Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Becker Jürgen Christian |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2024

Abstract (Zeitschrift)

** Becker, JC; Leiter-Stoppke, U; Gesierich, A; Ulrich, C; Kähler, KC; Pfoehler, C; Gambichler, T; Wolf, I; Herbst, R; Meier, F; Hassel, JC; Meiss, F; Mohr, P; Terheyden, P; Zouboulis, C; Stang, A; Galetzka, W; Ugurel-Becker, S; Lodde, GC Only early adjuvant radiotherapy, particularly of the tumor bed rather than the lymph node region, improves prognosis in Merkel cell carcinoma: Results from the prospective German MCC registry
ANN ONCOL. 2024; 35: S744-S744. Doi: 10.1016/j.annonc.2024.08.2136
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2021

Originalarbeit (Zeitschrift)

** Fan, K; Spassova, I; Gravemeyer, J; Ritter, C; Horny, K; Lange, A; Gambichler, T; Ødum, N; Schrama, D; Schadendorf, D; Ugurel, S; Becker, JC Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53.
Oncogene. 2021; 40(5):980-996 Doi: 10.1038/s41388-020-01576-6 [OPEN ACCESS]
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2020

Originalarbeit (Zeitschrift)

** Fan, K; Gravemeyer, J; Ritter, C; Rasheed, K; Gambichler, T; Moens, U; Shuda, M; Schrama, D; Becker, JC MCPyV Large T Antigen-Induced Atonal Homolog 1 Is a Lineage-Dependency Oncogene in Merkel Cell Carcinoma.
J Invest Dermatol. 2020; 140(1):56-65 Doi: 10.1016/j.jid.2019.06.135 [OPEN ACCESS]
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** Fan, K; Zebisch, A; Horny, K; Schrama, D; Becker, JC Highly Expressed miR-375 is not an Intracellular Oncogene in Merkel Cell Polyomavirus-Associated Merkel Cell Carcinoma.
Cancers (Basel). 2020; 12(3): Doi: 10.3390/cancers12030529 [OPEN ACCESS]
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** Madhusudhan, N; Pausan, MR; Halwachs, B; Durdević, M; Windisch, M; Kehrmann, J; Patra, V; Wolf, P; Boukamp, P; Moissl-Eichinger, C; Cerroni, L; Becker, JC; Gorkiewicz, G Molecular Profiling of Keratinocyte Skin Tumors Links Staphylococcus aureus Overabundance and Increased Human β-Defensin-2 Expression to Growth Promotion of Squamous Cell Carcinoma.
Cancers (Basel). 2020; 12(3): Doi: 10.3390/cancers12030541 [OPEN ACCESS]
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2019

Originalarbeit (Zeitschrift)

** Bhat, VK; Bernhart, E; Plastira, I; Fan, K; Ghaffari-Tabrizi-Wizsy, N; Wadsack, C; Rechberger, G; Eichmann, T; Asslaber, M; Spassova, I; Verhaegen, ME; Malle, E; Becker, JC; Sattler, W Pharmacological Inhibition of Serine Palmitoyl Transferase and Sphingosine Kinase-1/-2 Inhibits Merkel Cell Carcinoma Cell Proliferation.
J Invest Dermatol. 2019; 139(4):807-817 Doi: 10.1016/j.jid.2018.10.024 [OPEN ACCESS]
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** Weide, B; Eigentler, T; Catania, C; Ascierto, PA; Cascinu, S; Becker, JC; Hauschild, A; Romanini, A; Danielli, R; Dummer, R; Trefzer, U; Elia, G; Neri, D; Garbe, C A phase II study of the L19IL2 immunocytokine in combination with dacarbazine in advanced metastatic melanoma patients.
Cancer Immunol Immunother. 2019; 68(9):1547-1559 Doi: 10.1007/s00262-019-02383-z [OPEN ACCESS]
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2018

Originalarbeit (Zeitschrift)

** Bhat, VK; Krump, C; Bernhart, E; Becker, JC; Sattler, W; Ghaffari-Tabrizi-Wizsy, N A short-term in vivo model for Merkel Cell Carcinoma.
Exp Dermatol. 2018; 27(6):684-687 Doi: 10.1111/exd.13529 [OPEN ACCESS]
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** Fan, K; Ritter, C; Nghiem, P; Blom, A; Verhaegen, ME; Dlugosz, A; Ødum, N; Woetmann, A; Tothill, RW; Hicks, RJ; Sand, M; Schrama, D; Schadendorf, D; Ugurel, S; Becker, JC Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma.
Clin Cancer Res. 2018; 24(23):5873-5882 Doi: 10.1158/1078-0432.CCR-18-1184 [OPEN ACCESS]
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** Hillen, U; Leiter, U; Haase, S; Kaufmann, R; Becker, J; Gutzmer, R; Terheyden, P; Krause-Bergmann, A; Schulze, HJ; Hassel, J; Lahner, N; Wollina, U; Ziller, F; Utikal, J; Hafner, C; Ulrich, J; Machens, HG; Weishaupt, C; Hauschild, A; Mohr, P; Pföhler, C; Maurer, J; Wolff, P; Windemuth-Kieselbach, C; Schadendorf, D; Livingstone, E; Dermatologic Cooperative Oncology Group (DeCOG) Advanced cutaneous squamous cell carcinoma: A retrospective analysis of patient profiles and treatment patterns-Results of a non-interventional study of the DeCOG.
Eur J Cancer. 2018; 96(1):34-43 Doi: 10.1016/j.ejca.2018.01.075
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2017

Originalarbeit (Zeitschrift)

** Ofner, R; Ritter, C; Heidenreich, B; Kumar, R; Ugurel, S; Schrama, D; Becker, JC Distribution of TERT promoter mutations in primary and metastatic melanomas in Austrian patients.
J Cancer Res Clin Oncol. 2017; 143(4):613-617 Doi: 10.1007/s00432-016-2322-1 [OPEN ACCESS]
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** Ofner, R; Ritter, C; Ugurel, S; Cerroni, L; Stiller, M; Bogenrieder, T; Solca, F; Schrama, D; Becker, JC Non-reproducible sequence artifacts in FFPE tissue: an experience report.
J Cancer Res Clin Oncol. 2017; 143(7):1199-1207 Doi: 10.1007/s00432-017-2399-1 [OPEN ACCESS]
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** Ritter, C; Fan, K; Paschen, A; Reker Hardrup, S; Ferrone, S; Nghiem, P; Ugurel, S; Schrama, D; Becker, JC Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma.
Sci Rep. 2017; 7(1):2290-2290 Doi: 10.1038/s41598-017-02608-0 [OPEN ACCESS]
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Übersichtsarbeit

** Becker, JC; Stang, A; DeCaprio, JA; Cerroni, L; Lebbé, C; Veness, M; Nghiem, P Merkel cell carcinoma.
Nat Rev Dis Primers. 2017; 3:17077-17077 Doi: 10.1038/nrdp.2017.77 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Kumble, VB; Bernhart, E; Fan, K; Wadsack, C; Rechberger, G; Becker, J; Sattler, W Interference with sphingosine 1-phosphate synthesis affects Merkel cell carcinoma proliferation in vitro
J INVEST DERMATOL. 2017; 137(10):S296-S296.-47th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR); SEP 27-30, 2017; Salzburg, AUSTRIA. [Poster]
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** Ritter, C; Spassova, I; Fan, K; Herold, T; Boukamp, P; Becker, JC; Variant MCC cell lines are more closely related to SCC than to classical MCC cell lines.
EXP DERMATOL. .. 2017; 26(3):E82-E83.-44th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF); MAR 09-11, 2017; Gottingen, GERMANY. [Poster]
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2016

Originalarbeit (Zeitschrift)

** Ritter, C; Fan, K; Paulson, KG; Nghiem, P; Schrama, D; Becker, JC Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.
Sci Rep. 2016; 6:21678-21678 Doi: 10.1038/srep21678 [OPEN ACCESS]
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** Willmes, C; Kumar, R; Becker, JC; Fried, I; Rachakonda, PS; Poppe, LM; Hesbacher, S; Schadendorf, D; Sucker, A; Schrama, D; Ugurel, S SERPINB1 expression is predictive for sensitivity and outcome of cisplatin-based chemotherapy in melanoma.
Oncotarget. 2016; 7(9): 10117-10132. Doi: 10.18632/oncotarget.6956 [OPEN ACCESS]
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Kurzbericht/Letter

** Richtig, E; Asslaber, M; Partl, R; Avian, A; Berghold, A; Kapp, K; Preusser, M; Becker, JC; Curiel-Lewandrowski, C Lack of P-glycoprotein expression in melanoma brain metastases of different melanoma types.
CLIN NEUROPATHOL. 2016; 35(2): 89-92. Doi: 10.5414/NP300903
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Abstract (Zeitschrift)

** Bhat Kumble, V; Bernhart, E; Plastira, I; Kogelnik, N; Goritzer, M; Fan, K; Wadsack, C; Rechberger, G; Becker, J; Sattler, W Merkel cell carcinoma proliferation is regulated by sphingosine-1-phosphate-mediated pathways in vitro.
J INVEST DERMATOL. 2016; 136(9):S243-S243.-Annual Meeting of the European-Society-for-Dermatological-Research (ESDR); SEP 07-10, 2016; Munich, GERMANY. [Poster]
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** Lyngaa, R; Pedersen, NW; Linnemann, C; Schrama, D; Ibrani, D; Met, O; Straten, PT; Nghiem, P; Becker, JC; Hadrup, SR Using Merkel cell polyomavirus specific TCR gene therapy for treatment of Merkel cell carcinoma
EUR J IMMUNOL. .. 2016; 46: 128-128.-International Congress of Immunology (ICI); AUG 21-26, 2016; Melbourne, AUSTRALIA. [Poster]
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2015

Originalarbeit (Zeitschrift)

** Bagdonaite, I; Wandall, HH; Litvinov, IV; Nastasi, C; Becker, JC; Dabelsteen, S; Geisler, C; Bonefeld, CM; Zhang, Q; Wasik, MA; Zhou, Y; Sasseville, D; Ødum, N; Woetmann, A Ectopic expression of a novel CD22 splice-variant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma (CTCL) patients.
Oncotarget. 2015; 6(16):14374-14384 Doi: 10.18632/oncotarget.3720 [OPEN ACCESS]
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** Kim, EJ; Kim, YH; Rook, AH; Lerner, A; Duvic, M; Reddy, S; Robak, T; Becker, JC; Samtsov, A; McCulloch, W; Waksman, J; Whittaker, S Clinically significant responses achieved with romidepsin across disease compartments in patients with cutaneous T-cell lymphoma.
Leuk Lymphoma. 2015; 56(10):2847-2854 Doi: 10.3109/10428194.2015.1014360 [OPEN ACCESS]
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** Køllgaard, T; Ugurel-Becker, S; Idorn, M; Andersen, MH; Becker, JC; Straten, PT Pre-Vaccination Frequencies of Th17 Cells Correlate with Vaccine-Induced T-Cell Responses to Survivin-Derived Peptide Epitopes.
PLoS One. 2015; 10(7):e0131934-e0131934 Doi: 10.1371/journal.pone.0131934 [OPEN ACCESS]
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** Ugurel, S; Loquai, C; Kähler, K; Hassel, J; Berking, C; Zimmer, L; Haubitz, I; Satzger, I; Müller-Brenne, T; Mikhaimer, NC; Becker, JC; Kilian, KJ; Schadendorf, D; Heinzerling, L; Kaatz, M; Utikal, J; Göppner, D; Pföhler, C; Pflugfelder, A; Mössner, R; Gutzmer, R; Dermatologic Cooperative Oncology Group (DeCOG) A multicenter DeCOG study on predictors of vemurafenib therapy outcome in melanoma: pretreatment impacts survival.
Ann Oncol. 2015; 26(3):573-582 Doi: 10.1093/annonc/mdu573 [OPEN ACCESS]
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Übersichtsarbeit

** Stratigos, A; Garbe, C; Lebbe, C; Malvehy, J; del Marmol, V; Pehamberger, H; Peris, K; Becker, JC; Zalaudek, I; Saiag, P; Middleton, MR; Bastholt, L; Testori, A; Grob, JJ; European Dermatology Forum (EDF); European Association of Dermato-Oncology (EADO); European Organization for Research and Treatment of Cancer (EORTC) Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline.
Eur J Cancer. 2015; 51(14):1989-2007 Doi: 10.1016/j.ejca.2015.06.110
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Abstract (Zeitschrift)

** Ugurel, S; Loquai, C; Terheyden, P; Schadendorf, D; Richtig, E; Utikal, J; Gutzmer, R; Rass, K; Sunderkotter, C; Stein, A; Fluck, M; Kaatz, M; Trefzer, U; Hauschild, A; Stadler, R; Berking, C; Pehamberger, H; Kopp-Schneider, A; Becker, JC Ex-vivo sensitivity-directed combination chemotherapy compared to DTIC monochemotherapy in chemo-naive advanced metastastic melanoma (ChemoSensMM): a multicenter randomized phase-3 DeCOG trial
J DTSCH DERMATOL GES. 2015; 13: 18-19.-25. Deutscher Hautkrebskongress; Sept 10-12, 2015; München. [Oral Communication]
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2014

Originalarbeit (Zeitschrift)

** Adam, C; Baeurle, A; Brodsky, JL; Wipf, P; Schrama, D; Becker, JC; Houben, R The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma.
PLoS One. 2014; 9(4):e92041-e92041 Doi: 10.1371/journal.pone.0092041 [OPEN ACCESS]
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** Buder, K; Lapa, C; Kreissl, MC; Schirbel, A; Herrmann, K; Schnack, A; Bröcker, EB; Goebeler, M; Buck, AK; Becker, JC Somatostatin receptor expression in Merkel cell carcinoma as target for molecular imaging.
BMC Cancer. 2014; 14(3):268-268 Doi: 10.1186/1471-2407-14-268 [OPEN ACCESS]
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** Buder, K; Müller, PA; Beckmann, G; Ugurel, S; Bröcker, EB; Becker, JC Denileukin diftitox plus total skin electron beam radiation in patients with treatment-refractory cutaneous T-cell Lymphoma (mycosis fungoides): report of four cases.
Acta Derm Venereol. 2014; 94(1):94-96 Doi: 10.2340/00015555-1627 (- Case Report) [OPEN ACCESS]
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** Goldinger, SM; Zimmer, L; Schulz, C; Ugurel, S; Hoeller, C; Kaehler, KC; Schadendorf, D; Hassel, JC; Becker, J; Hauschild, A; Dummer, R; Dermatology Cooperative Oncology Group (DeCOG) Upstream mitogen-activated protein kinase (MAPK) pathway inhibition: MEK inhibitor followed by a BRAF inhibitor in advanced melanoma patients.
Eur J Cancer. 2014; 50(2):406-410 Doi: 10.1016/j.ejca.2013.09.014
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** Haugg, AM; Rennspiess, D; zur Hausen, A; Speel, EJ; Cathomas, G; Becker, JC; Schrama, D Fluorescence in situ hybridization and qPCR to detect Merkel cell polyomavirus physical status and load in Merkel cell carcinomas.
Int J Cancer. 2014; 135(12):2804-2815 Doi: 10.1002/ijc.28931 [OPEN ACCESS]
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** Heidenreich, B; Nagore, E; Rachakonda, PS; Garcia-Casado, Z; Requena, C; Traves, V; Becker, J; Soufir, N; Hemminki, K; Kumar, R Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.
Nat Commun. 2014; 5(5):3401-3401 Doi: 10.1038/ncomms4401 [OPEN ACCESS]
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** Houben, R; Schmid, CP; Maier, M; Wobser, M; Motschenbacher, S; Becker, JC; Vetter-Kauczok, CS; Weyandt, G; Hesbacher, S; Haferkamp, S p53 regulation by TRP2 is not pervasive in melanoma.
PLoS One. 2014; 9(1):e87440-e87440 Doi: 10.1371/journal.pone.0087440 [OPEN ACCESS]
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** Lyngaa, R; Pedersen, NW; Schrama, D; Thrue, CA; Ibrani, D; Met, O; Thor Straten, P; Nghiem, P; Becker, JC; Hadrup, SR T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors.
Clin Cancer Res. 2014; 20(7):1768-1778 Doi: 10.1158/1078-0432.CCR-13-2697 [OPEN ACCESS]
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** Paulson, KG; Tegeder, A; Willmes, C; Iyer, JG; Afanasiev, OK; Schrama, D; Koba, S; Thibodeau, R; Nagase, K; Simonson, WT; Seo, A; Koelle, DM; Madeleine, M; Bhatia, S; Nakajima, H; Sano, S; Hardwick, JS; Disis, ML; Cleary, MA; Becker, JC; Nghiem, P Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma.
Cancer Immunol Res. 2014; 2(11):1071-1079 Doi: 10.1158/2326-6066.CIR-14-0005 [OPEN ACCESS]
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** Ugurel, S; Mentzel, T; Utikal, J; Helmbold, P; Mohr, P; Pföhler, C; Schiller, M; Hauschild, A; Hein, R; Kämpgen, E; Kellner, I; Leverkus, M; Becker, JC; Ströbel, P; Schadendorf, D Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up.
Clin Cancer Res. 2014; 20(2):499-510 Doi: 10.1158/1078-0432.CCR-13-1411 [OPEN ACCESS]
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** Weide, B; Eigentler, TK; Pflugfelder, A; Zelba, H; Martens, A; Pawelec, G; Giovannoni, L; Ruffini, PA; Elia, G; Neri, D; Gutzmer, R; Becker, JC; Garbe, C Intralesional treatment of stage III metastatic melanoma patients with L19-IL2 results in sustained clinical and systemic immunologic responses.
Cancer Immunol Res. 2014; 2(7):668-678 Doi: 10.1158/2326-6066.CIR-13-0206 [OPEN ACCESS]
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Übersichtsarbeit

** Aigner, B; Ugurel, S; Kaddu, S; Becker, JC [Cutaneous sarcomas: update on selected fibrohistiocytic and myofibroblastic tumors].
Hautarzt. 2014; 65(7):614-622 Doi: 10.1007/s00105-013-2738-3
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** Becker, JC; thor Straten, P; Andersen, MH Self-reactive T cells: suppressing the suppressors.
Cancer Immunol Immunother. 2014; 63(4):313-319 Doi: 10.1007/s00262-013-1512-9
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** Hillen, U; Ulrich, M; Alter, M; Becker, JC; Gutzmer, R; Leiter, U; Lonsdorf, A; Messerschmidt, A; Ulrich, C [Cutaneous squamous cell carcinoma: a review with consideration of special patient groups].
Hautarzt. 2014; 65(7):590-599 Doi: 10.1007/s00105-013-2734-7
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Abstract (Zeitschrift)

** Fan, K; Ritter, C; Theiler, A; Houben, R; Schrama, D; Becker, JC Ectopic expression and secretion of miR-375 in MCC: Impact on the tumor microenvironment
J DTSCH DERMATOL GES. . 2014; 12: 8-9. [Poster]
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** Haferkamp, S; Schmid, C; Maier, M; Wobser, M; Motschenbacher, S; Maier, LJ; Becker, JC; Houben, R Tyrosinase-related protein 2 (TRP2) is not required for p53 regulation in melanoma
EXP DERMATOL. . 2014; 23(3):E44-E44.-41st Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF); MAR 13-15, 2014; Cologne, GERMANY. [Poster]
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** Krump, C; Becker, JC; Ghaffari Tabrizi-Wiszy, N; Strobl, H Chicken Chorioallantoic Membrane (CAM) as Model for Tumor-Stroma-Interaction of Merkel Cell Carcinoma (MCC) and Murine Melanoma (MM)
J DTSCH DERMATOL GES. 2014; 12: 17-18. [Poster]
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** Ofner, R; Kumar, R; Heidenreich, B; Schrama, D; Becker, JC TERT promoter mutations in melanoma
J DTSCH DERMATOL GES. . 2014; 12: 42-43. [Poster]
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** Ritter, C; Schrama, D; Houben, R; Becker, JC Enhanced MHC class I molecule expression on Merkel cell carcinoma by HDAC inhibitors
J DTSCH DERMATOL GES. . 2014; 12: 8-8. [Poster]
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** Schrama, D; Groesser, L; Haffner, C; Ugurel, S; Pastrana, D; Buck, C; Cerroni, L; Theiler, A; Becker, JC Presence of human polyomavirus 6 in mutation-specific BRAF inhibitor induced epithelial proliferations
J DTSCH DERMATOL GES. 2014; 12: 42-42.-Deutscher Hautkrebskongress und ADO-Jahrestagung; SEP 11-13 2014; Frankfurt am Main, GERMANY. [Poster]
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** Theiler, A; Schrama, D; Becker, JC PARP-1 activation in Merkel cell carcinoma (MCC)
J DTSCH DERMATOL GES. . 2014; 12: 18-18. [Poster]
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Kommentar

** Angermeyer, S; Hesbacher, S; Becker, JC; Schrama, D; Houben, R Response to Shuda et al.
J Invest Dermatol. 2014; 134(5):1481-1482 Doi: 10.1038/jid.2013.486 [OPEN ACCESS]
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** Becker, JC Tumor-educated myeloid cells: impact the micro- and macroenvironment.
Exp Dermatol. 2014; 23(3):157-158 Doi: 10.1111/exd.12241 [OPEN ACCESS]
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** Becker, JC; zur Hausen, A Cells of origin in skin cancer.
J Invest Dermatol. 2014; 134(10):2491-2493 Doi: 10.1038/jid.2014.233 [OPEN ACCESS]
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2013

Originalarbeit (Zeitschrift)

** Aigner, B; Richtig, E; Becker, JC; Lingitz, H; Niederkorn, RMA; Ugurel, S; Partial Response of Metastatic Mucosal Melanoma After Palliative Chemotherapy With Trofosfamide: A Case Report.
J Clin Oncol. 2013; 31(2):e31-e32 Doi: 10.1200/JCO.2012.44.2053 (- Case Report) [OPEN ACCESS]
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** Angermeyer, S; Hesbacher, S; Becker, JC; Schrama, D; Houben, R Merkel cell polyomavirus-positive Merkel cell carcinoma cells do not require expression of the viral small T antigen.
J Invest Dermatol. 2013; 133(8):2059-2064 Doi: 10.1038/jid.2013.82 [OPEN ACCESS]
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** Assaf, C; Becker, JC; Beyer, M; Cozzio, A; Dippel, E; Klemke, CD; Kurschat, P; Weichenthal, M; Stadler, R Treatment of advanced cutaneous T-cell lymphomas with non-pegylated liposomal doxorubicin--consensus of the lymphoma group of the Working Group Dermatologic Oncology.
J Dtsch Dermatol Ges. 2013; 11(4):338-347 Doi: 10.1111/ddg.12012
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** Becker, JC; Assaf, C; Vordermark, D; Reske, SN; Hense, J; Dettenborn, T; Seitz, O; Grabbe, S Brief S2k guidelines--Merkel cell carcinoma.
J Dtsch Dermatol Ges. 2013; 11 Suppl 3(42): 31- 38 Doi: 10.1111/ddg.12015_6
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** Duvic, M; Dummer, R; Becker, JC; Poulalhon, N; Romero, PO; Bernengo, MG; Lebbe, C; Assaf, C; Squier, M; Williams, D; Marshood, M; Tai, F; Prince, HM; Panobinostat activity in both bexarotene-exposed and -naive patients with refractory cutaneous T-cell lymphoma: Results of a phase II trial.
EUR J CANCER. 2013; 49(2): 386-394. Doi: 10.1016/j.ejca.2012.08.017
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** Hillen, U; Ulrich, C; Gutzmer, R; Becker, JC Association Dermatologic Oncology (ADO). Treatment of advanced squamous cell carcinoma].
J Dtsch Dermatol Ges. 2013; 11(7): 699-699. Doi: 10.1111/ddg.12151
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** Kruit, WH; Suciu, S; Dreno, B; Mortier, L; Robert, C; Chiarion-Sileni, V; Maio, M; Testori, A; Dorval, T; Grob, JJ; Becker, JC; Spatz, A; Eggermont, AM; Louahed, J; Lehmann, FF; Brichard, VG; Keilholz, U Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma.
J Clin Oncol. 2013; 31(19): 2413-2420. Doi: 10.1200/JCO.2012.43.7111 [OPEN ACCESS]
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** Larsen, SK; Munir, S; Woetmann, A; Frøsig, TM; Odum, N; Svane, IM; Becker, JC; Andersen, MH Functional characterization of Foxp3-specific spontaneous immune responses.
Leukemia. 2013; 27(12):2332-2340 Doi: 10.1038/leu.2013.196 [OPEN ACCESS]
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** Loader, DE; Feldmann, R; Baumgartner, M; Breier, F; Schrama, D; Becker, JC; Steiner, A Clinical remission of Merkel cell carcinoma after treatment with imatinib.
J Am Acad Dermatol. 2013; 69(4):e181-e183 Doi: 10.1016/j.jaad.2013.03.042 (- Case Report)
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** Pedersen, IH; Willerslev-Olsen, A; Vetter-Kauczok, C; Krejsgaard, T; Lauenborg, B; Kopp, KL; Geisler, C; Bonefeld, CM; Zhang, Q; Wasik, MA; Dabelsteen, S; Woetmann, A; Becker, JC; Odum, N; Vascular endothelial growth factor receptor-3 expression in mycosis fungoides.
LEUK LYMPHOMA. 2013; 54(4): 819-826. Doi: 10.3109/10428194.2012.726720
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** Sbiera, S; Kroiss, M; Thamm, T; Beyer, M; Majidi, F; Kuehner, D; Wobser, M; Becker, JC; Adam, P; Ronchi, C; Allolio, B; Fassnacht, M; Survivin in Adrenocortical Tumors Pathophysiological Implications and Therapeutic Potential.
HORMONE METAB RES. 2013; 45(2): 137-146. Doi: 10.1055/s-0032-1327750 [OPEN ACCESS]
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** Wölfel, T; Becker, JC; Schmitt, M Immune oncology in focus].
Onkologie. 2013; 36 Suppl 4(11):7-11 Doi: 10.1159/000350921 [OPEN ACCESS]
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Kurzbericht/Letter

** Munir, S; Andersen, GH; Woetmann, A; Ødum, N; Becker, JC; Andersen, MH Cutaneous T cell lymphoma cells are targets for immune checkpoint ligand PD-L1-specific, cytotoxic T cells.
Leukemia. 2013; 27(11):2251-2253 Doi: 10.1038/leu.2013.118 [OPEN ACCESS]
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** Richtig, E; Schrama, D; Ugurel, S; Fried, I; Niederkorn, A; Massone, C; Becker, JC BRAF mutation analysis of only one single metastatic lesion can restrict the treatment of melanoma - a case report.
Br J Dermatol. 2013; 168(2):428-430 Doi: 10.1111/j.1365-2133.2012.11121.x (- Case Report)
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** Schrama, D; Hesbacher, S; Becker, JC; Houben, R Survivin downregulation is not required for T antigen knockdown mediated cell growth inhibition in MCV infected merkel cell carcinoma cells.
Int J Cancer. 2013; 132(12):2980-2982 Doi: 10.1002/ijc.27962 [OPEN ACCESS]
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Übersichtsarbeit

** Becker, JC; Andersen, MH; Schrama, D; Thor Straten, P Immune-suppressive properties of the tumor microenvironment.
Cancer Immunol Immunother. 2013; 62(7):1137-1148 Doi: 10.1007/s00262-013-1434-6
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Editorial

** Becker, JC; Schrama, D; The Dark Side of Cyclophosphamide: Cyclophosphamide-Mediated Ablation of Regulatory T Cells.
J INVEST DERMATOL. 2013; 133(6): 1462-1465. Doi: 10.1038/jid.2013.67 [OPEN ACCESS]
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Fallbericht

** Tilz, H; Becker, JC; Legat, F; Schettini, AP; Inzinger, M; Massone, C Allopurinol in the treatment of acquired reactive perforating collagenosis.
An Bras Dermatol. 2013; 88(1):94-97 Doi: 10.1590/s0365-05962013000100012 (- Case Report) [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Abstract (Zeitschrift)

** Becker, J; Pflugfelder, A; Trefzer, U; Ugurel, S; Pfohler, C; Kellner, Y; Beissert, S; Kahler, K; Mohr, P; Zouboulis, C; Zimmer, L; Belloni, B; Berking, C; Schadendorf, D; Merkel Cell Carcinoma Register of the ADO - the first Evaluation.
J DTSCH DERMATOL GES. 2013; 11(9):909-910.-Deutscher Hautkrebskongress; September, 2013; Essen, D. [Oral Communication]
Web of Science

 

** Becker, JC Active Immunotherapy: Vaccination and adoptive cell transfer.
ONKOLOGIE. 2013; 36: 220-220.-DGHO; OCT, 2013; Wien. [Oral Communication]
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** Lyngaa, R; Thrue, CA; Straten, PT; Nghiem, P; Becker, JC; Hadrup, SR; CD8 T cell epitopes in large and small T antigens of merkel cell polyoma virus exclusively elicit anti-viral T-cell responses in merkel cell carcinoma patients.
J INVEST DERMATOL. 2013; 133: S10-S10.-International Investigative Dermatology Meeting; MAY 08-11, 2013; Edinburgh, SCOTLAND. [Oral Communication]
Web of Science

 

** Ritter, C; Becker, JC; Schrama, D; Reversible epigenetic silencing of NKG2D ligands MICA and MICB in Merkel cell carcinoma.
EXP DERMATOL. 2013; 22(3):E42-E42.-40th Annual Meeting of the Association-of-Dermatological-Research; MAR 14-16, 2013; Dessau, GERMANY. [Oral Communication]
Web of Science

 

** Ritter, C; Schrama, D; Becker, JC; Reinduction of epigenetically silenced NKG2D ligands MICA and MICB in Merkel cell carcinoma.
J DTSCH DERMATOL GES. 2013; 11(9):907-907.-ADO-Tagung; September, 2013; Essen, D. [Oral Communication]
Web of Science

 

** Schrama, D; Ritter, C; Becker, J; PDGFR alpha and Merkel Cell Carcinoma: pS478P Polymorphism and PDGFR-Inhibitors.
J DTSCH DERMATOL GES. 2013; 11(9):945-946.-ADO-Tagung; September, 2013; Essen, D. [Oral Communication]
Web of Science

 

** Schrama, D; Ugurel, S; Schadendorf, D; Becker, JC; No association of STAT3 rs4796793 SNP with response to IFN alpha therapy in patients with metastatic melanoma.
EXP DERMATOL. 2013; 22(3):E22-E22.-40th Annual Meeting of the Association-of-Dermatological-Research; MAR 14-16, 2013; Dessau, GERMANY. [Poster]
Web of Science

 

** Stumpf, C; Booken, N; Teichert, M; Wobser, M; Nashan, D; Dippel, E; Muller, CS; Becker, JC; Sachse, MM; Nicolay, JP; Goerdt, S; Thomas, M; Klemke, C; Augustin, HG; Felcht, M; An Angiopoietin-2 high Tie2 low endothelial phenotype correlates with an aggressive clinical course in primary cutaneous B-cell lymphomas [Abstract of the Working group of cutaneous lymphomas of the Arbeitsgemeinschaft fur Dermatologische Forschung (ADF), Germany].
EXP DERMATOL. 2013; 22(3):E42-E42.-40th Annual Meeting of the Association-of-Dermatological-Research; MAR 14-16, 2013; Dessau, GERMANY. [Poster]
Web of Science

 

** Theiler, A; Schrama, D; Becker, JC; Modulation of the Tumor Microenvironment by Microvesicles derived from the Merkel Cell Carcinoma (MCC).
J DTSCH DERMATOL GES. 2013; 11(9):959-960.-ADO-Tagung; Sept, 2013; Essen, D. [Oral Communication]
Web of Science

 

** Ugurel, S; Mentzel, T; Utikal, J; Helmbold, P; Mohr, P; Pfohler, C; Schiller, M; Hauschild, A; Hein, R; Kampgen, E; Kellner, I; Leverkus, M; Becker, J; Strobel, P; Schadendorf, D. Neo-adjuvant Therapy of Dermatofibrosarcoma protuberans with Imatinib: A multicenter Phase II Study of the ADO.
J DTSCH DERMATOL GES. 2013; 11(9):909-909.-ADO-Tagung; September, 2013; Essen, D. [Oral Communication]
Web of Science

 

Kommentar

** Ugurel, S; Paschen, A; Becker, JC Dacarbazine in melanoma: from a chemotherapeutic drug to an immunomodulating agent.
J Invest Dermatol. 2013; 133(2):289-292 Doi: 10.1038/jid.2012.341 [OPEN ACCESS]
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2012

Originalarbeit (Zeitschrift)

** Alb, M; Sie, C; Adam, C; Chen, S; Becker, JC; Schrama, D Cellular and cytokine-dependent immunosuppressive mechanisms of grm1-transgenic murine melanoma.
Cancer Immunol Immunother. 2012; 61(12):2239-2249 Doi: 10.1007/s00262-012-1290-9 [OPEN ACCESS]
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** Becker, JC; Andersen, MH; Hofmeister-Muller, V; Wobser, M; Frey, L; Sandig, C; Walter, S; Singh-Jasuja, H; Kampgen, E; Opitz, A; Zapatka, M; Brocker, EB; Straten, PT; Schrama, D; Ugurel, S; Survivin-specific T-cell reactivity correlates with tumor response and patient survival: a phase-II peptide vaccination trial in metastatic melanoma.
Cancer Immunol Immunother. 2012; 61(11):2091-2103 Doi: 10.1007/s00262-012-1266-9 [OPEN ACCESS]
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** Dummer, R; Quaglino, P; Becker, JC; Hasan, B; Karrasch, M; Whittaker, S; Morris, S; Weichenthal, M; Stadler, R; Bagot, M; Cozzio, A; Bernengo, MG; Knobler, R; Prospective International Multicenter Phase II Trial of Intravenous Pegylated Liposomal Doxorubicin Monochemotherapy in Patients With Stage IIB, IVA, or IVB Advanced Mycosis Fungoides: Final Results From EORTC 21012.
J CLIN ONCOL. 2012; 30(33): 4091-4097. Doi: 10.1200/JCO.2011.39.8065 [OPEN ACCESS]
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** Felcht, M; Heck, M; Weiss, C; Becker, JC; Dippel, E; Muller, CSL; Nashan, D; Sachse, MM; Nicolay, JP; Booken, N; Goerdt, S; Klemke, CD; Expression of the T-cell regulatory marker FOXP3 in primary cutaneous large B-cell lymphoma tumour cells.
BRIT J DERMATOL. 2012; 167(2): 348-358. Doi: 10.1111/j.1365-2133.2012.10987.x
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** Flaherty, KT; Robert, C; Hersey, P; Nathan, P; Garbe, C; Milhem, M; Demidov, LV; Hassel, JC; Rutkowski, P; Mohr, P; Dummer, R; Trefzer, U; Larkin, JMG; Utikal, J; Dreno, B; Nyakas, M; Middleton, MR; Becker, JC; Casey, M; Sherman, LJ; Wu, FS; Ouellet, D; Martin, AM; Patel, K; Schadendorf, D; Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma.
N ENGL J MED. 2012; 367(2): 107-114. Doi: 10.1056/NEJMoa1203421 [OPEN ACCESS]
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** Hafner, C; Houben, R; Baeurle, A; Ritter, C; Schrama, D; Landthaler, M; Becker, JC Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS One. 2012; 7(2):e31255-e31255 Doi: 10.1371/journal.pone.0031255 [OPEN ACCESS]
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** Houben, R; Adam, C; Baeurle, A; Hesbacher, S; Grimm, J; Angermeyer, S; Henzel, K; Hauser, S; Elling, R; Bröcker, EB; Gaubatz, S; Becker, JC; Schrama, D An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells.
Int J Cancer. 2012; 130(4): 847-856. Doi: 10.1002/ijc.26076 [OPEN ACCESS]
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** Vlahova, L; Doerflinger, Y; Houben, R; Becker, JC; Schrama, D; Weiss, C; Goebeler, M; Helmbold, P; Goerdt, S; Peitsch, WK P-cadherin expression in Merkel cell carcinomas is associated with prolonged recurrence-free survival.
Br J Dermatol. 2012; 166(5):1043-1052 Doi: 10.1111/j.1365-2133.2012.10853.x
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** Willmes, C; Adam, C; Alb, M; Völkert, L; Houben, R; Becker, JC; Schrama, D Type I and II IFNs inhibit Merkel cell carcinoma via modulation of the Merkel cell polyomavirus T antigens.
Cancer Res. 2012; 72(8): 2120-2128. Doi: 10.1158/0008-5472.CAN-11-2651 [OPEN ACCESS]
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Kurzbericht/Letter

** Houben, R; Grimm, J; Willmes, C; Weinkam, R; Becker, JC; Schrama, D Merkel cell carcinoma and Merkel cell polyomavirus: evidence for hit-and-run oncogenesis.
J Invest Dermatol. 2012; 132(1): 254-256. Doi: 10.1038/jid.2011.260 [OPEN ACCESS]
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** Schiffner, S; Chen, S; Becker, JC; Bosserhoff, AK Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases.
Exp Dermatol. 2012; 21(10):786-788 Doi: 10.1111/j.1600-0625.2012.01560.x [OPEN ACCESS]
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** Schrama, D; Buck, CB; Houben, R; Becker, JC No evidence for association of HPyV6 or HPyV7 with different skin cancers.
J Invest Dermatol. 2012; 132(1): 239-241. Doi: 10.1038/jid.2011.261 [OPEN ACCESS]
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Übersichtsarbeit

** Schrama, D; Ugurel, S; Becker, JC Merkel cell carcinoma: recent insights and new treatment options.
Curr Opin Oncol. 2012; 24(2): 141-149. Doi: 10.1097/CCO.0b013e32834fc9fe
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Abstract (Zeitschrift)

** Aigner, B; Richtig, E; Becker, J; Marterer, R; Niederkom, A; Lingitz, H; Ugurel, S; Partial Remission of metastatic Mucosal melanoma receiving palliative therapy with Trofosfamide.
J DTSCH DERMATOL GES. 2012; 10(9):695-695.-ADO; Hannover. [Poster]
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** Aigner, BA; Bodenlenz, M; Hofferer, C; Priedl, J; Dragatin, C; Kiefer, B; Korsatko, S; Liebenberger, L; Zahiragic, S; Raml, R; Magnes, C; Becker, JC; Pieber, TR; Sinner, F Dermal open-flow microperfusion as a novel technique for in vivo measurement of dermal interstitium
EXP DERMATOL. 2012; 21(3):e13-e13.-39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF); MAR 01-03, 2012; Marburg, GERMANY. [Poster]
Web of Science

 

** Fried, I; Wiesner, T; Becker, JC; Cerroni, L Subcutaneous panniculitis-like T-cell lymphomas do not show genetic aberrations with array CGH.
Experimental Dermatology. 2012; 21(3):e22--39th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF); March 01-03, 2012; Marburg, Germany. [Poster]
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** Haugg, A; Rennspiess, D; zur Hausen, A; Speel, EJM; Cathomas, G; Becker, J; Schrama, D Detection of Merkel Cell Polyomavirus in Formalin-Fixed and Paraffin-Embedded Tissues by Fluorescence In Situ Hybridisation and Its Correlation with qPCR
LAB INVEST. 2012; 92: 122A-122A.-101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP); MAR 17-23, 2012; Vancouver, CANADA. [Poster]
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** Haugg, A; Rennspiess, D; zur Hausen, A; Speel, EJM; Cathomas, J; Becker, J; Schrama, D Detection of Merkel Cell Polyomavirus in Formalin-Fixed and Paraffin-Embedded Tissues by Fluorescence In Situ Hybridisation and Its Correlation with qPCR
MODERN PATHOL. 2012; 25: 122A-122A.-101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology; MAR 17-23, 2012; Vancouver, CANADA. [Poster]
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** Speel, EM; Haugg, A; Rennspiess, D; zur Hausen, A; Cathomas, G; Becker, J; Schrama, D; Comprehensive Assessment of Merkel Cell Polyomavirus in Merkel Cell Carcinomas: Fluorescence in situ Hybridization Versus qPCR?.
J MOL DIAGN. 2012; 14(6):677-677.-Annual Meeting of the Association-for-Molecular-Pathology; OCT 25-27, 2012; Long Beach, CA. [Poster]
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** Vlahova, L; Dorflinger, Y; Houben, R; Brandner, JM; Becker, JC; Schrama, D; Goebeler, M; Helmbold, P; Weiss, C; Goerdt, S; Peitsch, WK P-cadherin expression in primary Merkel cell carcinomas is associated with prolonged recurrence-free survival
EXP DERMATOL. 2012; 21(3):e43-e43.-39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF); MAR 01-03, 2012; Marburg, GERMANY. [Oral Communication]
Web of Science

 

** Wiesner, T; Obenauf, AC; Murali, R; Fried, I; Griewank, KG; Ulz, P; Windpassinger, C; Wackernagel, W; Loy, S; Wolf, I; Viale, A; Lash, AE; Pirun, M; Socci, ND; Rütten, A; Palmedo, G; Abramson, D; Offit, K; Ott, A; Becker, JC; Cerroni, L; Kutzner, H, Bastian, BC; Speicher, MR Germline mutations in BAP1 predispose to melanocytic tumors.
Experimental Dermatology. 2012; 21(3):e22--39th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF); March 01-03, 2012; Marburg, Germany. [Poster]
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Kommentar

** Becker, JC; Schrama, D Control of central and peripheral tolerance to melanocyte differentiation antigens by GILT.
J INVEST DERMATOL. 2012; 132(1): 15-17. Doi: 10.1038/jid.2011.361 [OPEN ACCESS]
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2011

Originalarbeit (Zeitschrift)

** Andersen, RS; Sørensen, RB; Ritter, C; Svane, IM; Becker, JC; thor Straten, P; Andersen, MH Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors.
Cancer Immunol Immunother. 2011; 60(2):227-234 Doi: 10.1007/s00262-010-0933-y [OPEN ACCESS]
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** Egberts, F; Gutzmer, R; Ugurel, S; Becker, JC; Trefzer, U; Degen, A; Schenck, F; Frey, L; Wilhelm, T; Hassel, JC; Schadendorf, D; Livingstone, E; Mauch, C; Garbe, C; Berking, C; Rass, K; Mohr, P; Kaehler, KC; Weichenthal, M; Hauschild, A Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma: a multicenter phase II DeCOG trial.
Ann Oncol. 2011; 22(7):1667-1674 Doi: 10.1093/annonc/mdq648 [OPEN ACCESS]
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** Gutzmer, R; Becker, JC; Enk, A; Garbe, C; Hauschild, A; Leverkus, M; Reimer, G; Treudler, R; Tsianakas, A; Ulrich, C; Wollenberg, A; Homey, B Management of cutaneous side effects of EGFR inhibitors: recommendations from a German expert panel for the primary treating physician.
J Dtsch Dermatol Ges. 2011; 9(3):195-202 Doi: 10.1111/j.1610-0387.2010.07561.x [OPEN ACCESS]
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** Houben, R; Hesbacher, S; Schmid, CP; Kauczok, CS; Flohr, U; Haferkamp, S; Müller, CS; Schrama, D; Wischhusen, J; Becker, JC High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays.
PLoS One. 2011; 6(7):e22096-e22096 Doi: 10.1371/journal.pone.0022096 [OPEN ACCESS]
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** Paulson, KG; Iyer, JG; Tegeder, AR; Thibodeau, R; Schelter, J; Koba, S; Schrama, D; Simonson, WT; Lemos, BD; Byrd, DR; Koelle, DM; Galloway, DA; Leonard, JH; Madeleine, MM; Argenyi, ZB; Disis, ML; Becker, JC; Cleary, MA; Nghiem, P Transcriptome-Wide Studies of Merkel Cell Carcinoma and Validation of Intratumoral CD8+ Lymphocyte Invasion As an Independent Predictor of Survival
J CLIN ONCOL. 2011; 29(12): 1539-1546. Doi: 10.1200/JCO.2010.30.6308 [OPEN ACCESS]
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** Schrama, D; Becker, JC Merkel cell carcinoma--pathogenesis, clinical aspects and treatment.
J Eur Acad Dermatol Venereol. 2011; 25(10):1121-1129 Doi: 10.1111/j.1468-3083.2011.04032.x
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** Schrama, D; Peitsch, WK; Zapatka, M; Kneitz, H; Houben, R; Eib, S; Haferkamp, S; Moore, PS; Shuda, M; Thompson, JF; Trefzer, U; Pföhler, C; Scolyer, RA; Becker, JC Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma.
J Invest Dermatol. 2011; 131(8):1631-1638 Doi: 10.1038/jid.2011.115 [OPEN ACCESS]
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** Schrama, D; Scherer, D; Schneider, M; Zapatka, M; Bröcker, EB; Schadendorf, D; Ugurel, S; Kumar, R; Becker, JC ERCC5 p.Asp1104His and ERCC2 p.Lys751Gln Polymorphisms Are Independent Prognostic Factors for the Clinical Course of Melanoma.
J Invest Dermatol. 2011; 131(6):1280-1290 Doi: 10.1038/jid.2011.35 [OPEN ACCESS]
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** Werling, AM; Doerflinger, Y; Brandner, JM; Fuchs, F; Becker, JC; Schrama, D; Kurzen, H; Goerdt, S; Peitsch, WK Homo- and heterotypic cell-cell contacts in Merkel cells and Merkel cell carcinomas: heterogeneity and indications for cadherin switching.
Histopathology. 2011; 58(2):286-303 Doi: 10.1111/j.1365-2559.2011.03748.x
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** Wiesner, T; Obenauf, AC; Murali, R; Fried, I; Griewank, KG; Ulz, P; Windpassinger, C; Wackernagel, W; Loy, S; Wolf, I; Viale, A; Lash, AE; Pirun, M; Socci, ND; Rütten, A; Palmedo, G; Abramson, D; Offit, K; Ott, A; Becker, JC; Cerroni, L; Kutzner, H; Bastian, BC; Speicher, MR Germline mutations in BAP1 predispose to melanocytic tumors.
Nat Genet. 2011; 43(10):1018-1021 Doi: 10.1038/ng.910 [OPEN ACCESS]
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** Wobser, M; Kneitz, H; Bröcker, EB; Becker, JC Primary cutaneous diffuse large B-cell lymphoma, leg-type, treated with a modified R-CHOP immunochemotherapy - diagnostic and therapeutic challenges.
J Dtsch Dermatol Ges. 2011; 9(3):204-210 Doi: 10.1111/j.1610-0387.2010.07578.x
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** Zalaudek, I; Guelly, C; Pellacani, G; Hofmann-Wellenhof, R; Trajanoski, S; Kittler, H; Scope, A; Marghoob, AA; Longo, C; Leinweber, B; Ferrara, G; Saida, T; Grichnik, JM; Argenziano, G; Becker, JC The Dermoscopical and Histopathological Patterns of Nevi Correlate with the Frequency of BRAF Mutations.
J Invest Dermatol. 2011; 131(2): 542-545. Doi: 10.1038/jid.2010.332 [OPEN ACCESS]
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Übersichtsarbeit

** Ugurel, S; Becker, JC [Treatment of advanced metastatic melanoma].
Hautarzt. 2011; 62(6):423-429 Doi: 10.1007/s00105-010-2041-5
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Editorial

** Becker, JC; Gutzmer, R; Mauch, C Medicamentous Tumor therapy
HAUTARZT. 2011; 62(6): 412-413. Doi: 10.1007/s00105-010-2074-9 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Adam, C; Houben, R; Baeurle, A; Brodsky, JL; Wipf, P; Schrama, D; Becker, JC The HSP70 inhibitor MAL3-101 affects merkel cell carcinoma in vitro and in vivo
EXP DERMATOL. 2011; 20(2): P202 [Oral Communication]
Web of Science

 

** Buttstadt, N; Friebel, K; Heinemann, SH; Schonherr, R; Adam, C; Wulff, H; Becker, J The intermediate-conductance Ca(2+)-activated potassium channel K(Ca)3.1 as novel therapeutic target in malignant melanoma
J DTSCH DERMATOL GES. 2011; 9(9):796-796. [Poster]
Web of Science

 

** Felcht, M; Heck, M; Becker, JC; Dippel, E; Muller, CSL; Nashan, D; Sachse, MM; Nicolay, JP; Booken, N; Goerdt, S; Klemke, CD Prognosis in primary cutaneous B-cell lymphomas is determined by infiltration of T regulatory cells and FOXP3 expression of the tumor cells
J DTSCH DERMATOL GES. 2011; 9: 8-8. [Poster]
Web of Science

 

** Justich, A; Niederkorn, A; Tilz, H; Massone, C; Richtig, E; Becker, J; Ugurel, S Regression of a case of complete Paraplegia due to multiple Vertebral Body Metastases of a Melanoma being treated by BRAF-Inhibitor Vemurafenib
J DTSCH DERMATOL GES. 2011; 9(9):786-786.-21. Jahrestagung der ADO; Sept 15-17, 2011; Weimar, Deutschland. [Poster]
Web of Science

 

** Niederkorn, A; Tilz, HE; Justich, A; Richtig, E; Ugurel, S; Becker, J Response of an inoperative Relapse of a primary cutaneous large B-Cell-Lymphoma with endonasal Infiltration during Chemotherapy with pegylated liposomal Doxorubicine in Combination with Rituximab.
J DTSCH DERMATOL GES. 2011; 9(9):787-787.-21. Jahrestagung der ADO; Sept 15-17, 2011; Weimar, Deutschland. [Poster]
Web of Science

 

** Paulson, K; Tegeder, A; Willmes, C; Iyer, J; Schrama, D; Koelle, D; Cleary, M; Bhatia, S; Becker, J; Nghiem, P Reversal of local immune evasion mechanisms and regression of human Merkel cell carcinoma by intralesional injection of interferon-beta
J INVEST DERMATOL. 2011; 131: 547- [Poster]
Web of Science

 

** Richtig, E; Ugurel, S; Niederkorn, A; Justich, A; Tilz, H; Becker, J Onset and rapid Progression of Vitiligo in a Patient with metastatic malignant Melanoma under Ipilimumag Therapy - possibly triggered by an increase in ACTH Process?
J DTSCH DERMATOL GES. 2011; 9(9):784-784.-21. Jahrestagung der ADO; Sept 15-17, 2011; Weimar, Deutschland. [Poster]
Web of Science

 

** Richtig, E; Ugurel, S; Niederkorn, A; Justich, A; Tilz, H; Becker, J Increase of Pancreatic Enzymes and of the Cortisol Levels in Patients with metastatic Melanoma under a Therapy with Ipilimumab
J DTSCH DERMATOL GES. 2011; 9(9):784-784.-21. Jahrestagung der ADO; Sept 15-17, 2011; Weimar, Deutschland. [Poster]
Web of Science

 

** Schadendorf, D; Becker, J; Garbe, C; Hauschild, A Efficacy and Safety of Ipilimumab in Patients with Metastatic Melanoma: Summary of Results from two Ipilimumap Phase III Studies
J DTSCH DERMATOL GES. 2011; 9(9):778-779. [Poster]
Web of Science

 

** Schmid, C; Houben, R; Hesbacher, S; Kauczok, CS; Flohr, U; Haferkamp, S; Muller, C; Schrama, D; Wischhusen, J; Becker, J High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays
J DTSCH DERMATOL GES. 2011; 9(9):795-796. [Poster]
Web of Science

 

** Tilz, HE; Niederkorn, A; Justich, A; Prettenhofer, U; Massone, C; Richtig, E; Becker, J; Ugurel, S Successful Therapy of a Stewart Treves Angio Sarcoma by way of Radiation and Paclitaxel
J DTSCH DERMATOL GES. 2011; 9(9):789-789. [Poster]
Web of Science

 

** Willmes, C; Adam, C; Alb, M; Volkert, L; Houben, R; Becker, JC; Schrama, D Interferons affect cellular viability and class I major histocompatibility complex expression in both MCV positive and negative merkel cell carcinoma cell lines
EXP DERMATOL. 2011; 20(2): P212 [Poster]
Web of Science

 

Kommentar

** Becker, JC; Schrama, D Breaking immunological tolerance to melanocyte differentiation antigens by hypopigmenting agents: a new means for melanoma immunotherapy?
J Invest Dermatol. 2011; 131(6):1185-1187 Doi: 10.1038/jid.2011.94 [OPEN ACCESS]
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2010

Originalarbeit (Zeitschrift)

** Becker, JC Merkel cell carcinoma
ANN ONCOL. 2010; 21: 81-85. Doi: 10.1093/annonc/mdq366 [OPEN ACCESS]
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** Houben, R; Shuda, M; Weinkam, R; Schrama, D; Feng, H; Chang, Y; Moore, PS; Becker, JC Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J Virol. 2010; 84(14):7064-7072 Doi: 10.1128/JVI.02400-09 [OPEN ACCESS]
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** Kneitz, H; Bröcker, EB; Becker, JC Mycosis fungoides bullosa: a case report and review of the literature.
J Med Case Rep. 2010; 4(3):78-78 Doi: 10.1186/1752-1947-4-78 [OPEN ACCESS]
PubMed PUBMED Central FullText FullText_MUG

 

** Kopp, KL; Dabelsteen, S; Krejsgaard, T; Eriksen, KW; Geisler, C; Becker, JC; Wasik, M; Odum, N; Woetmann, A COX-2 is a novel target in therapy of mycosis fungoides.
Leukemia. 2010; 24(12):2127-2129 Doi: 10.1038/leu.2010.221 [OPEN ACCESS]
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** Kopp, KLM; Kauczok, CS; Lauenborg, B; Krejsgaard, T; Eriksen, KW; Zhang, Q; Wasik, MA; Geisler, C; Ralfkiaer, E; Becker, JC; Odum, N; Woetmann, A COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF)
LEUKEMIA. 2010; 24(6): 1179-1185. Doi: 10.1038/leu.2010.66 [OPEN ACCESS]
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** Krejsgaard, T; Kopp, K; Ralfkiaer, E; Willumsgaard, AE; Eriksen, KW; Labuda, T; Rasmussen, S; Mathiesen, AM; Geisler, C; Lauenborg, B; Becker, JC; Zhang, Q; Wasik, MA; Odum, N; Woetmann, A A novel xenograft model of cutaneous T-cell lymphoma.
Exp Dermatol. 2010; 19(12):1096-1102 Doi: 10.1111/j.1600-0625.2010.01138.x
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** Paulson, KG; Carter, JJ; Johnson, LG; Cahill, KW; Iyer, JG; Schrama, D; Becker, JC; Madeleine, MM; Nghiem, P; Galloway, DA Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.
Cancer Res. 2010; 70(21): 8388-8397. Doi: 10.1158/0008-5472.CAN-10-2128 [OPEN ACCESS]
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** Rollison, DE; Giuliano, AR; Becker, JC New Virus Associated With Merkel Cell Carcinoma Development
J NATL COMPR CANCER NETW. 2010; 8(8): 874-880. Doi: 10.6004/jnccn.2010.0064
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** Scurr, LL; Pupo, GM; Becker, TM; Lai, K; Schrama, D; Haferkamp, S; Irvine, M; Scolyer, RA; Mann, GJ; Becker, JC; Kefford, RF; Rizos, H IGFBP7 is not required for B-RAF-induced melanocyte senescence.
Cell. 2010; 141(4):717-727 Doi: 10.1016/j.cell.2010.04.021 [OPEN ACCESS]
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** Whittaker, SJ; Demierre, MF; Kim, EJ; Rook, AH; Lerner, A; Duvic, M; Scarisbrick, J; Reddy, S; Robak, T; Becker, JC; Samtsov, A; McCulloch, W; Kim, YH Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma.
J Clin Oncol. 2010; 28(29):4485-4491 Doi: 10.1200/JCO.2010.28.9066 [OPEN ACCESS]
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Kurzbericht/Letter

** Eberle, J; Spangler, B; Becker, JC; Heinemann, SH; Klein, CA; Kunz, M; Kuphal, S; Langer, P; Mauch, C; Meierjohann, S; Paschen, A; Schadendorf, D; Schartl, M; Schittek, B; Schonherr, R; Tuting, T; Zigrino, P; Bosserhoff, AK Multicentre study on standardisation of melanoma cell culture - an initiative of the German Melanoma Research Network
PIGM CELL MELANOMA R. 2010; 23(2): 296-298. Doi: 10.1111/j.1755-148X.2010.00684.x [OPEN ACCESS]
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** Houben, R; Schrama, D; Alb, M; Pfohler, C; Trefzer, U; Ugurel, S; Becker, JC Comparable expression and phosphorylation of the retinoblastoma protein in Merkel cell polyoma virus-positive and negative Merkel cell carcinoma.
Int J Cancer. 2010; 126(3):796-798 Doi: 10.1002/ijc.24790 [OPEN ACCESS]
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** Schrama, D; Kneitz, H; Willmes, C; Adam, C; Houben, R; Becker, JC Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma.
J Invest Dermatol. 2010; 130(3):897-898 Doi: 10.1038/jid.2009.304 [OPEN ACCESS]
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** Schrama, D; Thiemann, A; Houben, R; Kahler, KC; Becker, JC; Hauschild, A Distinction of 2 different primary Merkel cell carcinomas in 1 patient by Merkel cell polyomavirus genome analysis.
Arch Dermatol. 2010; 146(6):687-689 Doi: 10.1001/archdermatol.2010.121 (- Case Report)
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** Terheyden, P; Houben, R; Pajouh, P; Thorns, C; Zillikens, D; Becker, JC Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene.
J Invest Dermatol. 2010; 130(1):314-316 Doi: 10.1038/jid.2009.197 (- Case Report) [OPEN ACCESS]
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** Weeraratna, AT; Houben, R; O'Connell, MP; Becker, JC Lack of Wnt5A expression in Merkel cell carcinoma.
Arch Dermatol. 2010; 146(1):88-89 Doi: 10.1001/archdermatol.2009.348 [OPEN ACCESS]
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** Wobser, M; Göppner, D; Lang, SC; Beckmann, G; Flentje, M; Ugurel, S; Bröcker, EB; Becker, JC Durable complete remission of therapy-refractory, tumor-stage cutaneous T-cell lymphoma under radioimmunotherapy with electron beam irradiation and denileukin diftitox.
Arch Dermatol. 2010; 146(7):805-806 Doi: 10.1001/archdermatol.2010.147 (- Case Report)
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Übersichtsarbeit

** Agelli, M; Clegg, LX; Becker, JC; Rollison, DE The etiology and epidemiology of merkel cell carcinoma.
Curr Probl Cancer. 2010; 34(1):14-37 Doi: 10.1016/j.currproblcancer.2010.01.001
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** Becker, JC; Houben, R; Schrama, D; Voigt, H; Ugurel, S; Reisfeld, RA Mouse models for melanoma: a personal perspective.
Exp Dermatol. 2010; 19(2): 157-164. Doi: 10.1111/j.1600-0625.2009.00986.x [OPEN ACCESS]
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Abstract (Zeitschrift)

** Bauer, M; Terheyden, P; Becker, JC; Brocker, EB Prognostic factors in case of malignant brain metastasis: a retrospective analysis of 105 patients.
J DTSCH DERMATOL GES. 2010; 8(9):743-743.-20. Deutscher Hautkrebskongress und ADO Jahrestagung ; Sep 23-25, 2010; Kiel, Germany. [Oral Communication]
Web of Science

 

** Dummer, R; Whittaker, S; Hasan, B; Becker, JC; Weichenthal, M; Stadler, R; Karrasch, M; Bagot, M; Knobler, R; Bernengo, M EORTC 21012: Phase II Multicentre Study of Caelyx (TM) Monotherapy In Patients with Advanced Mycosis Fungoides Stage IIb, Iva and IVb with or without Previous Chemotherapy
BLOOD. 2010; 116(21):1164-1165. [Oral Communication]
Web of Science

 

** Hafner, C; Houben, R; Baeurle, A; Landthaler, M; Becker, JC Activation of the PI3K/AKT pathway and PIK3CA mutations in Merkel cell carcinoma.
J DTSCH DERMATOL GES. 2010; 8(9):739-739.-20. Deutscher Hautkrebskongress und ADO Jahrestagung; Sep 23-25, 2010; Kiel, Germany. [Oral Communication]
Web of Science

 

** Heinemann, A; Sucker, A; Moll, I; Steinle, A; Schadendorf, D; Becker, J; Ugurel, S; Paschen, A The Role of ULBP2 in Melanoma: Clinical Significance and Regulation.
J DTSCH DERMATOL GES. 2010; 8(9):749-749.-20. Deutscher Hautkrebskongress und ADO Jahrestagung ; Sep 23-25, 2010; Kiel, Germany . [Poster]
Web of Science

 

** Kopp, K; Kauczok, CS; Lauenborg, B; Krejsgaard, T; Eriksen, KW; Wasik, MA; Geisler, C; Ralfkiaer, E; Becker, JC; Odum, N; Woetmann, A COX-2-Dependent PGE2 Acts as Growth Factor in Mycosis Fungoides (MF)
SCAND J IMMUNOL. 2010; 71(6):PS045--39. Meeting of Scandinavian Society for Immunology jointly with the Baltic Immunological Society; Jun 2-5, 2010; Tallinn, Estonia. [Oral Communication]
Web of Science

 

** Schenck, F; Renne, J; Krengel, S; Degen, A; Kapp, A; Becker, JC; Gutzmer, R Metastatic Uveal Melanoma: Case Reports of three Patients treated with Sorafenib.
J DTSCH DERMATOL GES. 2010; 8(9):762-762.-20. Deutscher Hautkrebskongress und ADO Jahrestagung; Sep 23-25, 2010; Kiel, Germany . [Poster]
Web of Science

 

** Tilz, H; Wolf, I; Weger, W; Massone, C; Richtig, E; Becker, JC Ulcus terebrans in two farmers
J DTSCH DERMATOL GES. 2010; 8(9): 756-756. [Poster]
Web of Science

 

2009

Originalarbeit (Zeitschrift)

** Agarwala, SS; Becker, JC; Eggermont, AM; Flaherty, KT; Garbe, C; Goldstein, AM; Halpern, A; Kashani-Sabet, M; Hauschild, A; Kirkwood, JM; Leachman, S; Lorigan, P; McMahon, M; Messina, J; Ribas, A; Samlowski, WE; Schadendorf, D; Sondak, VK Meeting report: consensus from the first and second Global Workshops in Melanoma November 19-20, 2008.
Pigment Cell Melanoma Res. 2009; 22(5):532-543 Doi: 10.1111/j.1755-148X.2009.00602.x
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** Andersen, MH; Sorensen, RB; Brimnes, MK; Svane, IM; Becker, JC; Straten, PT Identification of heme oxygenase-1-specific regulatory CD8+ T cells in cancer patients.
J Clin Invest. 2009; 119(8):2245-2256 Doi: 10.1172/JCI38739 [OPEN ACCESS]
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** Beer, M; Winkelmann, V; Becker, JC; Terheyden, P; Stenzel, M; Brocker, EB; Hahn, D; Kostler, H Spectroscopic imaging of the human liver using 3D CSI: optimization and application in patients with metastatic uvea melanoma
Rofo. 2009; 181(1):60-66 Doi: 10.1055/s-2008-1027887 [OPEN ACCESS]
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** Groneck, L; Schrama, D; Fabri, M; Stephen, TL; Harms, F; Meemboor, S; Hafke, H; Bessler, M; Becker, JC; Kalka-Moll, WM Oligoclonal CD4+ T cells promote host memory immune responses to Zwitterionic polysaccharide of Streptococcus pneumoniae.
Infect Immun. 2009; 77(9):3705-3712 Doi: 10.1128/IAI.01492-08 [OPEN ACCESS]
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** Hofmann, UB; Kauczok-Vetter, CS; Houben, R; Becker, JC Overexpression of the KIT/SCF in uveal melanoma does not translate into clinical efficacy of imatinib mesylate.
Clin Cancer Res. 2009; 15(1):324-329 Doi: 10.1158/1078-0432.CCR-08-2243 [OPEN ACCESS]
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** Hofmann, UB; Voigt, H; Andersen, MH; Straten, PT; Becker, JC; Eggert, AO Identification and characterization of survivin-derived H-2Kb-restricted CTL epitopes.
Eur J Immunol. 2009; 39(5):1419-1424 Doi: 10.1002/eji.200839098
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** Hofmeister-Mueller, V; Vetter-Kauczok, CS; Ullrich, R; Meder, K; Lukanidin, E; Broecker, EB; Straten, PT; Andersen, MH; Schrama, D; Becker, JC Immunogenicity of HLA-A1-restricted peptides derived from S100A4 (metastasin 1) in melanoma patients.
Cancer Immunol Immunother. 2009; 58(8):1265-1273 Doi: 10.1007/s00262-008-0640-0 [OPEN ACCESS]
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** Houben, R; Ortmann, S; Drasche, A; Troppmair, J; Herold, MJ; Becker, JC Proliferation arrest in B-Raf mutant melanoma cell lines upon MAPK pathway activation.
J Invest Dermatol. 2009; 129(2):406-414 Doi: 10.1038/jid.2008.214 [OPEN ACCESS]
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** Houben, R; Voigt, H; Noelke, C; Hofmeister, V; Becker, JC; Schrama, D MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib.
Mol Cancer Ther. 2009; 8(2):433-440 Doi: 10.1158/1535-7163.MCT-08-1051 [OPEN ACCESS]
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** Krejsgaard, T; Vetter-Kauczok, CS; Woetmann, A; Kneitz, H; Eriksen, KW; Lovato, P; Zhang, Q; Wasik, MA; Geisler, C; Ralfkiaer, E; Becker, JC; Odum, N Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma.
Blood. 2009; 113(23):5896-5904 Doi: 10.1182/blood-2008-09-181024 [OPEN ACCESS]
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** Paschen, A; Sucker, A; Hill, B; Moll, I; Zapatka, M; Nguyen, XD; Sim, GC; Gutmann, I; Hassel, J; Becker, JC; Steinle, A; Schadendorf, D; Ugurel, S Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B.
Clin Cancer Res. 2009; 15(16):5208-5215 Doi: 10.1158/1078-0432.CCR-09-0886 [OPEN ACCESS]
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** Pastrana, DV; Tolstov, YL; Becker, JC; Moore, PS; Chang, Y; Buck, CB Quantitation of Human Seroresponsiveness to Merkel Cell Polyomavirus
PLOS PATHOG. 2009; 5(9): e1000578 Doi: 10.1371/journal.ppat.1000578 [OPEN ACCESS]
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** Reim, F; Dombrowski, Y; Ritter, C; Buttmann, M; Hausler, S; Ossadnik, M; Krockenberger, M; Beier, D; Beier, CP; Dietl, J; Becker, JC; Honig, A; Wischhusen, J Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells: selective escape of CD44high/CD24low/HER2low breast cancer stem cells.
Cancer Res. 2009; 69(20):8058-8066 Doi: 10.1158/0008-5472.CAN-09-0834 [OPEN ACCESS]
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** Sorensen, RB; Berge-Hansen, L; Junker, N; Hansen, CA; Hadrup, SR; Schumacher, TNM; Svane, IM; Becker, JC; Straten, PT; Andersen, MH The Immune System Strikes Back: Cellular Immune Responses against Indoleamine 2,3-dioxygenase
PLOS ONE. 2009; 4(9): e6910 Doi: 10.1371/journal.pone.0006910 [OPEN ACCESS]
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** Sorensen, RB; Faurschou, M; Troelsen, L; Schrama, D; Jacobsen, S; Becker, JC; Straten, PT; Andersen, MH Melanoma inhibitor of apoptosis protein (ML-IAP) specific cytotoxic T lymphocytes cross-react with an epitope from the auto-antigen SS56.
J Invest Dermatol. 2009; 129(8):1992-1999 Doi: 10.1038/jid.2009.10 [OPEN ACCESS]
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** Sorensen, RB; Junker, N; Kirkin, A; Voigt, H; Svane, IM; Becker, JC; Straten, PT; Andersen, MH The immunodominant HLA-A2-restricted MART-1 epitope is not presented on the surface of many melanoma cell lines.
Cancer Immunol Immunother. 2009; 58(5):665-675 Doi: 10.1007/s00262-008-0588-0
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** Tolstov, YL; Pastrana, DV; Feng, HC; Becker, JC; Jenkins, FJ; Moschos, S; Chang, Y; Buck, CB; Moore, PS Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays.
Int J Cancer. 2009; 125(6):1250-1256 Doi: 10.1002/ijc.24509 [OPEN ACCESS]
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** Voigt, H; Vetter-Kauczok, CS; Schrama, D; Hofmann, UB; Becker, JC; Houben, R CD147 impacts angiogenesis and metastasis formation.
Cancer Invest. 2009; 27(3):329-333 Doi: 10.1080/07357900802392675
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** Wobser, M; Kurzinger, N; Ugurel, S; Brocker, EB; Becker, JC Therapy of metastasized Merkel cell carcinoma with liposomal doxorubicin in combination with radiotherapy.
J Dtsch Dermatol Ges. 2009; 7(6):521-525 Doi: 10.1111/j.1610-0387.2008.06990.x
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** Wobser, M; Seitz, CS; Becker, JC; Brocker, EB Umbilical Endometriosis
GEBURTSH FRAUENHEILK. 2009; 69(4): 331-333. Doi: 10.1055/s-2008-1039239
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Kurzbericht/Letter

** Becker, JC; Houben, R; Ugurel, S; Trefzer, U; Pfohler, C; Schrama, D MC polyomavirus is frequently present in Merkel cell carcinoma of European patients.
J Invest Dermatol. 2009; 129(1):248-250 Doi: 10.1038/jid.2008.198 [OPEN ACCESS]
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** Hofmann, UB; Wobser, M; Kneitz, H; Kleine, P; Becker, JC; Brocker, EB; Ugurel, S Major response to paclitaxel combined with irradiation as second-line therapy in metastatic angiosarcoma of the face and scalp.
Br J Dermatol. 2009; 160(2):456-458 Doi: 10.1111/j.1365-2133.2008.08968.x (- Case Report)
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Übersichtsarbeit

** Becker, JC; Schrama, D; Houben, R Merkel cell carcinoma.
Cell Mol Life Sci. 2009; 66(1):1-8 Doi: 10.1007/s00018-008-8483-6
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** Houben, R; Schrama, D; Becker, JC Molecular pathogenesis of Merkel cell carcinoma.
Exp Dermatol. 2009; 18(3):193-198 Doi: 10.1111/j.1600-0625.2009.00853.x
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** Ugurel, S; Utikal, J; Becker, JC Tumor biomarkers in melanoma.
Cancer Control. 2009; 16(3):219-224 Doi: 10.1177/107327480901600303 [OPEN ACCESS]
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Editorial

** Becker, JC; Burgdorf, W Janus publications -- or two sides of the same coin
J DTSCH DERMATOL GES. 2009; 7(6): 493-494. Doi: 10.1111/j.1610-0387.2009.07054.x
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Kommentar

** Straten, PT; Becker, JC Adoptive cell transfer in the treatment of metastatic melanoma.
J Invest Dermatol. 2009; 129(12):2743-2745 Doi: 10.1038/jid.2009.204 [OPEN ACCESS]
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2008

Originalarbeit (Zeitschrift)

** Becker, JC; Hertl, M Targeted therapy
Hautarzt. 2008; 59(10):783-784 Doi: 10.1007/s00105-008-1641-9
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** Dummer, R; Hauschild, A; Becker, JC; Grob, JJ; Schadendorf, D; Tebbs, V; Skalsky, J; Kaehler, KC; Moosbauer, S; Clark, R; Meng, TC; Urosevic, M An exploratory study of systemic administration of the Toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma
CLIN CANCER RES. 2008; 14(3): 856-864. Doi: 10.1158/1078-0432.CCR-07-1938 [OPEN ACCESS]
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** Hartmann, A; Bedenk, C; Keikavoussi, P; Becker, JC; Hamm, H; Brocker, EB Vitiligo and melanoma-associated hypopigmentation (MAH): shared and discriminative features.
J DTSCH DERMATOL GES. 2008; 6(12): 1053-1059. Doi: 10.1111/j.1610-0387.2008.06755.x
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** Houben, R; Vetter-Kauczok, CS; Ortmann, S; Rapp, UR; Broecker, EB; Becker, JC Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.
J Invest Dermatol. 2008; 128(8):2003-2012 Doi: 10.1038/jid.2008.30 [OPEN ACCESS]
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** Houben, R; Wischhusen, J; Menaa, F; Synwoldt, P; Schrama, D; Brocker, EB; Becker, JC Melanoma stem cells: targets for successful Therapy?
J DTSCH DERMATOL GES. 2008; 6(7): 541-547. Doi: 10.1111/j.1610-0387.2008.06786.x
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** Krockenberger, M; Dombrowski, Y; Weidler, C; Ossadnik, M; Honig, A; Haeusler, S; Voigt, H; Becker, JC; Leng, L; Steinle, A; Weller, M; Bucala, R; Dietl, J; Wischhusen, J Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D
J IMMUNOL. 2008; 180(11): 7338-7348. Doi: 10.4049/jimmunol.180.11.7338 [OPEN ACCESS]
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** Ochsenreither, S; Fusi, A; Busse, A; Nagorsen, D; Schrama, D; Becker, J; Thiel, E; Keilholz, U Relative quantification of TCR Vbeta-chain families by real time PCR for identification of clonal T-cell populations.
J Transl Med. 2008; 6(1):34-34 Doi: 10.1186/1479-5876-6-34 [OPEN ACCESS]
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** Rappl, G; Schrama, D; Hombach, A; Meuer, EK; Schmidt, A; Becker, JC; Abken, H CD7(-) T cells are late memory cells generated from CD7(+) T cells
REJUV RES. 2008; 11(3): 543-556. Doi: 10.1089/rej.2007.0612
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** Schrama, D; Keller, G; Houben, R; Ziegler, CG; Vetter-Kauczok, CS; Ugurel, S; Becker, JC BRAFV600E mutations in malignant melanoma are associated with increased expressions of BAALC.
J Carcinog. 2008; 7(1):1-1 Doi: 10.1186/1477-3163-7-1 [OPEN ACCESS]
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** Schrama, D; Voigt, H; Eggert, AO; Xiang, R; Zhou, H; Schumacher, TNM; Andersen, MH; Straten, PT; Reisfeld, RA; Becker, JC Immunological tumor destruction in a murine melanoma model by targeted LT alpha independent of secondary lymphoid tissue
CANCER IMMUNOL IMMUNOTHER. 2008; 57(1): 85-95. Doi: 10.1007/s00262-007-0352-x
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** Spieth, K; Kaufmann, R; Dummer, R; Garbe, C; Becker, JC; Hauschild, A; Tilgen, W; Ugurel, S; Beyeler, M; Bröcker, EB; Kaehler, KC; Pföhler, C; Gille, J; Leiter, U; Schadendorf, D Temozolomide plus pegylated interferon alfa-2b as first-line treatment for stage IV melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group (DeCOG).
Ann Oncol. 2008; 19(4):801-806 Doi: 10.1093/annonc/mdm565 [OPEN ACCESS]
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** Ugurel, S; Schrama, D; Keller, G; Schadendorf, D; Brocker, EB; Houben, R; Zapatka, M; Fink, W; Kaufman, HL; Becker, JC Impact of the CCR5 gene polymorphism on the survival of metastatic melanoma patients receiving immunotherapy.
Cancer Immunol Immunother. 2008; 57(5):685-691 Doi: 10.1007/s00262-007-0407-z
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Übersichtsarbeit

** Andersen, MH; Sorensen, RB; Schrama, D; Svane, IM; Becker, JC; Straten, PT Cancer treatment: the combination of vaccination with other therapies.
CANCER IMMUNOL IMMUNOTHER. 2008; 57(11): 1735-1743. Doi: 10.1007/s00262-008-0480-y [OPEN ACCESS]
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** Becker, JC; Kauczok, CS; Ugurel, S; Eib, S; Brocker, EB; Houben, R Merkel cell carcinoma: molecular pathogenesis, clinical features and therapy.
J Dtsch Dermatol Ges. 2008; 6(9):709-719 Doi: 10.1111/j.1610-0387.2008.06830.x
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** Becker, JC; Ugurel, S; Schrama, D Strategies to optimize the use of targeted agents for tumor therapy.
J Dtsch Dermatol Ges. 2008; 6(4):281-285 Doi: 10.1111/j.1610-0387.2008.06496.x
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** Hofmeister, V; Schrama, D; Becker, JC Anti-cancer therapies targeting the tumor stroma
CANCER IMMUNOL IMMUNOTHER. 2008; 57(1): 1-17. Doi: 10.1007/s00262-007-0365-5
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** Schrama, D; Hauschild, A; Becker, JC Immunmodulatory antibodies in the treatment of skin cancer
Hautarzt. 2008; 59(10):806-813 Doi: 10.1007/s00105-008-1539-6
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2007

Originalarbeit (Zeitschrift)

** Andersen, MH; Svane, IM; Becker, JC; Straten, PT The universal character of the tumour-associated antigen survivin
CLIN CANCER RES. 2007; 13(20): 5991-5994. Doi: 10.1158/1078-0432.CCR-07-0686 [OPEN ACCESS]
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** Engert, S; Rieger, L; Kapp, M; Becker, JC; Dietl, J; Kammerer, U Profiling chemokines, cytokines and growth factors in human early pregnancy decidua by protein array.
Am J Reprod Immunol. 2007; 58(2):129-137 Doi: 10.1111/j.1600-0897.2007.00498.x
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** Houben, R; Ortmann, S; Schrama, D; Herold, MJ; Berberich, I; Reichardt, HM; Becker, JC Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.
J Invest Dermatol. 2007; 127(9):2116-2122 Doi: 10.1038/sj.jid.5700857 [OPEN ACCESS]
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** Stephen, TL; Fabri, M; Groneck, L; Rohn, TA; Hafke, H; Robinson, N; Rietdorf, J; Schrama, D; Becker, JC; Plum, G; Kronke, M; Kropshofer, H; Kalka-Moll, WM Transport of Streptococcus pneumoniae capsular polysaccharide in MHC class II tubules
PLOS PATHOG. 2007; 3(3): Doi: 10.1371/journal.ppat.0030032 [OPEN ACCESS]
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** Terheyden, P; Kortum, AK; Schulze, HJ; Durani, B; Remling, R; Mauch, C; Junghans, V; Schadendorf, D; Beiteke, U; Junger, M; Becker, JC; Brocker, EB Chemoimmunotherapy for cutaneous melanoma with dacarbazine and epifocal contact sensitizers: results of a nationwide survey of the German Dermatologic Co-operative Oncology Group.
J Cancer Res Clin Oncol. 2007; 133(7):437-444 Doi: 10.1007/s00432-006-0182-9
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** Ugurel, S; Houben, R; Schrama, D; Voigt, H; Zapatka, M; Schadendorf, D; Brocker, EB; Becker, JC Microphthalmia-associated transcription factor gene amplification in metastatic melanoma is a prognostic marker for patient survival, but not a predictive marker for chemosensitivity and chemotherapy response.
Clin Cancer Res. 2007; 13(21):6344-6350 Doi: 10.1158/1078-0432.CCR-06-2682 [OPEN ACCESS]
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** Ugurel, S; Thirumaran, RK; Bloethner, S; Gast, A; Sucker, A; Mueller-Berghaus, J; Rittgen, W; Hemminki, K; Becker, JC; Kumar, R; Schadendorf, D B-RAF and N-RAS Mutations Are Preserved during Short Time In Vitro Propagation and Differentially Impact Prognosis
PLOS ONE. 2007; 2(2): Doi: 10.1371/journal.pone.0000236 [OPEN ACCESS]
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** Voigt, H; Houben, R; Schrama, D; Hofmann, UB; Vetter-Kauczok, CS; Becker, JC Matrix metalloproteinase induction in the tumor stroma does not depend on CD147 expression in murine B16 melanoma.
Tumour Biol. 2007; 28(4):229-237 Doi: 10.1159/000107418
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** Weyandt, GH; Vetter-Kauczok, CS; Becker, JC; Brocker, EB; Hamm, H Successful dexamethasone pulse therapy for widespread erosive perianal lichen planus
Hautarzt. 2007; 58(3): 244- 245 Doi: 10.1007/s00105-006-1188-6 (- Case Report)
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** Wobser, M; Voigt, H; Eggert, AO; Houben, R; Kauczok, CS; Brocker, EB; Becker, JC Bcl-2 expression in rituximab refractory cutaneous B-cell lymphoma.
Br J Cancer. 2007; 96(10):1540-1543 Doi: 10.1038/sj.bjc.6603762 [OPEN ACCESS]
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** Wobser, M; Voigt, H; Houben, R; Eggert, AO; Freiwald, M; Kaemmerer, U; Kaempgen, E; Schrama, D; Becker, JC Dendritic cell based antitumor vaccination: impact of functional indoleamine 2,3-dioxygenase expression.
Cancer Immunol Immunother. 2007; 56(7):1017-1024 Doi: 10.1007/s00262-006-0256-1
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Kurzbericht/Letter

** Otto, K; Starz, H; Becker, JC; Schrama, D Overexpression of matrix metalloproteinases, chemokines, and chemokine receptors relevant for metastasis in experimental models not an indication of lymph node metastases in human melanoma.
Arch Dermatol. 2007; 143(7):947-948 Doi: 10.1001/archderm.143.7.947 [OPEN ACCESS]
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** Terheyden, P; Hofmann, MA; Weininger, M; Brocker, EB; Becker, JC Anti-vascular endothelial growth factor antibody bevacizumab in conjunction with chemotherapy in metastasising melanoma.
J Cancer Res Clin Oncol. 2007; 133(11):897-901 Doi: 10.1007/s00432-007-0251-8 (- Case Report)
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Kommentar

** Becker, JC; Brocker, EB; Schadendorf, D; Ugurel, S Imatinib in melanoma: a selective treatment option based on KIT mutation status?
J Clin Oncol. 2007; 25(7):e9-e9 Doi: 10.1200/JCO.2006.08.9664 [OPEN ACCESS]
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** Weyandt, GH; Becker, JC Initial treatment of anorectal melanoma.
Am J Surg. 2007; 194(3):420-421 Doi: 10.1016/j.amjsurg.2006.04.022
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2006

Originalarbeit (Zeitschrift)

** Andersen, MH; Soerensen, RB; Becker, JC; Straten, PT HLA-A24 and survivin: possibilities in therapeutic vaccination against cancer
J TRANSL MED. 2006; 4: 38 Doi: 10.1186/1479-5876-4-38 [OPEN ACCESS]
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** Becker, JC; Houben, R; Vetter, CS; Brocker, EB 2-D differential membrane proteome analysis of scarce protein samples.
Proteomics. 2006; 6(16):4506-4513 Doi: 10.1002/pmic.200600169 [OPEN ACCESS]
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** Becker, JC; Ugurel, S; Bröcker, EB; Schrama, D; Houben, R New therapeutic approaches for solid tumors: histone deacetylase, methyltransferase and proteasome inhibitors.
J Dtsch Dermatol Ges. 2006; 4(2):108-113 Doi: 10.1111/j.1610-0387.2006.05920.x
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** Fensterle, J; Trefzer, U; Berger, T; Andersen, MH; Ugurel, S; Becker, JC HLA-B8 association with late-stage melanoma - an immunological lesson?
BMC MED. 2006; 4: Doi: 10.1186/1741-7015-4-5 [OPEN ACCESS]
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** Hadrup, SR; Braendstrup, O; Jacobsen, GK; Mortensen, S; Pedersen, LO; Seremet, T; Andersen, MH; Becker, JC; Straten, PT Tumor infiltrating lymphocytes in seminoma lesions comprise clonally expanded cytotoxic T cells.
Int J Cancer. 2006; 119(4):831-838 Doi: 10.1002/ijc.21894
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** Houben, R; Michel, B; Vetter-Kauczok, CS; Pfohler, C; Laetsch, B; Wolter, MD; Leonard, JH; Trefzer, U; Ugurel, S; Schrama, D; Becker, JC Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma.
J Invest Dermatol. 2006; 126(5):1135-1142 Doi: 10.1038/sj.jid.5700170 [OPEN ACCESS]
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** Krejsgaard, T; Vetter-Kauczok, CS; Woetmann, A; Lovato, P; Labuda, T; Eriksen, KW; Zhang, Q; Becker, JC; Odum, N Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma.
Leukemia. 2006; 20(10):1759-1766 Doi: 10.1038/sj.leu.2404350 [OPEN ACCESS]
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** Schadendorf, D; Ugurel, S; Schuler-Thurner, B; Nestle, FO; Enk, A; Brocker, EB; Grabbe, S; Rittgen, W; Edler, L; Sucker, A; Zimpfer-Rechner, C; Berger, T; Kamarashev, J; Burg, G; Jonuleit, H; Tuttenberg, A; Becker, JC; Keikavoussi, P; Kampgen, E; Schuler, G Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG.
Ann Oncol. 2006; 17(4):563-570 Doi: 10.1093/annonc/mdj138 [OPEN ACCESS]
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** Schrama, D; Terheyden, P; Otto, K; Kammerer, U; Brocker, EB; Luhder, F; Cosman, D; Andersen, MH; Becker, JC Expression of the NKG2D ligand UL16 binding protein-1 (ULBP-1) on dendritic cells.
Eur J Immunol. 2006; 36(1):65-72 Doi: 10.1002/eji.200535115
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** Schrama, D; Voigt, H; Eggert, AO; Xiang, R; Reisfeld, RA; Becker, JC Therapeutic efficacy of tumor-targeted IL2 in LTalpha(-/-) mice depends on conditioned T cells.
Cancer Immunol Immunother. 2006; 55(7):861-866 Doi: 10.1007/s00262-005-0076-8
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** Straten, PT; Dahl, C; Schrama, D; Pedersen, LO; Andersen, MH; Seremet, T; Brocker, EB; Guldberg, P; Becker, JC Identification of identical TCRs in primary melanoma lesions and tumor free corresponding sentinel lymph nodes.
Cancer Immunol Immunother. 2006; 55(5):495-502 Doi: 10.1007/s00262-005-0023-8
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** Voigt, H; Schrama, D; Eggert, AO; Vetter, CS; Muller-Blech, K; Reichardt, HM; Andersen, MH; Becker, JC; Luhder, F CD28-mediated costimulation impacts on the differentiation of DC vaccination-induced T cell responses.
Clin Exp Immunol. 2006; 143(1):93-102 Doi: 10.1111/j.1365-2249.2005.02972.x [OPEN ACCESS]
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** Wobser, M; Keikavoussi, P; Kunzmann, V; Weininger, M; Andersen, MH; Becker, JC Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin.
Cancer Immunol Immunother. 2006; 55(10):1294-1298 Doi: 10.1007/s00262-005-0102-x (- Case Report)
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** Wobser, M; Siedel, C; Schrama, D; Brocker, EB; Becker, JC; Vetter-Kauczok, CS Expression pattern of the lymphatic and vascular markers VEGFR-3 and CD31 does not predict regional lymph node metastasis in cutaneous melanoma.
Arch Dermatol Res. 2006; 297(8):352-357 Doi: 10.1007/s00403-005-0633-1
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Kurzbericht/Letter

** Utikal, J; Thoelke, A; Becker, JC; Figl, R; Goerdt, S; Schadendorf, D; Ugurel, S Local cutaneous argyria mimicking melanoma metastases in a patient with disseminated melanoma.
J Am Acad Dermatol. 2006; 55(5 Suppl):S92-S94 Doi: 10.1016/j.jaad.2005.10.062 (- Case Report)
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Übersichtsarbeit

** Andersen, MH; Schrama, D; Straten, PT; Becker, JC Cytotoxic T cells.
J Invest Dermatol. 2006; 126(1):32-41 Doi: 10.1038/sj.jid.5700001 [OPEN ACCESS]
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** Becker, JC; Kirkwood, JM; Agarwala, SS; Dummer, R; Schrama, D; Hauschild, A Molecularly targeted therapy for melanoma: current reality and future options.
Cancer. 2006; 107(10):2317-2327 Doi: 10.1002/cncr.22273 [OPEN ACCESS]
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** Hofmeister, V; Vetter, C; Schrama, D; Brocker, EB; Becker, JC Tumor stroma-associated antigens for anti-cancer immunotherapy.
Cancer Immunol Immunother. 2006; 55(5):481-494 Doi: 10.1007/s00262-005-0070-1
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** Klemke, CD; Goerdt, S; Schrama, D; Becker, JC New insights into the molecular biology and targeted therapy of cutaneous T-cell lymphomas.
J Dtsch Dermatol Ges. 2006; 4(5):395-406 Doi: 10.1111/j.1610-0387.2006.05982.x
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** Schrama, D; Reisfeld, RA; Becker, JC Antibody targeted drugs as cancer therapeutics.
Nat Rev Drug Discov. 2006; 5(2):147-159 Doi: 10.1038/nrd1957
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Kommentar

** Ugurel, S; Houben, R; Becker, JC Molecular mechanisms in melanoma.
N Engl J Med. 2006; 355(13):1395-1396 Doi: 10.1056/NEJMc062093 [OPEN ACCESS]
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** Weyandt, GH; Becker, JC Prognostic factors and therapy for primary anorectal melanoma.
Int J Colorectal Dis. 2006; 21(5):488-489 Doi: 10.1007/s00384-004-0697-y
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2005

Originalarbeit (Zeitschrift)

** Andersen, MH; Reker, S; Kvistborg, P; Becker, JC; Straten, PT Spontaneous immunity against Bcl-xL in cancer patients.
J Immunol. 2005; 175(4):2709-2714 Doi: 10.4049/jimmunol.175.4.2709 [OPEN ACCESS]
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** Andersen, MH; Svane, IM; Kvistborg, P; Nielsen, OJ; Balslev, E; Reker, S; Becker, JC; Straten, PT Immunogenicity of Bcl-2 in patients with cancer
BLOOD. 2005; 105(2): 728-734. Doi: 10.1182/blood-2004-07-2548 [OPEN ACCESS]
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** Becker, JC; Vetter, CS Art in dermatologic surgery.
Arch Dermatol. 2005; 141(9):1186-1186 Doi: 10.1001/archderm.141.9.1186 [OPEN ACCESS]
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** Hofmann, UB; Eggert, AAO; Blass, K; Brocker, EB; Becker, JC Stromal cells as the major source for matrix metalloproteinase-2 in cutaneous melanoma.
Arch Dermatol Res. 2005; 297(4):154-160 Doi: 10.1007/s00403-005-0588-2
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** Meier, A; Reker, S; Svane, IM; Holten-Andersen, L; Becker, JC; Sondergaard, I; Andersen, MH; Straten, PT Spontaneous T-cell responses against peptides derived from the Taxol resistance-associated gene-3 (TRAG-3) protein in cancer patients
CANCER IMMUNOL IMMUNOTHER. 2005; 54(3): 219-228. Doi: 10.1007/s00262-004-0578-9
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** Ugurel, S; Hildenbrand, R; Zimpfer, A; La Rosee, P; Paschka, P; Sucker, A; Keikavoussi, P; Becker, JC; Rittgen, W; Hochhaus, A; Schadendorf, D Lack of clinical efficacy of imatinib in metastatic melanoma.
Br J Cancer. 2005; 92(8):1398-1405 Doi: 10.1038/sj.bjc.6602529 [OPEN ACCESS]
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** Vetter, CS; Muller-Blech, K; Schrama, D; Brocker, EB; Becker, JC Cytoplasmic and nuclear expression of survivin in melanocytic skin lesions.
Arch Dermatol Res. 2005; 297(1):26-30 Doi: 10.1007/s00403-005-0572-x
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** Xiang, R; Mizutani, N; Luo, YP; Chiodoni, C; Zhou, H; Mizutani, M; Ba, Y; Becker, JC; Reisfeld, RA A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication
CANCER RES. 2005; 65(2): 553-561. [OPEN ACCESS]
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** Zhou, H; Luo, YP; Lo, JF; Kaplan, CD; Mizutani, M; Mizutani, N; Lee, JD; Primus, FJ; Becker, JC; Xiang, R; Reisfeld, RA DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor.
Proc Natl Acad Sci U S A. 2005; 102(31):10846-10851 Doi: 10.1073/pnas.0502208102 [OPEN ACCESS]
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Kurzbericht/Letter

** Andersen, MH; Becker, JC; Straten, PT The antiapoptotic member of the Bcl-2 family Mcl-1 is a CTL target in cancer patients.
Leukemia. 2005; 19(3):484-485 Doi: 10.1038/sj.leu.2403621 [OPEN ACCESS]
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** Andersen, MH; Kvistborg, P; Becker, JC; Straten, PT Identification of an HLA-A1 restricted CTL epitope from Mcl-1.
Leukemia. 2005; 19(6):1084-1085 Doi: 10.1038/sj.leu.2403743 [OPEN ACCESS]
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Übersichtsarbeit

** Andersen, MH; Becker, JC; Straten, PT Regulators of apoptosis: suitable targets for immune therapy of cancer.
Nat Rev Drug Discov. 2005; 4(5):399-409 Doi: 10.1038/nrd1717
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** Becker, JC; Schrama, D; Bröcker, EB; Houben, R Kinase inhibitors for the therapy of malignant melanoma
J Dtsch Dermatol Ges. 2005; 3(10):762-767 Doi: 10.1111/j.1610-0387.2005.05016.x
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** Hofmann, UB; Houben, R; Brocker, EB; Becker, JC Role of matrix metalloproteinases in melanoma cell invasion.
Biochimie. 2005; 87(3-4):307-314 Doi: 10.1016/j.biochi.2005.01.013
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Korrespondenz

** Terheyden, P; Brocker, EB; Becker, JC Reply concerning clinical evaluation of in vitro chemosensitivity testing: the example of uveal melanoma by Terheyden et al. (2004)
J CANCER RES CLIN ONCOL. 2005; 131(5): 331-331. Doi: 10.1007/s00432-004-0631-2
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Originalarbeit (Konferenzband)

** Kaufmann, R; Spieth, K; Leiter, U; Mauch, C; von den Driesch, P; Vogt, T; Linse, R; Tilgen, W; Schadendorf, D; Becker, JC; Sebastian, G; Krengel, S; Kretschmer, L; Garbe, C; Dummer, R Temozolomide in combination with interferon-alfa versus temozolomide alone in patients with advanced metastatic melanoma: a randomized, phase III, multicenter study from the Dermatologic Cooperative Oncology Group.
J Clin Oncol. 2005; 23(35):9001-9007 Doi: 10.1200/JCO.2005.01.1551 [OPEN ACCESS]
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Kommentar

** Andersen, MH; Reker, S; Stratem, PT; Gehl, J; Geertsen, P; Becker, JC Concomitant administration of interleukin-2 during therapeutic vaccinations against cancer: the good, the bad, or the evil?
J Clin Oncol. 2005; 23(22):5265-5267 Doi: 10.1200/JCO.2004.00.9837 [OPEN ACCESS]
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** Becker, JC; Straten, PT; Andersen, MH The paradoxical association between Bcl-2 expression and prognosis: does the immune system make the difference?
Cancer Res. 2005; 65(7):2983-2983 Doi: 10.1158/0008-5472.CAN-05-0092 [OPEN ACCESS]
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2004

Originalarbeit (Zeitschrift)

** Andersen, MH; Fensterle, J; Ugurel, S; Reker, S; Houben, R; Guldberg, P; Berger, TG; Schadendorf, D; Trefzer, U; Brocker, EB; Straten, PT; Rapp, UR; Becker, JC Immunogenicity of constitutively active (V599E)BRaf
CANCER RES. 2004; 64(15): 5456-5460. Doi: 10.1158/0008-5472.CAN-04-0937 [OPEN ACCESS]
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** Andersen, MH; Reker, S; Becker, JC; Straten, PT The melanoma inhibitor of apoptosis protein: A target for spontaneous cytotoxic T cell responses
J INVEST DERMATOL. 2004; 122(2): 392-399. Doi: 10.1046/j.0022-202X.2004.22242.x [OPEN ACCESS]
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** Berger, TG; Haendle, I; Schrama, D; Luftl, M; Bauer, N; Pedersen, LO; Schuler-Thurner, B; Hohenberger, W; Straten, PT; Schuler, G; Becker, JC Circulation and homing of melanoma-reactive T cells to both cutaneous and visceral metastases after vaccination with monocyte-derived dendritic cells
INT J CANCER. 2004; 111(2): 229-237. Doi: 10.1002/ijc.20238 (- Case Report)
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** Eggert, AO; Andersen, MH; Voigt, H; Schrama, D; Kampgen, E; Straten, PT; Becker, JC Characterization of mouse MAGE-derived H-2K(b)-restricted CTL epitopes
EUR J IMMUNOL. 2004; 34(11): 3285-3290. Doi: 10.1002/eji.200324618
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** Fensterle, J; Becker, JC; Potapenko, T; Heimbach, V; Vetter, CS; Brocker, EB; Rapp, UR B-Raf specific antibody responses in melanoma patients
BMC CANCER. 2004; 4: Doi: 10.1186/1471-2407-4-62 [OPEN ACCESS]
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** Reker, S; Becker, JC; Svane, IM; Ralfkiaer, E; Straten, PT; Andersen, MH Hla-B35-restricted immune responses against survivin in cancer patients
INT J CANCER. 2004; 108(6): 937-941. Doi: 10.1002/ijc.11634
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** Reker, S; Meier, A; Holten-Andersen, L; Svane, IM; Becker, JC; Straten, PT; Andersen, MH Identification of novel survivin-derived CTL epitopes
CANCER BIOL THER. 2004; 3(2): 173-179. Doi: 10.4161/cbt.3.2.611 [OPEN ACCESS]
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** Schrama, D; Rong, XA; Eggert, AO; Andersen, MH; Pedersen, LO; Kampgen, E; Schumacher, TN; Reisfeld, RR; Becker, JC Shift from systemic to site-specific memory by tumor-targeted IL-2
J IMMUNOL. 2004; 172(10): 5843-5850. Doi: 10.4049/jimmunol.172.10.5843 [OPEN ACCESS]
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** Terheyden, P; Brocker, EB; Becker, JC Clinical evaluation of in vitro chemosensitivity testing: the example of uveal melanoma
J CANCER RES CLIN ONCOL. 2004; 130(7): 395-399. Doi: 10.1007/s00432-004-0569-4
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** Thor Straten, P; Schrama, D; Andersen, MH; Becker, JC T-cell clonotypes in cancer.
J Transl Med. 2004; 2(1):11-11 Doi: 10.1186/1479-5876-2-11 [OPEN ACCESS]
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** Vetter, CS; Lieb, W; Brocker, EB; Becker, JC Loss of nonclassical MHC molecules MIC-A/B expression during progression of uveal melanoma
BRIT J CANCER. 2004; 91(8): 1495-1499. Doi: 10.1038/sj.bjc.6602123 [OPEN ACCESS]
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** Zhou, H; Luo, YP; Mizutani, M; Mizutani, N; Becker, JC; Primus, FJ; Xiang, R; Reisfeld, RA A novel transgenic mouse model for immunological evaluation of carcinoembryonic antigen-based DNA minigene vaccines
J CLIN INVEST. 2004; 113(12): 1792-1798. Doi: 10.1172/JCI200421107 [OPEN ACCESS]
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Kurzbericht/Letter

** Andersen, MH; Becker, JC; Straten, PT Identification of an HLA-A3-restricted cytotoxic T lymphocyte (CTL) epitope from ML-IAP
J INVEST DERMATOL. 2004; 122(5): 1336-1337. Doi: 10.1111/j.0022-202X.2004.22508.x [OPEN ACCESS]
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** Weyandt, GH; Becker, JC Anorectal melanoma: issues of influence for therapeutic decisions
MELANOMA RES. 2004; 14(6): 563-563. Doi: 10.1097/00008390-200412000-00020
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Übersichtsarbeit

** Hartmann, A; Brocker, EB; Becker, JC Hypopigmentary skin disorders - Current treatment options and future directions
DRUGS. 2004; 64(1): 89-107. Doi: 10.2165/00003495-200464010-00006
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2003

Originalarbeit (Zeitschrift)

** Hauschild, A; Weichenthal, M; Balda, BR; Becker, JC; Wolff, HH; Tilgen, W; Schulte, KW; Ring, J; Schadendorf, D; Lischner, S; Burg, G; Dummer, R Prospective randomized trial of interferon alfa-2b and interleukin-2 as adjuvant treatment for resected intermediate- and high-risk primary melanoma without clinically detectable node metastasis.
J Clin Oncol. 2003; 21(15):2883-2888 Doi: 10.1200/JCO.2003.07.116 [OPEN ACCESS]
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** Hofmann, UB; Eggert, AAO; Blass, K; Brocker, EB; Becker, JC Expression of matrix metalloproteinases in the microenvironment of spontaneous and experimental melanoma metastases reflects the requirements for tumor formation
CANCER RES. 2003; 63(23): 8221-8225. [OPEN ACCESS]
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** Otto, K; Kaempgen, E; Dummer, W; Broecker, EB; Becker, JC Late-type allergy to Ultravist (iopromid).
Allergy. 2003; 58(3):261-262 Doi: 10.1034/j.1398-9995.2003.00062_3.x (- Case Report) [OPEN ACCESS]
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** Schrama, D; Eggert, AAO; Brocker, EB; Pedersen, LO; Straten, PT; Becker, JC Immunological consequences of the sentinel lymph-node biopsy - lessons from a melanoma patient
LANCET ONCOL. 2003; 4(7): 446-447. Doi: 10.1016/S1470-2045(03)01143-4 (- Case Report)
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** Terheyden, P; Schrama, D; Pedersen, LO; Andersen, MH; Kampgen, E; Straten, PT; Becker, JC Longitudinal analysis of MART-1/HLA-A2-reactive T cells over the course of melanoma progression
SCAND J IMMUNOL. 2003; 58(5): 566-571. Doi: 10.1046/j.1365-3083.2003.01324.x
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** Weyandt, GH; Eggert, AO; Houf, M; Raulf, F; Brocker, EB; Becker, JC Anorectal melanoma: surgical management guidelines according to tumour thickness
BRIT J CANCER. 2003; 89(11): 2019-2022. Doi: 10.1038/sj.bjc.6601409 [OPEN ACCESS]
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** Zimpfer-Rechner, C; Hofmann, U; Figl, R; Becker, JC; Trefzer, U; Keller, I; Hauschild, A; Schadendorf, D Randomized phase II study of weekly paclitaxel versus paclitaxel and carboplatin as second-line therapy in disseminated melanoma: a multicentre trial of the Dermatologic Co-operative Oncology Group (DeCOG).
Melanoma Res. 2003; 13(5):531-536 Doi: 10.1097/01.cmr.0000056274.56735.c6
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Übersichtsarbeit

** Andersen, MH; Gehl, J; Reker, S; Pedersen, LO; Becker, JC; Geertsen, P; Straten, PT Dynamic changes of specific T cell responses to melanoma correlate with IL-2 administration.
Semin Cancer Biol. 2003; 13(6):449-459 Doi: 10.1016/j.semcancer.2003.09.009
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Abstract (Zeitschrift)

** Berger, TG; Haendle, I; Schrama, D; Lueftl, M; Oestergaard-Pedersen, L; Schuler-Thurner, B; Straten, PT; Schuler, G; Becker, JC Circulation and homing of melanoma-reactive T cell clones to both cutaneous and visceral metastases following DC-vaccination
J INVEST DERMATOL. 2003; 121(5): 1251-1251.
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2002

Originalarbeit (Zeitschrift)

** Becker, JC; Terheyden, P; Kampgen, E; Wagner, S; Neumann, C; Schadendorf, D; Steinmann, A; Wittenberg, G; Lieb, W; Brocker, EB Treatment of disseminated ocular melanoma with sequential fotemustine, interferon alpha, and interleukin 2.
Br J Cancer. 2002; 87(8):840-845 Doi: 10.1038/sj.bjc.6600521 [OPEN ACCESS]
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** Eggert, AO; Becker, JC; Ammon, M; McLellan, AD; Renner, G; Merkel, A; Brocker, EB; Kampgen, E Specific peptide-mediated immunity against established melanoma tumors with dendritic cells requires IL-2 and fetal calf serum-free cell culture
EUR J IMMUNOL. 2002; 32(1): 122-127. Doi: 10.1002/1521-4141(200201)32:1<122::AID-IMMU122>3.0.CO;2-C
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** Niethammer, AG; Xiang, R; Becker, JC; Wodrich, H; Pertl, U; Karsten, G; Eliceiri, BP; Reisfeld, RA A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth.
Nat Med. 2002; 8(12):1369-1375 Doi: 10.1038/nm794
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** Pedersen, LO; Vetter, CS; Mingari, MC; Andersen, MH; Straten, PT; Brocker, EB; Becker, JC Differential expression of inhibitory or activating CD94/NKG2 subtypes on MART-1-reactive T cells in vitiligo versus melanoma: a case report.
J Invest Dermatol. 2002; 118(4):595-599 Doi: 10.1046/j.1523-1747.2002.01698.x (- Case Report) [OPEN ACCESS]
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** Schrama, D; Fuchs, E; Brocker, EB; Straten, PT; Becker, JC Identical T-cell receptor transcripts in multiple melanoma metastases.
Cancer Res. 2002; 62(20):5664-5667 [OPEN ACCESS]
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** Schrama, D; Pedersen, LO; Keikavoussi, P; Andersen, MH; Straten, PT; Brocker, EB; Kampgen, E; Becker, JC Aggregation of antigen-specific T cells at the inoculation site of mature dendritic cells.
J Invest Dermatol. 2002; 119(6):1443-1448 Doi: 10.1046/j.1523-1747.2002.19604.x [OPEN ACCESS]
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** Schrama, D; Straten, P; Bröcker, EB; Reisfeld, RA; Becker, JC Cytokine fusion protein treatment.
Recent Results Cancer Res. 2002; 160(20):185-194 Doi: 10.1007/978-3-642-59410-6_22
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** Vetter, CS; Groh, V; Straten, PT; Spies, T; Brocker, EB; Becker, JC Expression of stress-induced MHC class I related chain molecules on human melanoma.
J Invest Dermatol. 2002; 118(4):600-605 Doi: 10.1046/j.1523-1747.2002.01700.x [OPEN ACCESS]
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** Wack, C; Kirst, A; Becker, JC; Lutz, WK; Brocker, EB; Fischer, WH Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response.
Cancer Immunol Immunother. 2002; 51(8):431-439 Doi: 10.1007/s00262-002-0292-4
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Übersichtsarbeit

** Hofmann, UB; Becker, JC; Brocker, EB Role of matrix-degrading enzymes in melanoma progression
Hautarzt. 2002; 53(9):587-595 Doi: 10.1007/s00105-001-0301-0
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2001

Originalarbeit (Zeitschrift)

** Andersen, MH; Keikavoussi, P; Brocker, EB; Schuler-Thurner, B; Jonassen, M; Sondergaard, I; Straten, PT; Becker, JC; Kampgen, E Induction of systemic CTL responses in melanoma patients by dendritic cell vaccination: Cessation of CTL responses is associated with disease progression
INT J CANCER. 2001; 94(6): 820-824. Doi: 10.1002/ijc.1536
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** Andersen, MH; Pedersen, LO; Becker, JC; Straten, PT Identification of a cytotoxic T lymphocyte response to the apoptosis inhibitor protein survivin in cancer patients
CANCER RES. 2001; 61(3): 869-872. [OPEN ACCESS]
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** Andersen, MH; Pedersen, LO; Capeller, B; Brocker, EB; Becker, JC; Straten, PT Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients
CANCER RES. 2001; 61(16): 5964-5968. [OPEN ACCESS]
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** Schrama, D; Andersen, MH; Terheyden, P; Schroder, L; Pedersen, LO; Straten, PT; Becker, JC Oligoclonal T-cell receptor usage of melanocyte differentiation antigen-reactive T cells in stage IV melanoma patients
CANCER RES. 2001; 61(2): 493-496. [OPEN ACCESS]
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** Schrama, D; Straten, PT; Fischer, WH; McLellan, AD; Brocker, EB; Reisfeld, RA; Becker, JC Targeting of lymphotoxin-alpha to the tumor elicits an efficient immune response associated with induction of peripheral lymphoid-like tissue
IMMUNITY. 2001; 14(2): 111-121. Doi: 10.1016/S1074-7613(01)00094-2 [OPEN ACCESS]
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** Straten, PT; Guldberg, P; Schrama, D; Andersen, MH; Moerch, U; Seremet, T; Siedel, C; Reisfeld, RA; Becker, JC In situ cytokine therapy: redistribution of clonally expanded T cells
EUR J IMMUNOL. 2001; 31(1): 250-258. Doi: 10.1002/1521-4141(200101)31:1<250::AID-IMMU250>3.0.CO;2-8
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** Terheyden, P; Rickert, S; Kampgen, E; Munnich, S; Hofmann, UB; Brocker, EB; Becker, JC Nevus of Ota and choroidal melanoma
HAUTARZT. 2001; 52(9): 803-806. Doi: 10.1007/s001050170070
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** Wack, C; Becker, JC; Brocker, EB; Lutz, WK; Fischer, WH Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene: results from a murine tumour model
MELANOMA RES. 2001; 11(3): 247-253. Doi: 10.1097/00008390-200106000-00006
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2000

Originalarbeit (Zeitschrift)

** Becker, JC; Vetter, CS; Schrama, D; Brocker, EB; Straten, PT Differential expression of CD28 and CD94/NKG2 on T cells with identical TCR beta variable regions in primary melanoma and sentinel lymph node
EUR J IMMUNOL. 2000; 30(12): 3699-3706. Doi: 10.1002/1521-4141(200012)30:12<3699::AID-IMMU3699>3.0.CO;2-2
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** Hofmann, UB; Westphal, JR; Waas, ET; Becker, JC; Ruiter, DJ; van Muijen, GNP Coexpression of integrin alpha(v)beta3 and matrix metalloproteinase-2 (MMP-2) coincides with MMP-2 activation: correlation with melanoma progression.
J Invest Dermatol. 2000; 115(4):625-632 Doi: 10.1046/j.1523-1747.2000.00114.x [OPEN ACCESS]
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** Hofmann, UB; Westphal, JR; Zendman, AJW; Becker, JC; Ruiter, DJ; van Muijen, GNP Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression
J PATHOL. 2000; 191(3): 245-256. Doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH632>3.0.CO;2-#
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** Moerch, U; Schrama, D; Guldberg, P; Seremet, T; Zeuthen, J; Becker, JC; Straten, PT Comparative delineation of T cell clonotypes in coexisting syngeneic B16 melanoma
CANCER IMMUNOL IMMUNOTHER. 2000; 49(8): 426-432. Doi: 10.1007/s002620000136
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** Straten, PT; Kirkin, AF; Siim, E; Dahlstrom, K; Drzewiecki, KT; Seremet, T; Zeuthen, J; Becker, JC; Guldberg, P Tumor infiltrating lymphocytes in melanoma comprise high numbers of T-cell clonotypes that are lost during in vitro culture
CLIN IMMUNOL. 2000; 96(2): 94-99. Doi: 10.1006/clim.2000.4890
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** Terheyden, P; Becker, JC; Kampgen, E; Brocker, EB Sequential interferon-alpha 2b, interleukin-2 and fotemustine for patients with metastatic melanoma
MELANOMA RES. 2000; 10(5): 475-482. Doi: 10.1097/00008390-200010000-00010
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** Terheyden, P; Straten, PT; Brocker, EB; Kampgen, E; Becker, JC CD40-ligated dendritic cells effectively expand melanoma-specific CD8+ CTLs and CD4+ IFN-gamma-producing T cells from tumor-infiltrating lymphocytes.
J Immunol. 2000; 164(12):6633-6639 Doi: 10.4049/jimmunol.164.12.6633 [OPEN ACCESS]
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** Termeer, CC; Schirrmacher, V; Brocker, EB; Becker, JC Newcastle disease virus infection induces B7-1/B7-2-independent T-cell costimulatory activity in human melanoma cells
CANCER GENE THERAPY. 2000; 7(2): 316-323. Doi: 10.1038/sj.cgt.7700109
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** Vetter, CS; Straten, PT; Terheyden, P; Zeuthen, J; Brocker, EB; Becker, JC Expression of CD94/NKG2 subtypes on tumor-infiltrating lymphocytes in primary and metastatic melanoma
J INVEST DERMATOL. 2000; 114(5): 941-947. Doi: 10.1046/j.1523-1747.2000.00958.x [OPEN ACCESS]
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Kurzbericht/Letter

** Straten, PT; Guldberg, P; Moerch, U; Becker, JC Anti-melanocyte T cell responses - Methodology versus biology
J INVEST DERMATOL. 2000; 114(4): 738-739. Doi: 10.1046/j.1523-1747.2000.00932.x [OPEN ACCESS]
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Übersichtsarbeit

** Becker, JC; Kampgen, E; Brocker, EB Classical chemotherapy for metastatic melanoma
CLIN EXP DERMATOL. 2000; 25(6): 503-508. Doi: 10.1046/j.1365-2230.2000.00690.x
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Kommentar

** Becker, JC; Straten, PT T-cell clonality in immune responses.
Immunol Today. 2000; 21(2):107-107 Doi: 10.1016/S0167-5699(99)01532-7
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1999

Originalarbeit (Zeitschrift)

** Becker, JC; Guldberg, P; Zeuthen, J; Brocker, EB; Straten, PT Accumulation of identical T cells in melanoma and vitiligo-like leukoderma
J INVEST DERMATOL. 1999; 113(6): 1033-1038. Doi: 10.1046/j.1523-1747.1999.00805.x [OPEN ACCESS]
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** Conrad, CT; Ernst, NR; Dummer, W; Brocker, EB; Becker, JC Differential expression of transforming growth factor beta 1 and interleukin 10 in progressing and regressing areas of primary melanoma.
J Exp Clin Cancer Res. 1999; 18(2):225-232
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** Fischer, WH; Straten, PT; Terheyden, P; Becker, JC Function and dysfunction of CD4(+) T cells in the immune response to melanoma
CANCER IMMUNOL IMMUNOTHER. 1999; 48(7): 363-370. Doi: 10.1007/s002620050587
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** Straten, PT; Guldberg, P; Gronbaek, K; Hansen, MR; Kirkin, AF; Seremet, T; Zeuthen, J; Becker, JC In situ T cell responses against melanoma comprise high numbers of locally expanded T cell clonotypes.
J Immunol. 1999; 163(1):443-447 [OPEN ACCESS]
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** Terheyden, P; Siedel, C; Merkel, A; Kampgen, E; Brocker, EB; Becker, JC Predominant expression of Fas (CD95) ligand in metastatic melanoma revealed by longitudinal analysis.
J Invest Dermatol. 1999; 112(6):899-902 Doi: 10.1046/j.1523-1747.1999.00607.x [OPEN ACCESS]
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Übersichtsarbeit

** Straten, PT; Becker, JC; Guldberg, P; Zeuthen, J In situ T cells in melanoma.
Cancer Immunol Immunother. 1999; 48(7):386-395 Doi: 10.1007/s002620050591
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1998

Originalarbeit (Zeitschrift)

** Pertl, U; Xiang, R; Kleindienst, P; Becker, JC; Gillies, SD; Reisfeld, RA; Lode, HN Tumor targeting with immunocytokines. A novel approach for cancer therapy
MINERVA BIOTECNOLOGICA. 1998; 10(3): 89-99.
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** Straten, PT; Guldberg, P; Seremet, T; Reisfeld, RA; Zeuthen, J; Becker, JC Activation of preexisting T cell clones by targeted interleukin 2 therapy.
Proc Natl Acad Sci U S A. 1998; 95(15):8785-8790 Doi: 10.1073/pnas.95.15.8785 [OPEN ACCESS]
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** Terheyden, P; Hornschuh, B; Karl, S; Becker, JC; Brocker, EB Lichen planus associated with Becker's nevus.
J Am Acad Dermatol. 1998; 38(5 Pt 1):770-772 Doi: 10.1016/S0190-9622(98)70211-7 (- Case Report)
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** Trcka, J; Kampgen, E; Becker, JC; Schwaaf, A; Brocker, EB Immunochemotherapy of malignant melanoma. Epifocal administration of dinitrochlorobenzene (DNCB) combined with systemic chemotherapy with dacarbazine (DTIC)
Hautarzt. 1998; 49(1):17-22 Doi: 10.1007/s001050050695
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** Wagner, SN; Schultewolter, T; Wagner, C; Briedigkeit, L; Becker, JC; Kwasnicka, HM; Goos, M Immune response against human primary malignant melanoma: a distinct cytokine mRNA profile associated with spontaneous regression.
Lab Invest. 1998; 78(5):541-550
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Übersichtsarbeit

** Lode, HN; Xiang, R; Becker, JC; Gillies, SD; Reisfeld, RA Immunocytokines: a promising approach to cancer immunotherapy.
Pharmacol Ther. 1998; 80(3):277-292 Doi: 10.1016/S0163-7258(98)00033-3
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** Terheyden, P; Kampgen, E; Runger, TM; Brocker, EB; Becker, JC Immunochemotherapy of metastatic uveal melanoma with interferon alfa-2b, interleukin-2 and fotemustine. Case reports and review of the literature
Hautarzt. 1998; 49(10):770-773 Doi: 10.1007/s001050050823 (- Case Report)
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1997

Originalarbeit (Zeitschrift)

** Becker, JC; Bloebaum, CL; Hulme, KF Distributed computing for multidisciplinary design optimization using Java
STRUCT OPTIMIZATION. 1997; 14(4): 203-218. Doi: 10.1007/BF01197942
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** Becker, JC; Terheyden, P; Brocker, EB Molecular basis of T-cell dysfunction in melanoma
MELANOMA RES. 1997; 7: S51-S57. Doi: 10.1097/00008390-199706001-00197
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** Reisfeld, RA; Becker, JC; Gillies, SD Immunocytokines: a new approach to immunotherapy of melanoma
MELANOMA RES. 1997; 7: S99-S106. Doi: 10.1097/00008390-199708001-00016
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1996

Originalarbeit (Zeitschrift)

** Becker, JC; Pancook, JD; Gillies, SD; Furukawa, K; Reisfeld, RA T cell-mediated eradication of murine metastatic melanoma induced by targeted interleukin 2 therapy
J EXP MED. 1996; 183(5): 2361-2366. Doi: 10.1084/jem.183.5.2361 [OPEN ACCESS]
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** Becker, JC; Pancook, JD; Gillies, SD; Mendelsohn, J; Reisfeld, RA Eradication of human hepatic and pulmonary melanoma metastases in SCID mice by antibody-interleukin 2 fusion proteins
PROC NAT ACAD SCI USA. 1996; 93(7): 2702-2707. Doi: 10.1073/pnas.93.7.2702 [OPEN ACCESS]
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** Becker, JC; Varki, N; Brocker, EB; Reisfeld, RA Lymphocyte-mediated alopecia in C57BL/6 mice following successful immunotherapy for melanoma
J INVEST DERMATOL. 1996; 107(4): 627-632. Doi: 10.1111/1523-1747.ep12584237 [OPEN ACCESS]
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** Becker, JC; Varki, N; Gillies, SD; Furukawa, K; Reisfeld, RA An antibody-interleukin 2 fusion protein overcomes tumor heterogeneity by induction of a cellular immune response
PROC NAT ACAD SCI USA. 1996; 93(15): 7826-7831. Doi: 10.1073/pnas.93.15.7826 [OPEN ACCESS]
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** Becker, JC; Varki, N; Gillies, SD; Furukawa, K; Reisfeld, RA Long-lived and transferable tumor immunity in mice after targeted interleukin-2 therapy
J CLIN INVEST. 1996; 98(12): 2801-2804. Doi: 10.1172/JCI119107 [OPEN ACCESS]
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** Montgomery, AMP; Becker, JC; Siu, CH; Lemmon, VP; Cheresh, DA; Pancook, JD; Zhao, XN; Reisfeld, RA Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3.
J Cell Biol. 1996; 132(3):475-485 Doi: 10.1083/jcb.132.3.475 [OPEN ACCESS]
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** Pancook, JD; Becker, JC; Gillies, SD; Reisfeid, RA Eradication of established hepatic human neuroblastoma metastases in mice with severe combined immunodeficiency by antibody-targeted interleukin-2
CANCER IMMUNOL IMMUNOTHER. 1996; 42(2): 88-92. Doi: 10.1007/s002620050256
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** Reisfeld, RA; Gillies, SD; Mendelsohn, J; Varki, NM; Becker, JC Involvement of B lymphocytes in the growth inhibition of human pulmonary melanoma metastases in athymic nu/nu mice by in antibody-lymphotoxin fusion protein
CANCER RES. 1996; 56(8): 1707-1712. [OPEN ACCESS]
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** Straten, P; Becker, JC; Seremet, T; Brocker, EB; Zeuthen, J Clonal T cell responses in tumor infiltrating lymphocytes from both regressive and progressive regions of primary human malignant melanoma
J CLIN INVEST. 1996; 98(2): 279-284. Doi: 10.1172/JCI118790 [OPEN ACCESS]
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** Stromblad, S; Becker, JC; Yebra, M; Brooks, PC; Cheresh, DA Suppression of p53 activity and p21(WAF1/CIP1) expression by vascular cell integrin alpha v beta 3 during angiogenesis
J CLIN INVEST. 1996; 98(2): 426-433. Doi: 10.1172/JCI118808 [OPEN ACCESS]
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1995

Originalarbeit (Zeitschrift)

** BECKER, JC; BRABLETZ, T; KIRCHNER, T; CONRAD, CT; BROCKER, EB; REISFELD, RA NEGATIVE TRANSCRIPTIONAL REGULATION IN ANERGIC T-CELLS
PROC NAT ACAD SCI USA. 1995; 92(6): 2375-2378. Doi: 10.1073/pnas.92.6.2375 [OPEN ACCESS]
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** BECKER, JC; NIKROO, A; BRABLETZ, T; REISFELD, RA DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes.
Proc Natl Acad Sci U S A. 1995; 92(21):9727-9731 Doi: 10.1073/pnas.92.21.9727 [OPEN ACCESS]
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** DUMMER, R; GORE, ME; HANCOCK, BW; GUILLOU, PJ; GROBBEN, HC; BECKER, JC; OSKAM, R; DIELEMAN, JP; BURG, G A MULTICENTER PHASE-II CLINICAL-TRIAL USING DACARBAZINE AND CONTINUOUS-INFUSION INTERLEUKIN-2 FOR METASTATIC MELANOMA - CLINICAL-DATA AND IMMUNOMONITORING
CANCER. 1995; 75(4): 1038-1044. Doi: 10.1002/1097-0142(19950215)75:4<1038::AID-CNCR2820750421>3.0.CO;2-F
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** YEBRA, M; FILARDO, EJ; BAYNA, EM; KAWAHARA, E; BECKER, JC; CHERESH, DA Induction of carcinoma cell migration on vitronectin by NF-kappa B-dependent gene expression.
Mol Biol Cell. 1995; 6(7):841-850 Doi: 10.1091/mbc.6.7.841 [OPEN ACCESS]
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Übersichtsarbeit

** BROCKER, EB; BECKER, JC Immunology of melanoma
HAUTARZT. 1995; 46(11): 818-828.
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Kurzbericht/Note

** DUMMER, W; BECKER, JC; SCHWAAF, A; LEVERKUS, M; MOLL, T; BROCKER, EB ELEVATED SERUM LEVELS OF INTERLEUKIN-10 IN PATIENTS WITH METASTATIC MALIGNANT-MELANOMA
MELANOMA RES. 1995; 5(1): 67-68. Doi: 10.1097/00008390-199502000-00008
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1994

Originalarbeit (Zeitschrift)

** BECKER, JC; CZERNY, C; BROCKER, EB Maintenance of clonal anergy by endogenously produced IL-10.
Int Immunol. 1994; 6(10):1605-1612 Doi: 10.1093/intimm/6.10.1605 [OPEN ACCESS]
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** BECKER, JC; GILLITZER, R; BROCKER, EB A MEMBER OF THE MELANOMA ANTIGEN-ENCODING GENE (MAGE) FAMILY IS EXPRESSED IN HUMAN SKIN DURING WOUND-HEALING
INT J CANCER. 1994; 58(3): 346-348. Doi: 10.1002/ijc.2910580306
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** BECKER, JC; WINKLER, B; KLINGERT, S; BROCKER, EB ANTIPHOSPHOLIPID SYNDROME-ASSOCIATED WITH IMMUNOTHERAPY FOR PATIENTS WITH MELANOMA
CANCER. 1994; 73(6): 1621-1624. Doi: 10.1002/1097-0142(19940315)73:6<1621::AID-CNCR2820730613>3.0.CO;2-E
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** SCHULTZ, ES; DUMMER, R; BECKER, JC; ZILLIKENS, D; BURG, G INFLUENCE OF VARIOUS CYTOKINES ON THE INTERLEUKIN-2-DEPENDENT LYSIS OF MELANOMA-CELLS IN-VITRO
ARCH DERMATOL RES. 1994; 286(2): 73-76. Doi: 10.1007/BF00370730
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1993

Originalarbeit (Zeitschrift)

** BECKER, JC; BRABLETZ, T; CZERNY, C; TERMEER, C; BROCKER, EB TUMOR ESCAPE MECHANISMS FROM IMMUNOSURVEILLANCE - INDUCTION OF UNRESPONSIVENESS IN A SPECIFIC MHC-RESTRICTED CD4+ HUMAN T-CELL CLONE BY THE AUTOLOGOUS MHC CLASS-II+ MELANOMA
INT IMMUNOL. 1993; 5(12): 1501-1508. Doi: 10.1093/intimm/5.12.1501 [OPEN ACCESS]
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** BECKER, JC; SCHWINN, A; DUMMER, R; BURG, G; BROCKER, EB TUMOR-INFILTRATING LYMPHOCYTES IN PRIMARY MELANOMA - FUNCTIONAL CONSEQUENCES OF DIFFERENTIAL IL-2 RECEPTOR EXPRESSION
CLIN EXP IMMUNOL. 1993; 91(1): 121-125. Doi: 10.1111/j.1365-2249.1993.tb03365.x
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** BECKER, JC; SCHWINN, A; DUMMER, R; BURG, G; BROCKER, EB LESION-SPECIFIC ACTIVATION OF CLONED HUMAN TUMOR-INFILTRATING LYMPHOCYTES BY AUTOLOGOUS TUMOR-CELLS - INDUCTION OF PROLIFERATION AND CYTOKINE PRODUCTION
J INVEST DERMATOL. 1993; 101(1): 15-21. Doi: 10.1111/1523-1747.ep12358425 [OPEN ACCESS]
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** BECKER, JC; TERMEER, C; SCHMIDT, RE; BROCKER, EB SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 INHIBITS MHC-RESTRICTED SPECIFIC T-CELL TUMOR INTERACTION
J IMMUNOL. 1993; 151(12): 7224-7232.
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** DUMMER, R; BECKER, JC; EILLES, C; SCHAFER, E; BORNER, W; BURG, G T-CELLS MIGRATE TO TUMOR SITES AFTER EXTRACORPOREAL INTERLEUKIN-2 STIMULATION AND REINFUSION IN A PATIENT WITH METASTATIC MELANOMA
BRIT J DERMATOL. 1993; 128(4): 399-403. Doi: 10.1111/j.1365-2133.1993.tb00198.x
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1992

Originalarbeit (Zeitschrift)

** BECKER, JC; DUMMER, R; SCHMIDT, RE; BURG, G; HARTMANN, AA Shedding of soluble intercellular adhesion molecule 1 (ICAM-1) from melanoma cells and the effect on cellular cytotoxicity
IMMUN INFEKT. 1992; 20(2): 62-63.
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** BECKER, JC; DUMMER, R; SCHWINN, A; HARTMANN, AA; BURG, G Circulating intercellular adhesion molecule-1 in melanoma patients: induction by interleukin-2 therapy.
J Immunother (1991). 1992; 12(2):147-150 Doi: 10.1097/00002371-199208000-00010
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** BECKER, JC; DUMMER, R; VONWUSSOW, P; BURG, G; SCHMIDT, RE NON-MHC-RESTRICTED T-CELL INTERACTION WITH B-CELLS - ROLE OF THE T-CELL RECEPTOR
SCAND J IMMUNOL. 1992; 36(2): 177-181. Doi: 10.1111/j.1365-3083.1992.tb03089.x
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** DUMMER, R; POSSECKERT, G; NESTLE, F; WITZGALL, R; BURGER, M; BECKER, JC; SCHAFER, E; WIEDE, J; SEBALD, W; BURG, G Soluble interleukin-2 receptors inhibit interleukin 2-dependent proliferation and cytotoxicity: explanation for diminished natural killer cell activity in cutaneous T-cell lymphomas in vivo?
J INVEST DERMATOL. 1992; 98(1): 50-54. Doi: 10.1111/1523-1747.ep12494223 [OPEN ACCESS]
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Kurzbericht/Letter

** DUMMER, R; BECKER, JC; BOSER, B; HARTMANN, AA; BURG, G SUCCESSFUL THERAPY OF METASTATIC ECCRINE POROMA USING PERILESIONAL INTERFERON-ALFA AND INTERLEUKIN-2
ARCH DERMATOL. 1992; 128(8): 1127-1128. Doi: 10.1001/archderm.128.8.1127
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1991

Originalarbeit (Zeitschrift)

** BECKER, JC; DUMMER, R; HARTMANN, AA; BURG, G; SCHMIDT, RE Shedding of ICAM-1 from human melanoma cell lines induced by IFN-gamma and tumor necrosis factor-alpha. Functional consequences on cell-mediated cytotoxicity.
J Immunol. 1991; 147(12):4398-4401
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1990

Originalarbeit (Zeitschrift)

** BECKER, JC; KOLANUS, W; LONNEMANN, C; SCHMIDT, RE Human natural killer clones enhance in vitro antibody production by tumour necrosis factor alpha and gamma interferon.
SCAND J IMMUNOL. 1990; 32(2): 153-162. Doi: 10.1111/j.1365-3083.1990.tb02905.x
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