** = Publications listed in SCI/SSCI/Pubmed
** Birnhuber, A; Biasin, V; Jain, PP; Kwiatkowski, G; Boiarina, E; Wilhelm, J; Ahrens, K; Nagaraj, C; Olschewski, A; Witzenrath, M; Chlopicki, S; Marsh, LM; Tabeling, C; Kwapiszewska, G
Pulmonary vascular remodeling in Fra-2 transgenic mice is driven by type 2 inflammation and accompanied by pulmonary vascular hyperresponsiveness.
Am J Physiol Lung Cell Mol Physiol. 2025;
Doi: 10.1152/ajplung.00274.2024
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** Fließer, E; Jandl, K; Lins, T; Birnhuber, A; Valzano, F; Kolb, D; Foris, V; Heinemann, A; Olschewski, H; Evermann, M; Hoetzenecker, K; Kreuter, M; Voelkel, NF; Marsh, LM; Wygrecka, M; Kwapiszewska, G
Lung Fibrosis Is Linked to Increased Endothelial Cell Activation and Dysfunctional Vascular Barrier Integrity.
Am J Respir Cell Mol Biol. 2024; 71(3):318-331
Doi: 10.1165/rcmb.2024-0046OC
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** Zeder, K; Marsh, LM; Avian, A; Brcic, L; Birnhuber, A; Douschan, P; Foris, V; Sassmann, T; Hoetzenecker, K; Boehm, PM; Kwapiszewska, G; Olschewski, A; Olschewski, H; Kovacs, G
Compartment-specific remodeling patterns in end-stage chronic obstructive pulmonary disease with and without severe pulmonary hypertension.
J Heart Lung Transplant. 2024; 43(7):1090-1101
Doi: 10.1016/j.healun.2024.02.1044
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** Waked, P; Birnhuber, A; Kotzbeck, P; Foessl, I; Zabini, D; Marsh, LM; Crnkovic, S; Olschewski, A; Obermayer-Pietsch, B; Kwapiszewska, G; Biasin, V
Towards precision medicine: Systemic Sclerosis research in light of sex- differences
EUR RESPIR J. 2024; 64: PA2639-
Doi: 10.1183/13993003.congress-2024.PA2639
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** Waked, P; Birnhuber, A; Kotzbeck, P; Foessl, I; Zabini, D; Marsh, LM; Crnkovic, S; Olschewski, A; Obermayer-Pietsch, B; Kwapiszewska, G; Biasin, V
The Role of Testosterone in Modulating Systemic Sclerosis Severity: A Preclinical Study
WIEN KLIN WOCHENSCHR. 2024; 136: S527-S528.
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** Wygrecka, M; Schramm, F; Jablonska, E; Birnhuber, A; Schulte, L; Kreuter, M; Bonella, F; Panousis, C; Nolte, MW; Kwapiszewska, G; Renne, T; Preissner, KT; Prasse, A
Factor XII Deregulates Cell Communication and Contributes to Progression of Lung Fibrosis
EUR RESPIR J. 2024; 64: PA4245
Doi: 10.1183/13993003.congress-2024.PA4245
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** Jandl, K; Berg, JL; Birnhuber, A; Fliesser, E; Borek, I; Seeliger, B; David, S; Schmidt, JJ; Gorkiewicz, G; Zacharias, M; Welte, T; Olschewski, H; Heinemann, A; Wygrecka, M; Kwapiszewska, G
Basement membrane product, endostatin, as a link between inflammation, coagulation and vascular permeability in COVID-19 and non-COVID-19 acute respiratory distress syndrome.
Front Immunol. 2023; 14: 1188079
Doi: 10.3389/fimmu.2023.1188079
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** Borek, I; Birnhuber, A; Voelkel, NF; Marsh, LM; Kwapiszewska, G
The vascular perspective on acute and chronic lung disease.
J Clin Invest. 2023; 133(16):
Doi: 10.1172/JCI170502
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** Fliesser, E; Jandl, K; Birnhuber, A; Valzano, F; Foris, V; Evermann, M; Hötzenecker, K; Olschewski, H; Marsh, LM; Kreuter, M; Wygrecka, M; Kwapiszewska, G
Lung fibrosis possesses activated endothelial cells
WIEN KLIN WOCHENSCHR. Abstracts. 2023; 135(19-20):577-577.-47. Jahrestagung der ÖGP - 7. Jahrestagung der ÖGTC; OCT 23-25, 2023; Graz, Austria.
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** Lins, T; Fliesser, E; Valzano, F; Birnhuber, A; Kolb, D; Kojonazarov, B; Bartkuhn, M; Jandl, K; Kwapiszewska, G
Endothelial cell alterations as a driver of lung fibrosis in Fra2 transgenic SSc Emodel
WIEN KLIN WOCHENSCHR. Abstracts. 2023; 135(19-20):576-576.-47. Jahrestagung der ÖGP - 7. Jahrestagung der ÖGTC; OCT 23-25, 2023; Graz, Austria.
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** Zeder, K; Marsh, LM; Avian, A; Brcic, L; Birnhuber, A; Douschan, P; Foris, V; Sassmann, T; Hoetzenecker, K; Boehm, P; Kwapiszewska, G; Olschewski, A; Olschewski, H; Kovacs, G
Compartment-specific Remodeling of End-stage Chronic Obstructive Pulmonary Disease Patients With Severe Pulmonary Hypertension Based on Histological Lung Tissue Samples
AM J RESP CRIT CARE. 2023; 207: -International Conference of the American-Thoracic-Society (ATS); MAY 19-24, 2023; Washington, DC.
[Oral Communication]
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** Birnhuber, A; Jandl, K; Biasin, V; Fließer, E; Valzano, F; Marsh, LM; Krolczik, C; Olschewski, A; Wilhelm, J; Toller, W; Heinemann, A; Olschewski, H; Wygrecka, M; Kwapiszewska, G
Pirfenidone exacerbates Th2-driven vasculopathy in a mouse model of systemic sclerosis-associated interstitial lung disease.
Eur Respir J. 2022; 60(4):
Doi: 10.1183/13993003.02347-2021
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** Sauer, A; Seeliger, B; Jandl, K; Erfinanda, L; Wilhelm, J; Alexopoulos, I; Baal, N; Birnhuber, A; David, S; Welte, T; Barreto, G; Gaertner, U; Kwapiszewska, G; Seeger, W; Kuebler, WM; Schaefer, L; Wygrecka, M, , members, of, the, CAPNETZ, Study, Group
Circulating hyaluronic acid signature in CAP and ARDS - the role of pneumolysin in hyaluronic acid shedding.
Matrix Biol. 2022; 114: 67-83.
Doi: 10.1016/j.matbio.2022.11.003
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** Wygrecka, M; Birnhuber, A; Seeliger, B; Michalick, L; Pak, O; Schultz, AS; Schramm, F; Zacharias, M; Gorkiewicz, G; David, S; Welte, T; Schmidt, JJ; Weissmann, N; Schermuly, RT; Barreto, G; Schaefer, L; Markart, P; Brack, MC; Hippenstiel, S; Kurth, F; Sander, LE; Witzenrath, M; Kuebler, WM; Kwapiszewska, G; Preissner, KT
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19.
Blood Adv. 2022; 6(3):1074-1087
Doi: 10.1182/bloodadvances.2021004816
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** Zacharias, M; Kashofer, K; Wurm, P; Regitnig, P; Schütte, M; Neger, M; Ehmann, S; Marsh, LM; Kwapiszewska, G; Loibner, M; Birnhuber, A; Leitner, E; Thüringer, A; Winter, E; Sauer, S; Pollheimer, MJ; Vagena, FR; Lackner, C; Jelusic, B; Ogilvie, L; Durdevic, M; Timmermann, B; Lehrach, H; Zatloukal, K; Gorkiewicz, G
Host and microbiome features of secondary infections in lethal covid-19.
iScience. 2022; 25(9):104926
Doi: 10.1016/j.isci.2022.104926
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** Birnhuber, A; Biasin, V; Jain, P; Boiarina, E; Nagaraj, C; Olschewski, A; Witzenrath, M; Marsh, LM; Tabeling, C; Kwapiszewska, G
Th2-mediated pulmonary vascular hyperresponsiveness and remodelling in a mouse model of systemic sclerosis associated pulmonary arterial hypertension
WIEN KLIN WOCHENSCHR. 2022; 134(19-20):725-725.-Jahrestagung der Österreichischen Gesellschaft für Pneumologie; Salzburg, AUSTRIA.
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** Fliesser, E; Birnhuber, A; Marsh, LM; Bohm, P; Hotzenecker, K; Kovacs, G; Olschewski, H; Kreuter, M; Wygrecka, M; Kwapiszewska, G
Comprehensive Profiling of Endothelial Cell Surface and Adhesion Molecules in Pulmonary Fibrosis
AM J RESP CRIT CARE. 2022; 205: -ATS 2022;
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** Schramm, F; Hadzic, S; Jablonska, E; Birnhuber, A; Rubio, K; Schulte, L; Kreuter, M; Bonella, F; Barreto, G; Weissmann, N; Kwapiszewska, G; Renne, T; Markart, P; Preissner, TK; Prasse, A; Wygrecka, M
Cellular activities of factor XII in lung fibrosis
PNEUMOLOGIE. 2022; 76: S42-S42.
Doi: 10.1055/s-0042-1747785
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** Zeder, K; Marsh, L; Avian, A; Brcic, L; Birnhuber, A; Douschan, P; Foris, V; Sassmann, T; Hotzenecker, K; Bohm, P; Kwapiszewska, G; Olschewski, H; Kovacs, G
Remodeling of pulmonary arteries, airways and parenchyma in end-stage COPD patients with severe pulmonary hypertension
WIEN KLIN WOCHENSCHR. Abstracts 46. Jahrestagung der Österreichischen Gesellschaft für Pneumologie 6. Jahrestagung der Österreichischen Gesellschaft für Thoraxchirurgie. 2022; 134(19-20):724-724.-46. Jahrestagung der Österreichischen Gesellschaft für Pneumologie 6. Jahrestagung der Österreichischen Gesellschaft für Thoraxchirurgie; SEP 29 - OCT 1, 2022; Salzburg, AUSTRIA.
[Oral Communication]
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** Zeder, K; Marsh, LM; Avian, A; Brcic, L; Birnhuber, A; Douschan, P; Foris, V; Sassmann, T; Bohm, P; Hoetzenecker, K; Kwapiszewska, G; Olschewski, H; Kovacs, G
End-stage COPD patients with severe pulmonary hypertension have less airspace enlargement in histologic samples of explanted lungs
EUR RESPIR J. 2022; 60:
Doi: 10.1183/13993003.congress-2022.2013
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** Fließer, E; Birnhuber, A; Marsh, LM; Gschwandtner, E; Klepetko, W; Olschewski, H; Kwapiszewska, G
Dysbalance of ACE2 levels - a possible cause for severe COVID-19 outcome in COPD.
J Pathol Clin Res. 2021; 7(5):446-458
Doi: 10.1002/cjp2.224
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** Tabeling, C; Wienhold, SM; Birnhuber, A; Brack, MC; Nouailles, G; Kershaw, O; Firsching, TC; Gruber, AD; Lienau, J; Marsh, LM; Olschewski, A; Kwapiszewska, G; Witzenrath, M
Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia.
Am J Physiol Lung Cell Mol Physiol. 2021; 320(5):L916-L925
Doi: 10.1152/ajplung.00505.2020
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** Birnhuber, A; Fließer, E; Gorkiewicz, G; Zacharias, M; Seeliger, B; David, S; Welte, T; Schmidt, J; Olschewski, H; Wygrecka, M; Kwapiszewska, G
Between inflammation and thrombosis: endothelial cells in COVID-19.
Eur Respir J. 2021; 58(3):
Doi: 10.1183/13993003.00377-2021
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** Fliesser, E; Birnhuber, A; Bohm, P; Hotzenecker, K; Kovacs, G; Olschewski, H; Kwapiszewska, G
Late Breaking Abstract - A comprehensive analysis of endothelial cell markers in pulmonary fibrosis
EUR RESPIR J. ERS International Congress 2021 abstracts. 2021; 58: -ERS International Congress; SEP 5-8, 2021; Virtuell.
Doi: 10.1183/13993003.congress-2021.PA2058
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** Tabeling, C; Wienhold, SM; Birnhuber, A; Brack, MC; Nouailles, G; Kershaw, O; Firsching, TC; Gruber, AD; Lienau, J; Marsh, LM; Olschewski, A; Kwapiszewska, G; Witzenrath, M
Pulmonary fibrosis in mice increases susceptibility to pneumococcal pneumonia and bacteremia
EUR RESPIR J. ERS International Congress 2021 abstracts. 2021; 58: -ERS International Congress; SEP 5-8, 2021; Virtuell.
Doi: 10.1183/13993003.congress-2021.PA2314
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** Biasin, V; Crnkovic, S; Sahu-Osen, A; Birnhuber, A; El Agha, E; Sinn, K; Klepetko, W; Olschewski, A; Bellusci, S; Marsh, LM; Kwapiszewska, G
PDGFRα and αSMA mark two distinct mesenchymal cell populations involved in parenchymal and vascular remodeling in pulmonary fibrosis.
Am J Physiol Lung Cell Mol Physiol. 2020; 318(4):L684-L697
Doi: 10.1152/ajplung.00128.2019
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** Schnieder, J; Mamazhakypov, A; Birnhuber, A; Wilhelm, J; Kwapiszewska, G; Ruppert, C; Markart, P; Wujak, L; Rubio, K; Barreto, G; Schaefer, L; Wygrecka, M
Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores.
Matrix Biol. 2020; 88:69-88
Doi: 10.1016/j.matbio.2019.12.001
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** Birnhuber, A; Egemnazarov, B; Biasin, V; Bonyadi Rad, E; Wygrecka, M; Olschewski, H; Kwapiszewska, G; Marsh, LM
CDK4/6 inhibition enhances pulmonary inflammatory infiltration in bleomycin-induced lung fibrosis.
Respir Res. 2020; 21(1):167-167
Doi: 10.1186/s12931-020-01433-w
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** Biasin, V; Crnkovic, S; Sahu-Osen, A; Birnhuber, A; El Agha, E; Sinn, K; Klepetko, W; Olschewski, A; Bellusci, S; Marsh, LM; Kwapiszewska, G
PDGFRa and aSMA mark two distinct mesenchymal cell populations involved in parenchymal and vascular remodeling in pulmonary fibrosis.
EUR RESPIR J. 2020; 56:
Doi: 10.1183/13993003.congress-2020.3374
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** Birnhuber, A; Crnkovic, S; Marsh, LM; Biasin, V; Wilhelm, J; Graninger, W; Olschewski, A; Olschewski, H; Kwapiszewska, G
Exacerbated Lung Function and Eosinophilic Inflammation After Blockage of Innate Immune Signalling in a Mouse Model of Systemic Sclerosis-Associated Lung Fibrosis.
AM J RESP CRIT CARE. 2020; 201: -International Conference of the American-Thoracic-Society; 2020; ELECTR NETWORK.
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** Birnhuber, A; Crnkovic, S; Marsh, LM; Biasin, V; Wilhelm, J; Olschewski, H; Kwapiszewska, G
Pirfenidone exacerbates inflammatory influx to the lung in a mouse model of systemic sclerosis.
WIEN KLIN WOCHENSCHR. 2020; 132(19-20):617-618.
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** Birnhuber, A; Egemnazarov, B; Biasin, V; Rad, EB; Olschewski, H; Kwapiszewska, G; Marsh, L
The CDK4/6 inhibitor, palbociclib intensifies pulmonary inflammation in bleomycin-induced lung fibrosis.
EUR RESPIR J. 2020; 56:
Doi: 10.1183/13993003.congress-2020.2285
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** Crnkovic, S; Biasin, V; Osen, AS; Birnhuber, A; El Agha, E; Sinn, K; Klepetko, W; Olschewski, A; Bellusci, S; Marsh, LM; Kwapiszewska, G
Compartment-Specific Remodeling in Pulmonary Fibrosis Is Characterized by Involvement of Two Distinct Mesenchymal Cell Lineages.
AM J RESP CRIT CARE. 2020; 201: -International Conference of the American-Thoracic-Society; 2020; ELECTR NETWORK.
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** Valzano, F; Birnhuber, A; Marsh, L; Morley, M; Gschwandtner, E; Klepetko, W; Olschewski, H; Morrisey, E; Crnkovic, S; Kwapiszewska, G
Changes in pulmonary artery endothelial cell composition in pulmonary hypertension.
WIEN KLIN WOCHENSCHR. 2020; 132(19-20): 618-619.
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** Birnhuber, A; Crnkovic, S; Biasin, V; Marsh, LM; Odler, B; Sahu-Osen, A; Stacher-Priehse, E; Brcic, L; Schneider, F; Cikes, N; Ghanim, B; Klepetko, W; Graninger, W; Allanore, Y; Eferl, R; Olschewski, A; Olschewski, H; Kwapiszewska, G
IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis.
Eur Respir J. 2019; 54(3):
Doi: 10.1183/13993003.00154-2019
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** Zucker, MM; Wujak, L; Gungl, A; Didiasova, M; Kosanovic, D; Petrovic, A; Klepetko, W; Schermuly, RT; Kwapiszewska, G; Schaefer, L; Wygrecka, M
LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension.
Biochim Biophys Acta Mol Basis Dis. 2019; 1865(6):1604-1616
Doi: 10.1016/j.bbadis.2019.03.012
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** Birnhuber, A; Biasin, V; Schnoegl, D; Marsh, LM; Kwapiszewska, G
Transcription factor Fra-2 and its emerging role in matrix deposition, proliferation and inflammation in chronic lung diseases.
Cell Signal. 2019; 64:109408-109408
Doi: 10.1016/j.cellsig.2019.109408
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** Birnhuber, A; Crnkovic, S; Marsh, LM; Biasin, V; Graninger, W; Olschewski, A; Olschewski, H; Kwapiszewska, G
Targeting innate immunity exacerbates inflammation and pulmonary fibrosis in a systemic sclerosis-associated lung disease model
WIEN KLIN WOCHENSCHR. 2019; 131(19-20):512-512.
[Oral Communication]
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** Kwapiszewska, G; Gungl, A; Wilhelm, J; Marsh, LM; Puthenparampil, HT; Sinn, K; Didiasova, M; Klepetko, W; Kosanovic, D; Schermuly, RT; Wujak, L; Weiss, B; Schaefer, L; Schneider, M; Kreuter, M; Olschewski, A; Seeger, W; Olschewski, H; Wygrecka, M
Transcriptome profiling reveals the complexity of pirfenidone effects in IPF
EUR RESPIR J. 2019; 54: -European-Respiratory-Society (ERS) International Congress; SEP 28-OCT 02, 2019; Madrid, SPAIN.
Doi: 10.1183/13993003.congress-2019.PA1280
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** Zucker, MM; Wujak, L; Gungl, A; Didiasova, M; Kosanovic, D; Schermuly, R; Petrovic, A; Klepetko, W; Kwapiszewska, G; Schafer, L; Wygrecka, M
LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension
INTERNIST. 2019; 60: S48-S48.
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** Gungl, A; Biasin, V; Wilhelm, J; Olschewski, A; Kwapiszewska, G; Marsh, LM
Fra2 Overexpression in Mice Leads to Non-allergic Asthma Development in an IL-13 Dependent Manner.
Front Immunol. 2018; 9(10):2018-2018
Doi: 10.3389/fimmu.2018.02018
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** Kwapiszewska, G; Gungl, A; Wilhelm, J; Marsh, LM; Thekkekara Puthenparampil, H; Sinn, K; Didiasova, M; Klepetko, W; Kosanovic, D; Schermuly, RT; Wujak, L; Weiss, B; Schaefer, L; Schneider, M; Kreuter, M; Olschewski, A; Seeger, W; Olschewski, H; Wygrecka, M
Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis.
Eur Respir J. 2018; 52(5):
Doi: 10.1183/13993003.00564-2018
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** Odler, B; Foris, V; Gungl, A; Müller, V; Hassoun, PM; Kwapiszewska, G; Olschewski, H; Kovacs, G
Biomarkers for Pulmonary Vascular Remodeling in Systemic Sclerosis: A Pathophysiological Approach.
FRONT PHYSIOL. 2018; 9: 587-587.
Doi: 10.3389/fphys.2018.00587
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** Gungl, A; Biasin, V; Slaven, C; Marsh, LM; Kwapiszewska, G; Olschewski, H
Eosinophilic inflammation and worsening of lung function upon pirfenidone treatment in Fra-2 transgenic mice
EUR RESPIR J. 2018; 52: -28th International Congress of the European-Respiratory-Society (ERS); SEP 15-19, 2018; Paris, FRANCE.
Doi: 10.1183/13993003.congress-2018.PA997
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** Gungl, A; Slaven, C; Biasin, V; Marsh, LM; Odler, B; Sahu-Osen, A; Brcic, L; Ghanim, B; Klepetko, W; Graninger, W; Olschewski, A; Olschewski, H; Kwapiszewska, G
Blockade of IL-1 signalling exacerbates Th2 inflammation in the Fra-2 transgenic mouse model of systemic sclerosis
WIEN KLIN WOCHENSCHR. 2018; 130(19-20):605-606.
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** Marsh, LM; Gungl, A; Biasin, V; Olschewski, A; Kwapiszewska, G
AP-1 Subunit Overexpression Drives a Non-Allergic Asthma Phenotype in Mice
American Journal of Respiratory and Critical Care Medicine 2018;197:A1299. 2018; 197: -ATS 2018; May 18-23, 2018; San Diego, USA.
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** Gungl, A; Crnkovic, S; Biasin, V; Marsh, LM; Sahu-Osen, A; Stacher-Priehse, E; Brcic, L; Schneider, F; Cikes, N; Ghanim, B; Klepetko, W; Odler, B; Kovacs, G; Eferl, R; Olschewski, H; Olschewski, A; Kwapiszewska, G
Fos-Related Antigen 2 (fra-2)-Driven Interleukin-1 Expression Leads To Pulmonary Remodelling Via Interleukin-6 And Tenascin C In Systemic Sclerosis
AM J RESP CRIT CARE. 2017; 195: -International Conference of the American-Thoracic-Society (ATS); MAY 19-24, 2017; Washington, USA.
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** Biasin, V; Gungl, A; Marsh, LM; Crnkovic, S; Oslchewski, A; Kwapiszewska, G
Female prevalence in systemic sclerosis is mirrored in Fra-2 over-expressing mice
WIEN KLIN WOCHENSCHR. 2016; 128(19-20):763-763.
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** Gungl, A; Crnkovic, S; Biasin, V; Marsh, L; Sahu-Osen, A; Stacher-Priehse, E; Brcic, L; Schneider, F; Cikes, N; Ghanim, B; Klepetko, W; Odler, B; Kovacs, G; Eferl, R; Olschewski, H; Olschewski, A; Kwapiszewska, G
Fra-2 induces IL-1/IL-6-driven parenchymal and vascular remodelling in systemic sclerosis
WIEN KLIN WOCHENSCHR. 2016; 128(19-20):762-763.
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** Biasin, V; Wygrecka, M; Gungl, A; Ghanim, B; Klepetko, W; Marsh, LM; Olschewski, A; Kwapiszewska, G
Involvement of the proteases meprins in human lung fibrosis
WIEN KLIN WOCHENSCHR. 2015; 127(19-20):817-818.
[Oral Communication]
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** Loibl, M; Klein, I; Prattes, M; Schmidt, C; Kappel, L; Zisser, G; Gungl, A; Krieger, E; Pertschy, B; Bergler, H
The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1.
J Biol Chem. 2014; 289(7): 3913-3922.
Doi: 10.1074/jbc.M113.536110
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