Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Sedej Simon |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2025

Originalarbeit (Zeitschrift)

** Abdellatif, M; Vasques-Nóvoa, F; Trummer-Herbst, V; Durand, S; Koser, F; Islam, M; Nah, J; Sung, EA; Feng, R; Aprahamian, F; Prokesch, A; Zardoya-Laguardia, P; Sadoshima, J; Diwan, A; Linke, WA; Ferreira, JP; Kroemer, G; Sedej, S Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction.
Eur Heart J. 2025; Doi: 10.1093/eurheartj/ehaf062 [OPEN ACCESS]
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** Büttner, P; Augstein, A; Abdellatif, M; Lourenço, A; Leite-Moreira, A; Falcão-Pires, I; Werner, S; Thiele, H; Sedej, S; Schauer, A; Adams, V Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction.
ESC Heart Fail. 2025; 12(2):1474-1478 Doi: 10.1002/ehf2.15111 [OPEN ACCESS]
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** Byrne, NJ; Koentges, C; Khan, E; Pfeil, K; Sandulescu, R; Bakshi, S; Költgen, C; Vosko, I; Gollmer, J; Rathner, T; Rothf, G; Hoffmann, MM; Odening, KE; Orstmann, H; Potter, LA; Boded, C; Wolf, D; Sourij, H; Ljubojevic-Holzera, S; Wallnera, M; Rainer, PP; Sedej, S; Scherr, D; von Lewinski, D; Wende, AR; Zirlik, A; Bugger, H Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
J MOL CELL CARD PLUS. 2025; 12: 100299 Doi: 10.1016/j.jmccpl.2025.100299
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** Islam, M; Rawnsley, DR; Ma, X; Navid, W; Zhao, C; Guan, X; Foroughi, L; Murphy, JT; Navid, H; Weinheimer, CJ; Kovacs, A; Nigro, J; Diwan, A; Chang, RP; Kumari, M; Young, ME; Razani, B; Margulies, KB; Abdellatif, M; Sedej, S; Javaheri, A; Covey, DF; Mani, K; Diwan, A Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling.
J Clin Invest. 2025; 135(7): Doi: 10.1172/JCI163730 [OPEN ACCESS]
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Kurzbericht/Letter

** Stockner, A; Degli, Innocenti, M; Verma, D; Schmid, S; Fuerlinger, A; Varghese, A; Zirlik, A; Schreiber, R; Breinbauer, R; Abdellatif, M; Sedej, S Inhibition of Adipose Tissue Lipolysis Treats Obesity-Related HFpEF.
Circ Res. 2025; Doi: 10.1161/CIRCRESAHA.125.326251
PubMed FullText FullText_MUG

 

Übersichtsarbeit

** Fuerlinger, A; Stockner, A; Sedej, S; Abdellatif, M Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential.
Cardiovasc Diabetol. 2025; 24(1): 21 Doi: 10.1186/s12933-024-02566-8 [OPEN ACCESS]
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** Liberale, L; Tual-Chalot, S; Sedej, S; Ministrini, S; Georgiopoulos, G; Grunewald, M; Bäck, M; Bochaton-Piallat, ML; Boon, RA; Ramos, GC; de, Winther, MPJ; Drosatos, K; Evans, PC; Ferguson, JF; Forslund-Startceva, SK; Goettsch, C; Giacca, M; Haendeler, J; Kallikourdis, M; Ketelhuth, DFJ; Koenen, RR; Lacolley, P; Lutgens, E; Maffia, P; Miwa, S; Monaco, C; Montecucco, F; Norata, GD; Osto, E; Richardson, GD; Riksen, NP; Soehnlein, O; Spyridopoulos, I; Van, Linthout, S; Vilahur, G; Wentzel, JJ; Andrés, V; Badimon, L; Benetos, A; Binder, CJ; Brandes, RP; Crea, F; Furman, D; Gorbunova, V; Guzik, TJ; Hill, JA; Lüscher, TF; Mittelbrunn, M; Nencioni, A; Netea, MG; Passos, JF; Stamatelopoulos, KS; Tavernarakis, N; Ungvari, Z; Wu, JC; Kirkland, JL; Camici, GG; Dimmeler, S; Kroemer, G; Abdellatif, M; Stellos, K Roadmap for alleviating the manifestations of ageing in the cardiovascular system.
Nat Rev Cardiol. 2025; Doi: 10.1038/s41569-025-01130-5
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2024

Originalarbeit (Zeitschrift)

** Akhmetshina, A; Bianco, V; Bradić, I; Korbelius, M; Pirchheim, A; Kuentzel, KB; Eichmann, TO; Hinteregger, H; Kolb, D; Habisch, H; Liesinger, L; Madl, T; Sattler, W; Radović, B; Sedej, S; Birner-Gruenberger, R; Vujić, N; Kratky, D Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice.
Mol Metab. 2024; 79:101869 Doi: 10.1016/j.molmet.2023.101869 [OPEN ACCESS]
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** Hofer, SJ; Daskalaki, I; Abdellatif, M; Stelzl, U; Sedej, S; Tavernarakis, N; Kroemer, G; Madeo, F A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity.
Autophagy. 2024; Doi: 10.1080/15548627.2024.2396793 [OPEN ACCESS]
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** Hofer, SJ; Daskalaki, I; Bergmann, M; Friščić, J; Zimmermann, A; Mueller, MI; Abdellatif, M; Nicastro, R; Masser, S; Durand, S; Nartey, A; Waltenstorfer, M; Enzenhofer, S; Faimann, I; Gschiel, V; Bajaj, T; Niemeyer, C; Gkikas, I; Pein, L; Cerrato, G; Pan, H; Liang, Y; Tadic, J; Jerkovic, A; Aprahamian, F; Robbins, CE; Nirmalathasan, N; Habisch, H; Annerer, E; Dethloff, F; Stumpe, M; Grundler, F; Wilhelmi, de, Toledo, F; Heinz, DE; Koppold, DA; Rajput, Khokhar, A; Michalsen, A; Tripolt, NJ; Sourij, H; Pieber, TR; de, Cabo, R; McCormick, MA; Magnes, C; Kepp, O; Dengjel, J; Sigrist, SJ; Gassen, NC; Sedej, S; Madl, T; De, Virgilio, C; Stelzl, U; Hoffmann, MH; Eisenberg, T; Tavernarakis, N; Kroemer, G; Madeo, F Spermidine is essential for fasting-mediated autophagy and longevity.
Nat Cell Biol. 2024; 26(9):1571-1584 Doi: 10.1038/s41556-024-01468-x [OPEN ACCESS]
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Übersichtsarbeit

** Ozcan, M; Abdellatif, M; Javaheri, A; Sedej, S Risks and Benefits of Intermittent Fasting for the Aging Cardiovascular System.
Can J Cardiol. 2024; 40(8):1445-1457 Doi: 10.1016/j.cjca.2024.02.004
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** Zimmermann, A; Madeo, F; Diwan, A; Sadoshima, J; Sedej, S; Kroemer, G; Abdellatif, M Metabolic control of mitophagy.
Eur J Clin Invest. 2024; 54(4):e14138 Doi: 10.1111/eci.14138
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2023

Originalarbeit (Zeitschrift)

** Messerer, J; Wrede, C; Schipke, J; Brandenberger, C; Abdellatif, M; Eisenberg, T; Madeo, F; Sedej, S; Mühlfeld, C Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice.
J Anat. 2023; 242(1):91-101 Doi: 10.1111/joa.13618 [OPEN ACCESS]
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Kurzbericht/Letter

** Abdellatif, M; Madeo, F; Sedej, S; Kroemer, G Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age.
Expert Opin Ther Targets. 2023; 27(2):87-90 Doi: 10.1080/14728222.2023.2178420 (- Case Report)
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Übersichtsarbeit

** Abdellatif, M; Rainer, PP; Sedej, S; Kroemer, G Hallmarks of cardiovascular ageing.
Nat Rev Cardiol. 2023; Doi: 10.1038/s41569-023-00881-3
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Abstract (Zeitschrift)

** Byrne, N; Koentges, C; Khan, E; Pfeil, K; Sandulescu, R; Bakshi, S; Koltgen, C; Vosko, I; Gollmer, J; Hoffmann, M; Wolf, D; Ljubojevic-Holzer, S; Wallner, M; Rainer, P; Sedej, S; Scherr, D; von Lewinski, D; Wende, A; Zirlik, A; Bugger, H Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
WIEN KLIN WOCHENSCHR. 2023; 135: S398-S398.-Österreichische Kardiologische Gesellschaft (ÖKG); Salzburg, AUSTRIA. [Poster]
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** Gollmer, J; Horstmann, H; Potter, L; Vosko, I; Tomin, T; Pfeil, K; Briner-Gruenberger, R; Von Lewinski, D; Sedej, S; Scherr, D; Wende, AR; Rainer, P; Zirlik, A; Wolf, D; Bugger, H Molecular alterations of human diabetic heart disease revealed using single nucleus RNA sequencing
EUR HEART J. 2023; 44: -Annual Meeting of the European-Society-of-Cardiology (ESC); AUG 25-28, 2023; Amsterdam, NETHERLANDS. [Poster]
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2022

Originalarbeit (Zeitschrift)

** Abdellatif, M; Eisenberg, T; Heberle, AM; Thedieck, K; Kroemer, G; Sedej, S Cardiac PI3K p110 alpha attenuation delays aging and extends lifespan
CELL STRESS. 2022; 6(8): 72-75. Doi: 10.15698/cst2022.08.270 [OPEN ACCESS]
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** Abdellatif, M; Trummer-Herbst, V; Heberle, AM; Humnig, A; Pendl, T; Durand, S; Cerrato, G; Hofer, SJ; Islam, M; Voglhuber, J; Ramos, Pittol, JM; Kepp, O; Hoefler, G; Schmidt, A; Rainer, PP; Scherr, D; von, Lewinski, D; Bisping, E; McMullen, JR; Diwan, A; Eisenberg, T; Madeo, F; Thedieck, K; Kroemer, G; Sedej, S Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.
Circulation. 2022; 145(25):1853-1866 Doi: 10.1161/CIRCULATIONAHA.122.059863 [OPEN ACCESS]
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** Djalinac, N; Kolesnik, E; Maechler, H; Scheruebel-Posch, S; Pelzmann, B; Rainer, PP; Foessl, I; Wallner, M; Scherr, D; Heinemann, A; Sedej, S; Ljubojevic-Holzer, S; von, Lewinski, D; Bisping, E miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium.
Int J Mol Sci. 2022; 23(13): Doi: 10.3390/ijms23136962 [OPEN ACCESS]
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** Herrero-Galán, E; Martínez-Martín, I; Sánchez-González, C; Vicente, N; Bonzón-Kulichenko, E; Calvo, E; Suay-Corredera, C; Pricolo, MR; Fernández-Trasancos, Á; Velázquez-Carreras, D; Careaga, CB; Abdellatif, M; Sedej, S; Rainer, PP; Giganti, D; Pérez-Jiménez, R; Vázquez, J; Alegre-Cebollada, J Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics.
Redox Biol. 2022; 52:102306 Doi: 10.1016/j.redox.2022.102306 [OPEN ACCESS]
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** Koser, F; Hobbach, AJ; Abdellatif, M; Herbst, V; Türk, C; Reinecke, H; Krüger, M; Sedej, S; Linke, WA Acetylation and phosphorylation changes to cardiac proteins in experimental HFpEF due to metabolic risk reveal targets for treatment.
Life Sci. 2022; 309:120998 Doi: 10.1016/j.lfs.2022.120998
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** Ljubojević-Holzer, S; Kraler, S; Djalinac, N; Abdellatif, M; Voglhuber, J; Schipke, J; Schmidt, M; Kling, KM; Franke, GT; Herbst, V; Zirlik, A; von, Lewinski, D; Scherr, D; Rainer, PP; Kohlhaas, M; Nickel, A; Mühlfeld, C; Maack, C; Sedej, S Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling.
Cardiovasc Res. 2022; 118(6):1492-1505 Doi: 10.1093/cvr/cvab112 [OPEN ACCESS]
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** Pabel, S; Knierim, M; Stehle, T; Alebrand, F; Paulus, M; Sieme, M; Herwig, M; Barsch, F; Körtl, T; Pöppl, A; Wenner, B; Ljubojevic-Holzer, S; Molina, CE; Dybkova, N; Camboni, D; Fischer, TH; Sedej, S; Scherr, D; Schmid, C; Brochhausen, C; Hasenfuß, G; Maier, LS; Hamdani, N; Streckfuss-Bömeke, K; Sossalla, S Effects of Atrial Fibrillation on the Human Ventricle.
Circ Res. 2022; 130(7):994-1010 Doi: 10.1161/CIRCRESAHA.121.319718 [OPEN ACCESS]
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** Semeraro, MD; Almer, G; Kaiser, M; Zelzer, S; Meinitzer, A; Scharnagl, H; Sedej, S; Gruber, HJ; Herrmann, M The effects of long-term moderate exercise and Western-type diet on oxidative/nitrosative stress, serum lipids and cytokines in female Sprague Dawley rats.
Eur J Nutr. 2022; 61(1):255-268 Doi: 10.1007/s00394-021-02639-4 [OPEN ACCESS]
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** Semeraro, MD; Beltrami, AP; Kharrat, F; Almer, G; Sedej, S; Renner, W; Gruber, HJ; Curcio, F; Herrmann, M The impact of moderate endurance exercise on cardiac telomeres and cardiovascular remodeling in obese rats.
Front Cardiovasc Med. 2022; 9:1080077 Doi: 10.3389/fcvm.2022.1080077 [OPEN ACCESS]
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** Tarkhnishvili, A; Koentges, C; Pfeil, K; Gollmer, J; Byrne, NJ; Vosko, I; Lueg, J; Vogelbacher, L; Birkle, S; Tang, S; Bon-Nawul, Mwinyella, T; Hoffmann, MM; Odening, KE; Michel, NA; Wolf, D; Stachon, P; Hilgendorf, I; Wallner, M; Ljubojevic-Holzer, S; von, Lewinski, D; Rainer, P; Sedej, S; Sourij, H; Bode, C; Zirlik, A; Bugger, H Effects of Short Term Adiponectin Receptor Agonism on Cardiac Function and Energetics in Diabetic db/db Mice.
J Lipid Atheroscler. 2022; 11(2):161-177 Doi: 10.12997/jla.2022.11.2.161 [OPEN ACCESS]
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Übersichtsarbeit

** Abdellatif, M; Bugger, H; Kroemer, G; Sedej, S NAD+ and Vascular Dysfunction: From Mechanisms to Therapeutic Opportunities.
J Lipid Atheroscler. 2022; 11(2): 111-132. Doi: 10.12997/jla.2022.11.2.111 [OPEN ACCESS]
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Editorial

** Sedej, S; Abdellatif, M Metabolic therapy for managing heart failure with preserved ejection fraction.
J Mol Cell Cardiol. 2022; 168:68-69 Doi: 10.1016/j.yjmcc.2022.04.009
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Abstract (Zeitschrift)

** Abdellatif, M; Trummer-Herbst, V; Koser, F; Linke, W; Sadoshima, J; Diwan, A; Kroemer, G; Sedej, S Autophagy causally contributes to the cardioprotective effects of NAD
WIEN KLIN WOCHENSCHR. 2022; 134(SUPPL 2):82-82.-ÖKG Jahrestagung; 25-28 May; Salzburg, Austria. [Oral Communication]
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** Abdellatif, M; Trummer-Herbst, V; Prokesch, A; Zardoya-Laguardia, P; Linke, WA; Sadoshima, J; Diwan, A; Kroemer, G; Sedej, S Autophagy is required for NAD-based HFpEF therapy
EUR J HEART FAIL. 2022; 24: 9-9.-HFA Winter Meeting on Translational Heart Failure Research; JAN 27-28, 2022; Switzerland. [Oral Communication]
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** Gollmer, J; Potter, L; Vosko, I; Tomin, T; Birner-Gruenberger, R; Von Lewinski, D; Sedej, S; Scherr, D; Wende, AR; Rainer, P; Zirlik, A; Bugger, H Transcriptomic and proteomic profiling of human diabetic heart disease
EUR HEART J. 2022; 43: 2951-2951.
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** Koser, F; Abdellatif, M; Tuerk, C; Hobbach, AJ; Reinecke, H; Krueger, M; Sedej, S; Linke, WA Cardiac proteomic analyses in a rat model of heart failure with preserved ejection fraction (HFpEF) reveals key pathway modifications due to obesity
ACTA PHYSIOL. 2022; 236: 597-597. [Oral Communication]
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** Koser, F; Abdellatif, M; Turk, C; Hobbach, AJ; Reinecke, H; Kruger, M; Sedej, S; Linke, W Proteomic screening in a rat model of HFpEF reveals key pathway modifications due to obesity
J MOL CELL CARDIOL. 2022; 173: S16-S17. Doi: 10.1016/j.yjmcc.2022.08.034
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Kommentar

** Abdellatif, M; Madeo, F; Kroemer, G; Sedej, S Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.
Autophagy. 2022; 18(10): 2500-2502. Doi: 10.1080/15548627.2022.2095835 [OPEN ACCESS]
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** Sedej, S; Abdellatif, M Response by Sedej and Abdellatif to Letter Regarding Article, "Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity".
Circulation. 2022; 146(24): e332-e333. Doi: 10.1161/CIRCULATIONAHA.122.062496
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2021

Originalarbeit (Zeitschrift)

** Abdellatif, M; Trummer-Herbst, V; Koser, F; Durand, S; Adão, R; Vasques-Nóvoa, F; Freundt, JK; Voglhuber, J; Pricolo, MR; Kasa, M; Türk, C; Aprahamian, F; Herrero-Galán, E; Hofer, SJ; Pendl, T; Rech, L; Kargl, J; Anto-Michel, N; Ljubojevic-Holzer, S; Schipke, J; Brandenberger, C; Auer, M; Schreiber, R; Koyani, CN; Heinemann, A; Zirlik, A; Schmidt, A; von Lewinski, D; Scherr, D; Rainer, PP; von Maltzahn, J; Mühlfeld, C; Krüger, M; Frank, S; Madeo, F; Eisenberg, T; Prokesch, A; Leite-Moreira, AF; Lourenço, AP; Alegre-Cebollada, J; Kiechl, S; Linke, WA; Kroemer, G; Sedej, S Nicotinamide for the treatment of heart failure with preserved ejection fraction.
Sci Transl Med. 2021; 13(580): eabd7064 Doi: 10.1126/scitranslmed.abd7064 [OPEN ACCESS]
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** Helmstadter, KG; Ljubojevic-Holzer, S; Wood, BM; Taheri, KD; Sedej, S; Erickson, JR; Bossuyt, J; Bers, DM CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes.
Basic Res Cardiol. 2021; 116(1):11-11 Doi: 10.1007/s00395-021-00850-2 [OPEN ACCESS]
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** Klionsky, DJ; Abdel-Aziz, AK; Abdelfatah, S; Abdellatif, M; Abdoli, A; Abel, S; Abeliovich, H; Abildgaard, MH; Abudu, YP; Acevedo-Arozena, A; Adamopoulos, IE; Adeli, K; Adolph, TE; Adornetto, A; Aflaki, E; Agam, G; Agarwal, A; Aggarwal, BB; Agnello, M; Agostinis, P; Agrewala, JN; Agrotis, A; Aguilar, PV; Ahmad, ST; Ahmed, ZM; Ahumada-Castro, U; Aits, S; Aizawa, S; Akkoc, Y; Akoumianaki, T; Akpinar, HA; Al-Abd, AM; Al-Akra, L; Al-Gharaibeh, A; Alaoui-Jamali, MA; Alberti, S; Alcocer-Gómez, E; Alessandri, C; Ali, M; Alim, Al-Bari, MA; Aliwaini, S; Alizadeh, J; Almacellas, E; Almasan, A; Alonso, A; Alonso, GD; Altan-Bonnet, N; Altieri, DC; Álvarez, ÉMC; Alves, S; Alves, da, Costa, C; Alzaharna, MM; Amadio, M; Amantini, C; Amaral, C; Ambrosio, S; Amer, AO; Ammanathan, V; An, Z; Andersen, SU; Andrabi, SA; Andrade-Silva, M; Andres, AM; Angelini, S; et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
AUTOPHAGY. 2021; 17(1): 1-382. Doi: 10.1080/15548627.2020.1797280 [OPEN ACCESS]
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** Schroeder, S; Hofer, SJ; Zimmermann, A; Pechlaner, R; Dammbrueck, C; Pendl, T; Marcello, GM; Pogatschnigg, V; Bergmann, M; Müller, M; Gschiel, V; Ristic, S; Tadic, J; Iwata, K; Richter, G; Farzi, A; Üçal, M; Schäfer, U; Poglitsch, M; Royer, P; Mekis, R; Agreiter, M; Tölle, RC; Sótonyi, P; Willeit, J; Mairhofer, B; Niederkofler, H; Pallhuber, I; Rungger, G; Tilg, H; Defrancesco, M; Marksteiner, J; Sinner, F; Magnes, C; Pieber, TR; Holzer, P; Kroemer, G; Carmona-Gutierrez, D; Scorrano, L; Dengjel, J; Madl, T; Sedej, S; Sigrist, SJ; Rácz, B; Kiechl, S; Eisenberg, T; Madeo, F Dietary spermidine improves cognitive function.
Cell Rep. 2021; 35(2):108985-108985 Doi: 10.1016/j.celrep.2021.108985 [OPEN ACCESS]
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** Tomin, T; Schittmayer, M; Sedej, S; Bugger, H; Gollmer, J; Honeder, S; Darnhofer, B; Liesinger, L; Zuckermann, A; Rainer, PP; Birner-Gruenberger, R Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts.
Int J Mol Sci. 2021; 22(4): Doi: 10.3390/ijms22041787 [OPEN ACCESS]
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Übersichtsarbeit

** Abdellatif, M; Sedej, S; Kroemer, G NAD+ Metabolism in Cardiac Health, Aging, and Disease.
Circulation. 2021; 144(22): 1795-1817. Doi: 10.1161/CIRCULATIONAHA.121.056589
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** Voglhuber, J; Ljubojevic-Holzer, S; Abdellatif, M; Sedej, S Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics.
Front Nutr. 2021; 8: 758058 Doi: 10.3389/fnut.2021.758058 [OPEN ACCESS]
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Editorial

** Sedej, S; Bugger, H Editorial of Special Issue "Sirtuins in Health and Disease".
Int J Mol Sci. 2021; 22(10): Doi: 10.3390/ijms22105054 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Abdellatif, M; Trummer-Herbst, V; Koser, F; Durand, S; Adao, R; Von Lewinski, D; Rainer, P; Scherr, D; Zirlik, A; Leite-Moreira, A; Alegre-Cebollada, J; Kiechl, S; Linke, W; Kroemer, G; Sedej, S Boosting NAD+ metabolism improves diastolic dysfunction in animal models of aging, obesity and hypertension
WIEN KLIN WOCHENSCHR. 2021; 133(SUPPL 3):S53-S54. [Oral Communication]
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** Abdellatif, M; Trummer-Herbst, V; Koser, F; Sylvere, D; Adao, R; Vasques-Novoa, F; Freundt, JK; Von Lewinski, D; Leite-Moreira, AF; Lourenco, AP; Alegre-Cebollada, J; Kiechl, S; Linke, WA; Kroemer, G; Sedej, S Nicotinamide treats cardiac hallmarks of experimental heart failure with preserved ejection fraction
EUR J HEART FAIL. 2021; 23: 4-4.-HF Winter Meeting; JAN 20-21, 2021; Sophia Antipolis, France. [Oral Communication]
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** Abdellatif, M; Trummer-Herbst, V; Pendl, T; Hofer, S; Durand, S; Voglhuber, J; Von Lewinski, D; Rainer, P; Scherr, D; Zirlik, A; Eisenberg, T; Kroemer, G; Madeo, F; Bisping, E; Sedej, S Targeting IGF1 Signalling to Promote Cardiac Health and Longevity
WIEN KLIN WOCHENSCHR. 2021; 133(SUPPL 3):S35-S35. [Oral Communication]
Web of Science

 

** Djalinac, N; Voglhuber, J; Ljubojevic-Holzer, S; Sedej, S Autophagy-related gene 5 (Atg5) is required for maintaining subcellular calcium homeostasis during acute cardiac stress
WIEN KLIN WOCHENSCHR. 2021; 133(SUPPL 3):S50-S51.-Jahrestagung der ÖKG 2021; MAY 27 - 29, 2021; Salzburg, AUSTRIA. [Onlinepräsentation]
Web of Science

 

** Djalinac, N; Voglhuber, J; Ljubojevic-Holzer, S; Sedej, S Autophagy-related gene 5 (Atg5) is required for maintaining subcellular calcium homeostasis during acute cardiac stress
EUR HEART J. ESC Congress 2021 Abstract Supplement . 2021; 42(S1):3184-3184.-ESC Congress 2021 - The Digital Experience; AUG 27 - 30, 2021; Virtuell. [Onlinepräsentation]
Web of Science

 

** Pabel, S; Knierim, M; Alebrand, F; Paulus, M; Stehle, T; Sieme, M; Herwig, M; Barsch, F; Kortl, T; Ljubojevic, S; Poppl, A; Schmid, C; Fischer, T; Sedej, S; Scherr, D; Brochhausen, C; Hasenfuss, G; Maier, L; Hamdani, N; Streckfuss-Bomeke, K; Sossalla, S Effects of atrial fibrillation on ventricular function in the human heart
INTERNIST. 2021; 62(SUPPL 2):196-197. [Poster]
Web of Science

 

** Voglhuber, J; Abdellatif, M; Djalinac, N; Trummer-Herbst, V; Ljubojevic-Holzer, S; Sedej, S Altered spatio-specific CaMKII activation in autophagy deficient mice
EUR HEART J. ESC Congress 2021 Abstract Supplement. 2021; 42(S1):3284-3284.-ESC Congress 2021 - The Digital Experience; AUG 27 - 30, 2021; Virtuell. [Onlinepräsentation]
Web of Science

 

** Voglhuber, J; Abdellatif, M; Djalinac, N; Trummer-Herbst, V; Ljubojevic-Holzer, S; Sedej, S Altered spatio-specific CaMKII activation in autophagy deficient mice
WIEN KLIN WOCHENSCHR. 2021; 133(SUPPL 3):S35-S35.-Jahrestagung der ÖKG 2021; MAY 27-29, 2021; Salzburg, AUSTRIA - online. [Onlinepräsentation]
Web of Science

 

2020

Originalarbeit (Zeitschrift)

** Abdellatif, M; Ljubojevic-Holzer, S; Madeo, F; Sedej, S Autophagy in cardiovascular health and disease.
Prog Mol Biol Transl Sci. 2020; 172:87-106 Doi: 10.1016/bs.pmbts.2020.04.022
Web of Science PubMed FullText FullText_MUG

 

** Ahrendt, N; Steingrüber, T; Rajces, A; Lopez-Rodriguez, E; Eisenberg, T; Magnes, C; Madeo, F; Sedej, S; Schmiedl, A; Ochs, M; Mühlfeld, C; Schipke, J Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung.
Am J Physiol Lung Cell Mol Physiol. 2020; 319(2):L312-L324 Doi: 10.1152/ajplung.00423.2019
Web of Science PubMed FullText FullText_MUG

 

** Djalinac, N; Ljubojevic-Holzer, S; Matzer, I; Kolesnik, E; Jandl, K; Lohberger, B; Rainer, P; Heinemann, A; Sedej, S; von, Lewinski, D; Bisping, E The role of stretch, tachycardia and sodium-calcium exchanger in induction of early cardiac remodelling.
J Cell Mol Med. 2020; 24(15):8732-8743 Doi: 10.1111/jcmm.15504 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Ljubojevic-Holzer, S; Herren, AW; Djalinac, N; Voglhuber, J; Morotti, S; Holzer, M; Wood, BM; Abdellatif, M; Matzer, I; Sacherer, M; Radulovic, S; Wallner, M; Ivanov, M; Wagner, S; Sossalla, S; von Lewinski, D; Pieske, B; Brown, JH; Sedej, S; Bossuyt, J; Bers, DM CaMKIIδC Drives Early Adaptive Ca2+ Change and Late Eccentric Cardiac Hypertrophy.
Circ Res. 2020; 127(9):1159-1178 Doi: 10.1161/CIRCRESAHA.120.316947 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Korrespondenz

** Abdellatif, M; Sedej, S Cardiovascular benefits of intermittent fasting.
Cardiovasc Res. 2020; 116(3): e36-e38-e36-e38. Doi: 10.1093/cvr/cvaa022 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Abstract (Zeitschrift)

** Djalinac, N; Kolesnik, E; Maechler, H; Sedej, S; Rainer, P; Scher, D; Heinemann, A; Von Lewinski, D; Bisping, E MIR1183 as a new tissue biomarker with triggered acute response and upregulation in chronic atrial and ventricular remodeling.
EUR HEART J. 2020; 41: 3662-3662. [Poster]
Web of Science

 

** Pabel, S; Knierim, M; Alebrand, F; Paulus, M; Herting, J; Hollemann, D; Sedej, S; Von Lewinski, D; Fischer, T; Schmid, C; Hasenfuss, G; Brochhausen, C; Maier, L; Streckfuss-Boemeke, K; Sossalla, S Atrial fibrillation impairs ventricular function by altering excitation-contraction coupling in the human heart.
EUR HEART J. 2020; 41: 3711-3711. [Oral Communication]
Web of Science

 

2019

Originalarbeit (Zeitschrift)

** Carmona-Gutierrez, D; Zimmermann, A; Kainz, K; Pietrocola, F; Chen, G; Maglioni, S; Schiavi, A; Nah, J; Mertel, S; Beuschel, CB; Castoldi, F; Sica, V; Trausinger, G; Raml, R; Sommer, C; Schroeder, S; Hofer, SJ; Bauer, MA; Pendl, T; Tadic, J; Dammbrueck, C; Hu, Z; Ruckenstuhl, C; Eisenberg, T; Durand, S; Bossut, N; Aprahamian, F; Abdellatif, M; Sedej, S; Enot, DP; Wolinski, H; Dengjel, J; Kepp, O; Magnes, C; Sinner, F; Pieber, TR; Sadoshima, J; Ventura, N; Sigrist, SJ; Kroemer, G; Madeo, F The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.
Nat Commun. 2019; 10(1):651-651 Doi: 10.1038/s41467-019-08555-w [OPEN ACCESS]
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** Hofer, DC; Zirkovits, G; Pelzmann, HJ; Huber, K; Pessentheiner, AR; Xia, W; Uno, K; Miyazaki, T; Kon, K; Tsuneki, H; Pendl, T; Al Zoughbi, W; Madreiter-Sokolowski, CT; Trausinger, G; Abdellatif, M; Schoiswohl, G; Schreiber, R; Eisenberg, T; Magnes, C; Sedej, S; Eckhardt, M; Sasahara, M; Sasaoka, T; Nitta, A; Hoefler, G; Graier, WF; Kratky, D; Auwerx, J; Bogner-Strauss, JG N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.
FASEB J. 2019; 33(12):13808-13824 Doi: 10.1096/fj.201801323R [OPEN ACCESS]
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** Wierich, MC; Schipke, J; Brandenberger, C; Abdellatif, M; Eisenberg, T; Madeo, F; Sedej, S; Mühlfeld, C Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice.
Exp Gerontol. 2019; 119:82-88 Doi: 10.1016/j.exger.2019.01.026
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Korrektur

** Wierich, MC; Schipke, J; Brandenberger, C; Abdellatif, M; Eisenberg, T; Madeo, F; Sedej, S; Muhlfeld, C Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice (vol 199, pg 82, 2019)
EXP GERONTOL. 2019; 122: 139-139. Doi: 10.1016/j.exger.2019.05.009
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Abstract (Zeitschrift)

** Abdellatif, M; Herbst, V; Schmidt, A; Humnig, A; Pendl, T; Gross, A; Hofer, S; Madeo, F; Zirlik, A; Scherr, D; von Lewinski, D; Rainer, P; McMullen, J; Eisenberg, T; Bisping, E; Sedej, S Life stage determines the dual effects of IGF1 signalling on cardiac health and survival
WIEN KLIN WOCHENSCHR. 2019; 131: 250-250. [Oral Communication]
Web of Science

 

** Koser, F; Abdellatif, M; Turk, C; Kruger, M; Sedej, S; Linke, WA Unbiased screen of the cardiac proteome and effect of spermidine therapy on titin properties in a rat model of heart failure with preserved ejection fraction (HFpEF)
ACTA PHYSIOL. 2019; 227: -98th Meeting of the German Physiological Society ; SEP 30-OCT 02, 2019; Ulm, Germany. [Poster]
Web of Science

 

2018

Originalarbeit (Zeitschrift)

** Schneider, C; Wallner, M; Kolesnik, E; Herbst, V; Mächler, H; Pichler, M; von Lewinski, D; Sedej, S; Rainer, PP The Anti-Cancer Multikinase Inhibitor Sorafenib Impairs Cardiac Contractility by Reducing Phospholamban Phosphorylation and Sarcoplasmic Calcium Transients.
Sci Rep. 2018; 8(1):5295-5295 Doi: 10.1038/s41598-018-23630-w [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Übersichtsarbeit

** Abdellatif, M; Sedej, S; Carmona-Gutierrez, D; Madeo, F; Kroemer, G Autophagy in Cardiovascular Aging.
Circ Res. 2018; 123(7):803-824 Doi: 10.1161/CIRCRESAHA.118.312208 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Korrespondenz

** Sedej, S Ketone bodies to the rescue for an aging heart?
Cardiovasc Res. 2018; 114(1): e1-e2-e1-e2. Doi: 10.1093/cvr/cvx218 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Adao, R; Kraler, SC; Holzer, S; Leite-Moreira, A; Sedej, S; Bras-Silva, C Effects of urocortin-2 on cellular Ca2+homeostasis in right heart failure induced by pulmonary artery hypertension
EUR RESPIR J. . 2018; 52: -28th International Congress of the European-Respiratory-Society (ERS); SEP 15-19, 2018; Paris, FRANCE. Doi: 10.1183/13993003.congress-2018.OA1634 [Poster]
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** Kolesnik, E; Kapeller, S; Wallner, M; Rainer, PP;, Abdellatif, M; Maechler, H; Sedej, S; Von Lewinski D Acute administration of high levels of spermidine and spermine impair ryanodine receptor type 2-dependent contractility in human atrial tissue
European Journal of Heart Failure. 2018; 20(S1):630-630.-ESC Heart Failure 2018; MAY 26-29, 2018; Vienna, Austria. [Poster]
Web of Science

 

** Kraler, S; Abdellatif, M; Ljubojevic, S; Sedej, SS Beta-adrenergic effect on calcium cycling is potentiated in autophagy-deficient mouse cardiomyocytes
EUR J HEART FAIL. 2018; 20: 620-621. [Poster]
Web of Science

 

** Kraler, S; Abdellatif, M; Schipke, J; Kling, KM; Muhlfeld, C; Ljubojevic, S; Sedej, S Potentiated effect of isoprenaline on calcium homeostasis in mouse cardiomyocytes with inhibited autophagy
WIEN KLIN WOCHENSCHR. 2018; 130: 12-14.-Jahrestagung der Österreichischen Kardiologischen Gesellschaft; Jun 6-9, 2018 ; Salzburg, Austria. [Poster]
Web of Science

 

Kommentar

** Abdellatif, M; Sedej, S; Madeo, F; Kroemer, G Cardioprotective effects of autophagy induction in sepsis.
Ann Transl Med. 2018; 6(Suppl 1):S61-S61 Doi: 10.21037/atm.2018.10.23 [OPEN ACCESS]
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2017

Originalarbeit (Zeitschrift)

** Eisenberg, T; Abdellatif, M; Zimmermann, A; Schroeder, S; Pendl, T; Harger, A; Stekovic, S; Schipke, J; Magnes, C; Schmidt, A; Ruckenstuhl, C; Dammbrueck, C; Gross, AS; Herbst, V; Carmona-Gutierrez, D; Pietrocola, F; Pieber, TR; Sigrist, SJ; Linke, WA; Mühlfeld, C; Sadoshima, J; Dengjel, J; Kiechl, S; Kroemer, G; Sedej, S; Madeo, F Dietary spermidine for lowering high blood pressure.
Autophagy. 2017; 13(4):767-769 Doi: 10.1080/15548627.2017.1280225 [OPEN ACCESS]
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** Schreiber, R; Diwoky, C; Schoiswohl, G; Feiler, U; Wongsiriroj, N; Abdellatif, M; Kolb, D; Hoeks, J; Kershaw, EE; Sedej, S; Schrauwen, P; Haemmerle, G; Zechner, R Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue.
Cell Metab. 2017; 26(5):753-763 Doi: 10.1016/j.cmet.2017.09.004 [OPEN ACCESS]
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** Schweitzer, MK; Wilting, F; Sedej, S; Dreizehnter, L; Dupper, NJ; Tian, Q; Moretti, A; My, I; Kwon, O; Priori, SG; Laugwitz, KL; Storch, U; Lipp, P; Breit, A; Mederos Y Schnitzler, M; Gudermann, T; Schredelseker, J Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models.
JACC Basic Transl Sci. 2017; 2(6):737-747 Doi: 10.1016/j.jacbts.2017.06.008 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Abdellatif, M; Eisenberg, T; Schmidt, A; Linke, W A; Muehlfeld, C; JSadoshima, J; Kiechl, S; Kroemer, G; Madeo, F; Sedej, S The natural autophagy-inducer spermidine protects the aging heart and promotes longevity in mice
European Journal of Heart Failure. 2017; 19(S1):514-515.-Heart Failure 2017 and the 4th World Congress on Acute Heart Failure; April 29- May 2, 2017; Paris, France. [Poster]
Web of Science

 

** Schweitzer, M; Wilting, F; Sedej, S; Dreizehnter, L; Moretti, A; Kwon, O; Schnitzler, MMY; Gudermann, T; Schredelseker, J Suppression of arrhythmia by enhancing mitochondrial ca(2+) uptake in experimental ventricular tachycardia models
ACTA PHYSIOL. 2017; 219: 40-40. [Poster]
Web of Science

 

** Schweitzer, MK; Wilting, F; Sedej, S; Dreizehnter, L; Dupper, NJ; Moretti, A; Kwon, O; Priori, SG; Laugwitz, KL; Schnitzler, MMY; Gudermann, T; Schredelseker, J Suppression of Arrhythmia by Enhancing Mitochondrial Calcium Uptake in Experimental Models of Catecholaminergic Ventricular Tachycardia
BIOPHYS J. 2017; 112(3):95A-95A.-61st Annual Meeting of the Biophysical-Society; FEB 11-15, 2017; New Orleans, LA. Doi: 10.1016/j.bpj.2016.11.552 [Poster]
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** Sedei, S; Abdellatif, M; Eisenberg, T; Primessnig, U; Pendl, T; von Frieling-Salewsky, M; Magnes, C; Herbst, V; Kirsch, A; Meinitzer, A; Linke, WA; Kiechl, S; Kroemer, G; Madeo, F Spermidine feeding reduces high blood pressure and improves diastolic function in Dahl salt-sensitive rats
ACTA PHYSIOL. 2017; 221: 34-34. [Oral Communication]
Web of Science

 

2016

Originalarbeit (Zeitschrift)

** Eisenberg, T; Abdellatif, M; Schroeder, S; Primessnig, U; Stekovic, S; Pendl, T; Harger, A; Schipke, J; Zimmermann, A; Schmidt, A; Tong, M; Ruckenstuhl, C; Dammbrueck, C; Gross, AS; Herbst, V; Magnes, C; Trausinger, G; Narath, S; Meinitzer, A; Hu, Z; Kirsch, A; Eller, K; Carmona-Gutierrez, D; Büttner, S; Pietrocola, F; Knittelfelder, O; Schrepfer, E; Rockenfeller, P; Simonini, C; Rahn, A; Horsch, M; Moreth, K; Beckers, J; Fuchs, H; Gailus-Durner, V; Neff, F; Janik, D; Rathkolb, B; Rozman, J; de Angelis, MH; Moustafa, T; Haemmerle, G; Mayr, M; Willeit, P; von Frieling-Salewsky, M; Pieske, B; Scorrano, L; Pieber, T; Pechlaner, R; Willeit, J; Sigrist, SJ; Linke, WA; Mühlfeld, C; Sadoshima, J; Dengjel, J; Kiechl, S; Kroemer, G; Sedej, S; Madeo, F Cardioprotection and lifespan extension by the natural polyamine spermidine.
Nat Med. 2016; 22(12):1428-1438 Doi: 10.1038/nm.4222 [OPEN ACCESS]
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** Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; Acevedo Arozena, A; Adachi, H; Adams, CM; Adams, PD; Adeli, K; Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; ... Malli, R; ... Sedej, S; ... et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 2016; 12(1): 1-222. Doi: 10.1080/15548627.2015.1100356 [OPEN ACCESS]
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** Schipke, J; Grimm, C; Arnstein, G; Kockskämper, J; Sedej, S; Mühlfeld, C Cardiomyocyte loss is not required for the progression of left ventricular hypertrophy induced by pressure overload in female mice.
J Anat. 2016; 229(1):75-81 Doi: 10.1111/joa.12463 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Djalinac, N; Kaltenegger, H; Lohberger, B; Thon-Gutschi, EM; Herbst, V; Sedej, S; Bisping, E Tachycardia versus stretch: differential pattern of early cardiac remodeling
EUR HEART J. .. 2016; 37: 308-308.-Congress of the European-Society-of-Cardiology (ESC); AUG 27-31, 2016; Rome, ITALY. [Poster]
Web of Science

 

** Djalinac, N; Mhatre, K; Kaltenegger, H; Lohberger, B; Thon-Gutschi, EM; Herbst, V; Sedej, S; Heinzel, F; Bisping, E Differential characteristics of hypertrophy induced by tachycardia, neurohumoral activation or stretch
WIEN KLIN WOCHENSCHR. 2016; 128: S312-S312. [Poster]
Web of Science

 

** Kapeller, S; Kolesnik, E; Wallner, M; Rainer, P; Sedej, S; von Lewinski, D High levels of spermidine and spermine cause impaired force development, arrhythmias and negative inotropy in human atrial tissue
WIEN KLIN WOCHENSCHR. 2016; 128: S310-S311. [Poster]
Web of Science

 

** Schneider, C; Wallner, M; Abdellatif, M; von Lewinski, D; Pichler, M; Sedej, S; Rainer, P The anti-cancer tyrosine kinase inhibitor sorafenib reduces cardiac contractile force by reducing cardiomyocyte calcium transient amplitude
WIEN KLIN WOCHENSCHR. 2016; 128: S309-S310. [Poster]
Web of Science

 

2015

Übersichtsarbeit

** Heinzel, FR; Hohendanner, F; Jin, G; Sedej, S; Edelmann, F Myocardial hypertrophy and its role in heart failure with preserved ejection fraction.
J Appl Physiol (1985). 2015; 119(10):1233-1242 Doi: 10.1152/japplphysiol.00374.2015 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Drexler, MK; Wilting, F; Dreizehnter, L; Sedej, S; Moretti, A; Priori, S; Kwon, O; Gudermann, T; Schredelseker, J Pharmacological activation of mitochondrial Ca2+ uptake suppresses arrhythmogenic events in CPVT cardiomyocytes
N-S ARCH PHARMACOL. 2015; 388: S34-S34.-81st Annual Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und-Toxikologie-e-V; MAR 10-12, 2015; Kiel, GERMANY. [Poster]
Web of Science

 

2014

Originalarbeit (Zeitschrift)

** Eisenberg, T; Schroeder, S; Andryushkova, A; Pendl, T; Küttner, V; Bhukel, A; Mariño, G; Pietrocola, F; Harger, A; Zimmermann, A; Moustafa, T; Sprenger, A; Jany, E; Büttner, S; Carmona-Gutierrez, D; Ruckenstuhl, C; Ring, J; Reichelt, W; Schimmel, K; Leeb, T; Moser, C; Schatz, S; Kamolz, LP; Magnes, C; Sinner, F; Sedej, S; Fröhlich, KU; Juhasz, G; Pieber, TR; Dengjel, J; Sigrist, SJ; Kroemer, G; Madeo, F Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.
Cell Metab. 2014; 19(3):431-444 Doi: 10.1016/j.cmet.2014.02.010 [OPEN ACCESS]
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** Ljubojevic, S; Radulovic, S; Leitinger, G; Sedej, S; Sacherer, M; Holzer, M; Winkler, C; Pritz, E; Mittler, T; Schmidt, A; Sereinigg, M; Wakula, P; Zissimopoulos, S; Bisping, E; Post, H; Marsche, G; Bossuyt, J; Bers, DM; Kockskämper, J; Pieske, B Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.
Circulation. 2014; 130(3):244-255 Doi: 10.1161/CIRCULATIONAHA.114.008927 [OPEN ACCESS]
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** Sedej, S; Schmidt, A; Denegri, M; Walther, S; Matovina, M; Arnstein, G; Gutschi, EM; Windhager, I; Ljubojević, S; Negri, S; Heinzel, FR; Bisping, E; Vos, MA; Napolitano, C; Priori, SG; Kockskämper, J; Pieske, B Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.
J Am Coll Cardiol. 2014; 63(15):1569-1579 Doi: 10.1016/j.jacc.2013.11.010 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Ljubojevic, S; Radulovic, S; Sedej, S; Kockskaemper, J; Pieske, B; Alterations of Nuclear Ca2+- Dependent Signalling in Heart Failure.
BIOPHYS J. 2014; 106(2):115A-115A.-58th Annual Meeting of the Biophysical-Society; FEB 15-19, 2014; San Francisco, CA. Doi: 10.1016/j.bpj.2013.11.698 [Poster]
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** Sedej, S; Matovina, M; Schmidt, A; Ljubojevic, S; Heinzel, FR; Negri, S; Napolitano, C; Vos, MA; Priori, SG; Pieske, B Reduced pressure overload-induced myocardial remodeling in K201-treated mice with the R4496C cardiac ryanodine receptor mutation
CARDIOVASC RES. 2014; 103: -3rd Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology; JUL 04-06, 2014; Barcelona, SPAIN. Doi: 10.1093/cvr/cvu091.70 [Poster]
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Kommentar

** Eisenberg, T; Schroeder, S; Büttner, S; Carmona-Gutierrez, D; Pendl, T; Andryushkova, A; Mariño, G; Pietrocola, F; Harger, A; Zimmermann, A; Magnes, C; Sinner, F; Sedej, S; Pieber, TR; Dengjel, J; Sigrist, S; Kroemer, G; Madeo, F A histone point mutation that switches on autophagy.
Autophagy. 2014; 10(6):1143-1145 Doi: 10.4161/auto.28767 [OPEN ACCESS]
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2013

Originalarbeit (Zeitschrift)

** Hohendanner, F; Ljubojević, S; MacQuaide, N; Sacherer, M; Sedej, S; Biesmans, L; Wakula, P; Platzer, D; Sokolow, S; Herchuelz, A; Antoons, G; Sipido, K; Pieske, B; Heinzel, FR Intracellular dyssynchrony of diastolic cytosolic [Ca²⁺] decay in ventricular cardiomyocytes in cardiac remodeling and human heart failure.
Circ Res. 2013; 113(5):527-38 Doi: 10.1161/CIRCRESAHA.113.300895 [OPEN ACCESS]
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** Kirsch, AH; Smaczny, N; Riegelbauer, V; Sedej, S; Hofmeister, A; Stojakovic, T; Goessler, W; Brodmann, M; Pilger, E; Rosenkranz, AR; Eller, K; Eller, P Regulatory T cells improve nephrocalcinosis but not dystrophic cardiac calcinosis in DBA/2 mice.
Am J Pathol. 2013; 183(2):382-390 Doi: 10.1016/j.ajpath.2013.04.012 [OPEN ACCESS]
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** Mühlfeld, C; Schipke, J; Schmidt, A; Post, H; Pieske, B; Sedej, S Hypoinnervation is an early event in experimental myocardial remodelling induced by pressure overload.
J Anat. 2013; 222(6):634-644 Doi: 10.1111/joa.12044 [OPEN ACCESS]
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** Sedej, S; Klemen, MS; Schlüter, OM; Rupnik, MS Rab3a is critical for trapping alpha-MSH granules in the high Ca²⁺-affinity pool by preventing constitutive exocytosis.
PLoS One. 2013; 8(10):e78883-e78883 Doi: 10.1371/journal.pone.0078883 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Eller, P; Kirsch, A; Smaczny, N; Sedej, S; Hofmeister, A; Stojakovic, T; Brodmann, M; Pilger, E; Rosenkranz, A; Eller, K Regulatory T-cells modulate ectopic calcification in nephrocalcinosis and dystrophic cardiac calcinosis
EUR HEART J. 2013; 34: 508-508. [Oral Communication]
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** Kirsch, AH; Smaczny, N; Riegelbauer, V; Sedej, S; Hofmeister, A; Stojakovic, T; Brodmann, M; Pilger, E; Rosenkranz, A; Eller, K; Eller, P REGULATORY T-CELLS MODULATE NEPHROCALCINOSIS IN MICE.
NEPHROL DIALYSIS TRANSPLANT. 2013; 28: 406-406.-50th European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Congress; MAY 18-21, 2013; Istanbul, TURKEY. [Poster]
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** Ljubojevic, S; Radulovic, S; Sedej, S; Kockskaemper, J; Pieske, B; Early alterations of nuclear Ca2+-dependent signalling in cardiac hypertrophy.
EUR HEART J. 2013; 34: 6-6.-Congress of the European-Society-of-Cardiology (ESC); AUG 31-SEP 04, 2013; Amsterdam, NETHERLANDS. [Oral Communication]
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** Sacherer, M; Ljubojevic, S; Sedej, S; Stiegler, P; Sereinigg, M; Groschner, K; Antoons, G; Pieske, BM; Heinzel, FR; TRPC3 Channels in Angiotensin II-Induced Calcium- Dependent Arrhythmias in Mouse and Human Cardiomyocytes.
BIOPHYS J. 2013; 104(2):434A-434A.-57th Annual Meeting of the Biophysical-Society; FEB 02-06, 2013; Philadelphia, PA. Doi: 10.1016/j.bpj.2012.11.2416 [Oral Communication]
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2012

Originalarbeit (Zeitschrift)

** Bisping, E; Ikeda, S; Sedej, M; Wakula, P; McMullen, JR; Tarnavski, O; Sedej, S; Izumo, S; Pu, WT; Pieske, B Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy.
J Biol Chem. 2012; 287(13):9827-9834 Doi: 10.1074/jbc.M111.338749 [OPEN ACCESS]
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** Sacherer, M; Sedej, S; Wakuła, P; Wallner, M; Vos, MA; Kockskämper, J; Stiegler, P; Sereinigg, M; von Lewinski, D; Antoons, G; Pieske, BM; Heinzel, FR; CONTICA investigators JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium.
Br J Pharmacol. 2012; 167(3):493-504 Doi: 10.1111/j.1476-5381.2012.01995.x [OPEN ACCESS]
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Abstract (Zeitschrift)

** Ljubojevic, S; Sedej, S; Sacherer, M; Leitinger, G; Kockskaemper, J; Pieske, B; Nuclear remodeling and altered Ca handling of the nucleus - a novel concept of heart failure progression.
EUR HEART J. 2012; 33: 342-342.-Congress of the European-Society-of-Cardiology (ESC); AUG 25-29, 2012; Munchen, GERMANY. [Oral Communication]
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2011

Originalarbeit (Zeitschrift)

** Dybkova, N; Sedej, S; Napolitano, C; Neef, S; Rokita, AG; Hünlich, M; Brown, JH; Kockskämper, J; Priori, SG; Pieske, B; Maier, LS Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality.
J Am Coll Cardiol. 2011; 57(4):469-479 Doi: 10.1016/j.jacc.2010.08.639 [OPEN ACCESS]
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** Ljubojević, S; Walther, S; Asgarzoei, M; Sedej, S; Pieske, B; Kockskämper, J In situ calibration of nucleoplasmic versus cytoplasmic Ca²+ concentration in adult cardiomyocytes.
Biophys J. 2011; 100(10):2356-2366 Doi: 10.1016/j.bpj.2011.03.060 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Ljubojevic, S; Sedej, S; Holzer, M; Marsche, G; Marijanski, V; Kockskaemper, J; Pieske, B Subcellular localization and expression levels of TRPC3, ORAI1, and STIM1 in normal and hypertrophied mouse heart
EUR HEART J SUPPL. 2011; 13(A):A37-A37.-10th International Conference of Non-Invasive Cardiovascular Imaging; MAY 15-18, 2011; Amsterdam, NETHERLANDS. [Oral Communication]
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** Ljubojevic, S; Sedej, S; Sacherer, M; Kockskaemper, J; Pieske, B Perinuclear Ca Stores Remodeling During Hypertrophy and End-Stage Heart Failure
CIRC RES. . 2011; 109(12):E59-E59.-American-Heart-Association Scientific Sessions on Resuscitation Science Symposium; NOV 12-16, 2011; Orlando, FL. [Poster]
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2010

Originalarbeit (Zeitschrift)

** Sedej, S; Heinzel, FR; Walther, S; Dybkova, N; Wakula, P; Groborz, J; Gronau, P; Maier, LS; Vos, MA; Lai, FA; Napolitano, C; Priori, SG; Kockskämper, J; Pieske, B Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Cardiovasc Res. 2010; 87(1):50-59 Doi: 10.1093/cvr/cvq007 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Heinzel, FR; Khan, S; Sedej, S; Freidl, P; Hohendanner, F; Wakula, P; Korff, B; Engelhardt, SE; Pieskel, B Subcellular mechanisms of early impaired calcium homeostasis with chronic beta1-adrenergic stimulation in mice
EUR HEART J. 2010; 31: 895-895. [Oral Communication]
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** Sacherer, M; Sedej, S; Gronau, P; Vos, MA; Kockskaemper, J; Pieske, B; Heinzel, FR JTV519 (K201) decreases Ca2+ overload - induced arrhythmogenic Ca2+ release in mouse cardiac myocytes - the role of CaMKII
EUR HEART J. 2010; 31: 1039-1039. [Poster]
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** Sedej, S; Walther, S; Schmidt, A; Bisping, E; Heinzel, FR; Priori, SG; Kockskaemper, J; Pieske B Accelerated progression of stress-induced heart failure in mice with a human CPVT mutation
European Heart Journal2010; 31(1):314-314.-ESC Congress 2010; AUG 28-SEP 1, 2010; Stockholm, SWEDEN. [Oral Communication]
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2009

Originalarbeit (Zeitschrift)

** Sedej, S; Gurung, IS; Binz, T; Rupnik, M Phosphatidylinositol-4,5-bisphosphate-dependent Facilitation of the ATP-dependent Secretory Activity in Mouse Pituitary Cells.
Ann N Y Acad Sci. 2009; 1152(1): 165-173. Doi: 10.1111/j.1749-6632.2008.04002.x
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2006

Originalarbeit (Zeitschrift)

** Dudanova, I; Sedej, S; Ahmad, M; Masius, H; Sargsyan, V; Zhang, W; Riedel, D; Angenstein, F; Schild, D; Rupnik, M; Missler, M Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.
J Neurosci. 2006; 26(41):10599-10613 Doi: 10.1523/JNEUROSCI.1913-06.2006 [OPEN ACCESS]
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2005

Originalarbeit (Zeitschrift)

** Sedej, S; Rose, T; Rupnik, M cAMP increases Ca2+-dependent exocytosis through both PKA and Epac2 in mouse melanotrophs from pituitary tissue slices.
J Physiol. 2005; 567(Pt 3):799-813 Doi: 10.1113/jphysiol.2005.090381 [OPEN ACCESS]
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** Sedej, S; Rupnik, M; Zorec, R Endocytosis-dominated membrane area decrease requires Rab5 protein in rat melanotrophs.
Ann N Y Acad Sci. 2005; 1048(41):272-280 Doi: 10.1196/annals.1342.024
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** Turner, JE; Sedej, S; Rupnik, M Cytosolic Cl- ions in the regulation of secretory and endocytotic activity in melanotrophs from mouse pituitary tissue slices.
J Physiol. 2005; 566(Pt 2):443-453 Doi: 10.1113/jphysiol.2005.088997 [OPEN ACCESS]
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2004

Originalarbeit (Zeitschrift)

** Sedej, S; Tsujimoto, T; Zorec, R; Rupnik, M Voltage-activated Ca(2+) channels and their role in the endocrine function of the pituitary gland in newborn and adult mice.
J Physiol. 2004; 555(Pt 3):769-782 Doi: 10.1113/jphysiol.2003.058271 [OPEN ACCESS]
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