmakis, D; Filippatos, G; Ruschitzka, F; Seferovic, P; de Boer, RA; Heymans, S
Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology.
Eur Heart J. 2018; 39(48): 4243-4254.
Doi: 10.1093/eurheartj/ehy596
[OPEN ACCESS]
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** Merz, J; Albrecht, P; von Garlen, S; Ahmed, I; Dimanski, D; Wolf, D; Hilgendorf, I; Härdtner, C; Grotius, K; Willecke, F; Heidt, T; Bugger, H; Hoppe, N; Kintscher, U; von Zur Mühlen, C; Idzko, M; Bode, C; Zirlik, A; Stachon, P
Purinergic receptor Y2 (P2Y2)- dependent VCAM-1 expression promotes immune cell infiltration in metabolic syndrome.
Basic Res Cardiol. 2018; 113(6):45-45
Doi: 10.1007/s00395-018-0702-1
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** Tsushima, K; Bugger, H; Wende, AR; Soto, J; Jenson, GA; Tor, AR; McGlauflin, R; Kenny, HC; Zhang, Y; Souvenir, R; Hu, XX; Sloan, CL; Pereira, RO; Lira, VA; Spitzer, KW; Sharp, TL; Shoghi, KI; Sparagna, GC; Rog-Zielinska, EA; Kohl, P; Khalimonchuk, O; Schaffer, JE; Abel, ED
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.
Circ Res. 2018; 122(1): 58-73.
Doi: 10.1161/CIRCRESAHA.117.311307
[OPEN ACCESS]
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2017
Originalarbeit (Zeitschrift)
** Brado, J; Dechant, MJ; Menza, M; Komancsek, A; Lang, CN; Bugger, H; Foell, D; Jung, BA; Stiller, B; Bode, C; Odening, KE
Phase-contrast magnet resonance imaging reveals regional, transmural, and base-to-apex dispersion of mechanical dysfunction in patients with long QT syndrome.
Heart Rhythm. 2017; 14(9): 1388-1397.
Doi: 10.1016/j.hrthm.2017.04.045
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** Dressler, FF; Bodi, I; Menza, M; Moss, R; Bugger, H; Bode, C; Behrends, JC; Seemann, G; Odening, KE
Interregional electro-mechanical heterogeneity in the rabbit myocardium.
Prog Biophys Mol Biol. 2017; 130(Pt B): 344-355.
Doi: 10.1016/j.pbiomolbio.2017.06.016
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2016
Originalarbeit (Zeitschrift)
** Bodi, I; Grünert, SC; Becker, N; Stoelzle-Feix, S; Spiekerkoetter, U; Zehender, M; Bugger, H; Bode, C; Odening, KE
Mechanisms of acquired long QT syndrome in patients with propionic academia.
Heart Rhythm. 2016; 13(6): 1335-1345.
Doi: 10.1016/j.hrthm.2016.02.003
Web of Science
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** Koentges, C; Pfeil, K; Meyer-Steenbuck, M; Lother, A; Hoffmann, MM; Odening, KE; Hein, L; Bode, C; Bugger, H
Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3.
Can J Physiol Pharmacol. 2016; 94(1): 72-80.
Doi: 10.1139/cjpp-2015-0152
Web of Science
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** Lang, CN; Menza, M; Jochem, S; Franke, G; Perez Feliz, S; Brunner, M; Koren, G; Zehender, M; Bugger, H; Jung, BA; Foell, D; Bode, C; Odening, KE
Electro-mechanical dysfunction in long QT syndrome: Role for arrhythmogenic risk prediction and modulation by sex and sex hormones.
Prog Biophys Mol Biol. 2016; 120(1-3): 255-269.
Doi: 10.1016/j.pbiomolbio.2015.12.010
Web of Science
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Übersichtsarbeit
** Bugger, H; Witt, CN; Bode, C
Mitochondrial sirtuins in the heart.
Heart Fail Rev. 2016; 21(5): 519-528.
Doi: 10.1007/s10741-016-9570-7
Web of Science
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** Hölscher, ME; Bode, C; Bugger, H
Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?
Int J Mol Sci. 2016; 17(12):
Doi: 10.3390/ijms17122136
[OPEN ACCESS]
Web of Science
PubMed
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** Koentges, C; Bode, C; Bugger, H
SIRT3 in Cardiac Physiology and Disease.
Front Cardiovasc Med. 2016; 3(1):38-38
Doi: 10.3389/fcvm.2016.00038
[OPEN ACCESS]
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2015
Originalarbeit (Zeitschrift)
** Braun, M; Hettinger, N; Koentges, C; Pfeil, K; Cimolai, MC; Hoffmann, MM; Osterholt, M; Doenst, T; Bode, C; Bugger, H
Myocardial mitochondrial and contractile function are preserved in mice lacking adiponectin.
PLoS One. 2015; 10(3): e0119416-e0119416.
Doi: 10.1371/journal.pone.0119416
[OPEN ACCESS]
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** Ilkun, O; Wilde, N; Tuinei, J; Pires, KM; Zhu, Y; Bugger, H; Soto, J; Wayment, B; Olsen, C; Litwin, SE; Abel, ED
Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome.
J Mol Cell Cardiol. 2015; 85(7): 104-116.
Doi: 10.1016/j.yjmcc.2015.05.012
[OPEN ACCESS]
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** Koentges, C; König, A; Pfeil, K; Hölscher, ME; Schnick, T; Wende, AR; Schrepper, A; Cimolai, MC; Kersting, S; Hoffmann, MM; Asal, J; Osterholt, M; Odening, KE; Doenst, T; Hein, L; Abel, ED; Bode, C; Bugger, H
Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.
Basic Res Cardiol. 2015; 110(4): 37-37.
Doi: 10.1007/s00395-015-0495-4
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** Koentges, C; Pfeil, K; Schnick, T; Wiese, S; Dahlbock, R; Cimolai, MC; Meyer-Steenbuck, M; Cenkerova, K; Hoffmann, MM; Jaeger, C; Odening, KE; Kammerer, B; Hein, L; Bode, C; Bugger, H
SIRT3 deficiency impairs mitochondrial and contractile function in the heart.
Basic Res Cardiol. 2015; 110(4): 36-36.
Doi: 10.1007/s00395-015-0493-6
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** Mayer, SC; Gilsbach, R; Preissl, S; Monroy Ordonez, EB; Schnick, T; Beetz, N; Lother, A; Rommel, C; Ihle, H; Bugger, H; Rühle, F; Schrepper, A; Schwarzer, M; Heilmann, C; Bönisch, U; Gupta, SK; Wilpert, J; Kretz, O; von Elverfeldt, D; Orth, J; Aktories, K; Beyersdorf, F; Bode, C; Stiller, B; Krüger, M; Thum, T; Doenst, T; Stoll, M; Hein, L
Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure.
Circ Res. 2015; 117(7): 622-633.
Doi: 10.1161/CIRCRESAHA.115.306721
[OPEN ACCESS]
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** Wende, AR; O'Neill, BT; Bugger, H; Riehle, C; Tuinei, J; Buchanan, J; Tsushima, K; Wang, L; Caro, P; Guo, A; Sloan, C; Kim, BJ; Wang, X; Pereira, RO; McCrory, MA; Nye, BG; Benavides, GA; Darley-Usmar, VM; Shioi, T; Weimer, BC; Abel, ED
Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.
Mol Cell Biol. 2015; 35(5): 831-846.
Doi: 10.1128/MCB.01109-14
[OPEN ACCESS]
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Übersichtsarbeit
** Bugger, H; Bode, C
The vulnerable myocardium. Diabetic cardiomyopathy.
Hamostaseologie. 2015; 35(1): 17-24.
Doi: 10.5482/HAMO-14-09-0038
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** Cimolai, MC; Alvarez, S; Bode, C; Bugger, H
Mitochondrial Mechanisms in Septic Cardiomyopathy.
Int J Mol Sci. 2015; 16(8): 17763-17778.
Doi: 10.3390/ijms160817763
[OPEN ACCESS]
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2014
Übersichtsarbeit
** Bugger, H; Abel, ED
Molecular mechanisms of diabetic cardiomyopathy.
Diabetologia. 2014; 57(4): 660-671.
Doi: 10.1007/s00125-014-3171-6
[OPEN ACCESS]
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2013
Originalarbeit (Zeitschrift)
** Riehle, C; Wende, AR; Sena, S; Pires, KM; Pereira, RO; Zhu, Y; Bugger, H; Frank, D; Bevins, J; Chen, D; Perry, CN; Dong, XC; Valdez, S; Rech, M; Sheng, X; Weimer, BC; Gottlieb, RA; White, MF; Abel, ED
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.
J Clin Invest. 2013; 123(12): 5319-5333.
Doi: 10.1172/JCI71171
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** Zhu, Y; Pires, KM; Whitehead, KJ; Olsen, CD; Wayment, B; Zhang, YC; Bugger, H; Ilkun, O; Litwin, SE; Thomas, G; Kozma, SC; Abel, ED
Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.
PLoS One. 2013; 8(1): e54221-e54221.
Doi: 10.1371/journal.pone.0054221
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2012
Originalarbeit (Zeitschrift)
** Bugger, H; Riehle, C; Jaishy, B; Wende, AR; Tuinei, J; Chen, D; Soto, J; Pires, KM; Boudina, S; Theobald, HA; Luptak, I; Wayment, B; Wang, X; Litwin, SE; Weimer, BC; Abel, ED
Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.
J Mol Cell Cardiol. 2012; 52(5): 1019-1026.
Doi: 10.1016/j.yjmcc.2012.02.001
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Übersichtsarbeit
** König, A; Bode, C; Bugger, H
Diabetes mellitus and myocardial mitochondrial dysfunction: bench to bedside.
Heart Fail Clin. 2012; 8(4): 551-561.
Doi: 10.1016/j.hfc.2012.06.001
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Kommentar
** Bugger, H; Abel, ED
Endonuclease G: the link between mitochondria and cardiac hypertrophy?
Circ Res. 2012; 110(3): 378-380.
Doi: 10.1161/RES.0b013e318249dcc8
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2011
Originalarbeit (Zeitschrift)
** Bugger, H; Guzman, C; Zechner, C; Palmeri, M; Russell, KS; Russell, RR
Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation.
Cancer Chemother Pharmacol. 2011; 67(6): 1381-1388.
Doi: 10.1007/s00280-010-1441-7
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** Riehle, C; Wende, AR; Zaha, VG; Pires, KM; Wayment, B; Olsen, C; Bugger, H; Buchanan, J; Wang, X; Moreira, AB; Doenst, T; Medina-Gomez, G; Litwin, SE; Lelliott, CJ; Vidal-Puig, A; Abel, ED
PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.
Circ Res. 2011; 109(7): 783-793.
Doi: 10.1161/CIRCRESAHA.111.243964
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** Sloan, C; Tuinei, J; Nemetz, K; Frandsen, J; Soto, J; Wride, N; Sempokuya, T; Alegria, L; Bugger, H; Abel, ED
Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice.
Diabetes. 2011; 60(5): 1424-1434.
Doi: 10.2337/db10-1106
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2010
Originalarbeit (Zeitschrift)
** Bugger, H; Schwarzer, M; Chen, D; Schrepper, A; Amorim, PA; Schoepe, M; Nguyen, TD; Mohr, FW; Khalimonchuk, O; Weimer, BC; Doenst, T
Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure.
Cardiovasc Res. 2010; 85(2): 376-384.
Doi: 10.1093/cvr/cvp344
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Übersichtsarbeit
** Bugger, H; Abel, ED
Mitochondria in the diabetic heart.
Cardiovasc Res. 2010; 88(2): 229-240.
Doi: 10.1093/cvr/cvq239
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2009
Originalarbeit (Zeitschrift)
** Boudina, S; Bugger, H; Sena, S; O'Neill, BT; Zaha, VG; Ilkun, O; Wright, JJ; Mazumder, PK; Palfreyman, E; Tidwell, TJ; Theobald, H; Khalimonchuk, O; Wayment, B; Sheng, X; Rodnick, KJ; Centini, R; Chen, D; Litwin, SE; Weimer, BE; Abel, ED
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.
Circulation. 2009; 119(9): 1272-1283.
Doi: 10.1161/CIRCULATIONAHA.108.792101
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** Bugger, H; Chen, D; Riehle, C; Soto, J; Theobald, HA; Hu, XX; Ganesan, B; Weimer, BC; Abel, ED
Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.
Diabetes. 2009; 58(9): 1986-1997.
Doi: 10.2337/db09-0259
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** Liu, S; Okada, T; Assmann, A; Soto, J; Liew, CW; Bugger, H; Shirihai, OS; Abel, ED; Kulkarni, RN
Insulin signaling regulates mitochondrial function in pancreatic beta-cells.
PLoS One. 2009; 4(11): e7983-e7983.
Doi: 10.1371/journal.pone.0007983
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Übersichtsarbeit
** Bugger, H; Abel, ED
Rodent models of diabetic cardiomyopathy.
Dis Model Mech. 2009; 2(9-10): 454-466.
Doi: 10.1242/dmm.001941
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2008
Originalarbeit (Zeitschrift)
** Bray, MS; Shaw, CA; Moore, MW; Garcia, RA; Zanquetta, MM; Durgan, DJ; Jeong, WJ; Tsai, JY; Bugger, H; Zhang, D; Rohrwasser, A; Rennison, JH; Dyck, JR; Litwin, SE; Hardin, PE; Chow, CW; Chandler, MP; Abel, ED; Young, ME
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.
Am J Physiol Heart Circ Physiol. 2008; 294(2): H1036-H1047.
Doi: 10.1152/ajpheart.01291.2007
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** Bugger, H; Boudina, S; Hu, XX; Tuinei, J; Zaha, VG; Theobald, HA; Yun, UJ; McQueen, AP; Wayment, B; Litwin, SE; Abel, ED
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.
Diabetes. 2008; 57(11): 2924-2932.
Doi: 10.2337/db08-0079
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Übersichtsarbeit
** Bugger, H; Abel, ED
Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome.
Clin Sci (Lond). 2008; 114(3): 195-210.
Doi: 10.1042/CS20070166
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** Doenst, T; Bugger, H; Schwarzer, M; Faerber, G; Borger, MA; Mohr, FW
Three good reasons for heart surgeons to understand cardiac metabolism.
Eur J Cardiothorac Surg. 2008; 33(5): 862-871.
Doi: 10.1016/j.ejcts.2008.02.015
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2007
Originalarbeit (Zeitschrift)
** Boudina, S; Sena, S; Theobald, H; Sheng, X; Wright, JJ; Hu, XX; Aziz, S; Johnson, JI; Bugger, H; Zaha, VG; Abel, ED
Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.
Diabetes. 2007; 56(10): 2457-2466.
Doi: 10.2337/db07-0481
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2006
Originalarbeit (Zeitschrift)
** Bugger, H; Chemnitius, JM; Doenst, T
Differential changes in respiratory capacity and ischemia tolerance of isolated mitochondria from atrophied and hypertrophied hearts.
Metabolism. 2006; 55(8): 1097-1106.
Doi: 10.1016/j.metabol.2006.04.005
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** Bugger, H; Leippert, S; Blum, D; Kahle, P; Barleon, B; Marme, D; Doenst, T
Subtractive hybridization for differential gene expression in mechanically unloaded rat heart.
Am J Physiol Heart Circ Physiol. 2006; 291(6): H2714-H2722.
Doi: 10.1152/ajpheart.00445.2005
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** Doenst, T; Bugger, H; Leippert, S; Barleon, B; Marme, D; Beyersdorf, F
Differential gene expression in response to ventricular unloading in rat and human myocardium.
Thorac Cardiovasc Surg. 2006; 54(6): 381-387.
Doi: 10.1055/s-2006-924267
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