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** = Publications listed in SCI/SSCI/Pubmed

2025

Full paper/article (Journal)

** Gruden, E; Kienzl, M; Danner, L; Kaspret, DM; Pammer, A; Ristic, D; Kindler, O; Doyle, AD; Wright, BL; Taschler, U; Thomas, D; Gurke, R; Baumann-Durchschein, F; Konrad, J; Blesl, A; Schlager, H; Bärnthaler, T; Kargl, J; Schicho, R The endocannabinoid system drives eosinophil infiltration during eosinophilic esophagitis.
Cell Mol Gastroenterol Hepatol. 2025; 101515 Doi: 10.1016/j.jcmgh.2025.101515
PubMed FullText FullText_MUG

 

** Ristić, D; Bärnthaler, T; Gruden, E; Kienzl, M; Danner, L; Herceg, K; Sarsembayeva, A; Kargl, J; Schicho, R GPR55 in the tumor microenvironment of pancreatic cancer controls tumorigenesis.
Front Immunol. 2024; 15: 1513547 Doi: 10.3389/fimmu.2024.1513547 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Zotta, A; Toller-Kawahisa, J; Palsson-McDermott, EM; O'Carroll, SM; Henry, ÓC; Day, EA; McGettrick, AF; Ward, RW; Ryan, DG; Watson, MA; Brand, MD; Runtsch, MC; Maitz, K; Lueger, A; Kargl, J; Miljkovic, JL; Lavelle, EC; O'Neill, LAJ Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion.
Sci Adv. 2025; 11(4):eadq7307 Doi: 10.1126/sciadv.adq7307 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

2024

Full paper/article (Journal)

** Gruden, E; Kienzl, M; Ristic, D; Kindler, O; Kaspret, DM; Schmid, ST; Kargl, J; Sturm, E; Doyle, AD; Wright, BL; Baumann-Durchschein, F; Konrad, J; Blesl, A; Schlager, H; Schicho, R Mononuclear cell composition and activation in blood and mucosal tissue of eosinophilic esophagitis.
Front Immunol. 2024; 15: 1347259 Doi: 10.3389/fimmu.2024.1347259 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Kienzl, M; Maitz, K; Sarsembayeva, A; Valadez-Cosmes, P; Gruden, E; Ristic, D; Herceg, K; Kargl, J; Schicho, R Comparative Study of the Immune Microenvironment in Heterotopic Tumor Models.
Cancers (Basel). 2024; 16(2): Doi: 10.3390/cancers16020295 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Lyssy, F; Forstner, D; Brugger, BA; Ujčič, K; Guettler, J; Kupper, N; Wernitznig, S; Daxboeck, C; Neuper, L; El-Heliebi, A; Kloimboeck, T; Kargl, J; Huppertz, B; Ghaffari-Tabrizi-Wizsy, N; Gauster, M The chicken chorioallantoic membrane assay revisited - A face-lifted approach for new perspectives in placenta research.
Placenta. 2024; Doi: 10.1016/j.placenta.2024.04.013
PubMed FullText FullText_MUG

 

** Mildner, FO; Sykora, MM; Hackl, H; Amann, A; Zelger, B; Sprung, S; Buch, ML; Nocera, F; Moser, P; Maier, H; Augustin, F; Manzl, C; Kocher, F; Pircher, A; Lindenmann, J; Mykoliuk, I; Raftopoulou, S; Kargl, J; Wolf, D; Sopper, S; Gamerith, G Soluble PD-L1 shows no association to relapse and overall survival in early stage non-small cell lung cancer (NSCLC).
Lung Cancer. 2024; 196: 107955 Doi: 10.1016/j.lungcan.2024.107955
Web of Science PubMed FullText FullText_MUG

 

Review

** Santiso, A; Heinemann, A; Kargl, J Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4.
Pharmacol Rev. 2024; 76(3): 388-413. Doi: 10.1124/pharmrev.123.000901
Web of Science PubMed FullText FullText_MUG

 

Abstract (Journal)

** Cosic-Mujkanovic, N; Valadez-Cosmes, P; Maitz, K; Lueger, A; Mihalic, ZN; Runtsch, MC; Kienzl, M; Heinemann, A; Schicho, R; Marsche, G; Kargl, J THE ROLE OF NEUTROPHIL-DERIVED MYELOPEROXIDASE (MPO) IN NON-SMALL CELL LUNG CANCER METASTASIS
FREE RADICAL BIO MED. 2024; 218: 7-7.-Annual Meeting of the Society-for-Free-Radical-Research-Europe (SFRR-E); JUN 05-07, 2024; Istanbul, TURKEY. Doi: 10.1016/j.freeradbiomed.2024.04.032 [Poster]
Web of Science FullText FullText_MUG

 

** Lueger, A; Valadez-Cosmes, P; Maitz, K; Mujkanovic, NC; Kindler, O; Runtsch, M; Kargl, J Myeloperoxidase alters T cell function and plays an immunosuppressive role in non-small cell lung cancer
EUR J IMMUNOL. 2024; 54: 1593-1593.-7th European Conference of Immunology; SEP 01-04, 2024; Dublin, IRELAND. [Poster]
Web of Science

 

** Mihalic, Z; Kindler, O; Hoebler, AL; Wadsack, C; Pollheimer, J; Kargl, J NEUTROPHIL DYNAMICS IN EARLY PLACENTAL DEVELOPMENT: REGULATORS OF TROPHOBLAST INVASION?
PLACENTA. 2024; 154: E76-E77. [Poster]
Web of Science

 

** Runtsch, M; Kindler, O; Eichmann, T; Santiso, A; Maitz, K; Brcic, L; Lindenmann, J; Kargl, J The tumor microenvironment drives mitochondrial metabolic reprogramming in neutrophils during non-small cell lung cancer
EUR J IMMUNOL. 2024; 54: 176-176.-7th European Conference of Immunology; SEP 01-04, 2024; Dublin, IRELAND. [Oral Communication]
Web of Science

 

** Santiso, A; Kindler, O; Zhu, XD; Raftopoulou, S; Klymiuk, I; Maitz, K; Mihalic, Z; Houghton, AM; Kargl, J To B or not to B in NSCLC: Functional characterisation of tumor infiltrating B cells in NSCLC
EUR J IMMUNOL. 2024; 54: 1590-1590. [Poster]
Web of Science

 

** Zotta, A; O'Carroll, S; Palsson-McDermott, E; Toller-Kawahisa, J; Day, E; Ward, RW; Ryan, D; Runtsch, M; Maitz, K; Lueger, A; Kargl, J; Watson, M; Brand, M; Lavelle, E; O'Neill, L Mitochondrial respiratory complex III sustains IL-10 production in macrophages and promotes tumor-mediated immune evasion
EUR J IMMUNOL. 2024; 54: 181-181.-7th European Conference of Immunology; SEP 01-04, 2024; Dublin, IRELAND. [Oral Communication]
Web of Science

 

2023

Full paper/article (Journal)

** Cosic-Mujkanovic, N; Valadez-Cosmes, P; Maitz, K; Lueger, A; Mihalic, ZN; Runtsch, MC; Kienzl, M; Davies, MJ; Chuang, CY; Heinemann, A; Schicho, R; Marsche, G; Kargl, J Myeloperoxidase Alters Lung Cancer Cell Function to Benefit Their Survival.
Antioxidants (Basel). 2023; 12(8): Doi: 10.3390/antiox12081587 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Gruden, E; Kienzl, M; Hasenoehrl, C; Sarsembayeva, A; Ristic, D; Schmid, ST; Maitz, K; Taschler, U; Hahnefeld, L; Gurke, R; Thomas, D; Kargl, J; Schicho, R Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles.
Prostaglandins Leukot Essent Fatty Acids. 2023; 196: 102585 Doi: 10.1016/j.plefa.2023.102585
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** Maitz, K; Valadez-Cosmes, P; Raftopoulou, S; Kindler, O; Kienzl, M; Bolouri, H; Houghton, AM; Schicho, R; Heinemann, A; Kargl, J Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma.
Cancers (Basel). 2023; 15(24): 5767 Doi: 10.3390/cancers15245767 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Mihalic, ZN; Kloimböck, T; Cosic-Mujkanovic, N; Valadez-Cosmes, P; Maitz, K; Kindler, O; Wadsack, C; Heinemann, A; Marsche, G; Gauster, M; Pollheimer, J; Kargl, J Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells.
Redox Biol. 2023; 67:102885 Doi: 10.1016/j.redox.2023.102885 [OPEN ACCESS]
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** Sarsembayeva, A; Kienzl, M; Gruden, E; Ristic, D; Maitz, K; Valadez-Cosmes, P; Santiso, A; Hasenoehrl, C; Brcic, L; Lindenmann, J; Kargl, J; Schicho, R Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8+ T and NK cells.
Front Immunol. 2022; 13:997115 Doi: 10.3389/fimmu.2022.997115 [OPEN ACCESS]
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** Stadler, JT; Habisch, H; Prüller, F; Mangge, H; Bärnthaler, T; Kargl, J; Pammer, A; Holzer, M; Meissl, S; Rani, A; Madl, T; Marsche, G HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function.
Antioxidants (Basel). 2023; 12(11): Doi: 10.3390/antiox12112009 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Vondra, S; Hobler, AL; Lackner, AI; Raffetseder, J; Mihalic, ZN; Vogel, A; Saleh, L; Kunihs, V; Haslinger, P; Wahrmann, M; Husslein, H; Oberle, R; Kargl, J; Haider, S; Latos, P; Schabbauer, G; Knofler, M; Ernerudh, J; Pollheimer, J The human placenta shapes the phenotype of decidual macrophages
CELL REP. 2023; 42(1): 111977 Doi: 10.1016/j.celrep.2022.111977
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Abstract (Journal)

** Krivic, D; Bacsa, B; Maitz, KS; Graziani, A; Kargl, J; Groschner, K Photopharmacological dissociation of transcriptional activation and degranulation of mast cells
BIOPHYS J. 2023; 122(3): 256A-256A. [Poster]
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** Lueger, A; Valadez-Cosmes, P; Maitz, K; Cosic, N; Kindler, O; Runtsch, M; Kargl, J MYELOPEROXIDASE ALTERS T CELL FUNCTION AND PLAYS AN IMMUNOSUPPRESSIVE ROLE IN NON-SMALL CELL LUNG CANCER
FREE RADICAL BIO MED. 2023; 201: 50-50.-Annual Meeting of the Society for Free Radical Research Europe (SFRR E); JUN 06-09, 2023; Vienna, AUSTRIA. Doi: 10.1016/j.freeradbiomed.2023.03.203 [Poster]
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** Mihalic, ZN; Kindler, O; Raftopoulou, S; Santiso, A; Maitz, K; Fostner, D; Lackner, AI; Vondra, S; Hobler, AL; Gauster, M; Pollheimer, J; Kargl, J Neutrophils in Decidua Basalis Have a Distinct Phenotype and Function.
REPROD SCI. 2023; 30: 184A-184A.-70th Annual Meeting of the Society for Reproductive Investigation (SRI); MAR 21-25, 2023; Brisbane, AUSTRALIA.
Web of Science

 

** Mihalic, ZN; Raftopoulou, S; Kindler, O; Sanchez, AS; Maitz, KS; Valadez-Cosmes, P; Lackner, A; Vondra, S; Pollheimer, J; Kargl, J Neutrophil phenotype and function in first trimester pregnancy.
J REPROD IMMUNOL. 2023; 158: -16th Annual Meeting of the European-Society-for-Reproductive-Immunology (ESRI); MAR 29-APR 01, 2022; Paris, FRANCE. Doi: 10.1016/j.jri.2022.103577 [Poster]
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** Mujkanovic, NC; Valadez-Cosmes, P; Maitz, K; Lueger, A; Kindler, O; Marsche, G; Kargl, J MYELOPEROXIDASE IMPACTS LUNG CANCER CELLS AND DRIVES TUMOR PROGRESSION IN NON-SMALL CELL LUNG CANCER
FREE RADICAL BIO MED. 2023; 201: 53-53.-Annual Meeting of the Society for Free Radical Research Europe (SFRR E); JUN 06-09, 2023; Vienna, AUSTRIA. Doi: 10.1016/j.freeradbiomed.2023.03.214 [Poster]
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** Sparovec, TG; Mihalic, ZN; Schoell, W; Tomasch, G; El-Heliebi, A; Kroneis, T; Marteau, V; Trajanoski, Z; Jones, HN; Kargl, J; Gold, D Characterization of the Placental Bed Microenvironment in Placenta Accreta Spectrum Disorders
REPROD SCI. 2023; 30: 103A-103A.-70th Annual Meeting of the Society for Reproductive Investigation (SRI); MAR 21-25, 2023; Brisbane, AUSTRALIA. [Oral Communication]
Web of Science

 

** Valadez-Cosmes, P; Maitz, K; Kindler, O; Mujkanovic, NC; Lueger, A; Runtsch, M; Kargl, J ABILITY OF NEUTROPHILS TO CONSTRAIN IMMUNE RESPONSES AND PROMOTE TUMOUR DEVELOPMENT
FREE RADICAL BIO MED. 2023; 201: 5-6. Doi: 10.1016/j.freeradbiomed.2023.03.047 [Poster]
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2022

Full paper/article (Journal)

** Barth, DA; Stanzer, S; Spiegelberg, J; Bauernhofer, T; Absenger, G; Posch, F; Lipp, R; Halm, M; Szkandera, J; Balic, M; Gerger, A; Smolle, MA; Hutterer, GC; Klec, C; Jost, PJ; Kargl, J; Stradner, M; Pichler, M Evaluation of autoantibodies as predictors of treatment response and immune-related adverse events during the treatment with immune checkpoint inhibitors: A prospective longitudinal pan-cancer study.
Cancer Med. 2022; 11(16):3074-3083 Doi: 10.1002/cam4.4675 [OPEN ACCESS]
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** Barth, DA; Stanzer, S; Spiegelberg, JA; Bauernhofer, T; Absenger, G; Szkandera, J; Gerger, A; Smolle, MA; Hutterer, GC; Ahyai, SA; Madl, T; Posch, F; Riedl, JM; Klec, C; Jost, PJ; Kargl, J; Stradner, MH; Pichler, M Patterns of Peripheral Blood B-Cell Subtypes Are Associated With Treatment Response in Patients Treated With Immune Checkpoint Inhibitors: A Prospective Longitudinal Pan-Cancer Study.
Front Immunol. 2022; 13:840207 Doi: 10.3389/fimmu.2022.840207 [OPEN ACCESS]
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** Gorsek Sparovec, T; Markert, UR; Reif, P; Schoell, W; Moser, G; Feichtinger, J; Mihalic, ZN; Kargl, J; Gargett, CE; Gold, D The fate of human SUSD2+ endometrial mesenchymal stem cells during decidualization.
Stem Cell Res. 2022; 60: 102671 Doi: 10.1016/j.scr.2022.102671
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** Kuentzel, KB; Bradić, I; Mihalič, ZN; Korbelius, M; Rainer, S; Pirchheim, A; Kargl, J; Kratky, D Dysregulation of Placental Lipid Hydrolysis by High-Fat/High-Cholesterol Feeding and Gestational Diabetes Mellitus in Mice.
Int J Mol Sci. 2022; 23(20): 12286 Doi: 10.3390/ijms232012286 [OPEN ACCESS]
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** Prinz, F; Jonas, K; Balihodzic, A; Klec, C; Reicher, A; Barth, DA; Riedl, J; Gerger, A; Kiesslich, T; Mayr, C; Rinner, B; Kargl, J; Pichler, M MicroRNA mimics can distort physiological microRNA effects on immune checkpoints by triggering an antiviral interferon response.
RNA Biol. 2022; 19(1): 1305-1315. Doi: 10.1080/15476286.2022.2152978 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Zhang, H; Zhu, X; Friesen, TJ; Kwak, JW; Pisarenko, T; Mekvanich, S; Velasco, MA; Randolph, TW; Kargl, J; Houghton, AM Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils.
J Clin Invest. 2022; 132(22): Doi: 10.1172/JCI153643 [OPEN ACCESS]
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Review

** Marsche, G; Stadler, JT; Kargl, J; Holzer, M Understanding Myeloperoxidase-Induced Damage to HDL Structure and Function in the Vessel Wall: Implications for HDL-Based Therapies.
Antioxidants (Basel). 2022; 11(3): Doi: 10.3390/antiox11030556 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Raftopoulou, S; Valadez-Cosmes, P; Mihalic, ZN; Schicho, R; Kargl, J Tumor-Mediated Neutrophil Polarization and Therapeutic Implications.
Int J Mol Sci. 2022; 23(6): Doi: 10.3390/ijms23063218 [OPEN ACCESS]
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** Valadez-Cosmes, P; Raftopoulou, S; Mihalic, ZN; Marsche, G; Kargl, J Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target.
Pharmacol Ther. 2022; 236:108052 Doi: 10.1016/j.pharmthera.2021.108052
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Abstract (Journal)

** Kienzl, M; Gruden, E; Sarsembayeva, A; Maitz, K; Ristic, D; Valadez-Cosmes, P; Kargl, J; Schicho, R CRTH2 as a pro-tumorigenic driver in the tumor microenvironment of experimental models of colon cancer
EUR J IMMUNOL. 2022; 52: 281-281.-Joint meeting DFGI & ÖGAI; SEPT 7-10, 2022; Hannover, Germany. [Poster]
Web of Science

 

** Ristic, D; Kienzl, M; Sarsembayeva, A; Gruden, E; Kargl, J; Schicho, R Pro-tumorigenic role of GPR55 in the immune microenvironment of pancreatic cancer
EUR J IMMUNOL. 2022; 52: 291-291.-Joint meeting DFGI & ÖGAI; SEPT 7-10, 2022; Hannover, Germany. [Poster]
Web of Science

 

** Sarsembayeva, A; Kienzl, M; Gruden, E; Ristic, D; Kargl, J; Schicho, R Cannabinoid receptor 2 creates a suppressive tumor immune microenvironment in a mouse model of lung cancer and predicts responsiveness to anti-PD-1 antibody treatment
EUR J IMMUNOL. 2022; 52: 78-79.-Joint meeting DFGI & ÖGAI; SEPT 7-10, 2022; Hannover, Germany. [Oral Communication]
Web of Science FullText

 

** Sparovec, TG; Reif, P; Schoell, W; Markert, UR; Mihalic, ZN; Kargl, J; Gargett, C; Gold, D The Fate of SUSD2+Endometrial Mesenchymal Stem Cells During Decidualization
REPROD SCI. 2022; 29(SUPPL 1):182-182. [Oral Communication]
Web of Science

 

2021

Full paper/article (Journal)

** Abdellatif, M; Trummer-Herbst, V; Koser, F; Durand, S; Adão, R; Vasques-Nóvoa, F; Freundt, JK; Voglhuber, J; Pricolo, MR; Kasa, M; Türk, C; Aprahamian, F; Herrero-Galán, E; Hofer, SJ; Pendl, T; Rech, L; Kargl, J; Anto-Michel, N; Ljubojevic-Holzer, S; Schipke, J; Brandenberger, C; Auer, M; Schreiber, R; Koyani, CN; Heinemann, A; Zirlik, A; Schmidt, A; von Lewinski, D; Scherr, D; Rainer, PP; von Maltzahn, J; Mühlfeld, C; Krüger, M; Frank, S; Madeo, F; Eisenberg, T; Prokesch, A; Leite-Moreira, AF; Lourenço, AP; Alegre-Cebollada, J; Kiechl, S; Linke, WA; Kroemer, G; Sedej, S Nicotinamide for the treatment of heart failure with preserved ejection fraction.
Sci Transl Med. 2021; 13(580): eabd7064 Doi: 10.1126/scitranslmed.abd7064 [OPEN ACCESS]
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** Kienzl, M; Hasenoehrl, C; Maitz, K; Sarsembayeva, A; Taschler, U; Valadez-Cosmes, P; Kindler, O; Ristic, D; Raftopoulou, S; Santiso, A; Bärnthaler, T; Brcic, L; Hahnefeld, L; Gurke, R; Thomas, D; Geisslinger, G; Kargl, J; Schicho, R Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
Oncoimmunology. 2021; 10(1): 1965319 Doi: 10.1080/2162402X.2021.1965319 [OPEN ACCESS]
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** Valadez-Cosmes, P; Maitz, K; Kindler, O; Raftopoulou, S; Kienzl, M; Santiso, A; Mihalic, ZN; Brcic, L; Lindenmann, J; Fediuk, M; Pichler, M; Schicho, R; Houghton, AM; Heinemann, A; Kargl, J Identification of Novel Low-Density Neutrophil Markers Through Unbiased High-Dimensional Flow Cytometry Screening in Non-Small Cell Lung Cancer Patients.
Front Immunol. 2021; 12: 703846 Doi: 10.3389/fimmu.2021.703846 [OPEN ACCESS]
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Review

** Pansy, K; Uhl, B; Krstic, J; Szmyra, M; Fechter, K; Santiso, A; Thüminger, L; Greinix, H; Kargl, J; Prochazka, K; Feichtinger, J; Deutsch, AJ Immune Regulatory Processes of the Tumor Microenvironment under Malignant Conditions.
Int J Mol Sci. 2021; 22(24): Doi: 10.3390/ijms222413311 [OPEN ACCESS]
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** Taheri, M; Barth, DA; Kargl, J; Rezaei, O; Ghafouri-Fard, S; Pichler, M Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function.
Front Immunol. 2021; 12: 756042 Doi: 10.3389/fimmu.2021.756042 [OPEN ACCESS]
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Abstract (Journal)

** Kargl, J Neutrophils predict T-cell depletion and anti-PD1 treatment failure in NSCLC
FEBS OPEN BIO. 2021; 11: 38-38. [Onlinepräsentation]
Web of Science

 

** Mihalic, ZN; Raftopoulou, S; Kindler, O; Santiso Sanchez, A; Maitz, KS; Kern, S; Valadez-Cosmes, P; Kargl, J NEUTROPHIL PHENOTYPE AND FUNCTION IN FIRST TRIMESTER PREGNANCY
PLACENTA. 2021; 112: E23-E23.-International Federation of Placenta Associations; SEP 30-OCT 2, 2021; Amsterdam; NETHERLANDS. [Onlinepräsentation]
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** Mihalic, ZN; Raftopoulou, SN; Santiso Sanchez, A; Maitz, KS; Kindler, O; Valadez-Cosmes, P; Heinemann, A; Wadsack, C; Kargl, J Immune cell composition at the feto-maternal interface in health and disease
J IMMUNOL. 2021; 206: -IMMUNOLOGY2021; MAY 10-15, 2021; USA. [Poster]
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** Valadez-Cosmes, P; Cosic, N; Kienzl, M; Maitz, K; Raftopoulou, S; Houghton, AM; Heinemann, A; Davies, MJ; Kargl, J Exploring the role of neutrophil myeloperoxidase in lung cancer.
CANCER RES. 2021; 81(13):-AACR Annual Meeting; APR 10-15, 2021; Philadelphia, USA. [Onlinepräsentation]
Web of Science

 

2020

Full paper/article (Journal)

** Kienzl, M; Hasenoehrl, C; Valadez-Cosmes, P; Maitz, K; Sarsembayeva, A; Sturm, E; Heinemann, A; Kargl, J; Schicho, R IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils.
ONCOIMMUNOLOGY. 2020; 9(1): 1776059 Doi: 10.1080/2162402X.2020.1776059 [OPEN ACCESS]
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Review

** Kienzl, M; Kargl, J; Schicho, R The Immune Endocannabinoid System of the Tumor Microenvironment.
Int J Mol Sci. 2020; 21(23): Doi: 10.3390/ijms21238929 [OPEN ACCESS]
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2019

Full paper/article (Journal)

** Grill, M; Hasenoehrl, C; Kienzl, M; Kargl, J; Schicho, R Cellular localization and regulation of receptors and enzymes of the endocannabinoid system in intestinal and systemic inflammation.
Histochem Cell Biol. 2019; 151(1):5-20 Doi: 10.1007/s00418-018-1719-0 [OPEN ACCESS]
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** Kargl, J; Zhu, X; Zhang, H; Yang, GHY; Friesen, TJ; Shipley, M; Maeda, DY; Zebala, JA; McKay-Fleisch, J; Meredith, G; Mashadi-Hossein, A; Baik, C; Pierce, RH; Redman, MW; Thompson, JC; Albelda, SM; Bolouri, H; Houghton, AM Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC.
JCI Insight. 2019; 4(24): Doi: 10.1172/jci.insight.130850 [OPEN ACCESS]
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** Lastwika, KJ; Kargl, J; Zhang, Y; Zhu, X; Lo, E; Shelley, D; Ladd, JJ; Wu, W; Kinahan, P; Pipavath, SNJ; Randolph, TW; Shipley, M; Lampe, PD; Houghton, AM Tumor-derived Autoantibodies Identify Malignant Pulmonary Nodules.
Am J Respir Crit Care Med. 2019; 199(10):1257-1266 Doi: 10.1164/rccm.201804-0628OC [OPEN ACCESS]
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** Sroor, HM; Hassan, AM; Zenz, G; Valadez-Cosmes, P; Farzi, A; Holzer, P; El-Sharif, A; Gomaa, FAM; Kargl, J; Reichmann, F Experimental colitis reduces microglial cell activation in the mouse brain without affecting microglial cell numbers.
Sci Rep. 2019; 9(1): 20217-20217. Doi: 10.1038/s41598-019-56859-0 [OPEN ACCESS]
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** Theiler, A; Bärnthaler, T; Platzer, W; Richtig, G; Peinhaupt, M; Rittchen, S; Kargl, J; Ulven, T; Marsh, LM; Marsche, G; Schuligoi, R; Sturm, EM; Heinemann, A Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival.
J Allergy Clin Immunol. 2019; 144(3):764-776 Doi: 10.1016/j.jaci.2019.05.002 [OPEN ACCESS]
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** Veatch, JR; Jesernig, BL; Kargl, J; Fitzgibbon, M; Lee, SM; Baik, C; Martins, R; Houghton, AM; Riddell, SR Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic KRAS and ERBB2 (Her2) Driver Mutations.
CANCER IMMUNOL RES. 2019; 7(6): 910-922. Doi: 10.1158/2326-6066.CIR-18-0402 [OPEN ACCESS]
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Abstract (Journal)

** Pansy, K; Fechter, K; Kargl, J; Wenzl, K; Prochazka, K; Greinix, H; Haybaeck, J; Prokesch, A; Beham-Schmid, C; Feichtinger, J; Neumeister, P; Deutsch, A Nr4a1 is implicated in the regulation of immune checkpoints in aggressive lymphomas
ONCOL RES TREAT. 2019; 42: 135-135. [Oral Communication]
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2018

Full paper/article (Journal)

** Mark, NM; Kargl, J; Busch, SE; Yang, GHY; Metz, HE; Zhang, H; Hubbard, JJ; Pipavath, SNJ; Madtes, DK; Houghton, AM Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non-Small Cell Lung Cancer.
Am J Respir Crit Care Med. 2018; 197(3):325-336 Doi: 10.1164/rccm.201704-0795OC [OPEN ACCESS]
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** Veatch, JR; Lee, SM; Fitzgibbon, M; Chow, IT; Jesernig, B; Schmitt, T; Kong, YY; Kargl, J; Houghton, AM; Thompson, JA; McIntosh, M; Kwok, WW; Riddell, SR Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma.
J CLIN INVEST. 2018; 128(4): 1563-1568. Doi: 10.1172/JCI98689 [OPEN ACCESS]
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Abstract (Journal)

** Fechter, K; Pansy, K; Hauer, A; Kargl, J; Krogsdam, A; Greinix, H; Beham-Schmid, C; Neumeister, P; Prokesch, A; Deutsch, A Nr4a1 has as a tumor suppressive function in Myc-driven lymphomagenesis by altering the tumor microenvironment
ONCOL RES TREAT. 2018; 41: 82-82.-DHGO; Oktober 2018; Wien. [Poster]
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2017

Full paper/article (Journal)

** Amankulor, NM; Kim, Y; Arora, S; Kargl, J; Szulzewsky, F; Hanke, M; Margineantu, DH; Rao, A; Bolouri, H; Delrow, J; Hockenbery, D; Houghton, AM; Holland, EC Mutant IDH1 regulates the tumor-associated immune system in gliomas.
Genes Dev. 2017; 31(8):774-786 Doi: 10.1101/gad.294991.116 [OPEN ACCESS]
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** Kargl, J; Busch, SE; Yang, GH; Kim, KH; Hanke, ML; Metz, HE; Hubbard, JJ; Lee, SM; Madtes, DK; McIntosh, MW; Houghton, AM Neutrophils dominate the immune cell composition in non-small cell lung cancer.
Nat Commun. 2017; 8(5):14381-14381 Doi: 10.1038/ncomms14381 [OPEN ACCESS]
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** Roh-Johnson, M; Shah, AN; Stonick, JA; Poudel, KR; Kargl, J; Yang, GH; di Martino, J; Hernandez, RE; Gast, CE; Zarour, LR; Antoku, S; Houghton, AM; Bravo-Cordero, JJ; Wong, MH; Condeelis, J; Moens, CB Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo.
Dev Cell. 2017; 43(5):549-562 Doi: 10.1016/j.devcel.2017.11.003 [OPEN ACCESS]
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Abstract (Journal)

** Kargl, J; Yang, G; Metz, H; Houghton, AM Neutrophil elastase induces metastatic phenotype in vitro and in vivo
CLIN EXP METASTAS. 2017; 34(8): 506-506.
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2016

Full paper/article (Journal)

** Busch, SE; Hanke, ML; Kargl, J; Metz, HE; MacPherson, D; Houghton, AM Lung Cancer Subtypes Generate Unique Immune Responses.
J Immunol. 2016; 197(11):4493-4503 Doi: 10.4049/jimmunol.1600576 [OPEN ACCESS]
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** Kargl, J; Andersen, L; Hasenöhrl, C; Feuersinger, D; Stančić, A; Fauland, A; Magnes, C; El-Heliebi, A; Lax, S; Uranitsch, S; Haybaeck, J; Heinemann, A; Schicho, R GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis.
Br J Pharmacol. 2016; 173(1):142-154 Doi: 10.1111/bph.13345 [OPEN ACCESS]
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** Metz, HE; Kargl, J; Busch, SE; Kim, KH; Kurland, BF; Abberbock, SR; Randolph-Habecker, J; Knoblaugh, SE; Kolls, JK; White, MF; Houghton, AM Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma.
Proc Natl Acad Sci U S A. 2016; 113(31):8795-8800 Doi: 10.1073/pnas.1601989113 [OPEN ACCESS]
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2015

Full paper/article (Journal)

** Gregory, AD; Kliment, CR; Metz, HE; Kim, KH; Kargl, J; Agostini, BA; Crum, LT; Oczypok, EA; Oury, TA; Houghton, AM Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis.
J Leukoc Biol. 2015; 98(2): 143-152. Doi: 10.1189/jlb.3HI1014-493R [OPEN ACCESS]
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2014

Full paper/article (Journal)

** Balenga, NA; Martínez-Pinilla, E; Kargl, J; Schröder, R; Peinhaupt, M; Platzer, W; Bálint, Z; Zamarbide, M; Dopeso-Reyes, IG; Ricobaraza, A; Pérez-Ortiz, JM; Kostenis, E; Waldhoer, M; Heinemann, A; Franco, R Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling.
Br J Pharmacol. 2014; 171(23):5387-5406 Doi: 10.1111/bph.12850 [OPEN ACCESS]
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2013

Full paper/article (Journal)

** Kargl, J; Brown, AJ; Andersen, L; Dorn, G; Schicho, R; Waldhoer, M; Heinemann, A A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function.
J Pharmacol Exp Ther. 2013; 346(1):54-66 Doi: 10.1124/jpet.113.204180 [OPEN ACCESS]
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** Kargl, J; Haybaeck, J; Stančić, A; Andersen, L; Marsche, G; Heinemann, A; Schicho, R O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms.
J Mol Med (Berl). 2013; 91(4):449-458 Doi: 10.1007/s00109-012-0957-1 [OPEN ACCESS]
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2012

Full paper/article (Journal)

** Kargl, J; Balenga, N; Parzmair, GP; Brown, AJ; Heinemann, A; Waldhoer, M The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55.
J Biol Chem. 2012; 287(53):44234-44248 Doi: 10.1074/jbc.M112.364109 [OPEN ACCESS]
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** Kargl, J; Balenga, NA; Platzer, W; Martini, L; Whistler, JL; Waldhoer, M The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.
Br J Pharmacol. 2012; 165(8):2611-2619 Doi: 10.1111/j.1476-5381.2011.01562.x [OPEN ACCESS]
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2011

Full paper/article (Journal)

** Balenga, NA; Aflaki, E; Kargl, J; Platzer, W; Schröder, R; Blättermann, S; Kostenis, E; Brown, AJ; Heinemann, A; Waldhoer, M GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils.
Cell Res. 2011; 21(10):1452-1469 Doi: 10.1038/cr.2011.60 [OPEN ACCESS]
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Review

** Henstridge, CM; Balenga, NA; Kargl, J; Andradas, C; Brown, AJ; Irving, A; Sanchez, C; Waldhoer, M Minireview: recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55.
Mol Endocrinol. 2011; 25(11): 1835-1848. Doi: 10.1210/me.2011-1197 [OPEN ACCESS]
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Correction

** Balenga, NAB; Aflaki, E; Kargl, J; Platzer, W; Schroder, R; Blattermann, S; Kostenis, E; Brown, AJ; Heinemann, A; Waldhoer, M GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils (vol 21, pg 1452, 2011)
CELL RES. 2011; 21(11): 1641-1641. Doi: 10.1038/cr.2011.169 [OPEN ACCESS]
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2010

Full paper/article (Journal)

** Henstridge, CM; Balenga, NAB; Schroder, R; Kargl, JK; Platzer, W; Martini, L; Arthur, S; Penman, J; Whistler, JL; Kostenis, E; Waldhoer, M; Irving, AJ GPR55 ligands promote receptor coupling to multiple signalling pathways.
BRIT J PHARMACOL. 2010; 160(3): 604-614. Doi: 10.1111/j.1476-5381.2009.00625.x [OPEN ACCESS]
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** Moser, E; Kargl, J; Whistler, JL; Waldhoer, M; Tschische, P G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning g protein-coupled receptors.
PHARMACOLOGY. 2010; 86(1): 22-29. Doi: 10.1159/000314161 [OPEN ACCESS]
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