Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Birngruber Thomas |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2025

Originalarbeit (Zeitschrift)

** Foessl, I; Birngruber, T; Kotzbeck, P; Hofmann, E Ex Vivo Human Skin Model to Study Immediate and Early Local Responses to External Stimuli.
Methods Mol Biol. 2025; 2922:289-295 Doi: 10.1007/978-1-0716-4510-9_22
PubMed FullText FullText_MUG

 

2024

Originalarbeit (Zeitschrift)

** Monedeiro, F; Ehall, B; Tiffner, K; Eberl, A; Svehlikova, E; Prietl, B; Pfeifer, V; Senekowitsch, J; Remm, A; Rebane, A; Magnes, C; Pieber, T; Sinner, F; Birngruber, T Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis.
J Proteome Res. 2024; Doi: 10.1021/acs.jproteome.4c00153 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Tiffner, KI; Ramezanli, T; Boulgaropoulos, B; Birngruber, T; Bodenlenz, M; Lackner, BC; Raml, R; Jiang, Y; Raney, SG; Sinner, F Cutaneous pharmacokinetics-based bioequivalence: A clinical dermal open flow microperfusion verification study using lidocaine and prilocaine combination topical products
EUR J PHARM SCI. 2024; 200: 106827 Doi: 10.1016/j.ejps.2024.106827
Web of Science PubMed FullText FullText_MUG

 

2023

Originalarbeit (Zeitschrift)

** Altendorfer-Kroath, T; Asslaber, M; Hummer, J; Boulgaropoulos, B; Prietl, B; Pieber, TR; Bernhart, E; Birngruber, T Atraumatic access to human glioblastoma in a xenograft animal model by cerebral open flow microperfusion
J NEUROSCI METH. 2023; 393: 109893 Doi: 10.1016/j.jneumeth.2023.109893
Web of Science PubMed FullText FullText_MUG

 

Abstract (Zeitschrift)

** Fink, J; Hofmann, E; Eberl, A; Birngruber, T; Kamolz, LP; Kotzbeck, P DETAILED CHARACTERISATION OF INFLAMMATORY PROCESSES AFTER BURNS IN HUMAN EX VIVO MODELS
WOUND REPAIR REGEN. 2023; 31: S10-S11.
Web of Science

 

** Hofmann, E; Pignet, AL; Monedeiro, F; Fink, J; Schwarz, A; Eberl, A; Raml, R; Birngruber, T; Kamolz, LP; Kotzbeck, P INFLAMMATION IN WOUNDS PROMOTES CHANGES IN WOUND METABOLISM
WOUND REPAIR REGEN. 2023; 31: S15-S16. [Oral Communication]
Web of Science

 

** Tiffner, K; Ehall, B; Eberl, A; Bodenlenz, M; Pircher, T; Birngruber, T; Sinner, F; Svehlikova, E; Pieber, T Dermal open flow microperfusion (dOFM) to monitor local tissue response after dupilumab treatment in lesional and non-lesional skin of atopic dermatitis patients
J INVEST DERMATOL. 2023; 143(11):S348-S348.-5th Inflammatory Skin Disease Summit (ISDS); NOV 15-18, 2023; Vienna, AUSTRIA. [Poster]
Web of Science

 

2022

Originalarbeit (Zeitschrift)

** Holzer-Geissler, JCJ; Schwingenschuh, S; Zacharias, M; Einsiedler, J; Kainz, S; Reisenegger, P; Holecek, C; Hofmann, E; Wolff-Winiski, B; Fahrngruber, H; Birngruber, T; Kamolz, LP; Kotzbeck, P The Impact of Prolonged Inflammation on Wound Healing.
Biomedicines. 2022; 10(4): Doi: 10.3390/biomedicines10040856 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Übersichtsarbeit

** Birngruber, T; Tiffner, KI; Mautner, SI; Sinner, FM Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products.
Front Pharmacol. 2022; 13: 1061178 Doi: 10.3389/fphar.2022.1061178 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Abstract (Zeitschrift)

** Hofmann, E; Pignet, AL; Schwarz, A; Hecker, A; Schellnegger, M; Holzer-Geissler, JJC; Fink, J; Eberl, A; Raml, R; Birngruber, T; Kamolz, LP; Kotzbeck, P In vivo monitoring of inflammatory mediators during wound healing progression using dermal open flow microperfusion
WOUND REPAIR REGEN. Abstracts of the 51st Annual Meeting of the Japanese Society for Wound Healing. 2022; 30(5):A33-A33.-51st Annual Meeting of the Japanese Society for Wound Healing; NOV 26-28, 2022; Tochigi, JAPAN. [Oral Communication]
Web of Science

 

** Shukla, S; Ramezanli, T; Rantou, E; Tiffner, K; Birngruber, T; Sinner, F; Raney, S QUANTITATIVE DISCRIMINATION OF CUTANEOUS PHARMACOKINETIC PROFILES FOR TOPICAL DRUG PRODUCTS.
CLIN PHARMACOL THER. ASCPT Online Annual Meeting. 2022; 111: S47-S47.-American Society for Clinical Pharmacology and Therapeutics Annual Meeting; MAR 16-18, 2022; Virtuell. [Oral Communication]
Web of Science

 

2021

Originalarbeit (Zeitschrift)

** Foessl, I; Haudum, CW; Vidakovic, I; Prassl, R; Franz, J; Mautner, SI; Kainz, S; Hofmann, E; Obermayer-Pietsch, B; Birngruber, T; Kotzbeck, P miRNAs as Regulators of the Early Local Response to Burn Injuries.
Int J Mol Sci. 2021; 22(17): Doi: 10.3390/ijms22179209 [OPEN ACCESS]
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** Hofmann, E; Fink, J; Eberl, A; Prugger, EM; Kolb, D; Luze, H; Schwingenschuh, S; Birngruber, T; Magnes, C; Mautner, SI; Kamolz, LP; Kotzbeck, P A novel human ex vivo skin model to study early local responses to burn injuries.
Sci Rep. 2021; 11(1): 364-364. Doi: 10.1038/s41598-020-79683-3 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Hummer, J; Schwingenschuh, S; Raml, R; Boulgaropoulos, B; Schwagerle, G; Augustin, T; Sinner, F; Birngruber, T OFM-recirculation and OFM-suction: advanced in-vivo open flow microperfusion (OFM) methods for direct and absolute quantification of albumin in interstitial fluid.
BIOMED PHYS ENG EXPR. 2021; 6(6): 065031-065031. Doi: 10.1088/2057-1976/abc3a7 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

2020

Originalarbeit (Zeitschrift)

** Bernardelli de Mattos, I; Nischwitz, SP; Tuca, AC; Groeber-Becker, F; Funk, M; Birngruber, T; Mautner, SI; Kamolz, LP; Holzer, JCJ Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine.
Burns. 2020; 46(4):918-927 Doi: 10.1016/j.burns.2019.10.006
Web of Science PubMed FullText FullText_MUG

 

** Bodenlenz, M; Augustin, T; Birngruber, T; Tiffner, KI; Boulgaropoulos, B; Schwingenschuh, S; Raney, SG; Rantou, E; Sinner, F Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion.
Pharm Res. 2020; 37(10):204-204 Doi: 10.1007/s11095-020-02920-x [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Eirefelt, S; Hummer, J; Basse, LH; Bertelsen, M; Johansson, F; Birngruber, T; Sinner, F; Larsen, J; Nielsen, SF; Lambert, M Evaluating Dermal Pharmacokinetics and Pharmacodymanic Effect of Soft Topical PDE4 Inhibitors: Open Flow Microperfusion and Skin Biopsies.
Pharm Res. 2020; 37(12): 243-243. Doi: 10.1007/s11095-020-02962-1
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** Holzer, JCJ; Tiffner, K; Kainz, S; Reisenegger, P; de Mattos, IB; Funk, M; Lemarchand, T; Laaff, H; Bal, A; Birngruber, T; Kotzbeck, P; Kamolz, LP A novel human ex-vivo burn model and the local cooling effect of a bacterial nanocellulose-based wound dressing.
BURNS. 2020; 46(8): 1924-1932. Doi: 10.1016/j.burns.2020.06.024
Web of Science PubMed FullText FullText_MUG

 

Kommentar

** Hofmann, E; Nischwitz, SP; Holzer, JCJ; Kotzbeck, P; Birngruber, T; Kamolz, LP Choice and characterization of preclinical models - Towards understanding wound healing.
Burns. 2020; 46(1):251-253 Doi: 10.1016/j.burns.2019.03.026 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

2019

Originalarbeit (Zeitschrift)

** Altendorfer-Kroath, T; Schimek, D; Eberl, A; Rauter, G; Ratzer, M; Raml, R; Sinner, F; Birngruber, T Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances.
J Neurosci Methods. 2019; 311(4):394-401 Doi: 10.1016/j.jneumeth.2018.09.024
Web of Science PubMed FullText FullText_MUG

 

** Altendorfer-Kroath, T; Schwingenschuh, S; Schøndorff, PK; Heschel, M; Sinner, F; Birngruber, T Insulin Distribution in Human Adipose Tissue via a Novel Insulin Infusion Catheter.
Diabetes Technol Ther. 2019; 21(12):740-744 Doi: 10.1089/dia.2019.0195
Web of Science PubMed FullText FullText_MUG

 

** de Mattos, IB; Holzer, JCJ; Tuca, AC; Groeber-Becker, F; Funk, M; Popp, D; Mautner, S; Birngruber, T; Kamolz, LP Uptake of PHMB in a bacterial nanocellulose-based wound dressing: A feasible clinical procedure.
Burns. 2019; 45(4):898-904 Doi: 10.1016/j.burns.2018.10.023
Web of Science PubMed FullText FullText_MUG

 

** Holzer, JC; Birngruber, T; Mautner, S; Graff, A; Kamolz, LP Topical application of haemoglobin: a safety study.
J Wound Care. 2019; 28(3): 148-153. Doi: 10.12968/jowc.2019.28.3.148
Web of Science PubMed FullText FullText_MUG

 

** Pipper, C; Bordag, N; Reiter, B; Economides, K; Florian, P; Birngruber, T; Sinner, F; Bodenlenz, M; Eberl, A LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation.
J Lipid Res. 2019; 60(4):758-766 Doi: 10.1194/jlr.M087221 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Korrektur

** Kleinert, M; Kotzbeck, P; Altendorfer-Kroath, T; Birngruber, T; Tschöp, MH; Clemmensen, C Corrigendum to "Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice" [Molecular Metabolism 13 (2018) 77-82].
Mol Metab. 2019; 30(9):265-265 Doi: 10.1016/j.molmet.2019.11.001 [OPEN ACCESS]
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2018

Originalarbeit (Zeitschrift)

** Sukseree, S; László, L; Gruber, F; Bergmann, S; Narzt, MS; Nagelreiter, IM; Höftberger, R; Molnár, K; Rauter, G; Birngruber, T; Larue, L; Kovacs, GG; Tschachler, E; Eckhart, L Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7.
Mol Neurobiol. 2018; 55(11):8425-8437 Doi: 10.1007/s12035-018-0996-x [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Abstract (Zeitschrift)

** Bodenlenz, M; Birngruber, T; Prietl, B; Economides, K; Florian, P; Subramaniam, A; Hultsch, T; Raml, R; Eberl, A; Mautner, S; Sinner, F Characterization of the psoriasis-like inflammation in the imiquimod rat model using the clinical method of dermal open flow microperfusion
EXP DERMATOL. 2018; 27: 10-10.-3rd Inflammatory Skin Disease Summit; DEC 12-15, 2018; Vienna, AUSTRIA. [Poster]
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2017

Originalarbeit (Zeitschrift)

** Bodenlenz, M; Tiffner, KI; Raml, R; Augustin, T; Dragatin, C; Birngruber, T; Schimek, D; Schwagerle, G; Pieber, TR; Raney, SG; Kanfer, I; Sinner, F Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence.
Clin Pharmacokinet. 2017; 56(1):91-98 Doi: 10.1007/s40262-016-0442-z [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

** Kaineder, K; Birngruber, T; Rauter, G; Obermüller, B; Eichler, J; Münzker, J; Al-Zoughbi, W; Mautner, SI; Torekov, SS; Hartmann, B; Kotzbeck, P; Pieber, TR Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system.
Int J Obes (Lond). 2017; 41(8):1263-1270 Doi: 10.1038/ijo.2017.98 [OPEN ACCESS]
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** Tiffner, K; Boulgaropoulos, B; Höfferer, C; Birngruber, T; Porksen, N; Linnebjerg, H; Garhyan, P; Lam, ECQ; Knadler, MP; Pieber, TR; Sinner, F Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion.
Diabetes Technol Ther. 2017; 19(5):305-314 Doi: 10.1089/dia.2016.0384
Web of Science PubMed FullText FullText_MUG

 

Korrektur

** Bodenlenz, M; Tiffner, KI; Raml, R; Augustin, T; Dragatin, C; Birngruber, T; Schimek, D; Schwagerle, G; Pieber, TR; Raney, SG; Kanfer, I; Sinner, F Erratum to: Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence.
Clin Pharmacokinet. 2017; 56(1):99-99 Doi: 10.1007/s40262-016-0487-z [OPEN ACCESS]
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Abstract (Zeitschrift)

** Birngruber, T; Prietl, B; Bodenlenz, M; Florian, P; Subramaniam, A; Kainz, S; Rauter, G; Pieber, TR; Sinner, F Continuous sampling of immune cells in the skin by dermal open flow microperfusion
J INVEST DERMATOL. 2017; 137(10):S275-S275.-47th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR); SEP 27-30, 2017; Salzburg, AUSTRIA. Doi: 10.1016/j.jid.2017.07.684 [Poster]
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** Bucher, N; Adamczak, J; Fahrngruber, H; Reisenegger, P; Stutz, A; Wolff-Winiski, B; Kamolz, L; Sinner, F; Birngruber, T Porcine wound model of persistent inflammation in chronic wounds
J INVEST DERMATOL. 2017; 137(10):S312-S312.-47th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR); SEP 27-30, 2017; Salzburg, AUSTRIA. Doi: 10.1016/j.jid.2017.07.373 [Oral Communication]
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** Tiffner, K; Funk, M; Kamolz, L; Birngruber, T Local inflammatory response after topically applied burn stimulus investigated in excised human skin
J INVEST DERMATOL. 2017; 137(10):S312-S312.-47th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR); SEP 27-30, 2017; Salzburg, AUSTRIA. Doi: 10.1016/j.jid.2017.07.372 [Oral Communication]
Web of Science FullText FullText_MUG

 

2016

Originalarbeit (Zeitschrift)

** Eberl, A; Altendorfer-Kroath, T; Kollmann, D; Birngruber, T; Sinner, F; Raml, R; Magnes, C Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry.
Anal Biochem. 2016; 509(3):130-134 Doi: 10.1016/j.ab.2016.07.010
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Übersichtsarbeit

** Birngruber, T; Sinner, F Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue.
Drug Discov Today Technol. 2016; 20(5): 19-25. Doi: 10.1016/j.ddtec.2016.07.003
PubMed FullText FullText_MUG

 

2014

Originalarbeit (Zeitschrift)

** Birngruber, T; Ghosh, A; Hochmeister, S; Asslaber, M; Kroath, T; Pieber, TR; Sinner, F Long-term implanted cOFM probe causes minimal tissue reaction in the brain.
PLoS One. 2014; 9(3):e90221-e90221 Doi: 10.1371/journal.pone.0090221 [OPEN ACCESS]
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** Birngruber, T; Raml, R; Gladdines, W; Gatschelhofer, C; Gander, E; Ghosh, A; Kroath, T; Gaillard, PJ; Pieber, TR; Sinner, F Enhanced doxorubicin delivery to the brain administered through glutathione PEGylated liposomal doxorubicin (2B3-101) as compared with generic Caelyx,(®)/Doxil(®)--a cerebral open flow microperfusion pilot study.
J Pharm Sci. 2014; 103(7):1945-1948 Doi: 10.1002/jps.23994
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** Ghosh, A; Birngruber, T; Sattler, W; Kroath, T; Ratzer, M; Sinner, F; Pieber, TR Assessment of blood-brain barrier function and the neuroinflammatory response in the rat brain by using cerebral open flow microperfusion (cOFM).
PLoS One. 2014; 9(5):e98143-e98143 Doi: 10.1371/journal.pone.0098143 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Hochmeister, S; Birngruber, T; Adzemovic, MZ; Haindl, M; Fazekas, F; Ropele, S; Sinner, F Development of a cortical lesion in a new rat model of focal inflammatory demyelination in serial MRI
MULT SCLER J. 2014; 20: 237-237.-Joint ACTRIMS-ECTRIMS Meeting; SEP 10-13, 2014; Boston, MA. [Poster]
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2013

Originalarbeit (Zeitschrift)

** Birngruber, T; Ghosh, A; Perez-Yarza, V; Kroath, T; Ratzer, M; Pieber, TR; Sinner, F Cerebral open flow microperfusion: a new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier.
Clin Exp Pharmacol Physiol. 2013; 40(12):864-871 Doi: 10.1111/1440-1681.12174
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** Bodenlenz, M; Aigner, B; Dragatin, C; Liebenberger, L; Zahiragic, S; Höfferer, C; Birngruber, T; Priedl, J; Feichtner, F; Schaupp, L; Korsatko, S; Ratzer, M; Magnes, C; Pieber, TR; Sinner, F Clinical applicability of dOFM devices for dermal sampling.
Skin Res Technol. 2013; 19(4):474-483 Doi: 10.1111/srt.12071
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** Bodenlenz, M; Dragatin, C; Hoefferer, C; Birngruber, T; Priedl, J; Feichtner, F; Schaller, R; Aigner, B; Korsatko, S; Pieber, TR; Sinner, F Certified dOFM sampling devices provide access to target tissue in pharmaceutical trials.
Biomed Tech (Berl). 2013; 58 Suppl 1(12): Doi: 10.1515/bmt-2013-4133
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** Mader, JK; Birngruber, T; Korsatko, S; Deller, S; Köhler, G; Boysen, S; Augustin, T; Mautner, SI; Sinner, F; Pieber, TR; AP@home Consortium Enhanced absorption of insulin aspart as the result of a dispersed injection strategy tested in a randomized trial in type 1 diabetic patients.
Diabetes Care. 2013; 36(4):780-785 Doi: 10.2337/dc12-1319 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Hochmeister, S; Birngruber, T; Zeitelhofer-Adzemovic, M; Haindl, M; Sinner, F A new model of focal inflammatory demyelination in the neocortex of the rat
MULT SCLER J. 2013; 19(11): 137-138. [Poster]
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