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Bourgeois Benjamin Michel Rene |

Publications

** = Publications listed in SCI/SSCI/Pubmed

2025

Full paper/article (Journal)

** Bourgeois, B; Madl, T Methods to Study Structure and Dynamics of FOXO Proteins.
Methods Mol Biol. 2025; 2871: 85-98. Doi: 10.1007/978-1-0716-4217-7_8
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** Zhou, Q; Sagmeister, T; Hutten, S; Bourgeois, B; Pavkov-Keller, T; Dormann, D; Madl, T Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3.
Nat Commun. 2025; 16(1):4456 Doi: 10.1038/s41467-025-59802-2 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2024

Full paper/article (Journal)

** Hornegger, H; Anisimova, AS; Muratovic, A; Bourgeois, B; Spinetti, E; Niedermoser, I; Covino, R; Madl, T; Karagöz, GE IGF2BP1 phosphorylation in the disordered linkers regulates ribonucleoprotein condensate formation and RNA metabolism.
Nat Commun. 2024; 15(1): 9054 Doi: 10.1038/s41467-024-53400-4 [OPEN ACCESS]
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** Pilic, J; Gottschalk, B; Bourgeois, B; Habisch, H; Koshenov, Z; Oflaz, FE; Erdogan, YC; Miri, SM; Yiğit, EN; Aydın, MŞ; Öztürk, G; Eroglu, E; Shoshan-Barmatz, V; Madl, T; Graier, WF; Malli, R Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress.
Mol Cell. 2024; 84(14): 2732-2746.e5. Doi: 10.1016/j.molcel.2024.06.009
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** Tehlivets, O; Almer, G; Brunner, MS; Lechleitner, M; Sommer, G; Kolb, D; Leitinger, G; Diwoky, C; Wolinski, H; Habisch, H; Opriessnig, P; Bogoni, F; Pernitsch, D; Kavertseva, M; Bourgeois, B; Kukilo, J; Tehlivets, YG; Schwarz, AN; Züllig, T; Bubalo, V; Schauer, S; Groselj-Strele, A; Hoefler, G; Rechberger, GN; Herrmann, M; Eller, K; Rosenkranz, AR; Madl, T; Frank, S; Holzapfel, GA; Kratky, D; Mangge, H; Hörl, G Homocysteine contributes to atherogenic transformation of the aorta in rabbits in the absence of hypercholesterolemia.
BIOMED PHARMACOTHER. 2024; 178: 117244 Doi: 10.1016/j.biopha.2024.117244
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** Usluer, S; Galhuber, M; Khanna, Y; Bourgeois, B; Spreitzer, E; Michenthaler, H; Prokesch, A; Madl, T Disordered regions mediate the interaction of p53 and MRE11.
Biochim Biophys Acta Mol Cell Res. 2023; 1871(2): 119654 Doi: 10.1016/j.bbamcr.2023.119654
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** Zhang, F; Bischof, H; Burgstaller, S; Bourgeois, BMR; Malli, R; Madl, T Genetically encoded fluorescent sensor to monitor intracellular arginine methylation.
J Photochem Photobiol B. 2024; 252: 112867 Doi: 10.1016/j.jphotobiol.2024.112867
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2023

Full paper/article (Journal)

** Abuja, PM; Pabst, D; Bourgeois, B; Loibner, M; Ulz, C; Kufferath, I; Fackelmann, U; Stumptner, C; Kraemer, R; Madl, T; Zatloukal, K Residual Humidity in Paraffin-Embedded Tissue Reduces Nucleic Acid Stability.
Int J Mol Sci. 2023; 24(9): Doi: 10.3390/ijms24098010 [OPEN ACCESS]
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** Gui, T; Fleming, C; Manzato, C; Bourgeois, B; Sirati, N; Heuer, J; Papadionysiou, I; Montfort, DIV; Gijzen, MV; Smits, LMM; Burgering, BMT; Madl, T; Schuijers, J Targeted perturbation of signaling-driven condensates.
Mol Cell. 2023; 83(22): 4141-4157.e11. Doi: 10.1016/j.molcel.2023.10.023
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2022

Full paper/article (Journal)

** Horvath, A; Traub, J; Aliwa, B; Bourgeois, B; Madl, T; Stadlbauer, V Oral Intake of L-Ornithine-L-Aspartate Is Associated with Distinct Microbiome and Metabolome Changes in Cirrhosis.
NUTRIENTS. 2022; 14(4): Doi: 10.3390/nu14040748 [OPEN ACCESS]
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** Lenard, AJ; Zhou, Q; Madreiter-Sokolowski, C; Bourgeois, B; Habacher, H; Khanna, Y; Madl, T EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner.
Cells. 2022; 11(4): Doi: 10.3390/cells11040592 [OPEN ACCESS]
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** Spreitzer, E; Alderson, TR; Bourgeois, B; Eggenreich, L; Habacher, H; Brahmersdorfer, G; Pritišanac, I; Sánchez-Murcia, PA; Madl, T FOXO transcription factors differ in their dynamics and intra/intermolecular interactions.
Curr Res Struct Biol. 2022; 4:118-133 Doi: 10.1016/j.crstbi.2022.04.001 [OPEN ACCESS]
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** Zhang, F; Richter, G; Bourgeois, B; Spreitzer, E; Moser, A; Keilbach, A; Kotnik, P; Madl, T A General Small-Angle X-ray Scattering-Based Screening Protocol for Studying Physical Stability of Protein Formulations.
Pharmaceutics. 2021; 14(1): Doi: 10.3390/pharmaceutics14010069 [OPEN ACCESS]
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2021

Full paper/article (Journal)

** Bourgeois, B; Gui, TS; Hoogeboom, D; Hocking, HG; Richter, G; Spreitzer, E; Viertler, M; Richter, K; Madl, T; Burgering, BMT Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
CELL REP. 2021; 36(4): 109446 Doi: 10.1016/j.celrep.2021.109446 [OPEN ACCESS]
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** Klionsky, DJ; Abdel-Aziz, AK; Abdelfatah, S; Abdellatif, M; Abdoli, A; Abel, S; Abeliovich, H; Abildgaard, MH; Abudu, YP; Acevedo-Arozena, A; Adamopoulos, IE; Adeli, K; Adolph, TE; Adornetto, A; Aflaki, E; Agam, G; Agarwal, A; Aggarwal, BB; Agnello, M; Agostinis, P; Agrewala, JN; Agrotis, A; Aguilar, PV; Ahmad, ST; Ahmed, ZM; Ahumada-Castro, U; Aits, S; Aizawa, S; Akkoc, Y; Akoumianaki, T; Akpinar, HA; Al-Abd, AM; Al-Akra, L; Al-Gharaibeh, A; Alaoui-Jamali, MA; Alberti, S; Alcocer-Gómez, E; Alessandri, C; Ali, M; Alim, Al-Bari, MA; Aliwaini, S; Alizadeh, J; Almacellas, E; Almasan, A; Alonso, A; Alonso, GD; Altan-Bonnet, N; Altieri, DC; Álvarez, ÉMC; Alves, S; Alves, da, Costa, C; Alzaharna, MM; Amadio, M; Amantini, C; Amaral, C; Ambrosio, S; Amer, AO; Ammanathan, V; An, Z; Andersen, SU; Andrabi, SA; Andrade-Silva, M; Andres, AM; Angelini, S; et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹.
AUTOPHAGY. 2021; 17(1): 1-382. Doi: 10.1080/15548627.2020.1797280 [OPEN ACCESS]
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** Lenard, AJ; Hutten, S; Zhou, Q; Usluer, S; Zhang, F; Bourgeois, BMR; Dormann, D; Madl, T Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation.
FRONT MOL BIOSCI. 2021; 8: 689687 Doi: 10.3389/fmolb.2021.689687 [OPEN ACCESS]
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** Reisinger, AC; Posch, F; Hackl, G; Marsche, G; Sourij, H; Bourgeois, B; Eller, K; Madl, T; Eller, P Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients.
Nutrients. 2021; 13(9): Doi: 10.3390/nu13093106 [OPEN ACCESS]
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** Richter, G; Gui, T; Bourgeois, B; Koyani, CN; Ulz, P; Heitzer, E; von, Lewinski, D; Burgering, BMT; Malle, E; Madl, T β-catenin regulates FOXP2 transcriptional activity via multiple binding sites.
FEBS J. 2021; 288(10):3261-3284 Doi: 10.1111/febs.15656 [OPEN ACCESS]
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** Schmid, PWN; Lim, NCH; Peters, C; Back, KC; Bourgeois, B; Pirolt, F; Richter, B; Peschek, J; Puk, O; Amarie, OV; Dalke, C; Haslbeck, M; Weinkauf, S; Madl, T; Graw, J; Buchner, J Imbalances in the eye lens proteome are linked to cataract formation.
NAT STRUCT MOL BIOL. 2021; 28(2): 143-151. Doi: 10.1038/s41594-020-00543-9
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** Usluer, S; Spreitzer, E; Bourgeois, B; Madl, T p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR.
Int J Mol Sci. 2021; 22(21): Doi: 10.3390/ijms222111431 [OPEN ACCESS]
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** Zhou, Q; Usluer, S; Zhang, F; Lenard, AJ; Bourgeois, BMR; Madl, T ATP regulates RNA-driven cold inducible RNA binding protein phase separation.
PROTEIN SCI. 2021; 30(7): 1438-1453. Doi: 10.1002/pro.4123 [OPEN ACCESS]
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2020

Full paper/article (Journal)

** Bourgeois, B; Hutten, S; Gottschalk, B; Hofweber, M; Richter, G; Sternat, J; Abou-Ajram, C; Göbl, C; Leitinger, G; Graier, WF; Dormann, D; Madl, T Nonclassical nuclear localization signals mediate nuclear import of CIRBP.
Proc Natl Acad Sci U S A. 2020; 117(15): 8503-8514. Doi: 10.1073/pnas.1918944117 [OPEN ACCESS]
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** Duchardt-Ferner, E; Juen, M; Bourgeois, B; Madl, T; Kreutz, C; Ohlenschläger, O; Wöhnert, J Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine.
Nucleic Acids Res. 2020; 48(2):949-961 Doi: 10.1093/nar/gkz1113 [OPEN ACCESS]
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** Hutten, S; Usluer, S; Bourgeois, B; Simonetti, F; Odeh, HM; Fare, CM; Czuppa, M; Hruska-Plochan, M; Hofweber, M; Polymenidou, M; Shorter, J; Edbauer, D; Madl, T; Dormann, D Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions.
Cell Rep. 2020; 33(12):108538-108538 Doi: 10.1016/j.celrep.2020.108538 [OPEN ACCESS]
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** Jha, S; Taschler, U; Domenig, O; Poglitsch, M; Bourgeois, B; Pollheimer, M; Pusch, LM; Malovan, G; Frank, S; Madl, T; Gruber, K; Zimmermann, R; Macheroux, P Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.
J Biol Chem. 2020; 295(40):13711-13723 Doi: 10.1074/jbc.RA120.014183 [OPEN ACCESS]
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** Strandback, E; Lienhart, WD; Hromic-Jahjefendic, A; Bourgeois, B; Högler, A; Waltenstorfer, D; Winkler, A; Zangger, K; Madl, T; Gruber, K; Macheroux, P A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro.
FEBS Lett. 2020; 594(3):424-438 Doi: 10.1002/1873-3468.13636 [OPEN ACCESS]
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2019

Full paper/article (Journal)

** Koch, K; Strandback, E; Jha, S; Richter, G; Bourgeois, B; Madl, T; Macheroux, P Oxidative stress-induced structural changes in the microtubule-associated flavoenzyme Irc15p from Saccharomyces cerevisiae.
Protein Sci. 2019; 28(1):176-190 Doi: 10.1002/pro.3517 [OPEN ACCESS]
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2018

Full paper/article (Journal)

** Hofweber, M; Hutten, S; Bourgeois, B; Spreitzer, E; Niedner-Boblenz, A; Schifferer, M; Ruepp, MD; Simons, M; Niessing, D; Madl, T; Dormann, D Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
Cell. 2018; 173(3):706-719 Doi: 10.1016/j.cell.2018.03.004 [OPEN ACCESS]
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** Koyani, CN; Trummer, C; Shrestha, N; Scheruebel, S; Bourgeois, B; Plastira, I; Kickmaier, S; Sourij, H; Rainer, PP; Madl, T; Sattler, W; Pelzmann, B; Malle, E; von Lewinski, D Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes.
Front Physiol. 2018; 9:1622-1622 Doi: 10.3389/fphys.2018.01622 [OPEN ACCESS]
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Review

** Bourgeois, B; Madl, T Regulation of cellular senescence via the FOXO4-p53 axis.
FEBS Lett. 2018; 592(12):2083-2097 Doi: 10.1002/1873-3468.13057 [OPEN ACCESS]
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Abstract (Journal)

** Bourgeois, B; Burgering, B; Madl, T Unravelling the role of FOXO proteins in ageing and disease
FEBS OPEN BIO. 2018; 8: 46-46. [Poster]
Web of Science

2017

Full paper/article (Journal)

** Baar, MP; Brandt, RMC; Putavet, DA; Klein, JDD; Derks, KWJ; Bourgeois, BRM; Stryeck, S; Rijksen, Y; van Willigenburg, H; Feijtel, DA; van der Pluijm, I; Essers, J; van Cappellen, WA; van IJcken, WF; Houtsmuller, AB; Pothof, J; de Bruin, RWF; Madl, T; Hoeijmakers, JHJ; Campisi, J; de Keizer, PLJ Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Cell. 2017; 169(1):132-147 Doi: 10.1016/j.cell.2017.02.031 [OPEN ACCESS]
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** Lienhart, WD; Strandback, E; Gudipati, V; Koch, K; Binter, A; Uhl, MK; Rantasa, DM; Bourgeois, B; Madl, T; Zangger, K; Gruber, K; Macheroux, P Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).
FEBS J. 2017; 284(8):1233-1245 Doi: 10.1111/febs.14051 [OPEN ACCESS]
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2016

Full paper/article (Journal)

** Herrada, I; Bourgeois, B; Samson, C; Buendia, B; Worman, HJ; Zinn-Justin, S Purification and Structural Analysis of LEM-Domain Proteins.
Methods Enzymol. 2016; 569(4):43-61 Doi: 10.1016/bs.mie.2015.07.008
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** Suárez-Calvet, M; Neumann, M; Arzberger, T; Abou-Ajram, C; Funk, E; Hartmann, H; Edbauer, D; Kremmer, E; Göbl, C; Resch, M; Bourgeois, B; Madl, T; Reber, S; Jutzi, D; Ruepp, MD; Mackenzie, IR; Ansorge, O; Dormann, D; Haass, C Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
Acta Neuropathol. 2016; 131(4):587-604 Doi: 10.1007/s00401-016-1544-2 [OPEN ACCESS]
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2013

Full paper/article (Journal)

** Bourgeois, B; Gilquin, B; Tellier-Lebègue, C; Östlund, C; Wu, W; Pérez, J; El Hage, P; Lallemand, F; Worman, HJ; Zinn-Justin, S Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A.
Sci Signal. 2013; 6(280): ra49-ra49. Doi: 10.1126/scisignal.2003411 [OPEN ACCESS]
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2010

Full paper/article (Journal)

** Kondé, E; Bourgeois, B; Tellier-Lebegue, C; Wu, W; Pérez, J; Caputo, S; Attanda, W; Gasparini, S; Charbonnier, JB; Gilquin, B; Worman, HJ; Zinn-Justin, S Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-β signaling at the inner nuclear membrane.
Biochemistry. 2010; 49(37):8020-8032 Doi: 10.1021/bi101153w
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