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Moustafa Tarek |

** = Publications listed in SCI/SSCI/Pubmed

2024

Full paper/article (Journal)

** Behrens, J; Braren, I; Jaeckstein, MY; Lilie, L; Heine, M; Sass, F; Sommer, J; Silbert-Wagner, D; Fuh, MM; Worthmann, A; Straub, L; Moustafa, T; Heeren, J; Scheja, L An efficient AAV vector system of Rec2 serotype for intravenous injection to study metabolism in brown adipocytes in vivo.
Mol Metab. 2024; 101999 Doi: 10.1016/j.molmet.2024.101999 [OPEN ACCESS]
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Abstract (Journal)

** Evangelakos, I; Scheja, L; Moustafa, T; Heeren, J THE SYNTHETIC BILE ACID DERIVATIVE NORUDCA IMPAIRS MITOCHONDRIAL FUNCTION AND ADAPTIVE THERMOGENESIS
ATHEROSCLEROSIS. 2024; 395: -92nd EAS Congress; MAY 26-29, 2024; Lyon, FRANCE. [Oral Communication]
Web of Science

 

2022

Full paper/article (Journal)

** Haange, SB; Till, A; Bergh, PO; Fauler, G; Gigl, M; Lofgren-Sandblom, A; Schaap, FG; Clavel, T; Trautwein, C; Fenske, W; Kleigrewe, K; Marschall, HU; Damink, SWMO; Moustafa, T; von Bergen, M; Rolle-Kampczyk, U Ring Trial on Quantitative Assessment of Bile Acids Reveals a Method- and Analyte-Specific Accuracy and Reproducibility
METABOLITES. 2022; 12(7): 583 Doi: 10.3390/metabo12070583 [OPEN ACCESS]
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** Truong, JK; Bennett, AL; Klindt, C; Donepudi, AC; Malla, SR; Pachura, KJ; Zaufel, A; Moustafa, T; Dawson, PA; Karpen, SJ Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury
J LIPID RES. 2022; 63(9): 100261 Doi: 10.1016/j.jlr.2022.100261 [OPEN ACCESS]
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2021

Full paper/article (Journal)

** Zaufel, A; van, de, Wiel, SMW; Yin, L; Fauler, G; Chien, D; Dong, X; Gilmer, JF; Truong, JK; Dawson, PA; van, de, Graaf, SFJ; Fickert, P; Moustafa, T Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.
BBA-MOL BASIS DIS. 2021; 1867(8): 166153 Doi: 10.1016/j.bbadis.2021.166153 [OPEN ACCESS]
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2020

Full paper/article (Journal)

** Streidl, T; Karkossa, I; Segura, Muñoz, RR; Eberl, C; Zaufel, A; Plagge, J; Schmaltz, R; Schubert, K; Basic, M; Schneider, KM; Afify, M; Trautwein, C; Tolba, R; Stecher, B; Doden, HL; Ridlon, JM; Ecker, J; Moustafa, T; von, Bergen, M; Ramer-Tait, AE; Clavel, T The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice.
GUT MICROBES. 2020; 13(1): 1-21. Doi: 10.1080/19490976.2020.1854008 [OPEN ACCESS]
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2019

Full paper/article (Journal)

** Maresch, LK; Benedikt, P; Feiler, U; Eder, S; Zierler, KA; Taschler, U; Kolleritsch, S; Eichmann, TO; Schoiswohl, G; Leopold, C; Wieser, BI; Lackner, C; Rülicke, T; van, Klinken, J; Kratky, D; Moustafa, T; Hoefler, G; Haemmerle, G Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity.
Hepatol Commun. 2019; 3(2):227-245 Doi: 10.1002/hep4.1292 [OPEN ACCESS]
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2017

Abstract (Journal)

** Moustafa, T; Zaufel, A; Eichmann, T; Kolb-Lenz, D; Trauner, M; Fickert, P Regulation of the mechanistic target of rapamycin complex 1 (mTORC1) - nuclear hormone receptor signaling by bile acids
J HEPATOL. 2017; 66(1):S111-S111.-International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 19-23, 2017; Amsterdam, NETHERLANDS. Doi: 10.1016/S0168-8278(17)30481-6 [Poster]
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2016

Full paper/article (Journal)

** Eisenberg, T; Abdellatif, M; Schroeder, S; Primessnig, U; Stekovic, S; Pendl, T; Harger, A; Schipke, J; Zimmermann, A; Schmidt, A; Tong, M; Ruckenstuhl, C; Dammbrueck, C; Gross, AS; Herbst, V; Magnes, C; Trausinger, G; Narath, S; Meinitzer, A; Hu, Z; Kirsch, A; Eller, K; Carmona-Gutierrez, D; Büttner, S; Pietrocola, F; Knittelfelder, O; Schrepfer, E; Rockenfeller, P; Simonini, C; Rahn, A; Horsch, M; Moreth, K; Beckers, J; Fuchs, H; Gailus-Durner, V; Neff, F; Janik, D; Rathkolb, B; Rozman, J; de Angelis, MH; Moustafa, T; Haemmerle, G; Mayr, M; Willeit, P; von Frieling-Salewsky, M; Pieske, B; Scorrano, L; Pieber, T; Pechlaner, R; Willeit, J; Sigrist, SJ; Linke, WA; Mühlfeld, C; Sadoshima, J; Dengjel, J; Kiechl, S; Kroemer, G; Sedej, S; Madeo, F Cardioprotection and lifespan extension by the natural polyamine spermidine.
Nat Med. 2016; 22(12):1428-1438 Doi: 10.1038/nm.4222 [OPEN ACCESS]
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** Grumet, L; Eichmann, TO; Taschler, U; Zierler, KA; Leopold, C; Moustafa, T; Radovic, B; Romauch, M; Yan, C; Du, H; Haemmerle, G; Zechner, R; Fickert, P; Kratky, D; Zimmermann, R; Lass, A Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover.
J Biol Chem. 2016; 291(34):17977-87 Doi: 10.1074/jbc.M116.724054 [OPEN ACCESS]
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2015

Full paper/article (Journal)

** González, A; Shimobayashi, M; Eisenberg, T; Merle, DA; Pendl, T; Hall, MN; Moustafa, T TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiae.
PLoS One. 2015; 10(3):e0120250-e0120250 Doi: 10.1371/journal.pone.0120250 [OPEN ACCESS]
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** Heier, C; Radner, FP; Moustafa, T; Schreiber, R; Grond, S; Eichmann, TO; Schweiger, M; Schmidt, A; Cerk, IK; Oberer, M; Theussl, HC; Wojciechowski, J; Penninger, JM; Zimmermann, R; Zechner, R G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.
J Biol Chem. 2015; 290(43):26141-50 Doi: 10.1074/jbc.M115.671842 [OPEN ACCESS]
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** Leithner, K; Hrzenjak, A; Trötzmüller, M; Moustafa, T; Köfeler, HC; Wohlkoenig, C; Stacher, E; Lindenmann, J; Harris, AL; Olschewski, A; Olschewski, H PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.
Oncogene. 2015; 34(8):1044-1050 Doi: 10.1038/onc.2014.47
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** Weinert, BT; Moustafa, T; Iesmantavicius, V; Zechner, R; Choudhary, C Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions.
EMBO J. 2015; 34(21):2620-2632 Doi: 10.15252/embj.201591271 [OPEN ACCESS]
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Review

** Trauner, M; Halilbasic, E; Claudel, T; Steinacher, D; Fuchs, C; Moustafa, T; Pollheimer, M; Krones, E; Kienbacher, C; Traussnigg, S; Kazemi-Shirazi, L; Munda, P; Hofer, H; Fickert, P; Paumgartner, G Potential of nor-Ursodeoxycholic Acid in Cholestatic and Metabolic Disorders.
Dig Dis. 2015; 33(3):433-439 Doi: 10.1159/000371904
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Correction

** Weinert, BT; Iesmantavicius, V; Moustafa, T; Schölz, C; Wagner, SA; Magnes, C; Zechner, R; Choudhary, C Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae.
Mol Syst Biol. 2015; 11(10): 833-833. Doi: 10.15252/msb.156513 [OPEN ACCESS]
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2014

Full paper/article (Journal)

** Brahma, MK; Adam, RC; Pollak, NM; Jaeger, D; Zierler, KA; Pöcher, N; Schreiber, R; Romauch, M; Moustafa, T; Eder, S; Ruelicke, T; Preiss-Landl, K; Lass, A; Zechner, R; Haemmerle, G Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis.
J Lipid Res. 2014; 55(11):2229-2241 Doi: 10.1194/jlr.M044784 [OPEN ACCESS]
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** Eisenberg, T; Schroeder, S; Andryushkova, A; Pendl, T; Küttner, V; Bhukel, A; Mariño, G; Pietrocola, F; Harger, A; Zimmermann, A; Moustafa, T; Sprenger, A; Jany, E; Büttner, S; Carmona-Gutierrez, D; Ruckenstuhl, C; Ring, J; Reichelt, W; Schimmel, K; Leeb, T; Moser, C; Schatz, S; Kamolz, LP; Magnes, C; Sinner, F; Sedej, S; Fröhlich, KU; Juhasz, G; Pieber, TR; Dengjel, J; Sigrist, SJ; Kroemer, G; Madeo, F Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.
Cell Metab. 2014; 19(3):431-444 Doi: 10.1016/j.cmet.2014.02.010 [OPEN ACCESS]
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** Nagy, HM; Paar, M; Heier, C; Moustafa, T; Hofer, P; Haemmerle, G; Lass, A; Zechner, R; Oberer, M; Zimmermann, R Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A.
Biochim Biophys Acta. 2014; 1841(4):588-594 Doi: 10.1016/j.bbalip.2014.01.005 [OPEN ACCESS]
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** Weinert, BT; Iesmantavicius, V; Moustafa, T; Schölz, C; Wagner, SA; Magnes, C; Zechner, R; Choudhary, C Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae.
Mol Syst Biol. 2014; 10(2): 716-716. Doi: 10.1002/msb.134766 [OPEN ACCESS]
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Abstract (Journal)

** Leithner, K; Hrzenjak, A; Trotzmuller, M; Moustafa, T; Kofeler, HC; Wohlkoenig, C; Stacher, E; Harris, AL; Olschewski, A; Olschewski, H; Role of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase in lung cancer.
EUR J CANCER. 2014; 50: S84-S84.-EACR 23; Doi: 10.1016/S0959-8049(14)50315-2 [Poster]
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2013

Full paper/article (Journal)

** Fickert, P; Krones, E; Pollheimer, MJ; Thueringer, A; Moustafa, T; Silbert, D; Halilbasic, E; Yang, M; Jaeschke, H; Stokman, G; Wells, RG; Eller, K; Rosenkranz, AR; Eggertsen, G; Wagner, CA; Langner, C; Denk, H; Trauner, M Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice.
Hepatology. 2013; 58(6):2056-2069 Doi: 10.1002/hep.26599 [OPEN ACCESS]
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** Fickert, P; Pollheimer, MJ; Silbert, D; Moustafa, T; Halilbasic, E; Krones, E; Durchschein, F; Thüringer, A; Zollner, G; Denk, H; Trauner, M Differential effects of norUDCA and UDCA in obstructive cholestasis in mice.
J Hepatol. 2013; 58(6):1201-1208 Doi: 10.1016/j.jhep.2013.01.026 [OPEN ACCESS]
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2012

Full paper/article (Journal)

** Modica, S; Petruzzelli, M; Bellafante, E; Murzilli, S; Salvatore, L; Celli, N; Di Tullio, G; Palasciano, G; Moustafa, T; Halilbasic, E; Trauner, M; Moschetta, A Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis.
Gastroenterology. 2012; 142(2):355-65.e1-355-65.e4 Doi: 10.1053/j.gastro.2011.10.028 [OPEN ACCESS]
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** Moustafa, T; Fickert, P; Magnes, C; Guelly, C; Thueringer, A; Frank, S; Kratky, D; Sattler, W; Reicher, H; Sinner, F; Gumhold, J; Silbert, D; Fauler, G; Höfler, G; Lass, A; Zechner, R; Trauner, M Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
Gastroenterology. 2012; 142(1):140-151 Doi: 10.1053/j.gastro.2011.09.051
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Review

** Trauner, M; Halilbasic, E; Baghdasaryan, A; Moustafa, T; Krones, E; Fickert, P; Hofer, H; Penner, E Primary sclerosing cholangitis: new approaches to diagnosis, surveillance and treatment.
Dig Dis. 2012; 30 Suppl 1(6):39-47 Doi: 10.1159/000341123
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2011

Full paper/article (Journal)

** Haemmerle, G; Moustafa, T; Woelkart, G; Büttner, S; Schmidt, A; van, de, Weijer, T; Hesselink, M; Jaeger, D; Kienesberger, PC; Zierler, K; Schreiber, R; Eichmann, T; Kolb, D; Kotzbeck, P; Schweiger, M; Kumari, M; Eder, S; Schoiswohl, G; Wongsiriroj, N; Pollak, NM; Radner, FP; Preiss-Landl, K; Kolbe, T; Rülicke, T; Pieske, B; Trauner, M; Lass, A; Zimmermann, R; Hoefler, G; Cinti, S; Kershaw, EE; Schrauwen, P; Madeo, F; Mayer, B; Zechner, R ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.
Nat Med. 2011; 17(9):1076-85 Doi: 10.1038/nm.2439 [OPEN ACCESS]
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Review

** Trauner, M; Baghdasaryan, A; Claudel, T; Fickert, P; Halilbasic, E; Moustafa, T; Zollner, G Targeting nuclear bile acid receptors for liver disease.
Dig Dis. 2011; 29(1):98-102 Doi: 10.1159/000324141
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Abstract (Journal)

** Fickert, P; Silbert, D; Moustafa, T; Halilbasic, E; Krones, E; Durchschein, F; Thueringer, A; Pollheimer, MJ; Zollner, G; Denk, H; Trauner, M DIFFERENTIAL EFFECTS OF NORUDCA AND UDCA IN OBSTRUCTIVE CHOLESTASIS IN MICE
HEPATOLOGY. 2011; 54: 775A-775A.-62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); NOV 04-08, 2011; San Francisco, CA. [Poster]
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** Fickert, P; Thueringer, A; Moustafa, T; Silbert, D; Yang, M; Jaeschke, H; Stokman, G; Wells, R; Eller, K; Rosenkranz, AR; Eggertsen, G; Denk, H; Trauner, M TUBULOINTERSTITIAL KIDNEY FIBROSIS AND CHRONIC RENAL FAILURE IN LONG-TERM COMMON BILE-DUCT-LIGATED MICE AS A RESULT OF COLLECTING DUCT INJURY: THE ROLE OF OSTEOPONTIN, FXR, AND CYP8B1
HEPATOLOGY. 2011; 54: 1250A-1251A.-62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD); NOV 04-08, 2011; San Francisco, CA.
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** Fickert, P; Thueringer, A; Moustafa, T; Yang, M; Jaeschke, H; Wells, RG; Stokman, G; Denk, H; Trauner, M LONG-TERM COMMON BILE DUCT-LIGATION IN MICE INDUCES TUBULOINTERSTITIAL KIDNEY FIBROSIS AND CHRONIC RENAL FAILURE: ROLE OF BILE ACID NUCLEAR RECEPTOR FXR AND OSTEOPONTIN
J HEPATOL. 2011; 54: S244-S244.-46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL); 2011; Berlin, GERMANY. Doi: 10.1016/S0168-8278(11)60602-8
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2010

Full paper/article (Journal)

** Fickert, P; Thueringer, A; Moustafa, T; Silbert, D; Gumhold, J; Tsybrovskyy, O; Lebofsky, M; Jaeschke, H; Denk, H; Trauner, M The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice.
Lab Invest. 2010; 90(6):844-852 Doi: 10.1038/labinvest.2010.61 [OPEN ACCESS]
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Review

** Trauner, M; Claudel, T; Fickert, P; Moustafa, T; Wagner, M Bile acids as regulators of hepatic lipid and glucose metabolism.
Dig Dis. 2010; 28(1):220-224 Doi: 10.1159/000282091
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** Trauner, M; Fickert, P; Baghdasaryan, A; Claudel, T; Halilbasic, E; Moustafa, T; Wagner, M; Zollner, G New insights into autoimmune cholangitis through animal models.
Dig Dis. 2010; 28(1):99-104 Doi: 10.1159/000282072
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Abstract (Journal)

** Fuchs, CD; Moustafa, T; Haemmerle, G; Halilbasic, E; Gumhold, J; Silbert, D; Fickert, P; Zechner, R; Trauner, M ADIPOSE TRIGLYCERIDE LIPASE (ATGL) IS A NOVEL MODULATOR OF HEPATIC ER-STRESS
J HEPATOL. 2010; 52: S305-S305.-45th Annual Meeting of the European Association for the Study of the Liver; APR 14 - 18,2010; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(10)60787-8 [Oral Communication]
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** Moustafa, T; Fickert, P; Magnes, C; Frank, S; Kratky, D; Sinner, F; Gumhold, J; Silbert, D; Halsegger, S; Trauner M METABOLIC REPROGRAMMING OF LIPID METABOLISM BY THE SIDE-CHAIN MODIFIED BILE ACID, 24-NORURSODEOXYCHOLIC ACID, RESTORES INFLAMMATION-DRIVEN LIVER INJURY AND ABERRANT PROLIFERATION IN ABCB4-/- MICE
J HEPATOL. 2010; 52: S20-S21.-45th Annual Meeting of the European Association for the Study of the Liver; APR 14 - 18,2010; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(10)60049-9 [Oral Communication]
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2009

Full paper/article (Journal)

** Fickert, P; Fuchsbichler, A; Moustafa, T; Wagner, M; Zollner, G; Halilbasic, E; Stöger, U; Arrese, M; Pizarro, M; Solís, N; Carrasco, G; Caligiuri, A; Sombetzki, M; Reisinger, E; Tsybrovskyy, O; Zatloukal, K; Denk, H; Jaeschke, H; Pinzani, M; Trauner, M Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.
Am J Pathol. 2009; 175(6):2392-2405 Doi: 10.2353/ajpath.2009.090114 [OPEN ACCESS]
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** Halilbasic, E; Fiorotto, R; Fickert, P; Marschall, HU; Moustafa, T; Spirli, C; Fuchsbichler, A; Gumhold, J; Silbert, D; Zatloukal, K; Langner, C; Maitra, U; Denk, H; Hofmann, AF; Strazzabosco, M; Trauner, M Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice.
Hepatology. 2009; 49(6):1972-1981 Doi: 10.1002/hep.22891 [OPEN ACCESS]
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Full paper/article (Proceedings)

** Halilbasic, E; Fickert, P; Fiorotto, R; Marschall, HU; Moustafa, T; Fuchsbichler, A; Gumhold, J; Silbert, D; Langner, C; Maitra, U; Denk, H; Strazzabosco, M; Trauner, M Side-chain modification as critical determinant of the therapeutic properties of 24-norursodeoxycholic acid in Mdr2 (Abcb4) knockout mice
FALK SYMP. 2009; 165: 157-162. [Oral Communication]
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** Trauner, M; Fickert, P; Moustafa, T; Fuchsbichler, A; Claudel, T; Halilbasic, E; Kratky, D; Denk, H Potential role of ursodeoxycholic acid and its side-chain modified derivatives in the treatment of non-alcoholic fatty liver disease and associated atherosclerosis
FALK SYMP. 2009; 165: 151-156. [Oral Communication]
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2008

Full paper/article (Journal)

** Baghdasaryan, A; Fickert, P; Fuchsbichler, A; Silbert, D; Gumhold, J; Hörl, G; Langner, C; Moustafa, T; Halilbasic, E; Claudel, T; Trauner, M Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice.
Liver Int. 2008; 28(7):948-958 Doi: 10.1111/j.1478-3231.2008.01758.x
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** Magnes, C; Suppan, M; Pieber, TR; Moustafa, T; Trauner, M; Haemmerle, G; Sinner, FM Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS.
Anal Chem. 2008; 80(15):5736-5742 Doi: 10.1021/ac800031u
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Review

** Trauner, M; Fickert, P; Halilbasic, E; Moustafa, T Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases.
Wien Med Wochenschr. 2008; 158(19-20):542-548 Doi: 10.1007/s10354-008-0592-1
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Abstract (Journal)

** Fickert, P; Moustafa, T; Fuchsbichler, A; Claudel, T; Halilbasic, E; Zatloukal, K; Denk, H; Trauner, M Differential effects of nor UDCA and UDCA in the treatment of fatty liver and arteriosclerosis in western chow-fed ApoE knock out mice
J HEPATOL. 2008; 48: S42-S42.-Annual Meeting, EASL; April 2008; Milann, Italy. Doi: 10.1016/S0168-8278(08)60100-2 [Oral Communication]
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** Moustafa, T; Fickert, P; Silbert, D; Gumhold, J; Halilbasic, E; Trauner, MH LOSS OF FXR ATTENUATES SCLEROSING CHOLANGITIS AND BILIARY FIBROSIS IN MDR2(-/-) AND FXR(-/-) DOUBLE KNOCKOUT MICE
HEPATOLOGY. 2008; 48(4):777--59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases; OCT 31-NOV 04, 2008; San Francisco, CA. [Poster]
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** Moustafa, T; Halilbasic, E; Fickert, P; Fuchsbichler, A; Gumhold, J; Silbert, D; Denk, H; Trauner, M Side chain modified bile acids modulate endoplasmic reticulum stress in Mdr2(-/-) mice in vivo and bile duct epithelial cells in vitro
J HEPATOL. 2008; 48: S54-S55.-EASL Annula Meeting; April 2008; Milan Italy. Doi: 10.1016/S0168-8278(08)60127-0 [Oral Communication]
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2007

Full paper/article (Journal)

** Fickert, P; Stöger, U; Fuchsbichler, A; Moustafa, T; Marschall, HU; Weiglein, AH; Tsybrovskyy, O; Jaeschke, H; Zatloukal, K; Denk, H; Trauner, M A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.
Am J Pathol. 2007; 171(2):525-536 Doi: 10.2353/ajpath.2007.061133 [OPEN ACCESS]
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** Panzitt, K; Tschernatsch, MM; Guelly, C; Moustafa, T; Stradner, M; Strohmaier, HM; Buck, CR; Denk, H; Schroeder, R; Trauner, M; Zatloukal, K Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA.
Gastroenterology. 2007; 132(1):330-342 Doi: 10.1053/j.gastro.2006.08.026
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Review

** Fickert, P; Moustafa, T; Trauner, M Primary sclerosing cholangitis--the arteriosclerosis of the bile duct?
Lipids Health Dis. 2007; 6(2):3-3 Doi: 10.1186/1476-511X-6-3 [OPEN ACCESS]
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Abstract (Journal)

** Halilbasic, E; Fickert, P; Fuchsbichler, A; Moustafa, T; Stoeger, U; Ueno, Y; Denk, H; Trauner, M TNF alpha and LPS but not bile acids play a key role in the induction of reactive phenotype in bile duct epithelial cells in vitro
J HEPATOL. 2007; 46: S121-S121.-EASL; April 11-15, 2007; Barcelona/Spain. Doi: 10.1016/S0168-8278(07)61905-9 [Poster]
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** Moustafa, T; Fickert, P; Vesely, P; Silbert, D; Gumhold, J; Fuchsbichler, A; Denk, H; Guelly, C; Trauner, M Retention of toxic bile acids activate the mTOR, p70S6k/rps6 signaling pathway in mouse models of cholestatic liver injury
J HEPATOL. 2007; 46: S23-S23. Doi: 10.1016/S0168-8278(07)61646-8 [Oral Communication]
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** Wagner, M; Moustafa, T; Fickert, P; Zollner, G; Gumhold, J; Silbert, D; Fuchsbichler, A; Zatloukal, K; Denk, H; Trauner, M Absence of FXR protects mice from bile-infarcts in biliary obstruction by reduction of bile acid-independent bile flow: Implications for targeting FXR in treatment of cholestasis?
J HEPATOL. 2007; 46: S5-S5.-42th Annual Meeting, European Association for the Study of the Liver; April, 11-15, 2007; Barcelona, Spain. Doi: 10.1016/S0168-8278(07)61603-1 [Oral Communication]
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2006

Full paper/article (Journal)

** Boyer, JL; Trauner, M; Mennone, A; Soroka, CJ; Cai, SY; Moustafa, T; Zollner, G; Lee, JY; Ballatori, N Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.
Am J Physiol Gastrointest Liver Physiol. 2006; 290(6):G1124-G1130 Doi: 10.1152/ajpgi.00539.2005 [OPEN ACCESS]
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** Zollner, G; Wagner, M; Moustafa, T; Fickert, P; Silbert, D; Gumhold, J; Fuchsbichler, A; Halilbasic, E; Denk, H; Marschall, HU; Trauner, M Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.
Am J Physiol Gastrointest Liver Physiol. 2006; 290(5):G923-G932 Doi: 10.1152/ajpgi.00490.2005 [OPEN ACCESS]
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Abstract (Journal)

** Moustafa, T; Fickert, P; Guelly, C; Silbert, D; Gumhold, J; Fuchsbichler, A; Denk, H; Trauner, M Transcriptional profiling of Mdr2 knockout (Mdr2-/-) mice treated with nor-UDCA reveals global anti-inflammatory and anti-fibrotic effects
J HEPATOL. 2006; 44: S42-S42.-41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 26-30, 2006; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(06)80095-4 [Poster]
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** Moustafa, T; Fickert, P; Guelly, C; Silbert, D; Gumhold, J; Fuchsbichler, A; Denk, H; Trauner, M 24-nor-ursodeoxycholic acid abolishes enhanced cellular proliferation in Mdr2 (abcb4) knockout mice by modulation of mTOR, p70s6k and rps6 signaling
HEPATOLOGY. 44(4):602A-603A. [Poster]
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** Moustafa, T; Fickert, P; Prokesch, A; Wagner, M; Fuchsbichler, A; Silbert, D; Gumhold, J; Denk, H; Trajanoski, Z; Trauner, M Common bile-duct-ligation of FXR knockout mice results in severe hepatic steatosis due to enhancement in lipogenic gene expression
J HEPATOL. 44: S28-S28.-41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 26-30, 2006; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(06)80063-2 [Poster]
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** Stoger, U; Fickert, P; Fuchsbichler, A; Moustafa, T; Gumhold, J; Silbert, D; Zatlouka, K; Denk, H; Trauner, M 3.5-diethoxycarbonyl-1.4-dihydrocollidine (DDC) feeding induces cholestasis, chronic inflammatory bile duct damage and biliary fibrosis in mice
J HEPATOL. 44: S123-S124.-41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 26-30, 2006; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(06)80321-1 [Poster]
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** Zollner, G; Wagner, M; Moustafa, T; Fickert, P; Silbert, D; Gumhold, J; Helmut, D; Marschall, HU; Trauner, M Role of nuclear bile acid receptor FXR in regulation of bile acid detoxification and organic solute transporter (OST-alpha/beta) expression in bile acid-fed mice
J HEPATOL. 44: S124-S124.-41st Annual Meeting of the European-Association-for-the-Study-of-the-Liver; APR 26-30, 2006; Vienna, AUSTRIA. Doi: 10.1016/S0168-8278(06)80322-3 [Poster]
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2004

Abstract (Journal)

** Panzitt, K; Strohmaier, HM; Moustafa, T; Stradner, M; Gully, C; Buck, CR; Denk, H; Zatloukal, K A non-protein-coding RNA is a major deregulated gene in hepatocellular carcinoma and may act as a general modulator of gene expression
HEPATOLOGY 2004 40: 253A-253A.
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