Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Fröhlich Eleonore |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2024

Originalarbeit (Zeitschrift)

** Abdelhamid, M; Corzo, C; Urich, JAA; Slama, E; Fröhlich, E; Lochmann, D; Reyer, S; Freichel, T; Spoerk, M; Salar-Behzadi, S Personalization of lipid-based oral dosage forms via filament-based 3D-printing
APPL MATER TODAY. 2024; 40: 102399 Doi: 10.1016/j.apmt.2024.102399
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** George, M; Allerkamp, HH; Koshenov, Z; Oflaz, FE; Tam-Amersdorfer, C; Kolesnik, T; Rittchen, S; Lang, M; Fröhlich, E; Graier, W; Strobl, H; Wadsack, C Liver X receptor activation mitigates oxysterol-induced dysfunction in fetoplacental endothelial cells.
Biochim Biophys Acta Mol Cell Biol Lipids. 2024; 1869(3):159466 Doi: 10.1016/j.bbalip.2024.159466
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** Glader, C; Jeitler, R; Stanzer, S; Harbusch, N; Prietl, B; El-Heliebi, A; Selmani, A; Fröhlich, E; Mussbacher, M; Roblegg, E Investigation of nanostructured lipid carriers for fast intracellular localization screening using the Echo liquid handler.
Int J Pharm. 2024; 665:124698 Doi: 10.1016/j.ijpharm.2024.124698
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** Jeitler, R; Glader, C; König, G; Kaplan, J; Tetyczka, C; Remmelgas, J; Mußbacher, M; Fröhlich, E; Roblegg, E On the Structure, Stability, and Cell Uptake of Nanostructured Lipid Carriers for Drug Delivery.
Mol Pharm. 2024; Doi: 10.1021/acs.molpharmaceut.4c00392 [OPEN ACCESS]
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** Langthaler, S; Zumpf, C; Rienmüller, T; Shrestha, N; Fuchs, J; Zhou, R; Pelzmann, B; Zorn-Pauly, K; Fröhlich, E; Weinberg, SH; Baumgartner, C The bioelectric mechanisms of local calcium dynamics in cancer cell proliferation: an extension of the A549 in silico cell model.
Front Mol Biosci. 2024; 11: 1394398 Doi: 10.3389/fmolb.2024.1394398 [OPEN ACCESS]
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** Meindl, C; Öhlinger, K; Zrim, V; Ober, J; Jeitler, R; Roblegg, E; Fröhlich, E Skin Sensitization Potential of Sensitizers in the Presence of Metal Oxide Nanoparticles In Vitro.
Nanomaterials (Basel). 2024; 14(22): 1811 Doi: 10.3390/nano14221811 [OPEN ACCESS]
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** Radivojev, S; Kargl, L; Pinto, JT; Swedrowska, M; Malmlöf, M; Meindl, C; Forbes, B; Gerde, P; Paudel, A; Fröhlich, E Integration of mucus and its impact within in vitro setups for inhaled drugs and formulations: Identifying the limits of simple vs. complex methodologies when studying drug dissolution and permeability.
Int J Pharm. 2024; 661: 124455 Doi: 10.1016/j.ijpharm.2024.124455
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** Vidakovic, I; Kornmueller, K; Fiedler, D; Khinast, J; Fröhlich, E; Leitinger, G; Horn, C; Quehenberger, J; Spadiut, O; Prassl, R Archaeosomes for Oral Drug Delivery: From Continuous Microfluidics Production to Powdered Formulations.
Pharmaceutics. 2024; 16(6): 694 Doi: 10.3390/pharmaceutics16060694 [OPEN ACCESS]
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Übersichtsarbeit

** Fröhlich, E Local and systemic effects of microplastic particles through cell damage, release of chemicals and drugs, dysbiosis, and interference with the absorption of nutrients
J TOXICOL ENV HEAL B. 2024; 27(8): 315-344. Doi: 10.1080/10937404.2024.2406192
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** Fröhlich, E Animals in Respiratory Research.
Int J Mol Sci. 2024; 25(5): 2903 Doi: 10.3390/ijms25052903 [OPEN ACCESS]
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2023

Originalarbeit (Zeitschrift)

** Corzo, C; Crvenjak, D; Sotirov, K; Urich, JA; Ohlinger, K; Meindl, C; Lochmann, D; Reyer, S; Frohlich, E; Zimmer, A; Salar-Behzadi, S Lipid-based particle engineering via spray-drying for targeted delivery of antibiotics to the lung
INT J PHARMACEUT. 2023; 642: 123201 Doi: 10.1016/j.ijpharm.2023.123201
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** Meindl, C; Absenger-Novak, M; Jeitler, R; Roblegg, E; Frohlich, E Assessment of Carbon Nanotubes on Barrier Function, Ciliary Beating Frequency and Cytokine Release in In Vitro Models of the Respiratory Tract
NANOMATERIALS-BASEL. 2023; 13(4): 682 Doi: 10.3390/nano13040682 [OPEN ACCESS]
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** Schachner-Nedherer, AL; Fuchs, J; Vidakovic, I; Höller, O; Schratter, G; Almer, G; Fröhlich, E; Zimmer, A; Wabitsch, M; Kornmueller, K; Prassl, R Lipid Nanoparticles as a Shuttle for Anti-Adipogenic miRNAs to Human Adipocytes.
Pharmaceutics. 2023; 15(7): Doi: 10.3390/pharmaceutics15071983 [OPEN ACCESS]
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** Zeiringer, S; Wiltschko, L; Glader, C; Reiser, M; Absenger-Novak, M; Frohlich, E; Roblegg, E Development and Characterization of an In Vitro Intestinal Model Including Extracellular Matrix and Macrovascular Endothelium
MOL PHARMACEUT. 2023; Doi: 10.1021/acs.molpharmaceut.3c00532 [OPEN ACCESS]
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Übersichtsarbeit

** Frohlich, E The Variety of 3D Breast Cancer Models for the Study of Tumor Physiology and Drug Screening
INT J MOL SCI. 2023; 24(8): 7116 Doi: 10.3390/ijms24087116 [OPEN ACCESS]
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** Frohlich, E; Wahl, R Pars Distalis and Pars Tuberalis Thyroid-Stimulating Hormones and Their Roles in Macro-Thyroid-Stimulating Hormone Formation
INT J MOL SCI. 2023; 24(14): 11699 Doi: 10.3390/ijms241411699 [OPEN ACCESS]
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Editorial

** Frohlich, E; Loizou, GD Editorial: 3Rs-Strategies for reduction and refinement of animal studies
FRONT PHARMACOL. 2023; 14: 1200965 Doi: 10.3389/fphar.2023.1200965 [OPEN ACCESS]
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** Frohlich, E; Steinritz, D Editorial: Case reports in predictive toxicology: 2022
FRONT PHARMACOL. 2023; 14: 1180949 Doi: 10.3389/fphar.2023.1180949 [OPEN ACCESS]
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** Mehta, PP; Frohlich, E; Khan, R; Parihar, A; Kumar, CMS Editorial: Advances in orally inhaled and nasal drug products (OINDPs)
FRONT PHARMACOL. 2023; 14: 1185609 Doi: 10.3389/fphar.2023.1185609 [OPEN ACCESS]
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2022

Originalarbeit (Zeitschrift)

** Bernecker, C; Lima, M; Kolesnik, T; Lampl, A; Ciubotaru, C; Leita, R; Kolb, D; Froehlich, E; Schlenke, P; Holzapfel, GA; Dorn, I; Cojoc, D Biomechanical properties of native and cultured red blood cells-Interplay of shape, structure and biomechanics
FRONT PHYSIOL. 2022; 13: 979298 Doi: 10.3389/fphys.2022.979298 [OPEN ACCESS]
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** De Leon, G; Frohlich, E; Fink, E; Di Pizio, A; Salar-Behzadi, S Premexotac: Machine learning bitterants predictor for advancing pharmaceutical development
INT J PHARMACEUT. 2022; 628: 122263 Doi: 10.1016/j.ijpharm.2022.122263
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** Jeitler, R; Glader, C; Tetyczka, C; Zeiringer, S; Absenger-Novak, M; Selmani, A; Froehlich, E; Roblegg, E Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells
FRONT MOL BIOSCI. 2022; 9: 917921 Doi: 10.3389/fmolb.2022.917921 [OPEN ACCESS]
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** Selmani, A; Seibert, E; Tetyczka, C; Kuehnelt, D; Vidakovic, I; Kornmueller, K; Absenger-Novak, M; Radatović, B; Vinković, Vrček, I; Leitinger, G; Fröhlich, E; Bernkop-Schnürch, A; Roblegg, E; Prassl, R Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles.
Pharmaceutics. 2022; 14(4): Doi: 10.3390/pharmaceutics14040803 [OPEN ACCESS]
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Übersichtsarbeit

** Frohlich, E Non-Cellular Layers of the Respiratory Tract: Protection against Pathogens and Target for Drug Delivery
PHARMACEUTICS. 2022; 14(5): 992 Doi: 10.3390/pharmaceutics14050992 [OPEN ACCESS]
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** Frohlich, E; Wahl, R Insight into Potential Interactions of Thyroid Hormones, Sex Hormones and Their Stimulating Hormones in the Development of Non-Alcoholic Fatty Liver Disease
METABOLITES. 2022; 12(8): 718 Doi: 10.3390/metabo12080718 [OPEN ACCESS]
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2021

Originalarbeit (Zeitschrift)

** Ferrera-Gonzalez, J; Frances-Soriano, L; Galiana-Rosello, C; Gonzalez-Garcia, J; Gonzalez-Bejar, M; Froehlich, E; Perez-Prieto, J Initial Biological Assessment of Upconversion Nanohybrids
BIOMEDICINES. 2021; 9(10): 1419 Doi: 10.3390/biomedicines9101419 [OPEN ACCESS]
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** Kushwah, V; Arora, S; Tamás Katona, M; Modhave, D; Fröhlich, E; Paudel, A On Absorption Modeling and Food Effect Prediction of Rivaroxaban, a BCS II Drug Orally Administered as an Immediate-Release Tablet.
Pharmaceutics. 2021; 13(2): Doi: 10.3390/pharmaceutics13020283 [OPEN ACCESS]
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** Meindl, C; Öhlinger, K; Zrim, V; Steinkogler, T; Fröhlich, E Screening for Effects of Inhaled Nanoparticles in Cell Culture Models for Prolonged Exposure.
Nanomaterials (Basel). 2021; 11(3): Doi: 10.3390/nano11030606 [OPEN ACCESS]
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** Radivojev, S; Luschin-Ebengreuth, G; Pinto, JT; Laggner, P; Cavecchi, A; Cesari, N; Cella, M; Melli, F; Paudel, A; Frohlich, E Impact of simulated lung fluid components on the solubility of inhaled drugs and predicted in vivo performance
INT J PHARMACEUT. 2021; 606: 120893 Doi: 10.1016/j.ijpharm.2021.120893 [OPEN ACCESS]
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** Scheipl, S; Barnard, M; Lohberger, B; Zettl, R; Brcic, I; Liegl-Atzwanger, B; Rinner, B; Meindl, C; Fröhlich, E Drug combination screening as a translational approach toward an improved drug therapy for chordoma.
Cell Oncol (Dordr). 2021; 44(6):1231-1242 Doi: 10.1007/s13402-021-00632-x [OPEN ACCESS]
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** Tetyczka, C; Hartl, S; Jeitler, R; Absenger-Novak, M; Meindl, C; Frohlich, E; Riedl, S; Zweytick, D; Roblegg, E Cytokine-Mediated Inflammation in the Oral Cavity and Its Effect on Lipid Nanocarriers
NANOMATERIALS-BASEL. 2021; 11(5): 1330 Doi: 10.3390/nano11051330 [OPEN ACCESS]
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Übersichtsarbeit

** De León, G; Fröhlich, E; Salar-Behzadi, S Bitter taste in silico: A review on virtual ligand screening and characterization methods for TAS2R-bitterant interactions.
Int J Pharm. 2021; 600: 120486-120486. Doi: 10.1016/j.ijpharm.2021.120486
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** Frohlich, E Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary Lymphatics
BIOMEDICINES. 2021; 9(11): 1732 Doi: 10.3390/biomedicines9111732 [OPEN ACCESS]
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** Fröhlich, E Therapeutic Potential of Mesenchymal Stem Cells and Their Products in Lung Diseases-Intravenous Administration versus Inhalation.
Pharmaceutics. 2021; 13(2): Doi: 10.3390/pharmaceutics13020232 [OPEN ACCESS]
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** Fröhlich, E; Salar-Behzadi, S Oral inhalation for delivery of proteins and peptides to the lungs.
Eur J Pharm Biopharm. 2021; 163:198-211 Doi: 10.1016/j.ejpb.2021.04.003 [OPEN ACCESS]
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** Frohlich, E; Wahl, R Nanoparticles: Promising Auxiliary Agents for Diagnosis and Therapy of Thyroid Cancers
CANCERS. 2021; 13(16): 4063 Doi: 10.3390/cancers13164063 [OPEN ACCESS]
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** Frohlich, E; Wahl, R Physiological Role and Use of Thyroid Hormone Metabolites-Potential Utility in COVID-19 Patients
FRONT ENDOCRINOL. 2021; 12: 587518 Doi: 10.3389/fendo.2021.587518 [OPEN ACCESS]
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Editorial

** Frohlich, E "Biology and Medicine": A Section of Nanomaterials Addressing Interactions of Nanomaterials with All Forms of Life
NANOMATERIALS-BASEL. 2021; 11(9): 2294 Doi: 10.3390/nano11092294 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Radivojev, S; Luschin-Ebengreuth, G; Pinto, JT; Paudel, A; Frohlich, E THE RELEVANCE OF SIMULATED LUNG FLUID COMPOSITION ON THE DRUG SOLUBILITY AND PREDICTED IN-VIVO PERFORMANCE OF INHALED DRUG DELIVERY
J AEROSOL MED PULM D. 2021; 34(3):A11-A11. [Poster]
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2020

Originalarbeit (Zeitschrift)

** Fröhlich, E Issues with Cancer Spheroid Models in Therapeutic Drug Screening.
Curr Pharm Des. 2020; 26(18):2137-2148 Doi: 10.2174/1381612826666200218094200
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** Fröhlich, E; Öhlinger, K; Meindl, C; Corzo, C; Lochmann, D; Reyer, S; Salar-Behzadi, S In vitro toxicity screening of polyglycerol esters of fatty acids as excipients for pulmonary formulations.
Toxicol Appl Pharmacol. 2019; 386: 114833-114833. Doi: 10.1016/j.taap.2019.114833 [OPEN ACCESS]
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** Hennen, D; Hartmann, D; Rieger, PH; Oesterreicher, A; Wiener, J; Arbeiter, F; Feuchter, M; Frohlich, E; Pichelmayer, M; Schlogl, S; Griesser, T Exploiting the Carbon and Oxa Michael Addition Reaction for the Synthesis of Yne Monomers: Towards the Conversion of Acrylates to Biocompatible Building Blocks.
CHEMPHOTOCHEM. 2020; Doi: 10.1002/cptc.201900199
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** Milić, M; Vuković, B; Barbir, R; Pem, B; Milić, M; Šerić, V; Frőhlich, E; Vinković Vrček, I Effect of differently coated silver nanoparticles on hemostasis.
Platelets. 2020; 9(7):1-11 Doi: 10.1080/09537104.2020.1792432
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** Öhlinger, K; Absenger-Novak, M; Meindl, C; Ober, J; Fröhlich, E Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs.
Int J Mol Sci. 2020; 21(21): Doi: 10.3390/ijms21218391 [OPEN ACCESS]
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** Panov, V; Minigalieva, I; Bushueva, T; Fröhlich, E; Meindl, C; Absenger-Novak, M; Shur, V; Shishkina, E; Gurvich, V; Privalova, L; Katsnelson, BA Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations.
Dose Response. 2020; 18(1):1559325820914180-1559325820914180 Doi: 10.1177/1559325820914180 [OPEN ACCESS]
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** Pham, DT; Tetyczka, C; Hartl, S; Absenger-Novak, M; Frohlich, E; Tiyaboonchai, W; Roblegg, E Comprehensive investigations of fibroin and poly(ethylenimine) functionalized fibroin nanoparticles for ulcerative colitis treatment.
J DRUG DELIV SCI TEC. 2020; 57: 101484 Doi: 10.1016/j.jddst.2019.101484
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Abstract (Zeitschrift)

** Radivojev, S; Pinto, JT; Laggner, P; Fröhlich, E; Paudel, A STRUCTURAL INVESTIGATION INTO THE PHYSICAL INTERACTIONS OF ITRACONAZOLE WITH DPPC.
J AEROSOL MED PULM D. 2020; 33(2):A6-A7.-Drug Delivery to the Lungs; DEC 11-13; Edinburgh, Scotland. [Poster]
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2019

Originalarbeit (Zeitschrift)

** Bratuša, A; Elschner, T; Heinze, T; Fröhlich, E; Hribernik, S; Božič, M; Žagar, E; Kleinschek, KS; Thonhofer, M; Kargl, R Functional dextran amino acid ester particles derived from N-protected S-trityl-L-cysteine.
Colloids Surf B Biointerfaces. 2019; 181(8):561-566 Doi: 10.1016/j.colsurfb.2019.06.005
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** Fröhlich, E Understanding and Preventing Adverse Effects of Tacrolimus Metabolization in Transplant Patients.
Curr Drug Metab. 2019; 20(13):1039-1040 Doi: 10.2174/1389200219666180806154433
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** Geißler, D; Wegmann, M; Jochum, T; Somma, V; Sowa, M; Scholz, J; Fröhlich, E; Hoffmann, K; Niehaus, J; Roggenbuck, D; Resch-Genger, U An automatable platform for genotoxicity testing of nanomaterials based on the fluorometric γ-H2AX assay reveals no genotoxicity of properly surface-shielded cadmium-based quantum dots.
Nanoscale. 2019; 11(28):13458-13468 Doi: 10.1039/c9nr01021a [OPEN ACCESS]
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** Mischinger, J; Fröhlich, E; Mannweiler, S; Meindl, C; Absenger-Novak, M; Hutterer, GC; Seles, M; Augustin, H; Chromecki, TF; Jesche-Chromecki, J; Pummer, K; Zigeuner, R Prognostic value of B7-H1, B7-H3 and the stage, size, grade and necrosis (SSIGN) score in metastatic clear cell renal cell carcinoma.
Cent European J Urol. 2019; 72(1): 23-31. Doi: 10.5173/ceju.2018.1858 [OPEN ACCESS]
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** Öhlinger, K; Kolesnik, T; Meindl, C; Gallé, B; Absenger-Novak, M; Kolb-Lenz, D; Fröhlich, E Air-liquid interface culture changes surface properties of A549 cells.
Toxicol In Vitro. 2019; 60(7): 369-382. Doi: 10.1016/j.tiv.2019.06.014
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** Radivojev, S; Pinto, JT; Frohlich, E; Paudel, A Insights into DPI sensitivity to humidity: An integrated in-vitro-in-silico risk-assessment
J DRUG DELIV SCI TEC. 2019; 52: 803-817. Doi: 10.1016/j.jddst.2019.05.047
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** Steiner, V; Öhlinger, K; Corzo, C; Salar-Behzadi, S; Fröhlich, E Cytotoxicity screening of emulsifiers for pulmonary application of lipid nanoparticles.
Eur J Pharm Sci. 2019; 136:104968-104968 Doi: 10.1016/j.ejps.2019.104968
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** Zellnitz, S; Zellnitz, L; Müller, MT; Meindl, C; Schröttner, H; Fröhlich, E Impact of drug particle shape on permeability and cellular uptake in the lung.
EUR J PHARM SCI. 2019; 139: 105065-105065. Doi: 10.1016/j.ejps.2019.105065
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Übersichtsarbeit

** Fröhlich, E Biological Obstacles for Identifying In Vitro-In Vivo Correlations of Orally Inhaled Formulations.
PHARMACEUTICS. 2019; 11(7): Doi: 10.3390/pharmaceutics11070316 [OPEN ACCESS]
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** Fröhlich, E; Wahl, R The forgotten effects of thyrotropin-releasing hormone: Metabolic functions and medical applications.
Front Neuroendocrinol. 2019; 52(sup2):29-43 Doi: 10.1016/j.yfrne.2018.06.006 [OPEN ACCESS]
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** Fröhlich, E; Wahl, R Microbiota and Thyroid Interaction in Health and Disease.
Trends Endocrinol Metab. 2019; 30(8):479-490 Doi: 10.1016/j.tem.2019.05.008 [OPEN ACCESS]
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** Oliveira, H; Bednarkiewicz, A; Falk, A; Fröhlich, E; Lisjak, D; Prina-Mello, A; Resch, S; Schimpel, C; Vrček, IV; Wysokińska, E; Gorris, HH Critical Considerations on the Clinical Translation of Upconversion Nanoparticles (UCNPs): Recommendations from the European Upconversion Network (COST Action CM1403).
Adv Healthc Mater. 2019; 8(1):e1801233 Doi: 10.1002/adhm.201801233 [OPEN ACCESS]
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** Radivojev, S; Zellnitz, S; Paudel, A; Fröhlich, E Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs.
Int J Pharm. 2019; 556(1):45-56 Doi: 10.1016/j.ijpharm.2018.11.072
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** Zellnitz, S; Roblegg, E; Pinto, J; Fröhlich, E Delivery of Dry Powders to the Lungs: Influence of Particle Attributes from a Biological and Technological Point of View.
Curr Drug Deliv. 2019; 16(3):180-194 Doi: 10.2174/1567201815666181024143249
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Abstract (Zeitschrift)

** Pinto, JT; Radivojev, S; Frohlich, E; Paudel, A INSIGHTS INTO DPI SENSITIVITY TO HUMIDITY AND ITS CORRELATION TO FORMULATION PHYSICOCHEMICAL CHARACTERISTICS: A TEMPORAL STUDY USING TWO COMMERCIAL BUDESONIDE PRODUCTS
J AEROSOL MED PULM D. 2019; 32(2):A2-A2. [Poster]
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** Radivojev, S; Pinto, JT; Frohlich, E; Paudel, A INSIGHTS INTO HUMIDITY-INDUCED CHANGES ON THE IN-VITRO PULMONARY DEPOSITION AND THE PREDICTED PLASMA LEVELS OF BUDESONIDE FROM COMMERCIAL DPIS: A PHARMACOKINETIC MODEL ASSISTED RISK ASSESSMENT APPROACH
J AEROSOL MED PULM D. 2019; 32(2):A4-A4. [Poster]
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** Zellnitz, S; Muller, MT; Frohlich, E IMPACT OF BUDESONIDE PARTICLE SHAPE ON UPTAKE BY RESPIRATORY CELLS AND MACROPHAGES
J AEROSOL MED PULM D. 2019; 32(2):A7-A7. [Poster]
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2018

Originalarbeit (Zeitschrift)

** Fröhlich, E Comparison of conventional and advanced in vitro models in the toxicity testing of nanoparticles.
Artif Cells Nanomed Biotechnol. 2018; 46(sup2):1091-1107 Doi: 10.1080/21691401.2018.1479709 [OPEN ACCESS]
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** Fuchs, R; Stracke, A; Holzmann, V; Luschin-Ebengreuth, G; Meier-Allard, N; Ebner, N; Lassacher, TM; Absenger-Novak, M; Fröhlich, E; Schittmayer, M; Cano Crespo, S; Palacin, M; Rinner, B; Birner-Gruenberger, R Prazosin induced lysosomal tubulation interferes with cytokinesis and the endocytic sorting of the tumour antigen CD98hc.
Biochim Biophys Acta Mol Cell Res. 2018; 1865(9):1211-1229 Doi: 10.1016/j.bbamcr.2018.06.006 [OPEN ACCESS]
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** Rossi, I; Sonvico, F; McConville, JT; Rossi, F; Fröhlich, E; Zellnitz, S; Rossi, A; Del Favero, E; Bettini, R; Buttini, F Nebulized coenzyme Q10nanosuspensions: A versatile approach for pulmonary antioxidant therapy.
Eur J Pharm Sci. 2018; 113(3):159-170 Doi: 10.1016/j.ejps.2017.10.024
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** Teubl, BJ; Stojkovic, B; Docter, D; Pritz, E; Leitinger, G; Poberaj, I; Prassl, R; Stauber, RH; Fröhlich, E; Khinast, JG; Roblegg, E The effect of saliva on the fate of nanoparticles.
Clin Oral Investig. 2018; 22(2):929-940 Doi: 10.1007/s00784-017-2172-5 [OPEN ACCESS]
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** Zakaria, S; Fröhlich, E; Fauler, G; Gries, A; Weiß, S; Scharf, S First determination of fullerenes in the Austrian market and environment: quantitative analysis and assessment.
Environ Sci Pollut Res Int. 2018; 25(1):562-571 Doi: 10.1007/s11356-017-0213-x [OPEN ACCESS]
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Abstract (Zeitschrift)

** Zellnitz, S; Zellnitz, L; Roblegg, E; Frohlich, E IMPACT OF SALBUTAMOL SULPHATE PARTICLE PROPERTIES ON BIOLOGICAL EFFECTS IN THE LUNG
J AEROSOL MED PULM D. 2018; 31(2):A17-A17.-Drug Delivery to the Lungs; [Poster]
Web of Science

 

2017

Originalarbeit (Zeitschrift)

** Bode, GH; Coué, G; Freese, C; Pickl, KE; Sanchez-Purrà, M; Albaiges, B; Borrós, S; van Winden, EC; Tziveleka, LA; Sideratou, Z; Engbersen, JFJ; Singh, S; Albrecht, K; Groll, J; Möller, M; Pötgens, AJG; Schmitz, C; Fröhlich, E; Grandfils, C; Sinner, FM; Kirkpatrick, CJ; Steinbusch, HWM; Frank, HG; Unger, RE; Martinez-Martinez, P An in vitro and in vivo study of peptide-functionalized nanoparticles for brain targeting: The importance of selective blood-brain barrier uptake.
Nanomedicine. 2017; 13(3):1289-1300 Doi: 10.1016/j.nano.2016.11.009
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** Claudia, M; Kristin, Ö; Jennifer, O; Eva, R; Eleonore, F Comparison of fluorescence-based methods to determine nanoparticle uptake by phagocytes and non-phagocytic cells in vitro.
Toxicology. 2017; 378(2):25-36 Doi: 10.1016/j.tox.2017.01.001 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Eder, S; Beretta, M; Witschnigg, A; Koutsamanis, I; Eggenreich, K; Khinast, JG; Koscher, G; Paudel, A; Nickisch, K; Friedrich, M; Froehlich, E; Roblegg, E Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates.
AAPS PharmSciTech. 2017; 18(8):2971-2976 Doi: 10.1208/s12249-017-0788-z [OPEN ACCESS]
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** Fröhlich, E Toxicity of orally inhaled drug formulations at the alveolar barrier: parameters for initial biological screening.
Drug Deliv. 2017; 24(1):891-905 Doi: 10.1080/10717544.2017.1333172 [OPEN ACCESS]
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** Mayerhofer, R; Fröhlich, EE; Reichmann, F; Farzi, A; Kogelnik, N; Fröhlich, E; Sattler, W; Holzer, P Diverse action of lipoteichoic acid and lipopolysaccharide on neuroinflammation, blood-brain barrier disruption, and anxiety in mice.
Brain Behav Immun. 2017; 60(3):174-187 Doi: 10.1016/j.bbi.2016.10.011 [OPEN ACCESS]
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** Minigalieva, I; Bushueva, T; Fröhlich, E; Meindl, C; Öhlinger, K; Panov, V; Varaksin, A; Shur, V; Shishkina, E; Gurviсh, V; Katsnelson, B Are in vivo and in vitro assessments of comparative and combined toxicity of the same metallic nanoparticles compatible, or contradictory, or both? A juxtaposition of data obtained in respective experiments with NiO and Mn3O4 nanoparticles.
Food Chem Toxicol. 2017; 109(Pt 1):393-404 Doi: 10.1016/j.fct.2017.09.032
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** Payerl, C; Bračič, M; Zankel, A; Fischer, WJ; Kaschowitz, M; Fröhlich, E; Kargl, R; Stelzer, F; Spirk, S Nonspecific protein adsorption on cationically modified Lyocell fibers monitored by zeta potential measurements.
Carbohydr Polym. 2017; 164(5):49-56 Doi: 10.1016/j.carbpol.2017.01.088
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** Plohl, O; Kralj, S; Majaron, B; Fröhlich, E; Ponikvar-Svet, M; Makovec, D; Lisjak, D Amphiphilic coatings for the protection of upconverting nanoparticles against dissolution in aqueous media.
Dalton Trans. 2017; 46(21):6975-6984 Doi: 10.1039/c7dt00529f
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** Salar-Behzadi, S; Wu, S; Mercuri, A; Meindl, C; Stranzinger, S; Fröhlich, E Effect of the pulmonary deposition and in vitro permeability on the prediction of plasma levels of inhaled budesonide formulation.
Int J Pharm. 2017; 532(1):337-344 Doi: 10.1016/j.ijpharm.2017.08.124
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** Schaude, C; Fröhlich, E; Meindl, C; Attard, J; Binder, B; Mohr, GJ The Development of Indicator Cotton Swabs for the Detection of pH in Wounds.
Sensors (Basel). 2017; 17(6): Doi: 10.3390/s17061365 [OPEN ACCESS]
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** Schaude, C; Meindl, C; Fröhlich, E; Attard, J; Mohr, GJ Developing a sensor layer for the optical detection of amines during food spoilage.
Talanta. 2017; 170(5-6):481-487 Doi: 10.1016/j.talanta.2017.04.029
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** Stana, J; Stergar, J; Gradišnik, L; Flis, V; Kargl, R; Fröhlich, E; Stana Kleinschek, K; Mohan, T; Maver, U Multilayered Polysaccharide Nanofilms for Controlled Delivery of Pentoxifylline and Possible Treatment of Chronic Venous Ulceration.
Biomacromolecules. 2017; 18(9):2732-2746 Doi: 10.1021/acs.biomac.7b00523
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** Tetyczka, C; Griesbacher, M; Absenger-Novak, M; Fröhlich, E; Roblegg, E Development of nanostructured lipid carriers for intraoral delivery of Domperidone.
Int J Pharm. 2017; 526(1-2):188-198 Doi: 10.1016/j.ijpharm.2017.04.076
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Übersichtsarbeit

** Fröhlich, E Role of omics techniques in the toxicity testing of nanoparticles.
J Nanobiotechnology. 2017; 15(1):84-84 Doi: 10.1186/s12951-017-0320-3 [OPEN ACCESS]
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** Fröhlich, E Hemocompatibility of inhaled environmental nanoparticles: Potential use of in vitro testing.
J Hazard Mater. 2017; 336(28):158-167 Doi: 10.1016/j.jhazmat.2017.04.041
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** Fröhlich, E; Wahl, R Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases.
Front Immunol. 2017; 8(1):521-521 Doi: 10.3389/fimmu.2017.00521 [OPEN ACCESS]
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2016

Originalarbeit (Zeitschrift)

** Fröhlich, EE; Farzi, A; Mayerhofer, R; Reichmann, F; Jačan, A; Wagner, B; Zinser, E; Bordag, N; Magnes, C; Fröhlich, E; Kashofer, K; Gorkiewicz, G; Holzer, P Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication.
Brain Behav Immun. 2016; 56(6):140-155 Doi: 10.1016/j.bbi.2016.02.020 [OPEN ACCESS]
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** Kornmueller, K; Lehofer, B; Meindl, C; Fröhlich, E; Leitinger, G; Amenitsch, H; Prassl, R Peptides at the Interface: Self-Assembly of Amphiphilic Designer Peptides and Their Membrane Interaction Propensity.
Biomacromolecules. 2016; 17(11):3591-3601 Doi: 10.1021/acs.biomac.6b01089 [OPEN ACCESS]
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** Mercuri, A; Wu, S; Stranzinger, S; Mohr, S; Salar-Behzadi, S; Bresciani, M; Fröhlich, E In vitro and in silico characterisation of Tacrolimus released under biorelevant conditions.
Int J Pharm. 2016; 515(1-2):271-280 Doi: 10.1016/j.ijpharm.2016.10.020
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** Wu, S; Zellnitz, S; Mercuri, A; Salar-Behzadi, S; Bresciani, M; Fröhlich, E An in vitro and in silico study of the impact of engineered surface modifications on drug detachment from model carriers.
Int J Pharm. 2016; 513(1-2):109-117 Doi: 10.1016/j.ijpharm.2016.08.064
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Übersichtsarbeit

** Fröhlich, E Cellular elimination of nanoparticles.
Environ Toxicol Pharmacol. 2016; 46(11):90-94 Doi: 10.1016/j.etap.2016.07.003
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** Fröhlich, E Action of Nanoparticles on Platelet Activation and Plasmatic Coagulation.
Curr Med Chem. 2016; 23(5):408-430 Doi: 10.2174/0929867323666160106151428 [OPEN ACCESS]
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** Fröhlich, E; Mercuri, A; Wu, S; Salar-Behzadi, S Measurements of Deposition, Lung Surface Area and Lung Fluid for Simulation of Inhaled Compounds.
Front Pharmacol. 2016; 7(7):181-181 Doi: 10.3389/fphar.2016.00181 [OPEN ACCESS]
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** Fröhlich, E; Roblegg, E Oral uptake of nanoparticles: human relevance and the role of in vitro systems.
Arch Toxicol. 2016; 90(10):2297-2314 Doi: 10.1007/s00204-016-1765-0 [OPEN ACCESS]
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** Fröhlich, E; Wahl, R MECHANISMS IN ENDOCRINOLOGY: Impact of isolated TSH levels in and out of normal range on different tissues.
Eur J Endocrinol. 2016; 174(2):R29-R41 Doi: 10.1530/EJE-15-0713 [OPEN ACCESS]
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** Fröhlich, EE; Fröhlich, E Cytotoxicity of Nanoparticles Contained in Food on Intestinal Cells and the Gut Microbiota.
Int J Mol Sci. 2016; 17(4):509-509 Doi: 10.3390/ijms17040509 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Mercuri, A; Wu, S; Zellnitz, S; Salar-Behzadi, S; Bresciani, M; Khinast, J; Frohlich, E UNDERSTANDING THE IN VIVO IMPACT OF CARRIER-DRUG INTER-PARTICLE FORCES VIA ENGINEERED SURFACE MODIFICATIONS: AN IN SILICO INVESTIGATION
J AEROSOL MED PULM D. 2016; 29(3):A5-A5. [Poster]
Web of Science

 

** Salar-Behzadi, S; Wu, SQ; Meindl, C; Stranzinger, S; Mercuri, A; Mohr, S; Bresciani, M; Khinast, J; Frohlich, E ADVANCED IN SILICO MODELING OF THE PERFORMANCE OF INHALATION PRODUCTS
J AEROSOL MED PULM D. 2016; 29(3):A19-A19.-DDL26; [Poster]
Web of Science

 

** Wu, S; Mercuri, A; Salar-Behzadi, S; Schiaretti, F; Zambelli, E; Brogin, G; Govoni, M; Meindl, C; Stranzinger, S; Mohr, S; Dzidic, N; Bresciani, M; Frohlich, E INFLUENCE OF CALU-3 PERMEABILITY ON IN SILICO PHARMACOKINETIC PREDICTION OF INHALATION PRODUCTS
J AEROSOL MED PULM D. 2016; 29(3):A17-A18.-DDL26; Edinburgh. [Poster]
Web of Science

 

2015

Originalarbeit (Zeitschrift)

** Meindl, C; Kueznik, T; Bösch, M; Roblegg, E; Fröhlich, E Intracellular calcium levels as screening tool for nanoparticle toxicity.
J Appl Toxicol. 2015; 35(10):1150-1159 Doi: 10.1002/jat.3160 [OPEN ACCESS]
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** Meindl, C; Stranzinger, S; Dzidic, N; Salar-Behzadi, S; Mohr, S; Zimmer, A; Fröhlich, E Permeation of Therapeutic Drugs in Different Formulations across the Airway Epithelium In Vitro.
PLoS One. 2015; 10(8):e0135690-e0135690 Doi: 10.1371/journal.pone.0135690 [OPEN ACCESS]
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** Mrakovcic, M; Meindl, C; Leitinger, G; Roblegg, E; Fröhlich, E Carboxylated short single-walled carbon nanotubes but not plain and multi-walled short carbon nanotubes show in vitro genotoxicity.
Toxicol Sci. 2015; 144(1):114-127 Doi: 10.1093/toxsci/kfu260 [OPEN ACCESS]
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** Schimpel, C; Werzer, O; Fröhlich, E; Leitinger, G; Absenger-Novak, M; Teubl, B; Zimmer, A; Roblegg, E Atomic force microscopy as analytical tool to study physico-mechanical properties of intestinal cells.
Beilstein J Nanotechnol. 2015; 6(12):1457-1466 Doi: 10.3762/bjnano.6.151 [OPEN ACCESS]
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** Teubl, BJ; Leitinger, G; Schneider, M; Lehr, CM; Fröhlich, E; Zimmer, A; Roblegg, E The buccal mucosa as a route for TiO2 nanoparticle uptake.
Nanotoxicology. 2015; 9(2):253-261 Doi: 10.3109/17435390.2014.921343
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** Teubl, BJ; Schimpel, C; Leitinger, G; Bauer, B; Fröhlich, E; Zimmer, A; Roblegg, E Interactions between nano-TiO2 and the oral cavity: impact of nanomaterial surface hydrophilicity/hydrophobicity.
J Hazard Mater. 2015; 286(12):298-305 Doi: 10.1016/j.jhazmat.2014.12.064
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Übersichtsarbeit

** Fröhlich, E Value of phagocyte function screening for immunotoxicity of nanoparticles in vivo.
Int J Nanomedicine. 2015; 10(11):3761-3778 Doi: 10.2147/IJN.S83068 [OPEN ACCESS]
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** Fröhlich, E; Wahl, R Chemotherapy and chemoprevention by thiazolidinediones.
Biomed Res Int. 2015; 2015(3):845340-845340 Doi: 10.1155/2015/845340 [OPEN ACCESS]
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2014

Originalarbeit (Zeitschrift)

** Fröhlich, E; Meindl, C; Wagner, K; Leitinger, G; Roblegg, E Use of whole genome expression analysis in the toxicity screening of nanoparticles.
Toxicol Appl Pharmacol. 2014; 280(2):272-284 Doi: 10.1016/j.taap.2014.07.017 [OPEN ACCESS]
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** Mrakovcic, M; Meindl, C; Roblegg, E; Fröhlich, E Reaction of monocytes to polystyrene and silica nanoparticles in short-term and long-term exposures.
Toxicol Res (Camb). 2014; 3(2):86-97 Doi: 10.1039/C3TX50112D [OPEN ACCESS]
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** Prietl, B; Meindl, C; Roblegg, E; Pieber, TR; Lanzer, G; Fröhlich, E Nano-sized and micro-sized polystyrene particles affect phagocyte function.
Cell Biol Toxicol. 2014; 30(1):1-16 Doi: 10.1007/s10565-013-9265-y [OPEN ACCESS]
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** Schimpel, C; Teubl, B; Absenger, M; Meindl, C; Fröhlich, E; Leitinger, G; Zimmer, A; Roblegg, E Development of an advanced intestinal in vitro triple culture permeability model to study transport of nanoparticles.
Mol Pharm. 2014; 11(3):808-818 Doi: 10.1021/mp400507g
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Kurzbericht/Letter

** Wolf, P; Gruber-Wackernagel, A; Bambach, I; Schmidbauer, U; Mayer, G; Absenger, M; Fröhlich, E; Byrne, SN Photohardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell numbers in the papillary dermis.
Exp Dermatol. 2014; 23(6): 428-430. Doi: 10.1111/exd.12427 [OPEN ACCESS]
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Übersichtsarbeit

** Fröhlich, E; Roblegg, E Mucus as barrier for drug delivery by nanoparticles.
J Nanosci Nanotechnol. 2014; 14(1):126-136 Doi: 10.1166/jnn.2014.9015
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** Fröhlich, E; Salar-Behzadi, S Toxicological assessment of inhaled nanoparticles: role of in vivo, ex vivo, in vitro, and in silico studies.
Int J Mol Sci. 2014; 15(3):4795-4822 Doi: 10.3390/ijms15034795 [OPEN ACCESS]
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** Fröhlich, E; Wahl, R The current role of targeted therapies to induce radioiodine uptake in thyroid cancer.
CANCER TREAT REV. 2014; 40(5): 665-674. Doi: 10.1016/j.ctrv.2014.01.002
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Abstract (Zeitschrift)

** Wu, S; Salar-Behzadi, S; Frohlich, E COMPARISON OF IN SILICO AND IN VIVO PHARMACOKINETIC DATA FOR INHALATION PRODUCTS
J AEROSOL MED PULM D. 2014; 27(4):A19-A19. [Poster]
Web of Science

 

2013

Originalarbeit (Zeitschrift)

** Fröhlich, E; Bonstingl, G; Höfler, A; Meindl, C; Leitinger, G; Pieber, TR; Roblegg, E Comparison of two in vitro systems to assess cellular effects of nanoparticles-containing aerosols.
Toxicol In Vitro. 2013; 27(1):409-417 Doi: 10.1016/j.tiv.2012.08.008 [OPEN ACCESS]
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** Fröhlich, E; Meindl, C; Höfler, A; Leitinger, G; Roblegg, E Combination of small size and carboxyl functionalisation causes cytotoxicity of short carbon nanotubes.
Nanotoxicology. 2013; 7(7):1211-1224 Doi: 10.3109/17435390.2012.729274 [OPEN ACCESS]
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** Fröhlich, E; Wahl, R; Czarnocka, B; Duntas, L New diagnostic and therapeutic tools for thyroid cancer.
Int J Endocrinol. 2013; 2013(Pt 9):312378-312378 Doi: 10.1155/2013/312378 [OPEN ACCESS]
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** Gradauer, K; Barthelmes, J; Vonach, C; Almer, G; Mangge, H; Teubl, B; Roblegg, E; Dünnhaupt, S; Fröhlich, E; Bernkop-Schnürch, A; Prassl, R Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats.
J Control Release. 2013; 172(3):872-878 Doi: 10.1016/j.jconrel.2013.10.011 [OPEN ACCESS]
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** Meindl, C; Absenger, M; Roblegg, E; Fröhlich, E Suitability of cell-based label-free detection for cytotoxicity screening of carbon nanotubes.
Biomed Res Int. 2013; 2013(2):564804-564804 Doi: 10.1155/2013/564804 [OPEN ACCESS]
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** Mrakovcic, M; Absenger, M; Riedl, R; Smole, C; Roblegg, E; Fröhlich, LF; Fröhlich, E Assessment of long-term effects of nanoparticles in a microcarrier cell culture system.
PLoS One. 2013; 8(2):e56791-e56791 Doi: 10.1371/journal.pone.0056791 [OPEN ACCESS]
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** Teubl, BJ; Absenger, M; Fröhlich, E; Leitinger, G; Zimmer, A; Roblegg, E The oral cavity as a biological barrier system: design of an advanced buccal in vitro permeability model.
Eur J Pharm Biopharm. 2013; 84(2):386-393 Doi: 10.1016/j.ejpb.2012.10.021
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** Teubl, BJ; Meindl, C; Eitzlmayr, A; Zimmer, A; Fröhlich, E; Roblegg, E In-Vitro Permeability of Neutral Polystyrene Particles via Buccal Mucosa.
Small. 2013; 9(3):457-466 Doi: 10.1002/smll.201201789
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Übersichtsarbeit

** Fröhlich, E Cellular targets and mechanisms in the cytotoxic action of non-biodegradable engineered nanoparticles.
Curr Drug Metab. 2013; 14(9):976-988 Doi: 10.2174/1389200211314090004 [OPEN ACCESS]
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2012

Originalarbeit (Zeitschrift)

** Fröhlich, E; Maier, E; Wahl, R Interspecies differences in membrane-associated protease activities of thyrocytes and their relevance for thyroid cancer studies.
J Exp Clin Cancer Res. 2012; 31(4):45-45 Doi: 10.1186/1756-9966-31-45 [OPEN ACCESS]
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** Frohlich, E; Meindl, C; Roblegg, E; Ebner, B; Absenger, M; Pieber, TR; Action of polystyrene nanoparticles of different sizes on lysosomal function and integrity.
Part Fibre Toxicol. 2012; 9(16):26-26 Doi: 10.1186/1743-8977-9-26 [OPEN ACCESS]
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** Fröhlich, E; Meindl, C; Roblegg, E; Griesbacher, A; Pieber, TR Cytotoxity of nanoparticles is influenced by size, proliferation and embryonic origin of the cells used for testing.
Nanotoxicology. 2012; 6(4):424-439 Doi: 10.3109/17435390.2011.586478
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** Gradauer, K; Vonach, C; Leitinger, G; Kolb, D; Fröhlich, E; Roblegg, E; Bernkop-Schnürch, A; Prassl, R Chemical coupling of thiolated chitosan to preformed liposomes improves mucoadhesive properties.
Int J Nanomedicine. 2012; 7(8):2523-2534 Doi: 10.2147/IJN.S29980 [OPEN ACCESS]
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** Roblegg, E; Fröhlich, E; Meindl, C; Teubl, B; Zaversky, M; Zimmer, A Evaluation of a physiological in vitro system to study the transport of nanoparticles through the buccal mucosa.
Nanotoxicology. 2012; 6(4):399-413 Doi: 10.3109/17435390.2011.580863
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Übersichtsarbeit

** Fröhlich, E The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.
Int J Nanomedicine. 2012; 7(3):5577-5591 Doi: 10.2147/IJN.S36111 [OPEN ACCESS]
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** Fröhlich, E; Roblegg, E Models for oral uptake of nanoparticles in consumer products.
Toxicology. 2012; 291(1-3):10-17 Doi: 10.1016/j.tox.2011.11.004 [OPEN ACCESS]
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** Fröhlich, E; Wahl, R Do antidiabetic medications play a specific role in differentiated thyroid cancer compared to other cancer types?
Diabetes Obes Metab. 2012; 14(3): 204-213. Doi: 10.1111/j.1463-1326.2011.01491.x
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2011

Originalarbeit (Zeitschrift)

** Almer, G; Saba-Lepek, M; Haj-Yahya, S; Rohde, E; Strunk, D; Fröhlich, E; Prassl, R; Mangge, H Globular domain of adiponectin: promising target molecule for detection of atherosclerotic lesions.
Biologics. 2011; 5(2):95-105 Doi: 10.2147/BTT.S22863 [OPEN ACCESS]
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** Auer-Grumbach, M; Weger, M; Fink-Puches, R; Papić, L; Fröhlich, E; Auer-Grumbach, P; El Shabrawi-Caelen, L; Schabhüttl, M; Windpassinger, C; Senderek, J; Budka, H; Trajanoski, S; Janecke, AR; Haas, A; Metze, D; Pieber, TR; Guelly, C Fibulin-5 mutations link inherited neuropathies, age-related macular degeneration and hyperelastic skin.
Brain. 2011; 134(Pt 6):1839-1852 Doi: 10.1093/brain/awr076 [OPEN ACCESS]
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** Fröhlich, E; Engel, E; Wahl, R Decrease in dipeptidyl peptidase IV activity is linked to the efficacy of differentiating compounds in follicular thyroid carcinoma cell lines.
HORMONE METAB RES. 2011; 43(5): 364-366. Doi: 10.1055/s-0031-1273682 [OPEN ACCESS]
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** Guelly, C; Zhu, PP; Leonardis, L; Papic, L; Zidar, J; Schabhüttl, M; Strohmaier, H; Weis, J; Strom, TM; Baets, J; Willems, J; De Jonghe, P; Reilly, MM; Fröhlich, E; Hatz, M; Trajanoski, S; Pieber, TR; Janecke, AR; Blackstone, C; Auer-Grumbach, M Targeted high-throughput sequencing identifies mutations in atlastin-1 as a cause of hereditary sensory neuropathy type I.
Am J Hum Genet. 2011; 88(1):99-105 Doi: 10.1016/j.ajhg.2010.12.003 [OPEN ACCESS]
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** Luschnig-Schratl, P; Sturm, EM; Konya, V; Philipose, S; Marsche, G; Fröhlich, E; Samberger, C; Lang-Loidolt, D; Gattenlöhner, S; Lippe, IT; Peskar, BA; Schuligoi, R; Heinemann, A EP4 receptor stimulation down-regulates human eosinophil function.
Cell Mol Life Sci. 2011; 68(21): 3573-3587. Doi: 10.1007/s00018-011-0642-5 [OPEN ACCESS]
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** Rohde, E; Schallmoser, K; Reinisch, A; Hofmann, NA; Pfeifer, T; Fröhlich, E; Rechberger, G; Lanzer, G; Kratky, D; Strunk, D Pro-angiogenic induction of myeloid cells for therapeutic angiogenesis can induce mitogen-activated protein kinase p38-dependent foam cell formation.
Cytotherapy. 2011; 13(4):503-512 Doi: 10.3109/14653249.2010.536214 [OPEN ACCESS]
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2010

Originalarbeit (Zeitschrift)

** Abdelmoez, AA; Thurner, GC; Wallnöfer, EA; Klammsteiner, N; Kremser, C; Talasz, H; Mrakovcic, M; Fröhlich, E; Jaschke, W; Debbage, P Albumin-based nanoparticles as magnetic resonance contrast agents: II. Physicochemical characterisation of purified and standardised nanoparticles.
Histochem Cell Biol. 2010; 134(2): 171-196. Doi: 10.1007/s00418-010-0726-6
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** Auer-Grumbach, M; Olschewski, A; Papić, L; Kremer, H; McEntagart, ME; Uhrig, S; Fischer, C; Fröhlich, E; Bálint, Z; Tang, B; Strohmaier, H; Lochmüller, H; Schlotter-Weigel, B; Senderek, J; Krebs, A; Dick, KJ; Petty, R; Longman, C; Anderson, NE; Padberg, GW; Schelhaas, HJ; van Ravenswaaij-Arts, CM; Pieber, TR; Crosby, AH; Guelly, C Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C.
Nat Genet. 2010; 42(2):160-164 Doi: 10.1038/ng.508 [OPEN ACCESS]
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** Buchebner, M; Pfeifer, T; Rathke, N; Chandak, PG; Lass, A; Schreiber, R; Kratzer, A; Zimmermann, R; Sattler, W; Koefeler, H; Froehlich, E; Kostner, GM; Birner-Gruenberger, R; Chiang, KP; Haemmerle, G; Zechner, R; Levak-Frank, S; Cravatt, BF; Kratky, D Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363.
J Lipid Res. 2010; 51(10): 2896-2908. Doi: 10.1194/jlr.M004259 [OPEN ACCESS]
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** Chandak, PG; Radovic, B; Aflaki, E; Kolb, D; Buchebner, M; Fröhlich, E; Magnes, C; Sinner, F; Haemmerle, G; Zechner, R; Tabas, I; Levak-Frank, S; Kratky, D Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase.
J Biol Chem. 2010; 285(26):20192-20201 Doi: 10.1074/jbc.M110.107854 [OPEN ACCESS]
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** Frohlich, E The Neuron: The Basis for Processing and Propagation of Information in the Nervous System
NEUROQUANTOLOGY. 2010; 8(3): 403-415. Doi: 10.14704/nq.2010.8.3.300
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** Fröhlich, E Proteases in cutaneous malignant melanoma: relevance as biomarker and therapeutic target.
Cell Mol Life Sci. 2010; 67(23): 3947-3960. Doi: 10.1007/s00018-010-0469-5
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** Frohlich, E; Kueznik, T; Samberger, C; Roblegg, E; Wrighton, C; Pieber, TR Size-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymes.
TOXICOL APPL PHARMACOL. 2010; 242(3): 326-332. Doi: 10.1016/j.taap.2009.11.002
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** Janezic, G; Widni, EE; Haxhija, EQ; Stradner, M; Fröhlich, E; Weinberg, AM Proliferation analysis of the growth plate after diaphyseal midshaft fracture by 5'-bromo-2'-deoxy-uridine.
Virchows Arch. 2010; 457(1):77-85 Doi: 10.1007/s00428-010-0932-6
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** Millotti, G; Samberger, C; Frohlich, E; Sakloetsakun, D; Bernkop-Schnurch, A Chitosan-4-mercaptobenzoic acid: synthesis and characterization of a novel thiolated chitosan
J MATER CHEM. 2010; 20(12): 2432-2440. Doi: 10.1039/b916528b
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** Stollenwerk, MM; Pashkunova-Martic, I; Kremser, C; Talasz, H; Thurner, GC; Abdelmoez, AA; Wallnofer, EA; Helbok, A; Neuhauser, E; Klammsteiner, N; Klimaschewski, L; von Guggenberg, E; Frohlich, E; Keppler, B; Jaschke, W; Debbage, P Albumin-based nanoparticles as magnetic resonance contrast agents: I. Concept, first syntheses and characterisation.
HISTOCHEMISTRY CELL BIOL. 2010; 133(4): 375-404. Doi: 10.1007/s00418-010-0676-z
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Abstract (Zeitschrift)

** Wolf, P; Gruber-Wackernagel, A; Legat, F; Hofer, A; Bambach, I; Mayer, G; Absenger, M; Frohlich, E; Byrne, S Successful phototherapy of polymorphic light eruption patients is associated with a recruitment of mast cells into the skin
J INVEST DERMATOL. 2010; 130: S48-S48. [Oral Communication]
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2009

Originalarbeit (Zeitschrift)

** Fröhlich, E; Brossart, P; Wahl, R Induction of iodide uptake in transformed thyrocytes: a compound screening in cell lines.
Eur J Nucl Med Mol Imaging. 2009; 36(5):780-790 Doi: 10.1007/s00259-008-1024-6
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** Fröhlich, E; Fink, I; Wahl, R Is transketolase like 1 a target for the treatment of differentiated thyroid carcinoma? A study on thyroid cancer cell lines.
Invest New Drugs. 2009; 27(4): 297-303. Doi: 10.1007/s10637-008-9174-8
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** Frohlich, E; Samberger, C; Kueznik, T; Absenger, M; Roblegg, E; Zimmer, A; Pieber, TR Cytotoxicity of nanoparticles independent from oxidative stress.
J TOXICOL SCI. 2009; 34(4): 363-375. Doi: 10.2131/jts.34.363 [OPEN ACCESS]
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** Gaber, S; Fischerauer, EE; Fröhlich, E; Janezic, G; Amerstorfer, F; Weinberg, AM Chondrocyte apoptosis enhanced at the growth plate: a physeal response to a diaphyseal fracture.
Cell Tissue Res. 2009; 335(3):539-549 Doi: 10.1007/s00441-008-0735-0
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** Gibson, MI; Frohlich, E; Klok, HA Postpolymerization Modification of Poly(Pentafluorophenyl methacrylate): Synthesis of a Diverse Water-Soluble Polymer Library
J POLYM SCI A-POLYM CHEM. 2009; 47(17): 4332-4345. Doi: 10.1002/pola.23486
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** Mayer, A; Vadon, M; Rinner, B; Novak, A; Wintersteiger, R; Frohlich, E The role of nanoparticle size in hemocompatibility
TOXICOLOGY. 2009; 258(2-3): 139-147. Doi: 10.1016/j.tox.2009.01.015
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** Millotti, G; Samberger, C; Fröhlich, E; Bernkop-Schnürch, A Chitosan-graft-6-mercaptonicotinic acid: synthesis, characterization, and biocompatibility.
Biomacromolecules. 2009; 10(11): 3023-3027. Doi: 10.1021/bm9006248
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Kurzbericht/Letter

** Fröhlich, E; Maier, E; Mack, AF; Garbe, C Dipeptidyl peptidase II is not a marker for progression in melanoma.
J Dermatol Sci. 2009; 53(1): 68-71. Doi: 10.1016/j.jdermsci.2008.07.014
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Abstract (Zeitschrift)

** Rohde, E; Pfeifer, T; Schallmoser, K; Reinisch, A; Hofmann, NA; Froehlich, E; Rechberger, G; Lanzer, G; Kratky, D; Strunk, D Pro-atherogenic risk of cellular therapy for vascular regeneration?
BONE MARROW TRANSPLANT. 35th Annual Meeting of the European Group for Blood and Marrow Transplantation2009; 43(1):S203-S204.-35th Annual Meeting of the European Group for Blood and Marrow Transplantation; MAR 29-APR 01, 2009; Goteborg, SWEDEN. [Poster]
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2008

Originalarbeit (Zeitschrift)

** Fröhlich, E; Czarnocka, B; Brossart, P; Wahl, R Antitumor effects of arsenic trioxide in transformed human thyroid cells.
Thyroid. 2008; 18(11):1183-1193 Doi: 10.1089/thy.2008.0114
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Abstract (Zeitschrift)

** Mayer, A; Muhry, N; Novak, A; Frohlich, E Influence of size and surface charge on the hemocompatibility of polystyrene particles
TOXICOL LETT. 2008; 180: S223-S224.-45th Congress of the European-Societies-of-Toxicology; OCT 05-08, 2008; Rhodes, GREECE. Doi: 10.1016/j.toxlet.2008.06.100 [Poster]
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** Rohde, E; Aflaki, E; Froehlich, E; Lanzer, G; Kratky, D; Strunk, D Combating Cardiovascular Disease: Is there a Risk of Foam Cell Formation in Transplanted Angiocompetent Cells Compromising Intended Beneficial Effects of Vascular Regenerative Therapy?
Fiftieth annual meeting abstracts2008; 112(11):665-666.-American Society of Hematology 50th Annual Meeting and Exposition; DEC 6-9, 2008; San Francisco, USA. [Oral Communication]
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2005

Originalarbeit (Zeitschrift)

** Fröhlich, E; Machicao, F; Wahl, R Action of thiazolidinediones on differentiation, proliferation and apoptosis of normal and transformed thyrocytes in culture.
Endocr Relat Cancer. 2005; 12(2):291-303 Doi: 10.1677/erc.1.00973 [OPEN ACCESS]
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** Fröhlich, E; Mack, AF; Garbe, C; Klessen, C Distribution and colocalization of markers for proliferation, invasion, motility and neoangiogenesis in benign melanocytic naevi and malignant melanomas.
Br J Dermatol. 2005; 153(6):1159-1165 Doi: 10.1111/j.1365-2133.2005.06883.x
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2004

Originalarbeit (Zeitschrift)

** Fröhlich, E; Möhrle, M; Klessen, C Cathepsins in basal cell carcinomas: activity, immunoreactivity and mRNA staining of cathepsins B, D, H and L.
Arch Dermatol Res. 2004; 295(10):411-421 Doi: 10.1007/s00403-003-0449-9
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** Fröhlich, E; Witke, A; Czarnocka, B; Wahl, R Retinol has specific effects on binding of thyrotrophin to cultured porcine thyrocytes.
J Endocrinol. 2004; 183(3):617-626 Doi: 10.1677/joe.1.05693 [OPEN ACCESS]
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Übersichtsarbeit

** Fröhlich, E Proteases in malignant tumors. Their significance for pathogenesis and possible therapeutic consequences
Dtsch Med Wochenschr. 2004; 129(8):391-395 Doi: 10.1055/s-2004-819899
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2003

Originalarbeit (Zeitschrift)

** Fröhlich, E; Klessen, C Regional differences and post-mortem stability of enzymatic activities in the retinal pigment epithelium.
Graefes Arch Clin Exp Ophthalmol. 2003; 241(5):385-393 Doi: 10.1007/s00417-003-0640-x
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** Fröhlich, E; Maier, E; Klessen, C Isolation of bovine retinal pigment epithelial cells using adhesion to agarose: demonstration of cellular and regional heterogeneity.
J Histochem Cytochem. 2003; 51(1):121-124 Doi: 10.1177/002215540305100114
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2002

Übersichtsarbeit

** Fröhlich, E Structure and function of blood-tissue barriers
Dtsch Med Wochenschr. 2002; 127(49):2629-2634 Doi: 10.1055/s-2002-35932
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2001

Originalarbeit (Zeitschrift)

** Fröhlich, E; Brossart, P; Wahl, R Effects of retinoids on porcine thyrocytes under different culture conditions.
Histochem J. 2001; 33(5):295-304 Doi: 10.1023/A:1017981108387
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** Fröhlich, E; Klessen, C Enzymatic heterogeneity of bovine retinal pigment epithelial cells in vivo and in vitro.
Graefes Arch Clin Exp Ophthalmol. 2001; 239(1):25-34 Doi: 10.1007/s004170000218
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** Fröhlich, E; Schlagenhauff, B; Möhrle, M; Weber, E; Klessen, C; Rassner, G Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma.
Cancer. 2001; 91(5):972-982 Doi: 10.1002/1097-0142(20010301)91:5<972::AID-CNCR1087>3.0.CO;2-Q
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** Ligr, M; Velten, I; Fröhlich, E; Madeo, F; Ledig, M; Fröhlich, KU; Wolf, DH; Hilt, W The proteasomal substrate Stm1 participates in apoptosis-like cell death in yeast.
Mol Biol Cell. 2001; 12(8):2422-2432 Doi: 10.1091/mbc.12.8.2422 [OPEN ACCESS]
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2000

Originalarbeit (Zeitschrift)

** Fröhlich, E; Klessen, C Glutamine synthetase and marker enzymes of the blood-retina barrier in fetal bovine retinal pigment epithelial cells.
Graefes Arch Clin Exp Ophthalmol. 2000; 238(6):500-507 Doi: 10.1007/PL00007891
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1999

Originalarbeit (Zeitschrift)

** Fröhlich, E; Wahl, R Effects of retinol on follicular porcine thyrocytes in culture.
J Mol Med. 1999; 77(1):189-192 Doi: 10.1007/s001090050334
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** Madeo, F; Fröhlich, E; Ligr, M; Grey, M; Sigrist, SJ; Wolf, DH; Fröhlich, KU Oxygen stress: a regulator of apoptosis in yeast.
J Cell Biol. 1999; 145(4):757-767 Doi: 10.1083/jcb.145.4.757 [OPEN ACCESS]
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1998

Originalarbeit (Zeitschrift)

** Fröhlich, E; Wagner, HJ Development of multibank rod retinae in deep-sea fishes.
Vis Neurosci. 1998; 15(3): 477-483. Doi: 10.1017/S095252389815304X
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** Ligr, M; Madeo, F; Fröhlich, E; Hilt, W; Fröhlich, KU; Wolf, DH Mammalian Bax triggers apoptotic changes in yeast.
FEBS Lett. 1998; 438(1-2):61-65 Doi: 10.1016/S0014-5793(98)01227-7
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Übersichtsarbeit

** Wagner, HJ; Fröhlich, E; Negishi, K; Collin, SP The eyes of deep-sea fish. II. Functional morphology of the retina.
Prog Retin Eye Res. 1998; 17(4):637-685 Doi: 10.1016/S1350-9462(98)00003-2
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1997

Originalarbeit (Zeitschrift)

** Madeo, F; Fröhlich, E; Fröhlich, KU A yeast mutant showing diagnostic markers of early and late apoptosis.
J Cell Biol. 1997; 139(3):729-734 Doi: 10.1083/jcb.139.3.729 [OPEN ACCESS]
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1996

Originalarbeit (Zeitschrift)

** Fröhlich, E; Wagner, HJ Rod outer segment renewal in the retinae of deep-sea fish.
Vision Res. 1996; 36(19):3183-3194 Doi: 10.1016/0042-6989(96)00025-9
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1995

Originalarbeit (Zeitschrift)

** Biedermann, B; Fröhlich, E; Grosche, J; Wagner, HJ; Reichenbach, A Mammalian Müller (glial) cells express functional D2 dopamine receptors.
Neuroreport. 1995; 6(4): 609-612. Doi: 10.1097/00001756-199503000-00006
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** Fröhlich, E; Negishi, K; Wagner, HJ Patterns of rod proliferation in deep-sea fish retinae.
Vision Res. 1995; 35(13):1799-1811 Doi: 10.1016/0042-6989(94)00291-S
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** Fröhlich, E; Negishi, K; Wagner, HJ The occurrence of dopaminergic interplexiform cells correlates with the presence of cones in the retinae of fish.
Vis Neurosci. 1995; 12(2):359-369 Doi: 10.1017/S0952523800008038
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** Fröhlich, E; Schaumburg-Lever, G; Klessen, C Immunocytochemical and immunoelectron microscopic demonstration of cathepsin B in human malignant melanoma.
Br J Dermatol. 1995; 132(6): 867-875. Doi: 10.1111/j.1365-2133.1995.tb16941.x
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** Fröhlich, E; Wahl, R; Reutter, K Efficiency of various dissociation methods for the preparation of thyroid single cell suspensions.
Exp Clin Endocrinol Diabetes. 1995; 103(5):308-316 Doi: 10.1055/s-0029-1211371
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** Fröhlich, E; Wahl, R; Reutter, K Basal lamina formation by porcine thyroid cells grown in collagen- and laminin-deficient medium.
Histochem J. 1995; 27(8):602-608 Doi: 10.1007/BF02388459
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1993

Originalarbeit (Zeitschrift)

** Fröhlich, E; Schaumburg-Lever, G; Klessen, C Immunelectron microscopic localization of cathepsin B in human exocrine glands.
J Cutan Pathol. 1993; 20(1): 54-60. Doi: 10.1111/j.1600-0560.1993.tb01250.x
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1989

Originalarbeit (Zeitschrift)

** Gerhard, I; Fröhlich, E; Eggert-Kruse, W; Klinga, K; Runnebaum, B Relationship of sperm acrosin activity to semen and clinical parameters in infertile patients.
Andrologia. 1989; 21(2): 146-154. Doi: 10.1111/j.1439-0272.1989.tb02385.x
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