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Farzi Aitak |

** = Publications listed in SCI/SSCI/Pubmed

2025

Full paper/article (Journal)

** Farzi, A; Tatzl, E; Kashofer, K; Trajanoski, S; Herbert, MK; Holzer, P Antibiotic-induced decrease of bacterial load in guinea pig intestine reduces α2-adrenoceptor expression and activity in peristaltic motor inhibition.
Br J Pharmacol. 2025; Doi: 10.1111/bph.70001
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** Teppan, J; Bärnthaler, T; Farzi, A; Durrington, H; Gioan-Tavernier, G; Platt, H; Wolf, P; Heinemann, A; Böhm, EM The molecular circadian clock of eosinophils: A potential therapeutic target for asthma.
Am J Physiol Cell Physiol. 2025; Doi: 10.1152/ajpcell.00149.2025
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2024

Full paper/article (Journal)

** Teppan, J; Schwanzer, J; Rittchen, S; Bärnthaler, T; Lindemann, J; Nayak, B; Reiter, B; Luschnig, P; Farzi, A; Heinemann, A; Sturm, E The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation.
Front Immunol. 2024; 15: 1408772 Doi: 10.3389/fimmu.2024.1408772 [OPEN ACCESS]
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Abstract (Journal)

** Bukowski-Thall, G; Fellendorf, F; Gorkiewicz, S; Ip, KCK; Schmidt, L; Durdevic, M; Mörki, S; Wagner-Skacef, J; Bengesser, S; Lenger, M; Dalkner, N; Gorkiewicz, G; Högenauer, C; Madi, T; Moissl-Eichinger, C; Reininghaus, E; Farzi, A Fecal microbiota transplantation (FMT) from healthy and bipolar donors elicit distinct emotional behaviors and gut-brain metabolite profiles in mice
N-S ARCH PHARMACOL. 2024; 397: S5-S5.-90th DGPT Annual Meeting; MAR 13-15, 2024; Munich, GERMANY. [Poster]
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2023

Full paper/article (Journal)

** Chen, CY; Tien, CH; Chen, YH; Garrido, D; Farzi, A; Herzog, H; Fan, HY; Chen, YC Effect of Sucralose Intake on Human and Mouse/Rat Gut Microbiota Composition: A Systematic Review and Meta-Analysis
FOOD REV INT. 2023; Doi: 10.1080/87559129.2023.2212045
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** Ip, CK; Rezitis, J; Qi, Y; Bajaj, N; Koller, J; Farzi, A; Shi, YC; Tasan, R; Zhang, L; Herzog, H Critical role of lateral habenula circuits in the control of stress-induced palatable food consumption.
Neuron. 2023; 111(16):2583-2600.e6 Doi: 10.1016/j.neuron.2023.05.010
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2022

Full paper/article (Journal)

** Gao, K; Farzi, A; Ke, X; Yu, Y; Chen, C; Chen, S; Yu, T; Wang, H; Li, Y Oral administration of Lactococcus lactis WHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress.
Food Funct. 2022; 13(2):957-969 Doi: 10.1039/d1fo03723d
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** Hassan, AM; Mancano, G; Kashofer, K; Liebisch, G; Farzi, A; Zenz, G; Claus, SP; Holzer, P Anhedonia induced by high-fat diet in mice depends on gut microbiota and leptin.
Nutr Neurosci. 2022; 25(2):299-312 Doi: 10.1080/1028415X.2020.1751508 [OPEN ACCESS]
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2021

Full paper/article (Journal)

** Brunner, SM; Reichmann, F; Leitner, J; Wölfl, S; Bereswill, S; Farzi, A; Schneider, AM; Klieser, E; Neureiter, D; Emberger, M; Heimesaat, MM; Weghuber, D; Lang, R; Holzer, P; Kofler, B Galanin receptor 3 attenuates inflammation and influences the gut microbiota in an experimental murine colitis model.
Sci Rep. 2021; 11(1): 564-564. Doi: 10.1038/s41598-020-79456-y [OPEN ACCESS]
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** Farzi, A; Ip, CK; Reed, F; Enriquez, R; Zenz, G; Durdevic, M; Zhang, L; Holzer, P; Herzog, H Lack of peptide YY signaling in mice disturbs gut microbiome composition in response to high-fat diet.
FASEB J. 2021; 35(4): e21435-e21435. Doi: 10.1096/fj.202002215R [OPEN ACCESS]
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** Schroeder, S; Hofer, SJ; Zimmermann, A; Pechlaner, R; Dammbrueck, C; Pendl, T; Marcello, GM; Pogatschnigg, V; Bergmann, M; Müller, M; Gschiel, V; Ristic, S; Tadic, J; Iwata, K; Richter, G; Farzi, A; Üçal, M; Schäfer, U; Poglitsch, M; Royer, P; Mekis, R; Agreiter, M; Tölle, RC; Sótonyi, P; Willeit, J; Mairhofer, B; Niederkofler, H; Pallhuber, I; Rungger, G; Tilg, H; Defrancesco, M; Marksteiner, J; Sinner, F; Magnes, C; Pieber, TR; Holzer, P; Kroemer, G; Carmona-Gutierrez, D; Scorrano, L; Dengjel, J; Madl, T; Sedej, S; Sigrist, SJ; Rácz, B; Kiechl, S; Eisenberg, T; Madeo, F Dietary spermidine improves cognitive function.
Cell Rep. 2021; 35(2):108985-108985 Doi: 10.1016/j.celrep.2021.108985 [OPEN ACCESS]
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2020

Full paper/article (Journal)

** Gao, K; Mu, CL; Farzi, A; Zhu, WY Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain.
Adv Nutr. 2020; 11(3):709-723 Doi: 10.1093/advances/nmz127 [OPEN ACCESS]
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Review

** Wagner-Skacel, J; Dalkner, N; Moerkl, S; Kreuzer, K; Farzi, A; Lackner, S; Painold, A; Reininghaus, EZ; Butler, MI; Bengesser, S Sleep and Microbiome in Psychiatric Diseases.
Nutrients. 2020; 12(8): Doi: 10.3390/nu12082198 [OPEN ACCESS]
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Abstract (Journal)

** Reininghaus, E; Farzi, A; Reininghaus, B; Fellendorf, F; Platzer, M; Fischer, S; Dalkner, N; Birner, A; Hamm, C; Maget, A; Queissner, R; Bengesser, S; Rieger, A; Lenger, M Faecal microbiota transplantations from individuals with bipolar disorder.
BIPOLAR DISORD. 2020; 22: 84-84.-22nd Annual Conference of the International-Society-for-Bipolar-Disorders (ISBD); JUN 18-21, 2020; ELECTR NETWORK. [Poster]
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2019

Full paper/article (Journal)

** Gao, K; Pi, Y; Mu, CL; Farzi, A; Liu, Z; Zhu, WY Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota-brain axis.
J Neurochem. 2019; 149(5):641-659 Doi: 10.1111/jnc.14709
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** Ip, CK; Zhang, L; Farzi, A; Qi, Y; Clarke, I; Reed, F; Shi, YC; Enriquez, R; Dayas, C; Graham, B; Begg, D; Brüning, JC; Lee, NJ; Hernandez-Sanchez, D; Gopalasingam, G; Koller, J; Tasan, R; Sperk, G; Herzog, H Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions.
Cell Metab. 2019; 30(1):111-128 Doi: 10.1016/j.cmet.2019.04.001 [OPEN ACCESS]
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** Sroor, HM; Hassan, AM; Zenz, G; Valadez-Cosmes, P; Farzi, A; Holzer, P; El-Sharif, A; Gomaa, FAM; Kargl, J; Reichmann, F Experimental colitis reduces microglial cell activation in the mouse brain without affecting microglial cell numbers.
Sci Rep. 2019; 9(1): 20217-20217. Doi: 10.1038/s41598-019-56859-0 [OPEN ACCESS]
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** Zenz, G; Farzi, A; Fröhlich, EE; Reichmann, F; Holzer, P Intranasal Neuropeptide Y Blunts Lipopolysaccharide-Evoked Sickness Behavior but Not the Immune Response in Mice.
Neurotherapeutics. 2019; 16(4): 1335-1349. Doi: 10.1007/s13311-019-00758-9 [OPEN ACCESS]
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** Zenz, G; Jačan, A; Reichmann, F; Farzi, A; Holzer, P Intermittent Fasting Exacerbates the Acute Immune and Behavioral Sickness Response to the Viral Mimic Poly(I:C) in Mice.
Front Neurosci. 2019; 13: 359-359. Doi: 10.3389/fnins.2019.00359 [OPEN ACCESS]
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Review

** Farzi, A; Hassan, AM; Zenz, G; Holzer, P Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis.
Mol Aspects Med. 2019; 66(2):80-93 Doi: 10.1016/j.mam.2018.11.003 [OPEN ACCESS]
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2018

Full paper/article (Journal)

** Farzi, A; Lau, J; Ip, CK; Qi, Y; Shi, YC; Zhang, L; Tasan, R; Sperk, G; Herzog, H Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure.
Elife. 2018; 7: Doi: 10.7554/eLife.36494 [OPEN ACCESS]
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** Lau, J; Farzi, A; Qi, Y; Heilbronn, R; Mietzsch, M; Shi, YC; Herzog, H CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis.
Mol Metab. 2018; 7: 102-118. Doi: 10.1016/j.molmet.2017.10.015 [OPEN ACCESS]
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Review

** Farzi, A; Fröhlich, EE; Holzer, P Gut Microbiota and the Neuroendocrine System.
Neurotherapeutics. 2018; 15(1): 5-22. Doi: 10.1007/s13311-017-0600-5 [OPEN ACCESS]
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2017

Full paper/article (Journal)

** Hassan, AM; Jain, P; Mayerhofer, R; Fröhlich, EE; Farzi, A; Reichmann, F; Herzog, H; Holzer, P Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonism.
Sci Rep. 2017; 7(6):40968-40968 Doi: 10.1038/srep40968 [OPEN ACCESS]
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** Lau, J; Farzi, A; Enriquez, RF; Shi, YC; Herzog, H GPR88 is a critical regulator of feeding and body composition in mice.
Sci Rep. 2017; 7(1):9912-9912 Doi: 10.1038/s41598-017-10058-x [OPEN ACCESS]
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** Mayerhofer, R; Fröhlich, EE; Reichmann, F; Farzi, A; Kogelnik, N; Fröhlich, E; Sattler, W; Holzer, P Diverse action of lipoteichoic acid and lipopolysaccharide on neuroinflammation, blood-brain barrier disruption, and anxiety in mice.
Brain Behav Immun. 2017; 60(3):174-187 Doi: 10.1016/j.bbi.2016.10.011 [OPEN ACCESS]
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Review

** Holzer, P; Farzi, A; Hassan, AM; Zenz, G; Jačan, A; Reichmann, F Visceral Inflammation and Immune Activation Stress the Brain.
Front Immunol. 2017; 8:1613-1613 Doi: 10.3389/fimmu.2017.01613 [OPEN ACCESS]
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Abstract (Journal)

** Farzi, A; Reed, F; Zhang, L; Holzer, P; Herzog, H Peptide YY is a critical regulator of gut microbiota composition specifically under conditions of sucralose or high fat diet exposure
NEUROGASTROENT MOTIL. 2017; 29: 86-86.-Neuro GASTRO 2017; AUG 24-26, 2017; Cork, IRELAND. [Poster]
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2016

Full paper/article (Journal)

** Fröhlich, EE; Farzi, A; Mayerhofer, R; Reichmann, F; Jačan, A; Wagner, B; Zinser, E; Bordag, N; Magnes, C; Fröhlich, E; Kashofer, K; Gorkiewicz, G; Holzer, P Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication.
Brain Behav Immun. 2016; 56(6):140-155 Doi: 10.1016/j.bbi.2016.02.020 [OPEN ACCESS]
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** Grabner, GF; Eichmann, TO; Wagner, B; Gao, Y; Farzi, A; Taschler, U; Radner, FP; Schweiger, M; Lass, A; Holzer, P; Zinser, E; Tschöp, MH; Yi, CX; Zimmermann, R Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation.
J Biol Chem. 2016; 291(2):913-23 Doi: 10.1074/jbc.M115.683615 [OPEN ACCESS]
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2015

Full paper/article (Journal)

** Farzi, A; Halicka, J; Mayerhofer, R; Fröhlich, EE; Tatzl, E; Holzer, P Toll-like receptor 4 contributes to the inhibitory effect of morphine on colonic motility in vitro and in vivo.
Sci Rep. 2015; 5(5):9499-9499 Doi: 10.1038/srep09499 [OPEN ACCESS]
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** Farzi, A; Reichmann, F; Meinitzer, A; Mayerhofer, R; Jain, P; Hassan, AM; Fröhlich, EE; Wagner, K; Painsipp, E; Rinner, B; Holzer, P Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers.
Brain Behav Immun. 2015; 44(1):106-120 Doi: 10.1016/j.bbi.2014.08.011 [OPEN ACCESS]
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** Jain, P; Hassan, AM; Koyani, CN; Mayerhofer, R; Reichmann, F; Farzi, A; Schuligoi, R; Malle, E; Holzer, P Behavioral and molecular processing of visceral pain in the brain of mice: impact of colitis and psychological stress.
Front Behav Neurosci. 2015; 9(5):177-177 Doi: 10.3389/fnbeh.2015.00177 [OPEN ACCESS]
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** Reichmann, F; Hassan, AM; Farzi, A; Jain, P; Schuligoi, R; Holzer, P Dextran sulfate sodium-induced colitis alters stress-associated behaviour and neuropeptide gene expression in the amygdala-hippocampus network of mice.
Sci Rep. 2015; 5(6):9970-9970 Doi: 10.1038/srep09970 [OPEN ACCESS]
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Review

** Farzi, A; Reichmann, F; Holzer, P The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour.
Acta Physiol (Oxf). 2015; 213(3):603-627 Doi: 10.1111/apha.12445 [OPEN ACCESS]
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** Holzer, P; Hassan, AM; Jain, P; Reichmann, F; Farzi, A Neuroimmune pharmacological approaches.
Curr Opin Pharmacol. 2015; 25:13-22 Doi: 10.1016/j.coph.2015.09.003 [OPEN ACCESS]
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Abstract (Journal)

** Jain, P; Hassan, AM; Koyani, CN; Mayerhofer, R; Reichmann, F; Farzi, A; Schuligoi, R; Malle, E; Holzer, P Behavioral and molecular processing of visceral pain in the brain of mice: Impact of colitis and psychological stress
NEUROGASTROENT MOTIL. 2015; 27: 24-24.-NeuroGastro 2015; June 6-4, 2015; Istanbul, Turkey. [Oral Communication]
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2014

Full paper/article (Journal)

** Brunner, SM; Farzi, A; Locker, F; Holub, BS; Drexel, M; Reichmann, F; Lang, AA; Mayr, JA; Vilches, JJ; Navarro, X; Lang, R; Sperk, G; Holzer, P; Kofler, B GAL3 receptor KO mice exhibit an anxiety-like phenotype.
Proc Natl Acad Sci U S A. 2014; 111(19):7138-7143 Doi: 10.1073/pnas.1318066111 [OPEN ACCESS]
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** Hassan, AM; Jain, P; Reichmann, F; Mayerhofer, R; Farzi, A; Schuligoi, R; Holzer, P Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice.
Front Behav Neurosci. 2014; 8(6):386-386 Doi: 10.3389/fnbeh.2014.00386 [OPEN ACCESS]
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Review

** Holzer, P; Farzi, A Neuropeptides and the microbiota-gut-brain axis.
Adv Exp Med Biol. 2014; 817(4):195-219 Doi: 10.1007/978-1-4939-0897-4_9 [OPEN ACCESS]
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2013

Full paper/article (Journal)

** Painsipp, E; Köfer, MJ; Farzi, A; Dischinger, US; Sinner, F; Herzog, H; Holzer, P Neuropeptide Y and peptide YY protect from weight loss caused by Bacille Calmette-Guérin in mice.
Br J Pharmacol. 2013; 170(5):1014-1026 Doi: 10.1111/bph.12354 [OPEN ACCESS]
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2012

Full paper/article (Journal)

** Sen, A; Gider, P; Cavalieri, M; Freudenberger, P; Farzi, A; Schallert, M; Reichmann, F; Watzinger, N; Zweiker, R; Schmidt, R; Schmidt, H Association of cardiorespiratory fitness and morphological brain changes in the elderly: results of the Austrian Stroke Prevention Study.
Neurodegener Dis. 2012; 10(1-4):135-137 Doi: 10.1159/000334760 [OPEN ACCESS]
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Review

** Holzer, P; Reichmann, F; Farzi, A Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis.
Neuropeptides. 2012; 46(6):261-274 Doi: 10.1016/j.npep.2012.08.005 [OPEN ACCESS]
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Abstract (Journal)

** Farzi, A; Gorkiewicz, G; Holzer, P; Non-absorbable oral antibiotic treatment in mice affects multiple levels of the microbiota-gut-brain axis.
NEUROGASTROENTEROL MOTIL. 2012; 24: 78-78.-2012 Joint International Neurogastroenterology and Motility Meeting; SEP 6-8, 2012; Bologna, ITALY. [Poster]
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** Farzi, A; Painsipp, E; Holzer, P; Aggravation of Toll-like receptor-4 (TLR4) mediated sickness behaviour by nucleotide-binding oligomerization domain-2 (NOD2) activation.
EUR NEUROPSYCHOPHARMACOL. EUROPEAN NEUROPSYCHOPHARMACOLOGY22: S185-S185. AMSTERDAM: ELSEVIER SCIENCE BV; ( Presented at: 25th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Vienna, AUSTRIA, OCT 13-17, 2012) Doi: 10.1016/S0924-977X(12)70265-1 [Poster]
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