Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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** = Publikationen gelistet in SCI/SSCI/Pubmed

2024

Originalarbeit (Zeitschrift)

** Lohberger, B; Barna, S; Glänzer, D; Eck, N; Leithner, A; Georg, D DNA-PKcs Inhibition Sensitizes Human Chondrosarcoma Cells to Carbon Ion Irradiation via Cell Cycle Arrest and Telomere Capping Disruption.
Int J Mol Sci. 2024; 25(11): 6179 Doi: 10.3390/ijms25116179 [OPEN ACCESS]
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2023

Originalarbeit (Zeitschrift)

** Etschmaier, V; Glänzer, D; Eck, N; Schäfer, U; Leithner, A; Georg, D; Lohberger, B Proton and Carbon Ion Irradiation Changes the Process of Endochondral Ossification in an Ex Vivo Femur Organotypic Culture Model.
Cells. 2023; 12(18): 2301 Doi: 10.3390/cells12182301 [OPEN ACCESS]
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** Lohberger, B; Glänzer, D; Eck, N; Stasny, K; Falkner, A; Leithner, A; Georg, D The ATR Inhibitor VE-821 Enhances the Radiosensitivity and Suppresses DNA Repair Mechanisms of Human Chondrosarcoma Cells.
Int J Mol Sci. 2023; 24(3): Doi: 10.3390/ijms24032315 [OPEN ACCESS]
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** Lohberger, B; Kaltenegger, H; Eck, N; Glänzer, D; Leithner, A; Kretschmer, N The Biological Assessment of Shikonin and β,β-dimethylacrylshikonin Using a Cellular Myxofibrosarcoma Tumor Heterogeneity Model.
Int J Mol Sci. 2023; 24(21): Doi: 10.3390/ijms242115910 [OPEN ACCESS]
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2022

Originalarbeit (Zeitschrift)

** Lohberger, B; Barna, S; Glänzer, D; Eck, N; Kerschbaum-Gruber, S; Stasny, K; Leithner, A; Georg, D Cellular and Molecular Biological Alterations after Photon, Proton, and Carbon Ions Irradiation in Human Chondrosarcoma Cells Linked with High-Quality Physics Data.
Int J Mol Sci. 2022; 23(19): Doi: 10.3390/ijms231911464 [OPEN ACCESS]
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** Lohberger, B; Glänzer, D; Kaltenegger, H; Eck, N; Leithner, A; Bauer, R; Kretschmer, N; Steinecker-Frohnwieser, B Shikonin derivatives cause apoptosis and cell cycle arrest in human chondrosarcoma cells via death receptors and MAPK regulation.
BMC Cancer. 2022; 22(1):758 Doi: 10.1186/s12885-022-09857-x [OPEN ACCESS]
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** Lohberger, B; Kaltenegger, H; Eck, N; Glänzer, D; Sadoghi, P; Leithner, A; Bauer, R; Kretschmer, N; Steinecker-Frohnwieser, B Shikonin Derivatives Inhibit Inflammation Processes and Modulate MAPK Signaling in Human Healthy and Osteoarthritis Chondrocytes.
Int J Mol Sci. 2022; 23(6): Doi: 10.3390/ijms23063396 [OPEN ACCESS]
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** Paulitsch-Fuchs, AH; Bödendorfer, B; Wolrab, L; Eck, N; Dyer, NP; Lohberger, B Effect of Cobalt-Chromium-Molybdenum Implant Surface Modifications on Biofilm Development of S. aureus and S. epidermidis.
Front Cell Infect Microbiol. 2022; 12: 837124 Doi: 10.3389/fcimb.2022.837124 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Lohberger, B; Kaltenegger, H; Eck, N; Glanzer, D; Leithner, A; Bauer, R; Kretschmer, N; Steinecker-Frohnwieser, B THE SUPPRESSION OF INFLAMMATORY PROCESSES AND MODULATION OF MAPK SIGNALING BY SHIKONIN DERIVATIVES IN PRIMARY OA CHONDROCYTES
ANN RHEUM DIS. 2022; 81: 1159-1159. Doi: 10.1136/annrheumdis-2022-eular.1544 [Poster]
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2021

Originalarbeit (Zeitschrift)

** Lohberger, B; Eck, N; Glaenzer, D; Kaltenegger, H; Leithner, A Surface Modifications of Titanium Aluminium Vanadium Improve Biocompatibility and Osteogenic Differentiation Potential.
Materials (Basel). 2021; 14(6): Doi: 10.3390/ma14061574 [OPEN ACCESS]
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** Lohberger, B; Glaenzer, D; Eck, N; Steinecker-Frohnwieser, B; Leithner, A; Rinner, B; Kerschbaum-Gruber, S; Georg, D Effects of a combined therapy of bortezomib and ionizing radiation on chondrosarcoma three-dimensional spheroid cultures.
Oncol Lett. 2021; 21(6): 428-428. Doi: 10.3892/ol.2021.12689 [OPEN ACCESS]
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** Lohberger, B; Glänzer, D; Eck, N; Kerschbaum-Gruber, S; Mara, E; Deycmar, S; Madl, T; Kashofer, K; Georg, P; Leithner, A; Georg, D Activation of efficient DNA repair mechanisms after photon and proton irradiation of human chondrosarcoma cells.
Sci Rep. 2021; 11(1): 24116 Doi: 10.1038/s41598-021-03529-9 [OPEN ACCESS]
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** Paulitsch-Fuchs, AH; Wolrab, L; Eck, N; Dyer, NP; Bödendorfer, B; Lohberger, B TiAl6V4 Alloy Surface Modifications and Their Impact on Biofilm Development of S. aureus and S. epidermidis.
J Funct Biomater. 2021; 12(2): Doi: 10.3390/jfb12020036 [OPEN ACCESS]
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** Schadler, P; Lohberger, B; Stündl, N; Stradner, MH; Glänzer, D; Sadoghi, P; Leithner, A; Steinecker-Frohnwieser, B The Effect of Body Mass Index and Metformin on Matrix Gene Expression in Arthritic Primary Human Chondrocytes.
Cartilage. 2021; 13(2_suppl):1004S-1018S Doi: 10.1177/1947603520962558 [OPEN ACCESS]
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** Steinecker-Frohnwieser, B; Lohberger, B; Eck, N; Mann, A; Kratschmann, C; Leithner, A; Kullich, W; Weigl, L Nuclear Magnetic Resonance Therapy Modulates the miRNA Profile in Human Primary OA Chondrocytes and Antagonizes Inflammation in Tc28/2a Cells.
Int J Mol Sci. 2021; 22(11): 5959 Doi: 10.3390/ijms22115959 [OPEN ACCESS]
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2020

Originalarbeit (Zeitschrift)

** Krukiewicz, K; Putzer, D; Stuendl, N; Lohberger, B; Awaja, F Enhanced Osteogenic Differentiation of Human Primary Mesenchymal Stem and Progenitor Cultures on Graphene Oxide/Poly(methyl methacrylate) Composite Scaffolds.
Materials (Basel). 2020; 13(13): 2991 Doi: 10.3390/ma13132991 [OPEN ACCESS]
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** Lohberger, B; Bernhart, E; Stuendl, N; Glaenzer, D; Leithner, A; Rinner, B; Bauer, R; Kretschmer, N Periplocin mediates TRAIL-induced apoptosis and cell cycle arrest in human myxofibrosarcoma cells via the ERK/p38/JNK pathway.
Phytomedicine. 2020; 76: 153262-153262. Doi: 10.1016/j.phymed.2020.153262 [OPEN ACCESS]
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** Lohberger, B; Eck, N; Glaenzer, D; Lichtenegger, H; Ploszczanski, L; Leithner, A Cobalt Chromium Molybdenum Surface Modifications Alter the Osteogenic Differentiation Potential of Human Mesenchymal Stem Cells.
Materials (Basel). 2020; 13(19): Doi: 10.3390/ma13194292 [OPEN ACCESS]
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** Lohberger, B; Stuendl, N; Glaenzer, D; Rinner, B; Donohue, N; Lichtenegger, HC; Ploszczanski, L; Leithner, A CoCrMo surface modifications affect biocompatibility, adhesion, and inflammation in human osteoblasts.
Sci Rep. 2020; 10(1): 1682-1682. Doi: 10.1038/s41598-020-58742-9 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Lohberger, B; Stuendl, N; Glaenzer, D; Leithner, A; Steinecker-Frohnwieser, B COBALD CHROMIUM MOLYBDENUM SURFACE MODIFICATIONS ALTER THE OSTEOGENIC DIFFERENTIATION POTENTIAL OF HUMAN MESENCHYMAL STEM CELLS
OSTEOPOROSIS INT. Abstracts. 2020; 31(SUPPL 1):S520-S520.-WCO-IOF-ESCEO 2020 -World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases; AUG 20-22, 2020; Virtuell. [Poster]
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2019

Originalarbeit (Zeitschrift)

** Lohberger, B; Kaltenegger, H; Weigl, L; Mann, A; Kullich, W; Stuendl, N; Leithner, A; Steinecker-Frohnwieser, B Mechanical exposure and diacerein treatment modulates integrin-FAK-MAPKs mechanotransduction in human osteoarthritis chondrocytes.
Cell Signal. 2019; 56(2):23-30 Doi: 10.1016/j.cellsig.2018.12.010 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Lohberger, B; Weigl, L; Stuendl, N; Mann, A; Leithner, A; Kullich, W; Steinecker-Frohnwieser, B CHANGES IN THE MIRNA PROFILE AND HYPOXIC BEHAVIOUR OF HUMAN CHONDROCYTES BY THERAPEUTIC NUCLEAR MAGNETIC RESONANCE THERAPY (NMRT)
ANN RHEUM DIS. 2019; 78: 1514-1514. Doi: 10.1136/annrheumdis-2019-eular.7855 [Poster] [OPEN ACCESS]
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2018

Originalarbeit (Zeitschrift)

** Lohberger, B; Wagner, S; Wohlmuther, J; Kaltenegger, H; Stuendl, N; Leithner, A; Rinner, B; Kunert, O; Bauer, R; Kretschmer, N Periplocin, the most anti-proliferative constituent of Periploca sepium, specifically kills liposarcoma cells by death receptor mediated apoptosis.
Phytomedicine. 2018; 51:162-170 Doi: 10.1016/j.phymed.2018.10.008
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2017

Originalarbeit (Zeitschrift)

** Bernhart, E; Stuendl, N; Kaltenegger, H; Windpassinger, C; Donohue, N; Leithner, A; Lohberger, B Histone deacetylase inhibitors vorinostat and panobinostat induce G1 cell cycle arrest and apoptosis in multidrug resistant sarcoma cell lines.
Oncotarget. 2017; 8(44):77254-77267 Doi: 10.18632/oncotarget.20460 [OPEN ACCESS]
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** Heitzer, E; Sunitsch, S; Gilg, MM; Lohberger, B; Rinner, B; Kashofer, K; Stündl, N; Ulz, P; Szkandera, J; Leithner, A; Liegl-Atzwanger, B Expanded molecular profiling of myxofibrosarcoma reveals potentially actionable targets.
Mod Pathol. 2017; 30(12):1698-1709 Doi: 10.1038/modpathol.2017.94 [OPEN ACCESS]
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** Lohberger, B; Stuendl, N; Leithner, A; Rinner, B; Sauer, S; Kashofer, K; Liegl-Atzwanger, B Establishment of a novel cellular model for myxofibrosarcoma heterogeneity.
Sci Rep. 2017; 7(9):44700-44700 Doi: 10.1038/srep44700 [OPEN ACCESS]
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2016

Originalarbeit (Zeitschrift)

** Lohberger, B; Kaltenegger, H; Stuendl, N; Rinner, B; Leithner, A; Sadoghi, P Impact of cyclic mechanical stimulation on the expression of extracellular matrix proteins in human primary rotator cuff fibroblasts.
Knee Surg Sports Traumatol Arthrosc. 2016; 24(12):3884-3891 Doi: 10.1007/s00167-015-3790-6 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Lohberger, B; Leithner, A; Stuendl, N; Kaltenegger, H; Kullich, W; Steinecker-Frohnwieser, B DIACEREIN RETARDS CELL GROWTH OF CHONDROSARCOMA CELLS AT THE G2/M CELL CYCLE CHECKPOINT VIA CYCLIN B1/CDK1 AND CDK2 DOWNREGULATION
OSTEOPOROSIS INT. 2016; 27: S142-S142. [Poster]
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2015

Originalarbeit (Zeitschrift)

** Lohberger, B; Kretschmer, N; Bernhart, E; Rinner, B; Stuendl, N; Kaltenegger, H; Kahl, S; Bauer, R; Leithner, A 25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.
J Ethnopharmacol. 2015; 164(36):265-272 Doi: 10.1016/j.jep.2015.02.023
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** Lohberger, B; Leithner, A; Stuendl, N; Kaltenegger, H; Kullich, W; Steinecker-Frohnwieser, B Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation.
BMC Cancer. 2015; 15(3):891-891 Doi: 10.1186/s12885-015-1915-4 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Kretschmer, N; Lohberger, B; Bernhart, E; Rinner, B; Stuendl, N; Kaltenegger, H; Kahl, S; Bauer, R; Leithner, A Effects of 25-O-acetyl-23,24-dihydro-cucurbitacin F on cell viability, cell cycle distribution and apoptosis induction in human soft tissue sarcoma cells
PLANTA MED. . 2015; 81(16):1482-1482.-63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA); AUG 23-27, 2015; Budapest, HUNGARY. [Oral Communication]
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2014

Originalarbeit (Zeitschrift)

** Lohberger, B; Kaltenegger, H; Stuendl, N; Payer, M; Rinner, B; Leithner, A Effect of cyclic mechanical stimulation on the expression of osteogenesis genes in human intraoral mesenchymal stromal and progenitor cells.
Biomed Res Int. 2014; 2014(Pt 13):189516-189516 Doi: 10.1155/2014/189516 [OPEN ACCESS]
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2013

Originalarbeit (Zeitschrift)

** Lohberger, B; Rinner, B; Stuendl, N; Kaltenegger, H; Steinecker-Frohnwieser, B; Bernhart, E; Bonyadi Rad, E; Weinberg, AM; Leithner, A; Bauer, R; Kretschmer, N Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells.
PLoS One. 2013; 8(6):e66300-e66300 Doi: 10.1371/journal.pone.0066300 [OPEN ACCESS]
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** Lohberger, B; Stuendl, N; Wolf, E; Liegl-Atzwanger, B; Leithner, A; Rinner, B The novel myxofibrosarcoma cell line MUG-Myx1 expresses a tumourigenic stem-like cell population with high aldehyde dehydrogenase 1 activity.
BMC Cancer. 2013; 13(1):563-563 Doi: 10.1186/1471-2407-13-563 [OPEN ACCESS]
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2012

Originalarbeit (Zeitschrift)

** Kretschmer, N; Rinner, B; Stuendl, N; Kaltenegger, H; Wolf, E; Kunert, O; Boechzelt, H; Leithner, A; Bauer, R; Lohberger, B Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells.
Planta Med. 2012; 78(16):1749-1756 Doi: 10.1055/s-0032-1315385 [OPEN ACCESS]
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** Lohberger, B; Rinner, B; Stuendl, N; Absenger, M; Liegl-Atzwanger, B; Walzer, SM; Windhager, R; Leithner, A Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma.
PLoS One. 2012; 7(8):e43664-e43664 Doi: 10.1371/journal.pone.0043664 [OPEN ACCESS]
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