Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Darnhofer Barbara |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2025

Originalarbeit (Zeitschrift)

** Krammer, L; Darnhofer, B; Kljajic, M; Liesinger, L; Schittmayer, M; Neshchadin, D; Gescheidt, G; Kollau, A; Mayer, B; Fischer, RC; Wallner, S; Macheroux, P; Birner-Gruenberger, R; Breinbauer, R A general approach for activity-based protein profiling of oxidoreductases with redox-differentiated diarylhalonium warheads
CHEM SCI. 2025; Doi: 10.1039/d4sc08454c [OPEN ACCESS]
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** Zandl-Lang, M; Züllig, T; Holzer, M; Eichmann, TO; Darnhofer, B; Schwerin-Nagel, A; Zobel, J; Haidl, H; Biebl, A; Köfeler, H; Plecko, B Multi-omics profiling in spinal muscular atrophy (SMA): investigating lipid and metabolic alterations through longitudinal CSF analysis of Nusinersen-treated patients.
J Neurol. 2025; 272(3): 183 Doi: 10.1007/s00415-025-12909-4 [OPEN ACCESS]
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2023

Originalarbeit (Zeitschrift)

** Grill, B; Pavkov-Keller, T; Grininger, C; Darnhofer, B; Gruber, K; Hall, M; Schwab, H; Steiner, K Engineering TM1459 for Stabilisation against Inactivation by Amino Acid Oxidation
CHEM-ING-TECH. 2023; Doi: 10.1002/cite.202200176
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** Grossmann, T; Kirsch, A; Grill, M; Steffan, B; Karbiener, M; Brcic, L; Darnhofer, B; Birner-Gruenberger, R; Gugatschka, M Introducing a new type of alternative laryngeal mucosa model.
PLoS One. 2023; 18(6):e0287634 Doi: 10.1371/journal.pone.0287634 [OPEN ACCESS]
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Übersichtsarbeit

** Honeder, SE; Tomin, T; Schinagl, M; Pfleger, R; Hoehlschen, J; Darnhofer, B; Schittmayer, M; Birner-Gruenberger, R Research Advances Through Activity-Based Lipid Hydrolase Profiling
ISR J CHEM. 2023; Doi: 10.1002/ijch.202200078
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2022

Originalarbeit (Zeitschrift)

** Bhutada, P; Favre, S; Jaafar, M; Hafner, J; Liesinger, L; Unterweger, S; Bischof, K; Darnhofer, B; Siva, Sankar, D; Rechberger, G; Abou, Merhi, R; Lebaron, S; Birner-Gruenberger, R; Kressler, D; Henras, AK; Pertschy, B Rbp95 binds to 25S rRNA helix H95 and cooperates with the Npa1 complex during early pre-60S particle maturation.
Nucleic Acids Res. 2022; 50(17):10053-10077 Doi: 10.1093/nar/gkac724 [OPEN ACCESS]
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** Eisner, H; Riegler-Berket, L; Gamez, CFR; Sagmeister, T; Chalhoub, G; Darnhofer, B; Jazleena, PJ; Birner-Gruenberger, R; Pavkov-Keller, T; Haemmerle, G; Schoiswohl, G; Oberer, M The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1.
Int J Mol Sci. 2022; 23(21): Doi: 10.3390/ijms232113101 [OPEN ACCESS]
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** Gindlhuber, J; Schinagl, M; Liesinger, L; Darnhofer, B; Tomin, T; Schittmayer, M; Birner-Gruenberger, R Hepatocyte Proteome Alterations Induced by Individual and Combinations of Common Free Fatty Acids.
Int J Mol Sci. 2022; 23(6): Doi: 10.3390/ijms23063356 [OPEN ACCESS]
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** Grossmann, T; Darnhofer, B; Birner-Gruenberger, R; Kirsch, A; Gugatschka, M Descriptive proteomics of paired human vocal fold and buccal mucosa tissue.
Proteomics Clin Appl. 2022; 16(2):e2100050 Doi: 10.1002/prca.202100050 [OPEN ACCESS]
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** Kittler, S; Ebner, J; Besleaga, M; Larsbrink, J; Darnhofer, B; Birner-Gruenberger, R; Schobesberger, S; Akhgar, CK; Schwaighofer, A; Lendl, B; Spadiut, O Recombinant Protein L: Production, Purification and Characterization of a Universal Binding Ligand.
J Biotechnol. 2022; 359:108-115 Doi: 10.1016/j.jbiotec.2022.10.002
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** Stadler, KA; Becker, W; Darnhofer, B; Birner-Gruenberger, R; Zangger, K Overexpression of recombinant proteins containing non-canonical amino acids in Vibrio natriegens: p-azido-L-phenylalanine as coupling site for 19F-tags.
Amino Acids. 2022; 54(7):1041-1053 Doi: 10.1007/s00726-022-03148-2 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Honeder, SE; Gindlhuber, J; Tomin, T; Schittmayer, M; Brcic, L; Birner-Gruenberger, R Activity-based proteomic profiling reveals reduction of lipid hydrolase activity levels in non-small cell lung cancer tumors
MOL CELL PROTEOMICS. 2022; 21(8): S69-S69. Doi: 10.1016/j.mcpro.2022.100377 [Poster]
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2021

Originalarbeit (Zeitschrift)

** Darnhofer, B; Tomin, T; Liesinger, L; Schittmayer, M; Tomazic, PV; Birner-Gruenberger, R Comparative proteomics of common allergenic tree pollens of birch, alder, and hazel.
Allergy. 2021; 76(6):1743-1753 Doi: 10.1111/all.14694 [OPEN ACCESS]
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** Tomescu, MS; Sooklal, SA; Ntsowe, T; Naicker, P; Darnhofer, B; Archer, R; Stoychev, S; Swanevelder, D; Birner-Grunberger, R; Rumbold, K Transcriptome and proteome of the corm, leaf and flower of Hypoxis hemerocallidea (African potato)
PLOS ONE. 2021; 16(7): e0253741 Doi: 10.1371/journal.pone.0253741 [OPEN ACCESS]
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** Tomin, T; Schittmayer, M; Sedej, S; Bugger, H; Gollmer, J; Honeder, S; Darnhofer, B; Liesinger, L; Zuckermann, A; Rainer, PP; Birner-Gruenberger, R Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts.
Int J Mol Sci. 2021; 22(4): Doi: 10.3390/ijms22041787 [OPEN ACCESS]
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2020

Originalarbeit (Zeitschrift)

** Biundo, A; Braunschmid, V; Pretzler, M; Kampatsikas, I; Darnhofer, B; Birner-Gruenberger, R; Rompel, A; Ribitsch, D; Guebitz, GM Polyphenol oxidases exhibit promiscuous proteolytic activity.
COMMUN CHEM. 2020; 3(1): 62 Doi: 10.1038/s42004-020-0305-2 [OPEN ACCESS]
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** Drienovská, I; Gajdoš, M; Kindler, A; Takhtehchian, M; Darnhofer, B; Birner-Gruenberger, R; Dörr, M; Bornscheuer, UT; Kourist, R Folding assessment of incorporation of non-canonical amino acids facilitates expansion of functional group diversity for enzyme engineering.
Chemistry. 2020; Doi: 10.1002/chem.202002077 [OPEN ACCESS]
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** Schittmayer, M; Vujic, N; Darnhofer, B; Korbelius, M; Honeder, S; Kratky, D; Birner-Gruenberger, R Spatially Resolved Activity-based Proteomic Profiles of the Murine Small Intestinal Lipases.
Mol Cell Proteomics. 2020; 19(12):2104-2114 Doi: 10.1074/mcp.RA120.002171 [OPEN ACCESS]
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** Soleyman, NM; Darnhofer, B; Gruenberger, RB; Abnous, K; Borji, H Proteomic analysis of soluble protein extract of adult Toxocara cati.
Comp Immunol Microbiol Infect Dis. 2020; 73(11):101528-101528 Doi: 10.1016/j.cimid.2020.101528
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** Tomazic, PV; Darnhofer, B; Birner-Gruenberger, R Nasal mucus proteome and its involvement in allergic rhinitis.
Expert Rev Proteomics. 2020; 17(3):191-199 Doi: 10.1080/14789450.2020.1748502 [OPEN ACCESS]
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** Tomescu, MS; Davids, D; DuPlessis, M; Darnhofer, B; Birner-Gruenberger, R; Archer, R; Schwendenwein, D; Thallinger, G; Winkler, M; Rumbold, K High-throughput in-field bioprospecting for cyanogenic plants and hydroxynitrile lyases.
BIOCATAL BIOTRANSFOR. 2020; Doi: 10.1080/10242422.2020.1726895 [OPEN ACCESS]
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2019

Originalarbeit (Zeitschrift)

** Fladischer, P; Weingartner, A; Blamauer, J; Darnhofer, B; Birner-Gruenberger, R; Kardashliev, T; Ruff, AJ; Schwaneberg, U; Wiltschi, B A Semi-Rationally Engineered Bacterial Pyrrolysyl-tRNA Synthetase Genetically Encodes Phenyl Azide Chemistry.
Biotechnol J. 2019; 14(3):e1800125-e1800125 Doi: 10.1002/biot.201800125 [OPEN ACCESS]
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** Gugatschka, M; Darnhofer, B; Grossmann, T; Schittmayer, M; Hortobagyi, D; Kirsch, A; Karpf, E; Brcic, L; Birner-Gruenberger, R; Karbiener, M Proteomic Analysis of Vocal Fold Fibroblasts Exposed to Cigarette Smoke Extract: Exploring the Pathophysiology of Reinke's Edema.
Mol Cell Proteomics. 2019; 18(8):1511-1525 Doi: 10.1074/mcp.RA119.001272 [OPEN ACCESS]
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** Schilcher, I; Ledinski, G; Radulović, S; Hallström, S; Eichmann, T; Madl, T; Zhang, F; Leitinger, G; Kolb-Lenz, D; Darnhofer, B; Birner-Gruenberger, R; Wadsack, C; Kratky, D; Marsche, G; Frank, S; Cvirn, G Endothelial lipase increases antioxidative capacity of high-density lipoprotein.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019; 1864(10):1363-1374 Doi: 10.1016/j.bbalip.2019.06.011 [OPEN ACCESS]
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2018

Originalarbeit (Zeitschrift)

** Bhutada, G; Kavšček, M; Hofer, F; Gogg-Fassolter, G; Schweiger, M; Darnhofer, B; Kordiš, D; Birner-Gruenberger, R; Natter, K Characterization of a lipid droplet protein from Yarrowia lipolytica that is required for its oleaginous phenotype.
Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863(10):1193-1205 Doi: 10.1016/j.bbalip.2018.07.010 [OPEN ACCESS]
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** Tobola, F; Lelimousin, M; Varrot, A; Gillon, E; Darnhofer, B; Blixt, O; Birner-Gruenberger, R; Imberty, A; Wiltschi, B Effect of Noncanonical Amino Acids on Protein-Carbohydrate Interactions: Structure, Dynamics, and Carbohydrate Affinity of a Lectin Engineered with Fluorinated Tryptophan Analogs.
ACS Chem Biol. 2018; 13(8):2211-2219 Doi: 10.1021/acschembio.8b00377 [OPEN ACCESS]
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2017

Originalarbeit (Zeitschrift)

** Karbiener, M; Darnhofer, B; Frisch, MT; Rinner, B; Birner-Gruenberger, R; Gugatschka, M Comparative proteomics of paired vocal fold and oral mucosa fibroblasts.
J Proteomics. 2017; 155(6):11-21 Doi: 10.1016/j.jprot.2017.01.010 [OPEN ACCESS]
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** Lanfranchi, E; Pavkov-Keller, T; Koehler, EM; Diepold, M; Steiner, K; Darnhofer, B; Hartler, J; Van Den Bergh, T; Joosten, HJ; Gruber-Khadjawi, M; Thallinger, GG; Birner-Gruenberger, R; Gruber, K; Winkler, M; Glieder, A Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily.
Sci Rep. 2017; 7(5):46738-46738 Doi: 10.1038/srep46738 [OPEN ACCESS]
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Korrektur

** Lanfranchi, E; Pavkov-Keller, T; Koehler, EM; Diepold, M; Steiner, K; Darnhofer, B; Hartler, J; Bergh, TVD; Joosten, HJ; Gruber-Khadjawi, M; Thallinger, GG; Birner-Gruenberger, R; Gruber, K; Winkler, M; Glieder, A Erratum: Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily.
Sci Rep. 2017; 7: 46834-46834. Doi: 10.1038/srep46834 [OPEN ACCESS]
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2016

Originalarbeit (Zeitschrift)

** Krainer, FW; Darnhofer, B; Birner-Gruenberger, R; Glieder, A Recombinant production of a peroxidase-protein G fusion protein in Pichia pastoris.
J Biotechnol. 2016; 219(2):24-27 Doi: 10.1016/j.jbiotec.2015.12.020 [OPEN ACCESS]
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** Krainer, FW; Gerstmann, MA; Darnhofer, B; Birner-Gruenberger, R; Glieder, A Biotechnological advances towards an enhanced peroxidase production in Pichia pastoris.
J Biotechnol. 2016; 233(31):181-189 Doi: 10.1016/j.jbiotec.2016.07.012 [OPEN ACCESS]
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Übersichtsarbeit

** Sturmberger, L; Chappell, T; Geier, M; Krainer, F; Day, KJ; Vide, U; Trstenjak, S; Schiefer, A; Richardson, T; Soriaga, L; Darnhofer, B; Birner-Gruenberger, R; Glick, BS; Tolstorukov, I; Cregg, J; Madden, K; Glieder, A Refined Pichia pastoris reference genome sequence.
J Biotechnol. 2016; 235(6):121-131 Doi: 10.1016/j.jbiotec.2016.04.023 [OPEN ACCESS]
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2015

Originalarbeit (Zeitschrift)

** Kopecky, C; Haidinger, M; Birner-Grünberger, R; Darnhofer, B; Kaltenecker, CC; Marsche, G; Holzer, M; Weichhart, T; Antlanger, M; Kovarik, JJ; Werzowa, J; Hecking, M; Säemann, MD Restoration of renal function does not correct impairment of uremic HDL properties.
J Am Soc Nephrol. 2015; 26(3):565-575 Doi: 10.1681/ASN.2013111219 [OPEN ACCESS]
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2012

Originalarbeit (Zeitschrift)

** Birner-Gruenberger, R; Darnhofer, B; Chen, WQ; Monje, FJ; Lubec, G Proteomic characterization of the abdominal ganglion of Aplysia californica-A protein resource for neuroscience.
Proteomics. 2012; 12(15-16):2482-2486 Doi: 10.1002/pmic.201100641
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** Monje, FJ; Birner-Gruenberger, R; Darnhofer, B; Divisch, I; Pollak, DD; Lubec, G Proteomics reveals selective regulation of proteins in response to memory-related serotonin stimulation in Aplysia californica ganglia.
Proteomics. 2012; 12(3):490-499 Doi: 10.1002/pmic.201100418
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2010

Abstract (Zeitschrift)

** Singh, TP; Huettner, B; Koefeler, H; Mayer, G; Wallbrecht, K; Schon, MP; Wolf, P Platelet-activating factor blockade inhibits Th17 pathway and suppresses psoriatic-like skin disease in K5.hTGF-beta1 transgenic mice
J INVEST DERMATOL. 2010; 130: S3-S3. [Oral Communication]
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