** = Publikationen gelistet in SCI/SSCI/Pubmed
** Klec, C; Madreiter-Sokolowski, CT; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WF
Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells.
Cell Physiol Biochem. 2019; 52(1): 57-75.
Doi: 10.33594/000000005
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** Klec, C; Madreiter-Sokolowski, CT; Ziomek, G; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WF
Presenilin-1 Established ER-Ca2+ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose.
Cell Physiol Biochem. 2019; 53(3): 573-586.
Doi: 10.33594/000000158
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** Rayl, M; Truitt, M; Held, A; Sargeant, J; Thorsen, K; Hay, JC
Penta-EF-Hand Protein Peflin Is a Negative Regulator of ER-To-Golgi Transport.
PLoS One. 2016; 11(6):e0157227-e0157227
Doi: 10.1371/journal.pone.0157227
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** Wang, T; Grabski, R; Sztul, E; Hay, JC
p115-SNARE interactions: a dynamic cycle of p115 binding monomeric SNARE motifs and releasing assembled bundles.
Traffic. 2015; 16(2):148-171
Doi: 10.1111/tra.12242
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** Wang, T; Hay, JC
Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease.
Front Neurosci. 2015; 9(3):433-433
Doi: 10.3389/fnins.2015.00433
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** Helm, JR; Bentley, M; Thorsen, KD; Wang, T; Foltz, L; Oorschot, V; Klumperman, J; Hay, JC
Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.
J Biol Chem. 2014; 289(34):23609-23628
Doi: 10.1074/jbc.M114.561829
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** Bhandari, D; Zhang, J; Menon, S; Lord, C; Chen, S; Helm, JR; Thorsen, K; Corbett, KD; Hay, JC; Ferro-Novick, S
Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits.
Mol Biol Cell. 2013; 24(17):2727-2738
Doi: 10.1091/mbc.E13-02-0114
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** Thayanidhi, N; Liang, Y; Hasegawa, H; Nycz, DC; Oorschot, V; Klumperman, J; Hay, JC
R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed.
Biol Cell. 2012; 104(7):397-417
Doi: 10.1111/boc.201100048
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** Trahey, M; Oh, HS; Cameron, CE; Hay, JC
Poliovirus infection transiently increases COPII vesicle budding.
J Virol. 2012; 86(18):9675-9682
Doi: 10.1128/JVI.01159-12
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** Lord, C; Bhandari, D; Menon, S; Ghassemian, M; Nycz, D; Hay, J; Ghosh, P; Ferro-Novick, S
Sequential interactions with Sec23 control the direction of vesicle traffic.
Nature. 2011; 473(7346):181-186
Doi: 10.1038/nature09969
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** Bentley, M; Nycz, DC; Joglekar, A; Fertschai, I; Malli, R; Graier, WF; Hay, JC
Vesicular calcium regulates coat retention, fusogenicity, and size of pre-Golgi intermediates.
Mol Biol Cell. 2010; 21(6):1033-1046
Doi: 10.1091/mbc.E09-10-0914
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** Thayanidhi, N; Helm, JR; Nycz, DC; Bentley, M; Liang, Y; Hay, JC
Alpha-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs.
Mol Biol Cell. 2010; 21(11):1850-1863
Doi: 10.1091/mbc.E09-09-0801
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** Trahey, M; Hay, JC
Transport vesicle uncoating: it's later than you think.
F1000 Biol Rep. 2010; 2(7):47-47
Doi: 10.3410/B2-47
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** Cai, H; Yu, S; Menon, S; Cai, Y; Lazarova, D; Fu, C; Reinisch, K; Hay, JC; Ferro-Novick, S
TRAPPI tethers COPII vesicles by binding the coat subunit Sec23.
Nature. 2007; 445(7130):941-944
Doi: 10.1038/nature05527
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** Hay, JC
Calcium: a fundamental regulator of intracellular membrane fusion?
EMBO Rep. 2007; 8(3):236-240
Doi: 10.1038/sj.embor.7400921
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** Bentley, M; Liang, Y; Mullen, K; Xu, D; Sztul, E; Hay, JC
SNARE status regulates tether recruitment and function in homotypic COPII vesicle fusion.
J Biol Chem. 2006; 281(50):38825-38833
Doi: 10.1074/jbc.M606044200
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** Yu, S; Satoh, A; Pypaert, M; Mullen, K; Hay, JC; Ferro-Novick, S
mBet3p is required for homotypic COPII vesicle tethering in mammalian cells.
J Cell Biol. 2006; 174(3):359-368
Doi: 10.1083/jcb.200603044
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** Honda, A; Al-Awar, OS; Hay, JC; Donaldson, JG
Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE.
J Cell Biol. 2005; 168(7):1039-1051
Doi: 10.1083/jcb.200409138
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** Joglekar, AP; Hay, JC
Evidence for regulation of ER/Golgi SNARE complex formation by hsc70 chaperones.
Eur J Cell Biol. 2005; 84(5):529-542
Doi: 10.1016/j.ejcb.2004.12.028
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** Hasegawa, H; Yang, Z; Oltedal, L; Davanger, S; Hay, JC
Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6.
J Cell Sci. 2004; 117(Pt 19): 4495-4508.
Doi: 10.1242/jcs.01314
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** Williams, AL; Ehm, S; Jacobson, NC; Xu, D; Hay, JC
rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility.
Mol Biol Cell. 2004; 15(1):162-175
Doi: 10.1091/mbc.E03-07-0535
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** Xu, D; Hay, JC
Reconstitution of COPII vesicle fusion to generate a pre-Golgi intermediate compartment.
J Cell Biol. 2004; 167(6):997-1003
Doi: 10.1083/jcb.200408135
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** Hasegawa, H; Zinsser, S; Rhee, Y; Vik-Mo, EO; Davanger, S; Hay, JC
Mammalian ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain.
Mol Biol Cell. 2003; 14(2):698-720
Doi: 10.1091/mbc.E02-09-0556
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** Joglekar, AP; Xu, D; Rigotti, DJ; Fairman, R; Hay, JC
The SNARE motif contributes to rbet1 intracellular targeting and dynamics independently of SNARE interactions.
J Biol Chem. 2003; 278(16):14121-14133
Doi: 10.1074/jbc.M300659200
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** Hay, JC
SNARE complex structure and function.
Exp Cell Res. 2001; 271(1):10-21
Doi: 10.1006/excr.2001.5368
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** Xu, D; Joglekar, AP; Williams, AL; Hay, JC
Subunit structure of a mammalian ER/Golgi SNARE complex.
J Biol Chem. 2000; 275(50):39631-39639
Doi: 10.1074/jbc.M007684200
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** Chao, DS; Hay, JC; Winnick, S; Prekeris, R; Klumperman, J; Scheller, RH
SNARE membrane trafficking dynamics in vivo.
J Cell Biol. 1999; 144(5):869-881
Doi: 10.1083/jcb.144.5.869
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** Hay, JC; Klumperman, J; Oorschot, V; Steegmaier, M; Kuo, CS; Scheller, RH
Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs.
J Cell Biol. 1998; 141(7):1489-1502
Doi: 10.1083/jcb.141.7.1489
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** Hay, JC; Chao, DS; Kuo, CS; Scheller, RH
Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.
Cell. 1997; 89(1):149-158
Doi: 10.1016/S0092-8674(00)80191-9
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** Hay, JC; Scheller, RH
SNAREs and NSF in targeted membrane fusion.
Curr Opin Cell Biol. 1997; 9(4):505-512
Doi: 10.1016/S0955-0674(97)80026-9
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** Hay, JC; Hirling, H; Scheller, RH
Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus.
J Biol Chem. 1996; 271(10):5671-5679
Doi: 10.1074/jbc.271.10.5671
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** Hay, JC; Fisette, PL; Jenkins, GH; Fukami, K; Takenawa, T; Anderson, RA; Martin, TF
ATP-dependent inositide phosphorylation required for Ca(2+)-activated secretion.
Nature. 1995; 374(6518):173-177
Doi: 10.1038/374173a0
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** Hay, JC; Martin, TF
Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)-activated secretion.
Nature. 1993; 366(6455):572-575
Doi: 10.1038/366572a0
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** Hay, JC; Martin, TF
Resolution of regulated secretion into sequential MgATP-dependent and calcium-dependent stages mediated by distinct cytosolic proteins.
J Cell Biol. 1992; 119(1):139-151
Doi: 10.1083/jcb.119.1.139
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