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Sachdev Vinay |

** = Publications listed in SCI/SSCI/Pubmed

2021

Full paper/article (Journal)

** Sachdev, V; Duta-Mare, M; Korbelius, M; Vujić, N; Leopold, C; Freark, de, Boer, J; Rainer, S; Fickert, P; Kolb, D; Kuipers, F; Radovic, B; Gorkiewicz, G; Kratky, D Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase.
Cells. 2021; 10(10): Doi: 10.3390/cells10102619 [OPEN ACCESS]
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2020

Full paper/article (Journal)

** Vujić, N; Korbelius, M; Sachdev, V; Rainer, S; Zimmer, A; Huber, A; Radović, B; Kratky, D Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden.
Atherosclerosis. 2020; 310:26-36 Doi: 10.1016/j.atherosclerosis.2020.07.030 [OPEN ACCESS]
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2019

Full paper/article (Journal)

** Gali, CC; Fanaee-Danesh, E; Zandl-Lang, M; Albrecher, NM; Tam-Amersdorfer, C; Stracke, A; Sachdev, V; Reichmann, F; Sun, Y; Avdili, A; Reiter, M; Kratky, D; Holzer, P; Lass, A; Kandimalla, KK; Panzenboeck, U Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice.
Mol Cell Neurosci. 2019; 99: 103390-103390. Doi: 10.1016/j.mcn.2019.103390 [OPEN ACCESS]
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** Klec, C; Madreiter-Sokolowski, CT; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WF Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells.
Cell Physiol Biochem. 2019; 52(1): 57-75. Doi: 10.33594/000000005 [OPEN ACCESS]
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** Klec, C; Madreiter-Sokolowski, CT; Ziomek, G; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WF Presenilin-1 Established ER-Ca²⁺ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose.
Cell Physiol Biochem. 2019; 53(3): 573-586. Doi: 10.33594/000000158 [OPEN ACCESS]
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** Korbelius, M; Vujic, N; Sachdev, V; Obrowsky, S; Rainer, S; Gottschalk, B; Graier, WF; Kratky, D ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes.
Cell Rep. 2019; 28(7): 1923-1934. Doi: 10.1016/j.celrep.2019.07.030 [OPEN ACCESS]
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** Leopold, C; Duta-Mare, M; Sachdev, V; Goeritzer, M; Maresch, LK; Kolb, D; Reicher, H; Wagner, B; Stojakovic, T; Ruelicke, T; Haemmerle, G; Hoefler, G; Sattler, W; Kratky, D Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019; 1864(4):500-511 Doi: 10.1016/j.bbalip.2019.01.007 [OPEN ACCESS]
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Abstract (Journal)

** Vujic, N; Korbelius, M; Rainer, S; Sachdev, V; Radovic, B; Kratky, D EFFECTS OF INTESTINAL DGAT1 DEFICIENCY ON ATHEROSCLEROSIS IN APOE-KNOCKOUT MICE
ATHEROSCLEROSIS. 2019; 287: E28-E28.-87th Congress of the European-Atherosclerosis-Society (EAS); MAY 26-29, 2019; Maastricht, NETHERLANDS. Doi: 10.1016/j.atherosclerosis.2019.06.082 [Poster]
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2018

Full paper/article (Journal)

** Duta-Mare, M; Sachdev, V; Leopold, C; Kolb, D; Vujic, N; Korbelius, M; Hofer, DC; Xia, W; Huber, K; Auer, M; Gottschalk, B; Magnes, C; Graier, WF; Prokesch, A; Radovic, B; Bogner-Strauss, JG; Kratky, D Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis.
Biochim Biophys Acta. 2018; 1863(4):467-478 Doi: 10.1016/j.bbalip.2018.01.011 [OPEN ACCESS]
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** Nikam, A; Patankar, JV; Somlapura, M; Lahiri, P; Sachdev, V; Kratky, D; Denk, H; Zatloukal, K; Abuja, PM The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity.
Sci Rep. 2018; 8(1): 12964-12964. Doi: 10.1038/s41598-018-31389-3 [OPEN ACCESS]
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Abstract (Journal)

** Duta-Mare, M; Sachdev, V; Leopold, C; Kolb, D; Vujic, N; Korbelius, M; Hofer, D; Xia, W; Huber, K; Magnes, C; Radovic, B; Bogner-Strauss, J; Kratky, D LYSOSOMAL ACID LIPASE REGULATES FATTY ACID CHANNELING IN BROWN ADIPOSE TISSUE TO MAINTAIN THERMOGENESIS
ATHEROSCLEROSIS. 2018; 275: E15-E15.-86th Congress of the European-Atherosclerosis-Society (EAS); MAY 05-08, 2018; Lisbon, PORTUGAL. Doi: 10.1016/j.atherosclerosis.2018.06.927 [Oral Communication]
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** Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Doktorova, M; Scheicher, B; Goeritzer, M; Kolb, D; Turnbull, AV; Zimmer, A; Hoefler, G; Hussain, MM; Groen, AK; Kratky, D NOVEL ROLE OF A TRIGLYCERIDE-SYNTHESIZING ENZYME: DGAT1 AT THE CROSSROAD BETWEEN TRIGLYCERIDE AND CHOLESTEROL METABOLISM
ATHEROSCLEROSIS. 2018; 275: E10-E11.-86th Congress of the European-Atherosclerosis-Society (EAS); MAY 05-08, 2018; Lisbon, PORTUGAL. Doi: 10.1016/j.atherosclerosis.2018.06.915 [Oral Communication]
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2017

Abstract (Journal)

** Duta-Mare, M; Sachdev, V; Vujic, N; Huber, K; Xia, WM; Korbelius, M; Kratky, D LYSOSOMAL ACID LIPASE AND THERMOREGULATION DURING COLD EXPOSURE
ATHEROSCLEROSIS. 2017; 263: E71-E72.-85th Congress of the European-Atherosclerosis-Society (EAS); APR 23-26, 2017; Prague, CZECH REPUBLIC. Doi: 10.1016/j.atherosclerosis.2017.06.237 [Poster]
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** Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Boverhof, R; Doktorova, M; Scheicher, B; Kolb, D; Turnbull, AV; Zimmer, A; Hoefler, G; Hussain, MM; Groen, AK; Kratky, D NOVEL ROLE OF A TRIGLYCERIDE-SYNTHESIZING ENZYME: DGAT1 AT THE CROSSROAD BETWEEN TRIGLYCERIDE AND CHOLESTEROL METABOLISM
ATHEROSCLEROSIS. 2017; 263: E7-E7.-85th Congress of the European-Atherosclerosis-Society (EAS); APR 23-26, 2017; Prague, CZECH REPUBLIC. Doi: 10.1016/j.atherosclerosis.2017.06.048 [Oral Communication]
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2016

Full paper/article (Journal)

** Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Boverhof, R; Doktorova, M; Scheicher, B; Goeritzer, M; Kolb, D; Turnbull, AV; Zimmer, A; Hoefler, G; Hussain, MM; Groen, AK; Kratky, D Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Biochim Biophys Acta. 2016; 1861(9 Pt A):1132-1141 Doi: 10.1016/j.bbalip.2016.06.014 [OPEN ACCESS]
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** Vinod, M; Patankar, JV; Sachdev, V; Frank, S; Graier, WF; Kratky, D; Kostner, GM MiR-206 is expressed in pancreatic islets and regulates glucokinase activity.
Am J Physiol Endocrinol Metab. 2016; 311(1):E175-E185 Doi: 10.1152/ajpendo.00510.2015 [OPEN ACCESS]
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Abstract (Journal)

** Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Doktorova, M; Goeritzer, M; Scheicher, B; Kolb, D; Hoefler, G; Turnbull, AV; Zimmer, A; Hussain, MM; Groen, AK; Kratky, D LIPOPROTEINS AND LIPID METABOLISM: APOB CONTAINING LIPOPROTEINS. NOVEL ROLE OF A TRIGLYCERIDE-SYNTHESIZING ENZYME: DGAT1 AT THE CROSSROAD BETWEEN TRIGLYCERIDE AND CHOLESTEROL METABOLISM
ATHEROSCLEROSIS. 2016; 252: E98-E99.-Congress of the European-Atherosclerosis-Society (EAS); MAY 29-JUN 01, 2016; Innsbruck, AUSTRIA. Doi: 10.1016/j.atherosclerosis.2016.07.564
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2015

Full paper/article (Journal)

** Dražić, T; Sachdev, V; Leopold, C; Patankar, JV; Malnar, M; Hećimović, S; Levak-Frank, S; Habuš, I; Kratky, D Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors.
Bioorg Med Chem. 2015; 23(10):2353-2359 Doi: 10.1016/j.bmc.2015.03.067 [OPEN ACCESS]
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** Goeritzer, M; Vujic, N; Schlager, S; Chandak, PG; Korbelius, M; Gottschalk, B; Leopold, C; Obrowsky, S; Rainer, S; Doddapattar, P; Aflaki, E; Wegscheider, M; Sachdev, V; Graier, WF; Kolb, D; Radovic, B; Kratky, D Active autophagy but not lipophagy in macrophages with defective lipolysis.
Biochim Biophys Acta. 2015; 1851(10):1304-1316 Doi: 10.1016/j.bbalip.2015.06.005 [OPEN ACCESS]
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** Out, C; Patankar, JV; Doktorova, M; Boesjes, M; Bos, T; de Boer, S; Havinga, R; Wolters, H; Boverhof, R; van Dijk, TH; Smoczek, A; Bleich, A; Sachdev, V; Kratky, D; Kuipers, F; Verkade, HJ; Groen, AK Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.
J Hepatol. 2015; 63(3):697-704 Doi: 10.1016/j.jhep.2015.04.030 [OPEN ACCESS]
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Abstract (Journal)

** Vinod, M; Patankar, JV; Sachdev, V; Al-Zoughbi, WAEL; Hofler, G; Frank, SASA; Graier, WF; Kratky, D; Kostner, GM MICRO-RNA 206 AFFECTS GLUCOSE INDUCED INSULIN SECRETION UNDER HIGH-FAT DIET
ATHEROSCLEROSIS. 2015; 241(1):E83-E83.-83rd Congress of the European-Atherosclerosis-Society (EAS); MAR 22-25, 2015; Glasgow, SCOTLAND. Doi: 10.1016/j.atherosclerosis.2015.04.292 [Poster]
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** Vinod, M; Patankar, JV; Sachdev, V; Kostner, GM; Kratky, D; Graier, WF; Frank, S MIR-206, A NOVEL POST-TRANSCRIPTIONAL REGULATOR OF GLUCOKINASE.
ATHEROSCLEROSIS. 2015; 241(1):E85-E85.-83rd Congress of the European-Atherosclerosis-Society (EAS); MAR 22-25, 2015; Glasgow, SCOTLAND. Doi: 10.1016/j.atherosclerosis.2015.04.297 [Poster]
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2014

Full paper/article (Journal)

** Chirackal Manavalan, AP; Kober, A; Metso, J; Lang, I; Becker, T; Hasslitzer, K; Zandl, M; Fanaee-Danesh, E; Pippal, JB; Sachdev, V; Kratky, D; Stefulj, J; Jauhiainen, M; Panzenboeck, U Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in high density lipoprotein biogenesis and remodeling at the blood-brain barrier.
J Biol Chem. 2014; 289(8):4683-4698 Doi: 10.1074/jbc.M113.499129 [OPEN ACCESS]
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** Dražić, T; Molčanov, K; Sachdev, V; Malnar, M; Hećimović, S; Patankar, JV; Obrowsky, S; Levak-Frank, S; Habuš, I; Kratky, D Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors.
Eur J Med Chem. 2014; 87(9):722-734 Doi: 10.1016/j.ejmech.2014.10.014 [OPEN ACCESS]
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** Goeritzer, M; Schlager, S; Radovic, B; Madreiter, CT; Rainer, S; Thomas, G; Lord, CC; Sacks, J; Brown, AL; Vujic, N; Obrowsky, S; Sachdev, V; Kolb, D; Chandak, PG; Graier, WF; Sattler, W; Brown, JM; Kratky, D Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.
J Lipid Res. 2014; 55(12):2562-2575 Doi: 10.1194/jlr.M052613 [OPEN ACCESS]
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Abstract (Journal)

** Panzenboeck, U; Manavalan, APC; Kober, A; Schweinzer, C; Metso, J; Zandl, M; Fanaee-Danesh, E; Pippal, J; Lang, I; Sachdev, V; Kratky, D; Sattler, W; Jauhiainen, M LIVER-X RECEPTOR AGONISTS MODULATE HDL AND AMYLOID-BETA METABOLISM IN BRAIN CAPILLARY ENDOTHELIAL CELLS FORMING THE BLOOD-BRAIN BARRIER.
ATHEROSCLEROSIS. 2014; 235(2):E175-E175.-82nd Congress of the European-Atherosclerosis-Society (EAS); MAY 31-JUN 03, 2014; Madrid, SPAIN. Doi: 10.1016/j.atherosclerosis.2014.05.509 [Poster]
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2013

Short report/Letter

** Patankar, JV; Sachdev, V; Obrowsky, S; Levak-Frank, S; Kratky, D Intestinal GATA4 deficiency induces proximal fibroblast growth factor 15 expression and represses hepatic gluconeogenesis.
J Hepatol. 2013; 59(5):1147-1149 Doi: 10.1016/j.jhep.2013.07.003 [OPEN ACCESS]
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