Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Researchers.
- Curriculum.
- Publications.
- Presentations.
Institutions.
Projects.
Publications.
Partners.
Sponsors.
Equipment.
Knowhow.
Fields of Research.

Claudel Thierry |

Publications

** = Publications listed in SCI/SSCI/Pubmed

2025

Full paper/article (Journal)

** Dixon, ED; Claudel, T; Nardo, AD; Riva, A; Fuchs, CD; Mlitz, V; Busslinger, G; Scharnagl, H; Stojakovic, T; Senéca, J; Hinteregger, H; Grabner, GF; Kratky, D; Verkade, H; Zimmermann, R; Haemmerle, G; Trauner, M Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice.
J Hepatol. 2024; Doi: 10.1016/j.jhep.2024.09.037
Web of Science PubMed FullText FullText_MUG

** Zhu, C; Boucheron, N; Al-Rubaye, O; Chung, BK; Thorbjørnsen, LW; Köcher, T; Schuster, M; Claudel, T; Halilbasic, E; Kunczer, V; Muscate, F; Cavanagh, LL; Waltenberger, D; Lercher, A; Ohradanova-Repic, A; Schatzlmaier, P; Stojakovic, T; Scharnagl, H; Bergthaler, A; Stockinger, H; Huber, S; Bock, C; Kenner, L; Karlsen, TH; Ellmeier, W; Trauner, M 24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting T_H17 pathogenicity and transdifferentiation.
Gut. 2025; Doi: 10.1136/gutjnl-2024-333297
Web of Science PubMed FullText FullText_MUG

2023

Full paper/article (Journal)

** Fuchs, CD; Claudel, T; Mlitz, V; Riva, A; Menz, M; Brusilovskaya, K; Haller, F; Baumgartner, M; Königshofer, P; Unger, LW; Sjöland, W; Scharnagl, H; Stojakovic, T; Busslinger, G; Reiberger, T; Marschall, HU; Trauner, M GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2^-/- Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling.
Cell Mol Gastroenterol Hepatol. 2023; 16(5):847-856 Doi: 10.1016/j.jcmgh.2023.08.003 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2022

Abstract (Journal)

** Dixon, ED; Nardo, AD; Claudel, T; Fuchs, C; Mlitz, V; Stojakovic, T; Scharnagl, H; Grabner, G; Zimmermann, R; Trauner, M Chemical suppression of adipose triglyceride lipase improves non-alcoholic steatohepatitis in a diabetic and hyperlipidemic mouse model
J HEPATOL. 2022; 77: S688-S689. [Poster]
Web of Science

2021

Full paper/article (Journal)

** Tardelli, M; Bruschi, FV; Fuchs, CD; Claudel, T; Auer, N; Kunczer, V; Ronda, OAHO; Verkade, HJ; Stojakovic, T; Scharnagl, H; Trauner, M Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
Int J Mol Sci. 2021; 22(4): Doi: 10.3390/ijms22042126 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Zhu, C; Boucheron, N; Müller, AC; Májek, P; Claudel, T; Halilbasic, E; Baazim, H; Lercher, A; Viczenczova, C; Hainberger, D; Preglej, T; Sandner, L; Alteneder, M; Gülich, AF; Khan, M; Hamminger, P; Remetic, J; Ohradanova-Repic, A; Schatzlmaier, P; Donner, C; Fuchs, CD; Stojakovic, T; Scharnagl, H; Sakaguchi, S; Weichhart, T; Bergthaler, A; Stockinger, H; Ellmeier, W; Trauner, M 24-Norursodeoxycholic acid reshapes immunometabolism in CD8⁺ T cells and alleviates hepatic inflammation.
J Hepatol. 2021; 75(5):1164-1176 Doi: 10.1016/j.jhep.2021.06.036 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2020

Full paper/article (Journal)

** Fuchs, CD; Krivanec, S; Steinacher, D; Mlitz, V; Wahlström, A; Stahlman, M; Claudel, T; Scharnagl, H; Stojakovic, T; Marschall, HU; Trauner, M Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.
Liver Int. 2020; 40(6):1366-1377 Doi: 10.1111/liv.14423 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Nardo, AD; Grün, NG; Zeyda, M; Dumanic, M; Oberhuber, G; Rivelles, E; Helbich, TH; Markgraf, DF; Roden, M; Claudel, T; Trauner, M; Stulnig, TM Impact of osteopontin on the development of non-alcoholic liver disease and related hepatocellular carcinoma.
Liver Int. 2020; 40(7):1620-1633 Doi: 10.1111/liv.14464 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Tardelli, M; Bruschi, FV; Fuchs, CD; Claudel, T; Auer, N; Kunczer, V; Baumgartner, M; Ronda, OAHO; Jan Verkade, H; Stojakovic, T; Scharnagl, H; Habib, A; Zimmermann, R; Lotersztajn, S; Trauner, M Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis.
Hepatology. 2020; Doi: 10.1002/hep.30929 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2019

Full paper/article (Journal)

** Tardelli, M; Bruschi, FV; Claudel, T; Fuchs, CD; Auer, N; Kunczer, V; Stojakovic, T; Scharnagl, H; Habib, A; Grabner, GF; Zimmermann, R; Lotersztajn, S; Trauner, M Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.
J Lipid Res. 2019; 60(7):1284-1292 Doi: 10.1194/jlr.M093369 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Bruschi, F; Tardelli, M; Claudel, T; Zimmermann, R; Lotersztajn, S; Trauner, M Lack of monoacylglycerol lipase protects from MCD-induced hepatic inflammation and fibrosis
J HEPATOL. International Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL). 2019; 70(1):E58-E58.-International Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL); APR 10-14, 2019; Vienna, AUSTRIA. Doi: 10.1016/S0618-8278(19)30104-5 [Poster]
Web of Science FullText FullText_MUG

** Tardelli, M; Bruschi, F; Claudel, T; Auer, N; Kunczer, V; Stojakovic, T; Herac, M; Lotersztajn, S; Trauner, M Monoacylglycerol lipase deletion protects against obesity-induced hepatic steatosis via PPARg regulation in adipose tissue and fatty acid malabsorption in the intestine
J HEPATOL. 2019; 70: E548-E548. Doi: 10.1016/S0618-8278(19)31087-4 [Poster]
Web of Science FullText FullText_MUG

2018

Abstract (Journal)

** Fuchs, CD; Krivanec, S; Steinacher, D; Wahlstrom, A; Stahlman, M; Claudel, T; Scharnagl, H; Stojakovic, T; Marschall, HU; Trauner, MH Absence of Bsep Attenuates Mcd Diet Induced Hepatic Steatosis but Aggravates Inflammation in Mice
HEPATOLOGY. 2018; 68: 1003A-1004A.-Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting; NOV 09-13, 2018; San Francisco, CA. [Poster]
Web of Science

** Tardelli, M; Bruschi, FV; Claudel, T; Fuchs, CD; Auer, N; Kunczer, V; Stojakovic, T; Ronda, OAHO; Verkade, HJ; Lotersztajn, S; Trauner, MH Mice Lacking Monoacylglycerol Lipase Are Protected from Hepatic Inflammation and Biliary Fibrosis in Ddc-Induced Sclerosing Cholangitis.
HEPATOLOGY. . 2018; 68: 130A-130A.-Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting; NOV 09-13, 2018; San Francisco, CA. [Poster]
Web of Science

2017

Full paper/article (Journal)

** Fuchs, CD; Claudel, T; Scharnagl, H; Stojakovic, T; Trauner, M FXR controls CHOP expression in steatohepatitis.
FEBS Lett. 2017; 591(20):3360-3368 Doi: 10.1002/1873-3468.12845 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Steinacher, D; Claudel, T; Griessner, J; Einwallner, E; Ruhlemann, MC; Ronda, O; Heinsen, FA; Stojakovic, T; Scharnagl, H; Verkade, HJ; Haubensak, WE; Trauner, M NorUDCA improves liver injury and metabolic situation in mouse models of obesity and steatosis
J HEPATOL. 2017; 66(1):S168-S168.-International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 19-23, 2017; Amsterdam, NETHERLANDS. Doi: 10.1016/S0168-8278(17)30616-5 [Poster]
Web of Science FullText FullText_MUG

2015

Full paper/article (Journal)

** Das, SK; Stadelmeyer, E; Schauer, S; Schwarz, A; Strohmaier, H; Claudel, T; Zechner, R; Hoefler, G; Vesely, PW Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58.
Int J Mol Sci. 2015; 16(4):8555-8568 Doi: 10.3390/ijms16048555 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Mueller, M; Thorell, A; Claudel, T; Jha, P; Koefeler, H; Lackner, C; Hoesel, B; Fauler, G; Stojakovic, T; Einarsson, C; Marschall, HU; Trauner, M Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity.
J Hepatol. 2015; 62(6):1398-1404 Doi: 10.1016/j.jhep.2014.12.034 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Sombetzki, M; Fuchs, CD; Fickert, P; Österreicher, CH; Mueller, M; Claudel, T; Loebermann, M; Engelmann, R; Langner, C; Sahin, E; Schwinge, D; Guenther, ND; Schramm, C; Mueller-Hilke, B; Reisinger, EC; Trauner, M 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis.
J Hepatol. 2015; 62(4):871-878 Doi: 10.1016/j.jhep.2014.11.020 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Stiedl, P; McMahon, R; Blaas, L; Stanek, V; Svinka, J; Grabner, B; Zollner, G; Kessler, SM; Claudel, T; Müller, M; Mikulits, W; Bilban, M; Esterbauer, H; Eferl, R; Haybaeck, J; Trauner, M; Casanova, E Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis.
Hepatology. 2015; 61(2):613-626 Doi: 10.1002/hep.27408 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Review

** Trauner, M; Halilbasic, E; Claudel, T; Steinacher, D; Fuchs, C; Moustafa, T; Pollheimer, M; Krones, E; Kienbacher, C; Traussnigg, S; Kazemi-Shirazi, L; Munda, P; Hofer, H; Fickert, P; Paumgartner, G Potential of nor-Ursodeoxycholic Acid in Cholestatic and Metabolic Disorders.
Dig Dis. 2015; 33(3):433-439 Doi: 10.1159/000371904
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Fuchs, CD; Claudel, T; Halilbasic, E; Jha, P; Spindelboeck, W; Stojakovic, T; Trauner, M ROLE OF FXR CONTROLLED Chop IN MEDIATING BILE ACID EFFECTS IN NAFLD.
J HEPATOL. 2015; 62(S2):S689-S689.-50th Annual Meeting of the European Association for the Study of the Liver (EASL); APR 22-26, 2015; Vienna, AUSTRIA. [Poster]
Web of Science

** Steinacher, D; Claudel, T; Stojakovic, T; Trauner, M NorUDCA-Therapy leads to reduced Inflammation in Fat Tissue and the Liver, and improves Glucose-Tolerance in Ob/Ob Mouse Model of Obesity and Fatty Liver.
WIEN KLIN WOCHENSCHR. 2015; 127(17-18):738-738.-16. Jahrestagung der Österreichischen Adipositas Gesellschaft (ÖAG); OCT 23-24, 2015; Vienna, AUSTRIA. [Oral Communication]
Web of Science

** Steinacher, D; Claudel, T; Stojakovic, T; Trauner, M NorUDCA reduces liver injury and improves glucose sensitivity in a mouse model of obesity and steatosis.
HEPATOLOGY. . 2015; 62: 689A-689A.-66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); NOV 13-17, 2015; San Francisco, CA. [Oral Communication]
Web of Science

** Stiedl, P; McMahon, R; Blaas, L; Stanek, V; Svinka, J; Grabner, B; Zollner, G; Kressler, S; Claudel, T; Muller, M; Mikulits, W; Esterbauer, H; Eferl, R; Haybaeck, J; Trauner, M; Casanova, E THE ROLE OF GROWTH HORMONE RECEPTOR IN LIVER FIBROSIS AND CANCER
J HEPATOL. 2015; 62: S792-S792.-50th International Liver Congress of the European-Association-for-the-Study-of-the-Liver; APR 22-26, 2015; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(15)31366-0 [Poster]
Web of Science FullText FullText_MUG

2014

Full paper/article (Journal)

** Demetz, E; Schroll, A; Auer, K; Heim, C; Patsch, JR; Eller, P; Theurl, M; Theurl, I; Theurl, M; Seifert, M; Lener, D; Stanzl, U; Haschka, D; Asshoff, M; Dichtl, S; Nairz, M; Huber, E; Stadlinger, M; Moschen, AR; Li, X; Pallweber, P; Scharnagl, H; Stojakovic, T; März, W; Kleber, ME; Garlaschelli, K; Uboldi, P; Catapano, AL; Stellaard, F; Rudling, M; Kuba, K; Imai, Y; Arita, M; Schuetz, JD; Pramstaller, PP; Tietge, UJF; Trauner, M; Norata, GD; Claudel, T; Hicks, AA; Weiss, G; Tancevski, I The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.
Cell Metab. 2014; 20(5):787-798 Doi: 10.1016/j.cmet.2014.09.004 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Jha, P; Claudel, T; Baghdasaryan, A; Mueller, M; Halilbasic, E; Das, SK; Lass, A; Zimmermann, R; Zechner, R; Hoefler, G; Trauner, M Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.
Hepatology. 2014; 59(3):858-869 Doi: 10.1002/hep.26732 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Jha, P; Knopf, A; Koefeler, H; Mueller, M; Lackner, C; Hoefler, G; Claudel, T; Trauner, M; Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).
BBA-MOL BASIS DIS. 2014; 1842(7): 959-970. Doi: 10.1016/j.bbadis.2014.02.012 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Wree, A; Schlattjan, M; Bechmann, LP; Claudel, T; Sowa, JP; Stojakovic, T; Scharnagl, H; Köfeler, H; Baba, HA; Gerken, G; Feldstein, AE; Trauner, M; Canbay, A Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients.
Metabolism. 2014; 63(12):1542-1552 Doi: 10.1016/j.metabol.2014.09.001
Web of Science PubMed FullText FullText_MUG

Review

** Cuperus, FJ; Claudel, T; Gautherot, J; Halilbasic, E; Trauner, M The role of canalicular ABC transporters in cholestasis.
Drug Metab Dispos. 2014; 42(4):546-560 Doi: 10.1124/dmd.113.056358 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Fuchs, CD; Claudel, T; Trauner, M Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD.
Trends Endocrinol Metab. 2014; 25(11):576-585 Doi: 10.1016/j.tem.2014.08.001
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Fuchs, CD; Paumgartner, G; Wahlstrom, A; Chiba, P; Stojakovic, T; Claudel, T; Marschall, HU; Trauner, M Absence of BSEP/ABCB11 protects from cholestatic liver injury in mice.
HEPATOLOGY. 2014; 60: 405A-406A.-65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD); NOV 07-11, 2014; Boston, USA. [Poster]
Web of Science

Comment

** Stojakovic, T; Claudel, T; Trauner, M Editorial for 'randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis'.
Liver Int. 2014; 34(3):328-329 Doi: 10.1111/liv.12359 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2013

Full paper/article (Journal)

** Gautier, T; de Haan, W; Grober, J; Ye, D; Bahr, MJ; Claudel, T; Nijstad, N; Van Berkel, TJ; Havekes, LM; Manns, MP; Willems, SM; Hogendoorn, PC; Lagrost, L; Kuipers, F; Van Eck, M; Rensen, PC; Tietge, UJ Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice.
J Lipid Res. 2013; 54(8):2195-2205 Doi: 10.1194/jlr.M038141 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Huang, J; Das, SK; Jha, P; Al Zoughbi, W; Schauer, S; Claudel, T; Sexl, V; Vesely, P; Birner-Gruenberger, R; Kratky, D; Trauner, M; Hoefler, G The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism.
Biochim Biophys Acta. 2013; 1831(10):1555-1565 Doi: 10.1016/j.bbalip.2013.04.012 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Review

** Fuchs, C; Claudel, T; Trauner, M Bile acid-mediated control of liver triglycerides.
Semin Liver Dis. 2013; 33(4):330-342 Doi: 10.1055/s-0033-1358520
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Fuchs, CD; Claudel, T; Halilbasic, E; Jha, P; Spindelboeck, W; Stojakovic, T; Trauner, M FXR controlled CHOP as novel key player in NAFLD progression.
HEPATOLOGY. 2013; 58(S1):542A-542A.-64th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD); NOV 1-5, 2013; Washington, DC, USA. [Poster]
Web of Science

** Fuchs, CD; Claudel, T; Halilbasic, E; Stojakovic, T; Trauner, M INTRAHEPATIC CHANGES IN BILE ACID COMPOSITION PROTECTS BSEP (ABCB11) KO MICE FROM HEPATIC INFLAMMATION IN METHIONINE CHOLINE DEFICIENT DIET INDUCED NASH.
J HEPATOL. 2013; 58(S1):S32-S32.-48th Annual Meeting of the European Association for the Study of the Liver (EASL); APR 24-28, 2013; Amsterdam, THE NETHERLANDS. Doi: 10.1016/S0168-8278(13)60072-0 [Oral Communication]
Web of Science FullText FullText_MUG

** Mueller, M; Marschall, HU; Claudel, T; Wagner, M; Fickert, P; Lackner, C; Einarsson, C; Thorell, A; Trauner, M URSODEOXYCHOLIC ACID COUNTERACTS LIPOTOXICITY AND INDUCES UNFOLDED PROTEIN RESPONSE IN MORBIDLY OBESE PATIENTS
J HEPATOL. . 2013; 58: S517-S517.-International Liver Congress / 48th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL); APR 24-28, 2013; Amsterdam, NETHERLANDS. Doi: 10.1016/S0168-8278(13)61279-9 [Poster]
Web of Science FullText FullText_MUG

2012

Full paper/article (Journal)

** Chennamsetty, I; Claudel, T; Kostner, KM; Trauner, M; Kostner, GM FGF19 signaling cascade suppresses APOA gene expression.
Arterioscler Thromb Vasc Biol. 2012; 32(5):1220-1227 Doi: 10.1161/ATVBAHA.111.243055 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Chennamsetty, I; Kostner, KM; Claudel, T; Vinod, M; Frank, S; Weiss, TS; Trauner, M; Kostner, GM Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice.
J Lipid Res. 2012; 53(11):2405-2412 Doi: 10.1194/jlr.M029769 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Fuchs, CD; Claudel, T; Kumari, P; Haemmerle, G; Pollheimer, MJ; Stojakovic, T; Scharnagl, H; Halilbasic, E; Gumhold, J; Silbert, D; Koefeler, H; Trauner, M Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice.
Hepatology. 2012; 56(1):270-280 Doi: 10.1002/hep.25601 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Fuchs, C; Claudel, T; Kumari, P; Stojakovic, T; Halilbasic, E; Spindelboeck, W; Gonzalez, F; Trauner, M FXR IS A KEY PLAYER IN NAFLD DEVELOPMENT BY CONTROLLING CHOP EXPRESSION.
J HEPATOL. 2012; 56(S2):S490-S490.-47th Annual Meeting of the European Association for the Study of the Liver (EASL); APR 18-22, 2012; Barcelona, SPAIN. Doi: 10.1016/S0168-8278(12)61248-3 [Poster]
Web of Science FullText FullText_MUG

** Fuchs, CD; Claudel, T; Stojakovic, T; Haemmerle, G; Trauner, M Changes in hepatic bile acid composition protect BSEP (ABCB11) KO mice from hepatic inflammation in methionine choline deficient (MCD)-diet induced NASH.
HEPATOLOGY. 2012; 56: 873A-874A.-63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD); NOV 09-13, 2012; Boston, USA. [Poster]
Web of Science

** Halilbasic, E; Claudel, T; Bachhofner, N; Kapusta, C; Fickert, P; Trauner, M Norursodeoxycholic Acid Counteracts Hepatic Acute Phase Response via Modulation of NF kappa B Signaling
HEPATOLOGY. 2012; 56: 539A-540A.-63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); NOV 09-13, 2012; Boston, MA.
Web of Science

2011

Full paper/article (Journal)

** Baghdasaryan, A; Claudel, T; Gumhold, J; Silbert, D; Adorini, L; Roda, A; Vecchiotti, S; Gonzalez, FJ; Schoonjans, K; Strazzabosco, M; Fickert, P; Trauner, M Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output.
Hepatology. 2011; 54(4):1303-1312 Doi: 10.1002/hep.24537 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG Google Scholar

** Chennamsetty, I; Claudel, T; Kostner, KM; Baghdasaryan, A; Kratky, D; Levak-Frank, S; Frank, S; Gonzalez, FJ; Trauner, M; Kostner, GM Farnesoid X receptor represses hepatic human APOA gene expression.
J Clin Invest. 2011; 121(9):3724-3734 Doi: 10.1172/JCI45277 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Gachon, F; Leuenberger, N; Claudel, T; Gos, P; Jouffe, C; Fleury Olela, F; de Mollerat du Jeu, X; Wahli, W; Schibler, U Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity.
Proc Natl Acad Sci U S A. 2011; 108(12):4794-4799 Doi: 10.1073/pnas.1002862108 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Review

** Claudel, T; Zollner, G; Wagner, M; Trauner, M Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease.
Biochim Biophys Acta. 2011; 1812(8):867-878 Doi: 10.1016/j.bbadis.2010.12.021 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG Google Scholar

** Trauner, M; Baghdasaryan, A; Claudel, T; Fickert, P; Halilbasic, E; Moustafa, T; Zollner, G Targeting nuclear bile acid receptors for liver disease.
Dig Dis. 2011; 29(1):98-102 Doi: 10.1159/000324141
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Baghdasaryan, A; Claudel, T; Gumhold, J; Silbert, D; Adorini, L; Gonzalez, F; Schoonjans, K; Fickert, P; Trauner, M FXR BUT NOT TGR5 ACTIVATION STIMULATES HCO3-RICH BILE SECRETION AND AMELIORATES LIVER DAMAGE IN MDR2-/- (ABCB4-/-) MOUSE MODEL OF CHRONIC LIVER INJURY
HEPATOLOGY. 2011; 54: 425A-425A.-62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); NOV 04-08, 2011; San Francisco, CA. [Oral Communication]
Web of Science

** Fuchs, CD; Claudel, T; Kumari, P; Stojakovic, T; Haemmerle, G; Halilbasic, E; Gumhold, J; Silbert, D; Koefeler, H; Zechner, R; Trauner, M ATGL (PNPLA2) KNOCKOUT MICE ARE PROTECTED FROM HEPATIC ER-STRESS VIA OLEIC ACID ACCUMULATION.
J HEPATOL. 2011; 54: S41-S42.-46th Annual Meeting of the European Association for the Study of the Liver (EASL); MAR 30-APR 3, 2011; Berlin, GERMANY. Doi: 10.1016/S0168-8278(11)60095-0 [Poster]
Web of Science FullText FullText_MUG

** Fuchs, CD; Claudel, T; Stojakovic, T; Silbert, D; Maurer, B; Trauner, M BSEP (ABCB11) KO MICE ARE PROTECTED FROM HEPATIC INFLAMMATION IN METHIONINE CHOLINE DEFICIENT DIET INDUCED NASH.
HEPATOLOGY. 2011; 54: 1169A-1169A.-62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD); NOV 04-08, 2011; San Francisco, USA. [Poster]
Web of Science

** Kumari, P; Claudel, T; Kofeler, H; Schittmayer, M; Grunberger, RB; Baghdasaryan, A; Das, S; Zechner, R; Hofler, G; Trauner, M ADIPOSE TRIGLYCERIDE LIPASE (PNPLA2) IS A NOVEL KEY PLAYER IN PROTECTION FROM NASH
HEPATOLOGY. 2011; 54: 1154A-1154A.-62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); NOV 04-08, 2011; San Francisco, CA. [Poster]
Web of Science

2010

Full paper/article (Journal)

** Baghdasaryan, A; Claudel, T; Kosters, A; Gumhold, J; Silbert, D; Thüringer, A; Leski, K; Fickert, P; Karpen, SJ; Trauner, M Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation.
Gut. 2010; 59(4):521-530 Doi: 10.1136/gut.2009.186528 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Stojakovic, T; Claudel, T; Putz-Bankuti, C; Fauler, G; Scharnagl, H; Wagner, M; Sourij, H; Stauber, RE; Winkler, K; März, W; Wascher, TC; Trauner, M Low-dose atorvastatin improves dyslipidemia and vascular function in patients with primary biliary cirrhosis after one year of treatment.
Atherosclerosis. 2010; 209(1): 178-183. Doi: 10.1016/j.atherosclerosis.2009.08.052
Web of Science PubMed FullText FullText_MUG Google Scholar

Review

** Trauner, M; Claudel, T; Fickert, P; Moustafa, T; Wagner, M Bile acids as regulators of hepatic lipid and glucose metabolism.
Dig Dis. 2010; 28(1):220-224 Doi: 10.1159/000282091
Web of Science PubMed FullText FullText_MUG Google Scholar

** Trauner, M; Fickert, P; Baghdasaryan, A; Claudel, T; Halilbasic, E; Moustafa, T; Wagner, M; Zollner, G New insights into autoimmune cholangitis through animal models.
Dig Dis. 2010; 28(1):99-104 Doi: 10.1159/000282072
Web of Science PubMed FullText FullText_MUG Google Scholar

Abstract (Journal)

** Baghdasaryan, A; Claudel, T; Gumhold, J; Silbert, D; Halsegger, S; Adorini, L; Strazzabosco, M; Fickert, P; Trauner, M THERAPEUTIC TARGETING OF NUCLEAR AND MEMBRANE BILE ACID RECEPTORS IN A MOUSE MODEL OF CHRONIC CHOLESTASIS
HEPATOLOGY. 2010; 52(4):724--The 61st Annual Meeting of the Americal Association fro teh Study of liver Diseases; OCT 29-NOV 02, 2010; Boston, MA, USA. [Poster]
Web of Science

** Baghdasaryan, A; Claudel, T; Gumhold, J; Silbert, D; Halsegger, S; Volkl, R; Adorini, L; Fickert, P; Trauner, M THERAPEUTIC EFFECTS OF FXR AND TGR5 ACTIVATION IN THE MDR2 (ABCB4)(-/-) MOUSE MODEL OF SCLEROSING CHOLANGITIS
J HEPATOL. 2010; 52: S354-S354.-45th Annual Meeting of the European Association for the Study of the Liver; APR 14 - 18,2010; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(10)60914-2 [Oral Communication]
Web of Science FullText FullText_MUG

** Halilbasic, E; Claudel, T; Gumhold, J; Halsegger, S; Silbert, D; Fickert, P; Trauner, M PREGNANCY RESOLVES LIVER FIBROSIS AND IMPROVES SCLEROSING CHOLANGITIS IN MDR2 (ABCB4) -/- MICE VIA DIRECT ANTI-INFLAMMATORY EFFECTS OF SEX HORMONES
J HEPATOL. 2010; 52: S24-S24.-45th Annual Meeting of the European Association for the Study of the Liver; APR 14 - 18,2010; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(10)60052-9 [Oral Communication]
Web of Science FullText FullText_MUG

** Kumari, P; Claudel, T; Kofeler, H; Schittmayer, M; Grunberger, RB; Zechner, R; Hofler, G; Trauner, M ADIPOSE TRIGLYCERIDE LIPASE (ATGL) IS A NOVEL KEY PLAYER IN PROTECTION FROM ACUTE HEPATIC INFLAMMATION
J HEPATOL. 2010; 52: S19-S19.-International Liver Congress 2010 the 45th annual meeting of the European Association for the Study of the Liver (EASL) ; APR 14 -18, 2010; Doi: 10.1016/S0168-8278(10)60045-1 [Oral Communication]
Web of Science FullText FullText_MUG

** Stojakovic, T; Claudel, T; Putz-Bankuti, C; Fauler, G; Scharnagl, H; Wagner, M; Sourij, H; Stauber, RE; Winkler, K; Marz, W; Wascher, TC; Trauner, M LOW-DOSE ATORVASTATIN IMPROVES DYSLIPIDEMIA AND VASCULAR FUNCTION IN PATIENTS WITH PRIMARY BILIARY CIRRHOSIS AFTER ONE YEAR OF TREATMENT.
J HEPATOL. 2010; 52: S431-S432.-45th Annual Meeting of the European Association for the Study of the Liver (EASL); APR 14-18, 2010; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(10)61118-X [Poster]
Web of Science FullText FullText_MUG

2009

Full paper/article (Journal)

** Le Martelot, G; Claudel, T; Gatfield, D; Schaad, O; Kornmann, B; Lo Sasso, G; Moschetta, A; Schibler, U REV-ERB alpha Participates in Circadian SREBP Signaling and Bile Acid Homeostasis
PLOS BIOL. 2009; 7(9): e1000181 Doi: 10.1371/journal.pbio.1000181 [OPEN ACCESS]
Web of Science FullText FullText_MUG

Abstract (Journal)

** Jahnel, J; Claudel, T; Baghdasaryan, A; Langner, C; Fickert, P; Trauner, M; Hauer, AC; Silbert, A; Gumhold, J; Fuchsbichler, A PHOSPHOLIPIDS AND COLITIS: IMPACT OF NUTRITIONAL AND BILIARY LACK OF PHOSPHOLIPIDS IN A COLITIS MOUSE MODEL
ACTA PAEDIAT. 2009; 98: 29-30.-50th Annual Meeting of the European Society for Paediatric Research ; October 9-12, 2009 ; Hamburg, Germany. [Oral Communication]
Web of Science

Full paper/article (Proceedings)

** Trauner, M; Fickert, P; Moustafa, T; Fuchsbichler, A; Claudel, T; Halilbasic, E; Kratky, D; Denk, H Potential role of ursodeoxycholic acid and its side-chain modified derivatives in the treatment of non-alcoholic fatty liver disease and associated atherosclerosis
FALK SYMP. 2009; 165: 151-156. [Oral Communication]
Web of Science

2008

Full paper/article (Journal)

** Baghdasaryan, A; Fickert, P; Fuchsbichler, A; Silbert, D; Gumhold, J; Hörl, G; Langner, C; Moustafa, T; Halilbasic, E; Claudel, T; Trauner, M Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice.
Liver Int. 2008; 28(7):948-958 Doi: 10.1111/j.1478-3231.2008.01758.x
Web of Science PubMed FullText FullText_MUG Google Scholar

Abstract (Journal)

** Baghdasaryan, A; Kosters, A; Claudel, T; Fuchsbichler, A; Gumhold, J; Silbert, D; Leski, K; Fickert, P; Karpen, SJ; Trauner, M Curcumin improves liver injury and biliary fibrosis in MDR2 (ABCB4) knockout mice by inducing anti-oxidative response, but not via modification of bile acid transport/metabolism
J HEPATOL. 2008; 48: S171-S171.-EASL Annual Meeting; April 2008; Milan Italy. Doi: 10.1016/S0168-8278(08)60450-X [Poster]
Web of Science FullText FullText_MUG

** Fickert, P; Moustafa, T; Fuchsbichler, A; Claudel, T; Halilbasic, E; Zatloukal, K; Denk, H; Trauner, M Differential effects of nor UDCA and UDCA in the treatment of fatty liver and arteriosclerosis in western chow-fed ApoE knock out mice
J HEPATOL. 2008; 48: S42-S42.-Annual Meeting, EASL; April 2008; Milann, Italy. Doi: 10.1016/S0168-8278(08)60100-2 [Oral Communication]
Web of Science FullText FullText_MUG

2007

Full paper/article (Journal)

** Nohara, A; Kawashiri, MA; Claudel, T; Mizuno, M; Tsuchida, M; Takata, M; Katsuda, S; Miwa, K; Inazu, A; Kuipers, F; Kobayashi, J; Koizumi, J; Yamagishi, M; Mabuchi, H High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.
Arterioscler Thromb Vasc Biol. 2007; 27(4): 923-928. Doi: 10.1161/01.ATV.0000258945.76141.8a [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Review

** Claudel, T; Cretenet, G; Saumet, A; Gachon, F Crosstalk between xenobiotics metabolism and circadian clock.
FEBS Lett. 2007; 581(19): 3626-3633. Doi: 10.1016/j.febslet.2007.04.009 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2005

Review

** Claudel, T; Staels, B; Kuipers, F The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism.
Arterioscler Thromb Vasc Biol. 2005; 25(10): 2020-2030. Doi: 10.1161/01.ATV.0000178994.21828.a7 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2004

Full paper/article (Journal)

** Sirvent, A; Claudel, T; Martin, G; Brozek, J; Kosykh, V; Darteil, R; Hum, DW; Fruchart, JC; Staels, B The farnesoid X receptor induces very low density lipoprotein receptor gene expression.
FEBS Lett. 2004; 566(1-3): 173-177. Doi: 10.1016/j.febslet.2004.04.026
Web of Science PubMed FullText FullText_MUG

Review

** Claudel, T; Sturm, E; Kuipers, F; Staels, B The farnesoid X receptor: a novel drug target?
Expert Opin Investig Drugs. 2004; 13(9):1135-1148 Doi: 10.1517/13543784.13.9.1135
Web of Science PubMed FullText FullText_MUG

** Kuipers, F; Claudel, T; Sturm, E; Staels, B The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism.
Rev Endocr Metab Disord. 2004; 5(4): 319-326. Doi: 10.1023/B:REMD.0000045103.00467.9a
Web of Science PubMed FullText FullText_MUG

2003

Full paper/article (Journal)

** Barbier, O; Torra, IP; Sirvent, A; Claudel, T; Blanquart, C; Duran-Sandoval, D; Kuipers, F; Kosykh, V; Fruchart, JC; Staels, B FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.
Gastroenterology. 2003; 124(7): 1926-1940. Doi: 10.1016/S0016-5085(03)00388-3
Web of Science PubMed FullText FullText_MUG

** Claudel, T; Inoue, Y; Barbier, O; Duran-Sandoval, D; Kosykh, V; Fruchart, J; Fruchart, JC; Gonzalez, FJ; Staels, B Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.
Gastroenterology. 2003; 125(2):544-555 Doi: 10.1016/S0016-5085(03)00896-5
Web of Science PubMed FullText FullText_MUG

** Pineda Torra, I; Claudel, T; Duval, C; Kosykh, V; Fruchart, JC; Staels, B Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.
Mol Endocrinol. 2003; 17(2):259-272 Doi: 10.1210/me.2002-0120 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2002

Full paper/article (Journal)

** Claudel, T; Sturm, E; Duez, H; Torra, IP; Sirvent, A; Kosykh, V; Fruchart, JC; Dallongeville, J; Hum, DW; Kuipers, F; Staels, B Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
J Clin Invest. 2002; 109(7):961-971 Doi: 10.1172/JCI14505 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2001

Full paper/article (Journal)

** Claudel, T; Leibowitz, MD; Fiévet, C; Tailleux, A; Wagner, B; Repa, JJ; Torpier, G; Lobaccaro, JM; Paterniti, JR; Mangelsdorf, DJ; Heyman, RA; Auwerx, J Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.
Proc Natl Acad Sci U S A. 2001; 98(5):2610-2615 Doi: 10.1073/pnas.041609298 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

↑ Top of page / Navigation