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Heitzer Ellen |

Publications

** = Publications listed in SCI/SSCI/Pubmed

2025

Full paper/article (Journal)

** Pantel, K; Alix-Panabières, C; Hofman, P; Stoecklein, NH; Lu, YJ; Lianidou, E; Giacomini, P; Koch, C; de, Jager, V; Deans, ZC; Fairley, J; Patton, SJ; Toledo, RA; Schuuring, E; Heitzer, E; Hendrix, A; Ricklefs, FL; Thakur, BK; von, Bubnoff, N; Pierga, JY; Gebhardt, C; Andersen, CL; Fijneman, R; Malats, N; Hallermayr, A; Chelala, C; Joosse, SA; Ciliberto, G Fostering the implementation of liquid biopsy in clinical practice: meeting report 2024 of the European Liquid Biopsy Society (ELBS).
J Exp Clin Cancer Res. 2025; 44(1):156 Doi: 10.1186/s13046-025-03398-4 [OPEN ACCESS]
PubMed FullText FullText_MUG

** Unseld, M; Kühberger, S; Graf, R; Beichler, C; Braun, M; Dandachi, N; Heitzer, E; Prager, GW Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil-treated metastatic colorectal cancer patients.
Mol Oncol. 2025; Doi: 10.1002/1878-0261.13755
Web of Science PubMed FullText FullText_MUG

Review

** de, Jager, VD; Giacomini, P; Fairley, JA; Toledo, RA; Patton, SJ; Joosse, SA; Koch, C; Deans, ZC; Pantel, K; Heitzer, E; Schuuring, E, , ELBS, ctDNA, Workshop, Group Reporting of molecular test results from cell-free DNA analyses: expert consensus recommendations from the 2023 European Liquid Biopsy Society ctDNA Workshop.
EBioMedicine. 2025; 114:105636 Doi: 10.1016/j.ebiom.2025.105636 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Guigal-Stephan, N; Lockhart, B; Moser, T; Heitzer, E A perspective review on the systematic implementation of ctDNA in phase I clinical trial drug development.
J Exp Clin Cancer Res. 2025; 44(1):79 Doi: 10.1186/s13046-025-03328-4 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

2024

Full paper/article (Journal)

** Bonstingl, L; Skofler, C; Ulz, C; Zinnegger, M; Sallinger, K; Schönberger, J; Schuch, K; Pankratz, K; Borrás-Cherrier, A; Somodi, V; Abuja, PM; Oberauner-Wappis, L; Moser, T; Heitzer, E; Bauernhofer, T; Kroneis, T; El-Heliebi, A Clinical Application of ISO and CEN/TS Standards for Liquid Biopsies-Information Everybody Wants but Nobody Wants to Pay For.
Clin Chem. 2024; 70(9): 1140-1150. Doi: 10.1093/clinchem/hvae079
Web of Science PubMed FullText FullText_MUG

** Bonstingl, L; Zinnegger, M; Sallinger, K; Pankratz, K; Müller, CT; Pritz, E; Odar, C; Skofler, C; Ulz, C; Oberauner-Wappis, L; Borrás-Cherrier, A; Somođi, V; Heitzer, E; Kroneis, T; Bauernhofer, T; El-Heliebi, A Advanced single-cell and spatial analysis with high-multiplex characterization of circulating tumor cells and tumor tissue in prostate cancer: Unveiling resistance mechanisms with the CoDuCo in situ assay.
Biomark Res. 2024; 12(1): 140 Doi: 10.1186/s40364-024-00680-z [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Reinisch, I; Michenthaler, H; Sulaj, A; Moyschewitz, E; Krstic, J; Galhuber, M; Xu, R; Riahi, Z; Wang, T; Vujic, N; Amor, M; Zenezini, Chiozzi, R; Wabitsch, M; Kolb, D; Georgiadi, A; Glawitsch, L; Heitzer, E; Schulz, TJ; Schupp, M; Sun, W; Dong, H; Ghosh, A; Hoffmann, A; Kratky, D; Hinte, LC; von, Meyenn, F; Heck, AJR; Blüher, M; Herzig, S; Wolfrum, C; Prokesch, A Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape.
Nat Commun. 2024; 15(1): 1391 Doi: 10.1038/s41467-024-45724-y [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Stitz, R; Stoiber, F; Silye, R; Vlachos, G; Andaloro, S; Rebhan, E; Dunzinger, M; Pühringer, F; Gallo, C; El-Heliebi, A; Heitzer, E; Hauser-Kronberger, C Clinical Implementation of a Noninvasive, Multi-Analyte Droplet Digital PCR Test to Screen for Androgen Receptor Alterations.
J Mol Diagn. 2024; 26(6):467-478 Doi: 10.1016/j.jmoldx.2024.02.009
Web of Science PubMed FullText FullText_MUG

Review

** Hasenleithner, SO; Heitzer, E Liquid profiling for patients with advanced cancer is ready for clinical integration
MEMO-MAG EUR MED ONC. 2024; Doi: 10.1007/s12254-024-00978-6
Web of Science FullText FullText_MUG

** Klocker, EV; Hasenleithner, S; Bartsch, R; Gampenrieder, SP; Egle, D; Singer, CF; Rinnerthaler, G; Hubalek, M; Schmitz, K; Bago-Horvath, Z; Petzer, A; Heibl, S; Heitzer, E; Balic, M; Gnant, M Clinical applications of next-generation sequencing-based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression.
Mol Oncol. 2024; Doi: 10.1002/1878-0261.13671
Web of Science PubMed FullText FullText_MUG

Editorial

** Moser, T; Heitzer, E Surpassing sensitivity limits in liquid biopsy.
Science. 2024; 383(6680): 260-261. Doi: 10.1126/science.adn1886
Web of Science PubMed FullText FullText_MUG

Correction

** Bonstingl, L; Zinnegger, M; Sallinger, K; Pankratz, K; Müller, CT; Pritz, E; Odar, C; Skofler, C; Ulz, C; Oberauner-Wappis, L; Borrás-Cherrier, A; Somođi, V; Heitzer, E; Kroneis, T; Bauernhofer, T; El-Heliebi, A Correction: Advanced single-cell and spatial analysis with high-multiplex characterization of circulating tumor cells and tumor tissue in prostate cancer: unveiling resistance mechanisms with the CoDuCo in situ assay.
Biomark Res. 2024; 12(1): 150 Doi: 10.1186/s40364-024-00698-3 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** de Jager, VD; Giacomini, P; Fairley, J; Toledo, RDA; Patton, S; Joosse, S; Koch, C; Deans, S; Heitzer, E; Schuuring, E Reporting of molecular test results from cell-free DNA analyses: Expert consensus recommendations from the 2023 European Liquid Biopsy Society ctDNA workshop
ANN ONCOL. 2024; 35: S259-S259. Doi: 10.1016/j.annonc.2024.08.120
Web of Science FullText FullText_MUG

** Hallermayr, A; Wohlfrom, T; Steinke-Lange, V; Benet-Pagès, A; Scharf, F; Heitzer, E; Mansmann, U; Haberl, C; de Wit, M; Vogelsang, H; Rentsch, M; Holinski-Feder, E; Pickl, JMA Liquid biopsy in colorectal cancer - Beyond the targeted analysis of single variants
ONCOL RES TREAT. 2024; 47: 27-27.-36. Deutscher Krebskongress; FEB 21-24, 2024; Berlin, GERMANY. [Oral Communication]
Web of Science

** Moik, F; Riedl, JM; Edlinger, L; Esterl, T; Hasenleithner, S; Kostmann, S; Cebular, L; Jahn, S; Kashofer, K; Zacharias, M; Hoefler, G; Heitzer, E; Gerger, A; Jost, PJ Practice patterns and treatment outcomes of molecular tumour board (MTB)-based personalized cancer therapies: A single-center experience
ANN ONCOL. 2024; 35: S262-S263. Doi: 10.1016/j.annonc.2024.08.130
Web of Science FullText FullText_MUG

2023

Full paper/article (Journal)

** Hallermayr, A; Kessler, T; Steinke-Lange, V; Heitzer, E; Holinski-Feder, E; Speicher, M The utility of liquid biopsy in clinical genetic diagnosis of cancer and monogenic mosaic disorders
MED GENET-BERLIN. 2023; 35(4): 275-284. Doi: 10.1515/medgen-2023-2066
Web of Science FullText FullText_MUG

** Karner, C; Anders, I; Vejzovic, D; Szkandera, J; Scheipl, S; Deutsch, AJA; Weiss, L; Vierlinger, K; Kolb, D; Kühberger, S; Heitzer, E; Habisch, H; Zhang, F; Madl, T; Reininger-Gutmann, B; Liegl-Atzwanger, B; Rinner, B Targeting epigenetic features in clear cell sarcomas based on patient-derived cell lines.
J Transl Med. 2023; 21(1): 54 Doi: 10.1186/s12967-022-03843-4 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Pai, CC; Heitzer, E; Bertrand, S; Toumazou, S; Humphrey, TC; Kearsey, SE Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe.
PLoS One. 2023; 18(1): e0271016 Doi: 10.1371/journal.pone.0271016 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Pencik, J; Philippe, C; Schlederer, M; Atas, E; Pecoraro, M; Grund-Gröchke, S; Li, W; Tracz, A; Heidegger, I; Lagger, S; Trachtová, K; Oberhuber, M; Heitzer, E; Aksoy, O; Neubauer, HA; Wingelhofer, B; Orlova, A; Witzeneder, N; Dillinger, T; Redl, E; Greiner, G; D'Andrea, D; Östman, JR; Tangermann, S; Hermanova, I; Schäfer, G; Sternberg, F; Pohl, EE; Sternberg, C; Varady, A; Horvath, J; Stoiber, D; Malcolm, TI; Turner, SD; Parkes, EE; Hantusch, B; Egger, G; Rose-John, S; Poli, V; Jain, S; Armstrong, CWD; Hoermann, G; Goffin, V; Aberger, F; Moriggl, R; Carracedo, A; McKinney, C; Kennedy, RD; Klocker, H; Speicher, MR; Tang, DG; Moazzami, AA; Heery, DM; Hacker, M; Kenner, L STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway
MOL CANCER. 2023; 22(1): 133 Doi: 10.1186/s12943-023-01825-8 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Short report/Letter

** Kränke, T; Loibner, M; Arzberger, E; Wieczorek, G; Krenz, T; Attig, H; Hofmann-Wellenhof, E; Fischer, B; Eberhard, A; Oberauner-Wappis, L; Ulz, CM; Fried, I; Cerroni, L; Oelmueller, U; Zatloukal, K; Hofmann-Wellenhof, R; Heitzer, E Non-invasive molecular profiling of skin lesions using tape-stripping.
Skin Res Technol. 2023; 29(5):e13322 Doi: 10.1111/srt.13322 [OPEN ACCESS]
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Review

** Moser, T; Kühberger, S; Lazzeri, I; Vlachos, G; Heitzer, E Bridging biological cfDNA features and machine learning approaches.
Trends Genet. 2023; 39(4): 285-307. Doi: 10.1016/j.tig.2023.01.004
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Dandachi, N; Graf, R; Pancheri, L; Dobric, N; Klocker, EV; Suppan, C; Jost, PJ; Heitzer, E; Balic, M A head-to-head comparison for detecting PIK3CA mutations in circulating tumor DNA of advanced HR+/HER2-breast cancer patients
ANN ONCOL. 2023; 34: S1162-S1163.-Annual Meeting of the European-Society-for-Medical-Oncology (ESMO); OCT 20-24, 2023; Madrid, SPAIN. Doi: 10.1016/j.annonc.2023.09.1289 [Poster]
Web of Science FullText FullText_MUG

** Dobric, N; Dandachi, N; Klocker, EV; Suppan, C; Graf, R; Hasenleithner, S; Jost, PJ; Heitzer, E; Balic, M Comparison of ctDNA profiles from HR+/HER2-low and HR+/HER2-0 advanced breast cancer patients
ANN ONCOL. 2023; 34: S387-S387.-Annual Meeting of the European-Society-for-Medical-Oncology (ESMO); OCT 20-24, 2023; Madrid, SPAIN. Doi: 10.1016/j.annonc.2023.09.667 [Poster]
Web of Science FullText FullText_MUG

** Hallermayr, A; Steinke-Lange, V; Benetpagès, A; Wohlfrom, T; Scharf, F; Heitzer, E; Haberl, C; de Wit, M; Vogelsang, H; Rentsch, M; Holinski-Feder, E; Romic-Pickl, J Development of combined somatic copy number alteration and fragmentation analysis for monitoring in colorectal cancer patients using liquid biopsy
EUR J HUM GENET. 2023; 31: 558-559. [Poster]
Web of Science

** Pantel, K; Andersen, CL; Schuuring, E; Malats, N; Heitzer, E; Vat, L; Kiernan, E; Chin, E; Barrett, C; Kapp, R; Thomas, M; Gerling, M; Reck, M; Löhr, M; Hofman, P; Hiltermann, N; Alix-Panabières, C; Smit, J; Bolisetty, M; Karasarides, M GUIDE.MRD: A Consortium guiding multi-modal therapies against minimal residual disease (MRD) by liquid biopsy to assess implementation of circulating tumor DNA (ctDNA) in clinical practice to improve patient outcomes
ANN ONCOL. 2023; 34: S276-S277.-Annual Meeting of the European-Society-for-Medical-Oncology (ESMO); OCT 20-24, 2023; Barcelona, SPAIN. Doi: 10.1016/j.annonc.2023.09.2960 [Poster]
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** Riedl, JM; Steinlechner, SM; Moik, F; Heitzer, E; Jahn, S; Hasenleithner, S; Doleschal, B; Weiss, L; Seeber, A; Rumpold, H; Winder, T; Greil, R; Jost, PJ; Hoefler, G; Speicher, M; Gerger, A SOUND: A phase II trial evaluating the efficacy of molecular profiling of circulating ± tumor tissue DNA for salvagetherapy matching in patients with advanced and refractory carcinoma
ANN ONCOL. 2023; 34: S1186-S1186.-Annual Meeting of the European-Society-for-Medical-Oncology (ESMO); OCT 20-24, 2023; Barcelona, SPAIN. Doi: 10.1016/j.annonc.2023.09.1349 [Poster]
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Biographical-Item

** Verheyen, S; Heitzer, E; Geigl, J Obituary Prof. Dr. med. Michael Speicher
MED GENET-BERLIN. 2023; 35(4): 297-298. Doi: 10.1515/medgen-2023-2063
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2022

Full paper/article (Journal)

** Donker, HC; Schuuring, E; Heitzer, E; Groen, HJM Decoding circulating tumor DNA to identify durable benefit from immunotherapy in lung cancer
LUNG CANCER. 2022; 170: 52-57. Doi: 10.1016/j.lungcan.2022.05.013
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** Galhuber, M; Michenthaler, H; Heininger, C; Reinisch, I; Nössing, C; Krstic, J; Kupper, N; Moyschewitz, E; Auer, M; Heitzer, E; Ulz, P; Birner-Gruenberger, R; Liesinger, L; Lenihan-Geels, GN; Oster, M; Spreitzer, E; Zenezini, Chiozzi, R; Schulz, TJ; Schupp, M; Madl, T; Heck, AJR; Prokesch, A Complementary omics strategies to dissect p53 signaling networks under nutrient stress.
Cell Mol Life Sci. 2022; 79(6):326 Doi: 10.1007/s00018-022-04345-8 [OPEN ACCESS]
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** Hallermayr, A; Wohlfrom, T; Steinke-Lange, V; Benet-Pages, A; Scharf, F; Heitzer, E; Mansmann, U; Haberl, C; de Wit, M; Vogelsang, H; Rentsch, M; Holinski-Feder, E; Pickl, JMA Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients
J HEMATOL ONCOL. 2022; 15(1): 125 Doi: 10.1186/s13045-022-01342-z [OPEN ACCESS]
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** Klec, C; Knutsen, E; Schwarzenbacher, D; Jonas, K; Pasculli, B; Heitzer, E; Rinner, B; Krajina, K; Prinz, F; Gottschalk, B; Ulz, P; Deutsch, A; Prokesch, A; Jahn, SW; Lellahi, SM; Perander, M; Barbano, R; Graier, WF; Parrella, P; Calin, GA; Pichler, M ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform.
Cell Mol Life Sci. 2022; 79(7): 391 Doi: 10.1007/s00018-022-04402-2 [OPEN ACCESS]
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** Palles, C; Martin, L; Domingo, E; Chegwidden, L; McGuire, J; Cuthill, V; Heitzer, E; Kerr, R; Kerr, D; Kearsey, S; Clark, SK; Tomlinson, I; Latchford, A, , CORGI, Consortium The clinical features of polymerase proof-reading associated polyposis (PPAP) and recommendations for patient management.
Fam Cancer. 2022; Doi: 10.1007/s10689-021-00256-y [OPEN ACCESS]
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** Seidel, MG; Kashofer, K; Moser, T; Thueringer, A; Liegl-Atzwanger, B; Leithner, A; Szkandera, J; Benesch, M; El-Heliebi, A; Heitzer, E Clinical implementation of plasma cell-free circulating tumor DNA quantification by digital droplet PCR for the monitoring of Ewing sarcoma in children and adolescents.
Front Pediatr. 2022; 10: 926405 Doi: 10.3389/fped.2022.926405 [OPEN ACCESS]
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** Sorger, H; Dey, S; Vieyra-Garcia, PA; Pölöske, D; Teufelberger, AR; de, Araujo, ED; Sedighi, A; Graf, R; Spiegl, B; Lazzeri, I; Braun, T; Garces, de, Los, Fayos, Alonso, I; Schlederer, M; Timelthaler, G; Kodajova, P; Pirker, C; Surbek, M; Machtinger, M; Graier, T; Perchthaler, I; Pan, Y; Fink-Puches, R; Cerroni, L; Ober, J; Otte, M; Albrecht, JD; Tin, G; Abdeldayem, A; Manaswiyoungkul, P; Olaoye, OO; Metzelder, ML; Orlova, A; Berger, W; Wobser, M; Nicolay, JP; André, F; Nguyen, VA; Neubauer, HA; Fleck, R; Merkel, O; Herling, M; Heitzer, E; Gunning, PT; Kenner, L; Moriggl, R; Wolf, P Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma.
EMBO Mol Med. 2022; 14(12):e15200 Doi: 10.15252/emmm.202115200 [OPEN ACCESS]
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** Suppan, C; Graf, R; Jahn, S; Zhou, Q; Klocker, EV; Bartsch, R; Terbuch, A; Kashofer, K; Regitnig, P; Lindenmann, J; Posch, F; Gerritsmann, H; Jost, PJ; Heitzer, E; Dandachi, N; Balic, M Sensitive and robust liquid biopsy-based detection of PIK3CA mutations in hormone-receptor-positive metastatic breast cancer patients.
Br J Cancer. 2022; 126(3):456-463 Doi: 10.1038/s41416-021-01601-9 [OPEN ACCESS]
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** Zhou, Q; Gampenrieder, SP; Frantal, S; Rinnerthaler, G; Singer, CF; Egle, D; Pfeiler, G; Bartsch, R; Wette, V; Pichler, A; Petru, E; Dubsky, PC; Bago-Horvath, Z; Fesl, C; Rudas, M; Ståhlberg, A; Graf, R; Weber, S; Dandachi, N; Filipits, M; Gnant, M; Balic, M; Heitzer, E Persistence of ctDNA in Patients with Breast Cancer During Neoadjuvant Treatment Is a Significant Predictor of Poor Tumor Response.
Clin Cancer Res. 2022; 28(4):697-707 Doi: 10.1158/1078-0432.CCR-21-3231 [OPEN ACCESS]
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Review

** Heitzer, E; van den Broek, D; Denis, MG; Hofman, P; Hubank, M; Mouliere, F; Paz-Ares, L; Schuuring, E; Sultmann, H; Vainer, G; Verstraaten, E; de Visser, L; Cortinovis, D Recommendations for a practical implementation of circulating tumor DNA mutation testing in metastatic non-small-cell lung cancer
ESMO OPEN. 2022; 7(2): 100399 Doi: 10.1016/j.esmoop.2022.100399 [OPEN ACCESS]
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Editorial

** Andersen, CL; Heitzer, E ctDNA-guided adjuvant chemotherapy for colorectal cancer-ready for prime time?
CANCER CELL. 2022; 40(9): 911-913. Doi: 10.1016/j.ccell.2022.08.017
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Abstract (Journal)

** Dey, S; Sorger, H; Vieyra-Garcia, P; Teufelberger, A; Herling, M; Heitzer, E; Gunning, PT; Kenner, L; Moriggl, R; Wolf, P STAT3/5 locus gain is a disease marker and therapeutic target in leukemic/ cutaneous T cell lymphoma
J INVEST DERMATOL. 2022; 142(12): S254-S254.
Web of Science

2021

Full paper/article (Journal)

** Angus, L; Deger, T; Jager, A; Martens, JWM; de, Weerd, V; van, Heuvel, I; van, den, Bent, MJ; Sillevis, Smitt, PAE; Kros, JM; Bindels, EMJ; Heitzer, E; Sleijfer, S; Jongen, JLM; Wilting, SM Detection of Aneuploidy in Cerebrospinal Fluid from Patients with Breast Cancer Can Improve Diagnosis of Leptomeningeal Metastases.
CLIN CANCER RES. 2021; 27(10): 2798-2806. Doi: 10.1158/1078-0432.CCR-20-3954
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** Buder, A; Heitzer, E; Waldispühl-Geigl, J; Weber, S; Moser, T; Hochmair, MJ; Hackner, K; Errhalt, P; Setinek, U; Filipits, M Somatic Copy-Number Alterations in Plasma Circulating Tumor DNA from Advanced EGFR-Mutated Lung Adenocarcinoma Patients.
BIOMOLECULES. 2021; 11(5): Doi: 10.3390/biom11050618 [OPEN ACCESS]
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** Dandachi, N; Posch, F; Graf, R; Suppan, C; Klocker, EV; Müller, HD; Lindenmann, J; Terbuch, A; Heitzer, E; Balic, M Longitudinal tumor fraction trajectories predict risk of progression in metastatic HR⁺ breast cancer patients undergoing CDK4/6 treatment.
Mol Oncol. 2021; 15(9):2390-2400 Doi: 10.1002/1878-0261.12870 [OPEN ACCESS]
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** Grill, M; Lazzeri, I; Kirsch, A; Steurer, N; Grossmann, T; Karbiener, M; Heitzer, E; Gugatschka, M Vocal Fold Fibroblasts in Reinke's Edema Show Alterations Involved in Extracellular Matrix Production, Cytokine Response and Cell Cycle Control.
Biomedicines. 2021; 9(7): Doi: 10.3390/biomedicines9070735 [OPEN ACCESS]
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** Lohberger, B; Scheipl, S; Heitzer, E; Quehenberger, F; de, Jong, D; Szuhai, K; Liegl-Atzwanger, B; Rinner, B Higher cMET dependence of sacral compared to clival chordoma cells: contributing to a better understanding of cMET in chordoma.
Sci Rep. 2021; 11(1): 12466 Doi: 10.1038/s41598-021-92018-0 [OPEN ACCESS]
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** Richter, G; Gui, T; Bourgeois, B; Koyani, CN; Ulz, P; Heitzer, E; von, Lewinski, D; Burgering, BMT; Malle, E; Madl, T β-catenin regulates FOXP2 transcriptional activity via multiple binding sites.
FEBS J. 2021; 288(10):3261-3284 Doi: 10.1111/febs.15656 [OPEN ACCESS]
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** Riedl, JM; Hasenleithner, SO; Pregartner, G; Scheipner, L; Posch, F; Groller, K; Kashofer, K; Jahn, SW; Bauernhofer, T; Pichler, M; Stöger, H; Berghold, A; Hoefler, G; Speicher, MR; Heitzer, E; Gerger, A Profiling of circulating tumor DNA and tumor tissue for treatment selection in patients with advanced and refractory carcinoma: a prospective, two-stage phase II Individualized Cancer Treatment trial.
Ther Adv Med Oncol. 2021; 13:1758835920987658 Doi: 10.1177/1758835920987658 [OPEN ACCESS]
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** Scheipl, S; Brcic, I; Moser, T; Fischerauer, S; Riedl, J; Bergovec, M; Smolle, M; Posch, F; Gerger, A; Pichler, M; Stoeger, H; Leithner, A; Heitzer, E; Liegl-Atzwanger, B; Szkandera, J Molecular profiling of soft-tissue sarcomas with FoundationOne^® Heme identifies potential targets for sarcoma therapy: a single-centre experience.
Ther Adv Med Oncol. 2021; 13:17588359211029125 Doi: 10.1177/17588359211029125 [OPEN ACCESS]
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** Schrom, S; Hebesberger, T; Wallner, SA; Anders, I; Richtig, E; Brandl, W; Hirschmugl, B; Garofalo, M; Bernecker, C; Schlenke, P; Kashofer, K; Wadsack, C; Aigelsreiter, A; Heitzer, E; Riedl, S; Zweytick, D; Kretschmer, N; Richtig, G; Rinner, B MUG Mel3 Cell Lines Reflect Heterogeneity in Melanoma and Represent a Robust Model for Melanoma in Pregnancy.
Int J Mol Sci. 2021; 22(21): Doi: 10.3390/ijms222111318 [OPEN ACCESS]
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** Soriano, I; Vazquez, E; De, Leon, N; Bertrand, S; Heitzer, E; Toumazou, S; Bo, Z; Palles, C; Pai, CC; Humphrey, TC; Tomlinson, I; Cotterill, S; Kearsey, SE Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
PLOS GENET. 2021; 17(7): e1009526 Doi: 10.1371/journal.pgen.1009526 [OPEN ACCESS]
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** Stitz, R; Buder, A; Silye, R; Baumgartner, B; Pühringer, F; Filipits, M; Oberndorfer, E; Heitzer, E Validation of a next-generation sequencing assay for the detection of EGFR mutations in cell-free circulating tumor DNA.
EXP MOL PATHOL. 2021; 123: 104685 Doi: 10.1016/j.yexmp.2021.104685
Web of Science PubMed FullText FullText_MUG

** Unseld, M; Belic, J; Pierer, K; Zhou, Q; Moser, T; Bauer, R; Piringer, G; Gerger, A; Siebenhüner, A; Speicher, M; Heitzer, E; Prager, GW A higher ctDNA fraction decreases survival in regorafenib-treated metastatic colorectal cancer patients. Results from the regorafenib's liquid biopsy translational biomarker phase II pilot study.
Int J Cancer. 2021; 148(6):1452-1461 Doi: 10.1002/ijc.33303 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Weber, S; van der Leest, P; Donker, HC; Schlange, T; Timens, W; Tamminga, M; Hasenleithner, SO; Graf, R; Moser, T; Spiegl, B; Yaspo, ML; Terstappen, LWMM; Sidorenkov, G; Hiltermann, TJN; Speicher, MR; Schuuring, E; Heitzer, E; Groen, HJM Dynamic Changes of Circulating Tumor DNA Predict Clinical Outcome in Patients With Advanced Non-Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors
JCO PRECIS ONCOL. 2021; 5: 1540-1553. Doi: 10.1200/PO.21.00182
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Dey, S; Sorger, H; Vieyra-Garcia, P; Araujo, ED; Graf, R; Spiegl, B; Schlederer, M; Graier, T; Perchthaler, I; Fink-Puches, R; Cerroni, L; Surbek, M; Pirker, C; Berger, W; Orlova, A; Herling, M; Merkel, O; Neubauer, HA; Gunning, PT; Heitzer, E; Kenner, L; Moriggl, R; Wolf, P STAT5 is a therapeutically targetable vulnerability in leukemic cutaneous T-cell lymphoma
EXP DERMATOL. 2021; 30(3):E100-E101. [Poster]
Web of Science

** Dey, S; Sorger, H; Vieyra-Garcia, PA; de Araujo, ED; Graf, R; Spiegl, B; Lazzeri, I; Herling, M; Neubauer, HA; Merkel, O; Heitzer, E; Gunning, PT; Kenner, L; Moriggl, R; Wolf, P Chromosome # 17q (17q11.2-17q21.31) gain is a disease marker and therapeutic vulnerability in Sezary Syndrome
EXP DERMATOL. 2021; 30: 14-14.-4th Inflammatory Skin Disease Summit; NOV 03-06, 2021; New York, NY. [Poster]
Web of Science

** Suppan, C; Zhou, Q; Jahn, S; Graf, R; Klocker, EV; Terbuch, A; Kashofer, K; Posch, F; Gerritsmann, H; Dandachi, N; Heitzer, E; Balic, M Comparison of liquid biopsy and tissue based detection of PIK3CAmutations in HR positive metastatic breast cancer patients
CANCER RES. 2021; 81(4): [Poster]
Web of Science

2020

Full paper/article (Journal)

** Bourrier, C; Pierga, JY; Xuereb, L; Salaun, H; Proudhon, C; Speicher, MR; Belic, J; Heitzer, E; Lockhart, BP; Guigal-Stephan, N Shallow Whole-Genome Sequencing from Plasma Identifies FGFR1 Amplified Breast Cancers and Predicts Overall Survival.
Cancers (Basel). 2020; 12(6): Doi: 10.3390/cancers12061481 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Daga, S; Rosenberger, A; Kashofer, K; Heitzer, E; Quehenberger, F; Halbwedl, I; Graf, R; Krisper, N; Prietl, B; Höfler, G; Reinisch, A; Zebisch, A; Sill, H; Wölfler, A Sensitive and broadly applicable residual disease detection in acute myeloid leukemia using flow cytometry-based leukemic cell enrichment followed by mutational profiling.
Am J Hematol. 2020; 95(10):1148-57 Doi: 10.1002/ajh.25918 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Dutta, S; Pregartner, G; Rücker, FG; Heitzer, E; Zebisch, A; Bullinger, L; Berghold, A; Döhner, K; Sill, H Functional Classification of TP53 Mutations in Acute Myeloid Leukemia.
Cancers (Basel). 2020; 12(3): Doi: 10.3390/cancers12030637 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Gerber, T; Taschner-Mandl, S; Saloberger-Sindhöringer, L; Popitsch, N; Heitzer, E; Witt, V; Geyeregger, R; Hutter, C; Schwentner, R; Ambros, IM; Ambros, PF Assessment of Pre-Analytical Sample Handling Conditions for Comprehensive Liquid Biopsy Analysis.
J Mol Diagn. 2020; 22(8):1070-1086 Doi: 10.1016/j.jmoldx.2020.05.006 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Hofmann, L; Sallinger, K; Haudum, C; Smolle, M; Heitzer, E; Moser, T; Novy, M; Gesson, K; Kroneis, T; Bauernhofer, T; El-Heliebi, A A Multi-Analyte Approach for Improved Sensitivity of Liquid Biopsies in Prostate Cancer.
Cancers (Basel). 2020; 12(8): Doi: 10.3390/cancers12082247 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Karastaneva, A; Nebral, K; Schlagenhauf, A; Baschin, M; Palankar, R; Juch, H; Heitzer, E; Speicher, MR; Höfler, G; Grigorow, I; Urban, C; Benesch, M; Greinacher, A; Haas, OA; Seidel, MG Novel phenotypes observed in patients with ETV6-linked leukaemia/familial thrombocytopenia syndrome and a biallelic ARID5B risk allele as leukaemogenic cofactor.
J Med Genet. 2020; 57(6):427-433 Doi: 10.1136/jmedgenet-2019-106339
Web of Science PubMed FullText FullText_MUG

** Lampignano, R; Neumann, MHD; Weber, S; Kloten, V; Herdean, A; Voss, T; Groelz, D; Babayan, A; Tibbesma, M; Schlumpberger, M; Chemi, F; Rothwell, DG; Wikman, H; Galizzi, J-P; Bergheim, IR; Russnes, H; Mussolin, B; Bonin, S; Voight, C; Musa, H; Pinzani, P; Lianidou, E; Brady, G; Speicher, MR; Pantel, K; Betsou, F, Schuuring, E; Kubista, M; Ammerlaan, W; Sprenger-Haussels, M; Schlange, T; Heitzer, E Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows
The Open Clinical Chemistry Journal. 2020; 66(1): 149-160. Doi: 10.1373/clinchem.2019.306837 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Moser, T; Waldispuehl-Geigl, J; Belic, J; Weber, S; Zhou, Q; Hasenleithner, SO; Graf, R; Terzic, JA; Posch, F; Sill, H; Lax, S; Kashofer, K; Hoefler, G; Schoellnast, H; Heitzer, E; Geigl, JB; Bauernhofer, T; Speicher, MR On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer.
NPJ Precis Oncol. 2020; 4(1):30 Doi: 10.1038/s41698-020-00134-3 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Perakis, SO; Weber, S; Zhou, Q; Graf, R; Hojas, S; Riedl, JM; Gerger, A; Dandachi, N; Balic, M; Hoefler, G; Schuuring, E; Groen, HJM; Geigl, JB; Heitzer, E; Speicher, MR Comparison of three commercial decision support platforms for matching of next-generation sequencing results with therapies in patients with cancer.
ESMO Open. 2020; 5(5):e000872 Doi: 10.1136/esmoopen-2020-000872 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Smith, CG; Moser, T; Mouliere, F; Field-Rayner, J; Eldridge, M; Riediger, AL; Chandrananda, D; Heider, K; Wan, JCM; Warren, AY; Morris, J; Hudecova, I; Cooper, WN; Mitchell, TJ; Gale, D; Ruiz-Valdepenas, A; Klatte, T; Ursprung, S; Sala, E; Riddick, ACP; Aho, TF; Armitage, JN; Perakis, S; Pichler, M; Seles, M; Wcislo, G; Welsh, SJ; Matakidou, A; Eisen, T; Massie, CE; Rosenfeld, N; Heitzer, E; Stewart, GD Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors.
Genome Med. 2020; 12(1): 23-23. Doi: 10.1186/s13073-020-00723-8 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Weber, S; Spiegl, B; Perakis, SO; Ulz, CM; Abuja, PM; Kashofer, K; Leest, PV; Azpurua, MA; Tamminga, M; Brudzewsky, D; Rothwell, DG; Mohan, S; Sartori, A; Lampignano, R; Konigshofer, Y; Sprenger-Haussels, M; Wikman, H; Bergheim, IR; Kloten, V; Schuuring, E; Speicher, MR; Heitzer, E Technical Evaluation of Commercial Mutation Analysis Platforms and Reference Materials for Liquid Biopsy Profiling.
Cancers (Basel). 2020; 12(6): 1588 Doi: 10.3390/cancers12061588 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Zhou, Q; Perakis, SO; Ulz, P; Mohan, S; Riedl, JM; Talakic, E; Lax, S; Tötsch, M; Hoefler, G; Bauernhofer, T; Pichler, M; Gerger, A; Geigl, JB; Heitzer, E; Speicher, MR Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer.
Genome Med. 2020; 12(1):20 Doi: 10.1186/s13073-020-0719-6 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Short report/Letter

** Pabst, G; Lind, K; Graf, R; Zebisch, A; Stölzel, F; Döhner, K; Heitzer, E; Reinisch, A; Sill, H TP53 mutated AML subclones exhibit engraftment in a humanized bone marrow ossicle mouse model.
Ann Hematol. 2020; 99(3):653-655 Doi: 10.1007/s00277-020-03920-y [OPEN ACCESS]
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Review

** Heitzer, E; Auinger, L; Speicher, MR Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living.
Trends Mol Med. 2020; 26(5):519-528 Doi: 10.1016/j.molmed.2020.01.012
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Editorial

** Chiu, RWK; Heitzer, E; Lo, YMD; Mouliere, F; Tsui, DWY Cell-Free DNA Fragmentomics: The New "Omics" on the Block.
CLIN CHEM. 2020; 66(12): 1480-1484. Doi: 10.1093/clinchem/hvaa258 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Heitzer, E POINT Circulating Tumor DNA for Modern Cancer Management.
CLIN CHEM. 2020; 66(1): 143-145. Doi: 10.1373/clinchem.2019.304774
Web of Science PubMed FullText FullText_MUG

Correction

** Ulz, P; Perakis, S; Zhou, Q; Moser, T; Belic, J; Lazzeri, I; Wölfler, A; Zebisch, A; Gerger, A; Pristauz, G; Petru, E; White, B; Roberts, CES; John, JS; Schimek, MG; Geigl, JB; Bauernhofer, T; Sill, H; Bock, C; Heitzer, E; Speicher, MR Publisher Correction: Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection.
Nat Commun. 2020; 11(1): 1965-1965. Doi: 10.1038/s41467-020-15799-4 [OPEN ACCESS]
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Abstract (Journal)

** Gerger, A; Riedl, JM; Perakis, S; Pregartner, G; Scheipner, L; Posch, F; Groller, K; Kashofer, K; Jahn, SW; Bauernhofer, T; Pichler, M; Stoger, H; Berghold, A; Hofler, G; Speicher, M; Heitzer, E Profiling of circulating tumour DNA for treatment selection in patients with advanced and refractory carcinoma: A prospective, two-stage phase II individualized cancer treatment trial.
ANN ONCOL. 2020; 31: S1095-S1096.-ESMO Virtual Congress; SEP 19-OCT 18, 2020; ELECTR NETWORK. Doi: 10.1016/j.annonc.2020.08.1331 [Onlinepräsentation] [OPEN ACCESS]
Web of Science FullText FullText_MUG

** Moser, T; Waldispuehl-Geigl, J; Belic, J; Perakis, S; Weber, S; Zhou, Q; Sill, H; Lax, S; Kashofer, K; Hoefler, G; Schoellnast, H; Bauernhofer, T; Heitzer, E; Geigl, JB; Speicher, MR Early circulating tumor DNA dynamics as a real-time predictor of FOLFOX efficacy in advanced colorectal cancer patients
CANCER RES. 2020; 80(16): Doi: 10.1158/1538-7445.AM2020-4295 [Poster]
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** Perakis, SO; Weber, S; Graf, R; Zhou, Q; Riedl, JM; Dandachi, N; Balic, M; Gerger, A; Schuuring, E; Groen, HJ; Geigl, JB; Speicher, MR; Heitzer, E Identification of actionable targets in advanced cancer patients from circulating tumor DNA using clinical decision support platforms
CANCER RES. 2020; 80(16):-AACR Annual Meeting; JUN 22-24, 2020; ELECTR NETWORK. Doi: 10.1158/1538-7445.AM2020-1315 [Poster]
Web of Science FullText FullText_MUG

** Riedl, J; Perakis, S; Pregartner, G; Scheipner, L; Posch, F; Groller, K; Kashofer, K; Jahn, SW; Bauernhofer, T; Pichler, M; Stoger, H; Berghold, A; Hofler, G; Speicher, M; Heitzer, E; Gerger, A Individualized cancer treatment based on molecular profiling of circulating tumor DNA in patients with advanced and refractory carcinoma: a prospective phase II trial.
ONCOL RES TREAT. 2020; 43(SUPPL 4):249-249.-DGHO Jahrestagung; 09.10. -11.10.2020; Basel (virtueller Kongress). [Oral Communication]
Web of Science

** Suppan, C; Zhou, Q; Graf, R; Klocker, V; Terbuch, A; Dandachi, N; Heitzer, E; Balic, M Liquid biopsy-based detection of PIK3Ca mutations in HR positive metastastic breast cancer patients.
ANN ONCOL. 2020; 31: S41-S41.-ESMO Breast Cancer Virtual Meeting; MAY 23-24, 2020; ELECTR NETWORK. Doi: 10.1016/j.annonc.2020.03.213 [Poster] [OPEN ACCESS]
Web of Science FullText FullText_MUG

2019

Full paper/article (Journal)

** de Wit, S; Rossi, E; Weber, S; Tamminga, M; Manicone, M; Swennenhuis, JF; Groothuis-Oudshoorn, CGM; Vidotto, R; Facchinetti, A; Zeune, LL; Schuuring, E; Zamarchi, R; Hiltermann, TJN; Speicher, MR; Heitzer, E; Terstappen, LWMM; Groen, HJM Single tube liquid biopsy for advanced non-small cell lung cancer.
Int J Cancer. 2019; 144(12): 3127-3137. Doi: 10.1002/ijc.32056 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Heitzer, E; Groenewoud, A; Meditz, K; Lohberger, B; Liegl-Atzwanger, B; Prokesch, A; Kashofer, K; Behrens, D; Haybaeck, J; Kolb-Lenz, D; Koefeler, H; Riedl, S; Schaider, H; Fischer, C; Snaar-Jagalska, BE; de'Jong, D; Szuhai, K; Zweytick, D; Rinner, B Human melanoma brain metastases cell line MUG-Mel1, isolated clones and their detailed characterization.
Sci Rep. 2019; 9(1):4096-4096 Doi: 10.1038/s41598-019-40570-1 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Kalmbach, A; Schröder, C; Klein-Hitpass, L; Nordström, K; Ulz, P; Heitzer, E; Speicher, MR; Rahmann, S; Wieczorek, D; Horsthemke, B; Bramswig, NC Genome-Wide Analysis of the Nucleosome Landscape in Individuals with Coffin-Siris Syndrome.
Cytogenet Genome Res. 2019; 159(1): 1-11. Doi: 10.1159/000503266 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Prochazka, KT; Pregartner, G; Rücker, FG; Heitzer, E; Pabst, G; Wölfler, A; Zebisch, A; Berghold, A; Döhner, K; Sill, H Clinical implications of subclonal TP53 mutations in acute myeloid leukemia.
Haematologica. 2019; 104(3):516-523 Doi: 10.3324/haematol.2018.205013 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Riethdorf, S; Hildebrandt, L; Heinzerling, L; Heitzer, E; Fischer, N; Bergmann, S; Mauermann, O; Waldispühl-Geigl, J; Coith, C; Schön, G; Peine, S; Schuler, G; Speicher, MR; Moll, I; Pantel, K Detection and Characterization of Circulating Tumor Cells in Patients with Merkel Cell Carcinoma.
CLIN CHEM. 2019; 65(3): 462-472. Doi: 10.1373/clinchem.2018.297028
Web of Science PubMed FullText FullText_MUG

** Schutgens, F; Rookmaaker, MB; Margaritis, T; Rios, A; Ammerlaan, C; Jansen, J; Gijzen, L; Vormann, M; Vonk, A; Viveen, M; Yengej, FY; Derakhshan, S; de Winter-de Groot, KM; Artegiani, B; van Boxtel, R; Cuppen, E; Hendrickx, APA; Van Den Heuvel-Eibrink, MM; Heitzer, E; Lanz, H; Beekman, J; Murk, JL; Masereeuw, R; Holstege, F; Drost, J; Verhaar, MC; Clevers, H Tubuloids derived from human adult kidney and urine for personalized disease modeling
NAT BIOTECHNOL. 2019; 37(3): 303-+. Doi: 10.1038/s41587-019-0048-8
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** Suppan, C; Brcic, I; Tiran, V; Mueller, HD; Posch, F; Auer, M; Ercan, E; Ulz, P; Cote, RJ; Datar, RH; Dandachi, N; Heitzer, E; Balic, M Untargeted Assessment of Tumor Fractions in Plasma for Monitoring and Prognostication from Metastatic Breast Cancer Patients Undergoing Systemic Treatment.
Cancers (Basel). 2019; 11(8): Doi: 10.3390/cancers11081171 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Ulz, P; Perakis, S; Zhou, Q; Moser, T; Belic, J; Lazzeri, I; Wölfler, A; Zebisch, A; Gerger, A; Pristauz, G; Petru, E; White, B; Roberts, CES; John, JS; Schimek, MG; Geigl, JB; Bauernhofer, T; Sill, H; Bock, C; Heitzer, E; Speicher, MR Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection.
Nat Commun. 2019; 10(1): 4666-4666. Doi: 10.1038/s41467-019-12714-4 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Short report/Letter

** Müller, M; Graf, R; Kashofer, K; Macher, S; Wölfler, A; Zebisch, A; Hrzenjak, A; Heitzer, E; Sill, H Detection of AML-specific TP53 mutations in bone marrow-derived mesenchymal stromal cells cultured under hypoxia conditions.
Ann Hematol. 2019; 98(8):2019-2020 Doi: 10.1007/s00277-019-03680-4 [OPEN ACCESS]
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Review

** Heitzer, E; Haque, IS; Roberts, CES; Speicher, MR Current and future perspectives of liquid biopsies in genomics-driven oncology.
NAT REV GENET. 2019; 20(2): 71-88. Doi: 10.1038/s41576-018-0071-5
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** Marcuello, M; Vymetalkova, V; Neves, RPL; Duran-Sanchon, S; Vedeld, HM; Tham, E; van Dalum, G; Flügen, G; Garcia-Barberan, V; Fijneman, RJ; Castells, A; Vodicka, P; Lind, GE; Stoecklein, NH; Heitzer, E; Gironella, M Circulating biomarkers for early detection and clinical management of colorectal cancer.
MOL ASPECTS MED. 2019; 69(9): 107-122. Doi: 10.1016/j.mam.2019.06.002 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Balic, M; Suppan, C; Brcic, I; Tiran, V; Mueller, DH; Posch, F; Ulz, P; Heitzer, E; Dandachi, N Untargeted assessment of tumour fractions in plasma for monitoring and prognostication from metastatic breast cancer patients undergoing systemic treatment
ANN ONCOL. 2019; 30: 110-+.-44th Congress of the European-Society-for-Medical-Oncology (ESMO); SEP 27-OCT 01, 2019; Barcelona, SPAIN. [Poster]
Web of Science

** Brudzewsky, D; Lampignano, R; Weber, S; Sartori, A; Mohan, S; Konigshofer, Y; Davis, L; Rothwell, D; Schuuring, E; Garlick, RK; Schlange, T; Heitzer, E Multicenter evaluation of circulating tumor DNA assays
CANCER RES. 2019; 79(13): Doi: 10.1158/1538-7445.AM2019-438 [Poster]
Web of Science FullText FullText_MUG

** Crnobrnja, B; Knez, J; Sobocan, M; Cas-Sikosek, N; Vogrin, V; Repnik, K; Heitzer, E; Potocnik, U; Takac, I FREE - CELL TUMOR DNA AS A BIOMARKER FOR EARLY BREAST CANCER
INT J GYNECOL CANCER. 2019; 29: A178-A178. Doi: 10.1136/ijgc-2019-ESGO.263 [Oral Communication]
Web of Science FullText FullText_MUG

** Dandachi, N; Suppan, C; Brcic, L; Tiran, V; Mueller, DH; Posch, F; Ulz, P; Heitzer, E; Balic, M Monitoring therapy response and assessing prognosis by untargeted FAST-SeqS of circulating tumor DNA in metastatic breast cancer patients
ONCOL RES TREAT. 2019; 42: 41-41. [Poster]
Web of Science

** Moser, T; Smith, CG; Seles, M; Wcislo, G; Eldridge, M; Perakis, S; Mouliere, F; Lazzeri, I; Heider, K; Warren, A; Rosenfeld, N; Stewart, GD; Heitzer, E Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors.
CANCER RES. 2019; 79(13):-AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology; MAR 29-APR 03, 2019; Atlanta, GA. Doi: 10.1158/1538-7445.AM2019-1367 [Poster]
Web of Science FullText FullText_MUG

** Pantel, K; Terstappen, LW; Manaresi, N; Groen, HJ; Schuuring, EM; Heitzer, E; Speicher, M; Naume, B; Kyte, JA; Schlange, T Standardization and clinical implementation of liquid biopsy assays - IMI's CANCER-ID
CANCER RES. 2019; 79(13):-Annual Meeting of the American-Association-for-Cancer-Research (AACR); MAR 29-APR 03, 2019; Atlanta, GA. Doi: 10.1158/1538-7445.SABCS18-3190 [Poster]
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** Perakis, SO; Ulz, P; Riedl, JM; Scheipner, L; Kashofer, K; Hoefler, G; Geigl, JB; Speicher, MR; Heitzer, E; Gerger, A Molecular-biological tumor profiling for drug treatment selection in patients with advanced and refractory carcinoma: A prospective, two-stage Phase II individualized cancer treatment study
CANCER RES. 2019; 79(13):-Annual Meeting of the American-Association-for-Cancer-Research (AACR); MAR 29-APR 03, 2019; Atlanta, GA. Doi: 10.1158/1538-7445.AM2019-CT130 [Poster]
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2018

Full paper/article (Journal)

** Belic, J; Graf, R; Bauernhofer, T; Cherkas, Y; Ulz, P; Waldispuehl-Geigl, J; Perakis, S; Gormley, M; Patel, J; Li, W; Geigl, JB; Smirnov, D; Heitzer, E; Gross, M; Speicher, MR Genomic alterations in plasma DNA from patients with metastasized prostate cancer receiving abiraterone or enzalutamide.
Int J Cancer. 2018; 143(5): 1236-1248. Doi: 10.1002/ijc.31397 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Gaksch, L; Kashofer, K; Heitzer, E; Quehenberger, F; Daga, S; Hofer, S; Halbwedl, I; Graf, R; Krisper, N; Hoefler, G; Zebisch, A; Sill, H; Wölfler, A Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia.
Am J Hematol. 2018; 93(1):23-30 Doi: 10.1002/ajh.24922 [OPEN ACCESS]
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** Hasenoehrl, C; Feuersinger, D; Sturm, EM; Bärnthaler, T; Heitzer, E; Graf, R; Grill, M; Pichler, M; Beck, S; Butcher, L; Thomas, D; Ferreirós, N; Schuligoi, R; Schweiger, C; Haybaeck, J; Schicho, R G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1.
Int J Cancer. 2018; 142(1):121-132 Doi: 10.1002/ijc.31030 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Kolb-Lenz, D; Fuchs, R; Lohberger, B; Heitzer, E; Meditz, K; Pernitsch, D; Pritz, E; Groselj-Strele, A; Leithner, A; Liegl-Atzwanger, B; Rinner, B Characterization of the endolysosomal system in human chordoma cell lines: is there a role of lysosomes in chemoresistance of this rare bone tumor?
Histochem Cell Biol. 2018; 150(1): 83-92. Doi: 10.1007/s00418-018-1673-x [OPEN ACCESS]
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Review

** Heitzer, E; Speicher, MR One size does not fit all: Size-based plasma DNA diagnostics.
SCI TRANSL MED. 2018; 10(466): eaav3873 Doi: 10.1126/scitranslmed.aav3873
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** Zhou, Q; Moser, T; Perakis, S; Heitzer, E Untargeted profiling of cell-free circulating DNA
TRANSL CANCER RES. 2018; 7: S140-S152. Doi: 10.21037/tcr.2017.10.11
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Editorial

** Heitzer, E; Speicher, MR Digital Circulating Tumor Cell Analyses for Prostate Cancer Precision Oncology.
Cancer Discov. 2018; 8(3): 269-271. Doi: 10.1158/2159-8290.CD-18-0075 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Belic, J; Graf, R; Bauernhofer, T; Cherkas, Y; Peter, U; Waldispuehl-Geigl, J; Perakis, S; Gormley, M; Patel, J; Li, WM; Geigl, JB; Smirnov, D; Heitzer, E; Gross, M; Speicher, MR Analysis of circulating tumor DNA reveals genomic alterations in metastatic prostate cancer patients treated with abiraterone acetate plus prednisone or enzalutamide
CANCER RES. 2018; 78(13):-Annual Meeting of the American-Association-for-Cancer-Research (AACR); APR 14-18, 2018; Chicago, IL. Doi: 10.1158/1538-7445.AM2018-2959 [Oral Communication]
Web of Science FullText FullText_MUG

** Pabst, G; Prochazka, K; Pregartner, G; Rücker, FG; Heitzer, E; Woelfler ,A; Zebisch, A; Berghold, A; Döhner, K; Sill H. Impact of TP53 mutated subclones in acute myeloid leukemia
Blood. 2018; 132(Suppl ):-Annual Meeting of the American Society of Hematology; December 1-4, 2018; San Diego. Doi: 10.1182/blood-2018-99-110667 [Poster]
Web of Science FullText FullText_MUG

** Suppan, C; Brcic, I; Heitzer, E; Tiran, V; Mueller, HD; Auer, M; Cote, RJ; Datar, R; Dandachi, N; Balic, M Prognostic impact of tumor fractions in plasma assessed with mFAST-SeqS on overall survival of metastatic breast cancer undergoing systemic treatment
EUR J CANCER. 2018; 92: S136-S136.-11th European Breast Cancer Conference (EBCC); MAR 21-23, 2018; Barcelona, SPAIN. [Poster]
Web of Science

** Tamminga, M; de Wit, S; Swennenhuis, JF; Heitzer, E; Speicher, M; Hiltermann, TJN; Schuuring, EM; Terstappen, LWM; Groen, HJ Circulating tumor cells measured in the pulmonary vein and radial artery during surgery of non-small cell lung cancer
CANCER RES. 2018; 78(13): Doi: 10.1158/1538-7445.AM2018-5594
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** Yang, J; Marass, F; Ulz, P; Shady, M; Cheng, ML; Kothari, P; Gedvilaite, E; Somnay, S; Shukla, N; Modak, S; Slotkin, EK; Rathkopf, DE; Gopaumar, I; Scher, HI; Razavi, P; Feldman, DR; Li, BT; Chapman, PB; Rosenberg, JE; Bajorin, DF; Scher, HI; Berger, MF; Seshan, VE; Socci, ND; Solit, DB; Heitzer, E; Tsui, DWY Estimation of tumor-derived mutant allele fractions in cfDNA by shallow whole genome sequencing and fragment size analysis
CANCER RES. 2018; 78(13): Doi: 10.1158/1538-7445.AM2018-LB-227
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2017

Full paper/article (Journal)

** Heitzer, E; Sunitsch, S; Gilg, MM; Lohberger, B; Rinner, B; Kashofer, K; Stündl, N; Ulz, P; Szkandera, J; Leithner, A; Liegl-Atzwanger, B Expanded molecular profiling of myxofibrosarcoma reveals potentially actionable targets.
Mod Pathol. 2017; 30(12):1698-1709 Doi: 10.1038/modpathol.2017.94 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Lal, R; Lind, K; Heitzer, E; Ulz, P; Aubell, K; Kashofer, K; Middeke, JM; Thiede, C; Schulz, E; Rosenberger, A; Hofer, S; Feilhauer, B; Rinner, B; Svendova, V; Schimek, MG; Rücker, FG; Hoefler, G; Döhner, K; Zebisch, A; Wölfler, A; Sill, H Somatic TP53 mutations characterize preleukemic stem cells in acute myeloid leukemia.
Blood. 2017; 129(18): 2587-2591. Doi: 10.1182/blood-2016-11-751008 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Perakis, S; Auer, M; Belic, J; Heitzer, E Advances in Circulating Tumor DNA Analysis.
Adv Clin Chem. 2017; 80(10):73-153 Doi: 10.1016/bs.acc.2016.11.005
Web of Science PubMed FullText FullText_MUG

** Rinner, B; Gandolfi, G; Meditz, K; Frisch, MT; Wagner, K; Ciarrocchi, A; Torricelli, F; Koivuniemi, R; Niklander, J; Liegl-Atzwanger, B; Lohberger, B; Heitzer, E; Ghaffari-Tabrizi-Wizsy, N; Zweytick, D; Zalaudek, I MUG-Mel2, a novel highly pigmented and well characterized NRAS mutated human melanoma cell line.
Sci Rep. 2017; 7(1):2098-2098 Doi: 10.1038/s41598-017-02197-y [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Stiegelbauer, V; Vychytilova-Faltejskova, P; Karbiener, M; Pehserl, AM; Reicher, A; Resel, M; Heitzer, E; Ivan, C; Bullock, M; Ling, H; Deutsch, A; Wulf-Goldenberg, A; Adiprasito, JB; Stoeger, H; Haybaeck, J; Svoboda, M; Stotz, M; Hoefler, G; Slaby, O; Calin, GA; Gerger, A; Pichler, M miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5.
Clin Cancer Res. 2017; 23(17):5255-5266 Doi: 10.1158/1078-0432.CCR-17-0023 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Tiran, V; Lindenmann, J; Brcic, L; Heitzer, E; Stanzer, S; Tabrizi-Wizsy, NG; Stacher, E; Stoeger, H; Popper, HH; Balic, M; Dandachi, N Primary patient-derived lung adenocarcinoma cell culture challenges the association of cancer stem cells with epithelial-to-mesenchymal transition.
Sci Rep. 2017; 7(1):10040-10040 Doi: 10.1038/s41598-017-09929-0 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Tiran, V; Stanzer, S; Heitzer, E; Meilinger, M; Rossmann, C; Lax, S; Tsybrovskyy, O; Dandachi, N; Balic, M Genetic profiling of putative breast cancer stem cells from malignant pleural effusions.
PLoS One. 2017; 12(4):e0175223-e0175223 Doi: 10.1371/journal.pone.0175223 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Short report/Letter

** Moser, T; Ulz, P; Zhou, Q; Perakis, S; Geigl, JB; Speicher, MR; Heitzer, E Single-Stranded DNA Library Preparation Does Not Preferentially Enrich Circulating Tumor DNA.
Clin Chem. 2017; 63(10):1656-1659 Doi: 10.1373/clinchem.2017.277988 [OPEN ACCESS]
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Review

** Heitzer, E; Perakis, S; Geigl, JB; Speicher, MR The potential of liquid biopsies for the early detection of cancer.
NPJ Precis Oncol. 2017; 1(1):36-36 Doi: 10.1038/s41698-017-0039-5 [OPEN ACCESS]
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** Ulz, P; Heitzer, E; Geigl, JB; Speicher, MR Patient monitoring through liquid biopsies using circulating tumor DNA.
Int J Cancer. 2017; 141(5):887-896 Doi: 10.1002/ijc.30759 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Case Report

** Smolle, MA; Heitzer, E; Geigl, JB; Al, Kaissi, A; Liegl-Atzwanger, B; Seidel, MG; Holzer, LA; Leithner, A A novel mutation in ATRX associated with intellectual disability, syndromic features, and osteosarcoma.
Pediatr Blood Cancer. 2017; 64(10): Doi: 10.1002/pbc.26522 (- Case Report)
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Gaksch, L; Kashofer, K; Heitzer, E; Daga, S; Hofer, S; Krisper, N; Hofler, G; Zebisch, A; Sill, H; Wolfler, A Persistence of non-DNMT3A mutations predicts relapse in cytogenetically normal AML
ONCOL RES TREAT. 2017; 40: 140-141. [Oral Communication]
Web of Science

** Graier, T; Auer, M; Heitzer, E; Ulz, P; Perakis, S; Speicher, MR; Geigl, JB Rapid single-cell copy-number aberration analysis using high- throughput sequencing.
EUR J CANCER. 2017; 72: S24-S24.-ECCO European Cancer Congress; JAN 27-30, 2017; Amsterdam, NETHERLANDS. Doi: 10.1016/S0959-8049(17)30159-4 [Poster]
Web of Science FullText FullText_MUG

** Heitzer, E Circulating tumor DNA as a liquid biopsy for cancer
MOL CYTOGENET. 2017; 10: -EUROPEAN CYTOGENETICS CONFERENCE; JUN 30 - JUL 3, 2017; Florence, ITALY. [Oral Communication]
Web of Science

** Suppan, C; Tiran, V; Heitzer, E; Auer, M; Cote, RJ; Datar, RH; Dandachi, N; Balic, M Serial blood draws in metastatic breast cancer patients undergoing systemic treatment analysed by size based CTC detection and mFAST Seq cell free DNA analysis
EUR J CANCER. 2017; 72: S39-S40. Doi: 10.1016/S0959-8049(17)30211-3 [Poster]
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2016

Full paper/article (Journal)

** Belic, J; Koch, M; Ulz, P; Auer, M; Gerhalter, T; Mohan, S; Fischereder, K; Petru, E; Bauernhofer, T; Geigl, JB; Speicher, MR; Heitzer, E mFast-SeqS as a Monitoring and Pre-screening Tool for Tumor-Specific Aneuploidy in Plasma DNA.
Adv Exp Med Biol. 2016; 924:147-155 Doi: 10.1007/978-3-319-42044-8_28
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** Gellner, V; Tomazic, PV; Lohberger, B; Meditz, K; Heitzer, E; Mokry, M; Koele, W; Leithner, A; Liegl-Atzwanger, B; Rinner, B Establishment of clival chordoma cell line MUG-CC1 and lymphoblastoid cells as a model for potential new treatment strategies.
Sci Rep. 2016; 6(7):24195-24195 Doi: 10.1038/srep24195 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Heitzer, E; Ulz, P; Geigl, JB Circulating tumor DNA as liquid biopsy for cancer
BIOCHIM CLIN. 2016; 40(3): 270-281. Doi: 10.19186/BC_2016.016
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** Liegl-Atzwanger, B; Heitzer, E; Flicker, K; Müller, S; Ulz, P; Saglam, O; Tavassoli, F; Devouassoux-Shisheboran, M; Geigl, J; Moinfar, F Exploring chromosomal abnormalities and genetic changes in uterine smooth muscle tumors.
Mod Pathol. 2016; 29(10):1262-1277 Doi: 10.1038/modpathol.2016.107 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Schäfer, C; Paprotka, T; Heitzer, E; Eccleston, M; Noe, J; Holdenrieder, S; Diehl, F; Thierry, A Academia Meets Industry.
Adv Exp Med Biol. 2016; 924(10):201-215 Doi: 10.1007/978-3-319-42044-8_36
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** Ulz, P; Belic, J; Graf, R; Auer, M; Lafer, I; Fischereder, K; Webersinke, G; Pummer, K; Augustin, H; Pichler, M; Hoefler, G; Bauernhofer, T; Geigl, JB; Heitzer, E; Speicher, MR Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.
Nat Commun. 2016; 7(15):12008-12008 Doi: 10.1038/ncomms12008 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Ulz, P; Gerger, A; Belic, J; Heitzer, E Potentials, challenges and limitations of a molecular characterization of circulating tumor DNA for the management of cancer patients
LABORATORIUMSMEDIZIN. 2016; 40(5): 323-334. Doi: 10.1515/labmed-2016-0049 [OPEN ACCESS]
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** Ulz, P; Thallinger, GG; Auer, M; Graf, R; Kashofer, K; Jahn, SW; Abete, L; Pristauz, G; Petru, E; Geigl, JB; Heitzer, E; Speicher, MR Inferring expressed genes by whole-genome sequencing of plasma DNA.
Nat Genet. 2016; 48(10):1273-1278 Doi: 10.1038/ng.3648
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Short report/Letter

** Gambichler, T; Skrygan, M; Reininghaus, L; Schulze, HJ; Schaller, J; Hessam, S; Colato, C; Girolomoni, G; Heitzer, E Lysyl oxidase-like 2 promoter hypermethylation in mid-dermal elastolysis.
Br J Dermatol. 2016; 175(6):1354-1356 Doi: 10.1111/bjd.14666
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** Ulz, P; Heitzer, E; Speicher, MR Co-occurrence of MYC amplification and TP53 mutations in human cancer.
Nat Genet. 2016; 48(2): 104-106. Doi: 10.1038/ng.3468
Web of Science PubMed FullText FullText_MUG

Review

** Heitzer, E; Ulz, P; Geigl, JB; Speicher, MR Non-invasive detection of genome-wide somatic copy number alterations by liquid biopsies.
Mol Oncol. 2016; 10(3):494-502 Doi: 10.1016/j.molonc.2015.12.004 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Ulz, P; Geigl, JB; Speicher, MR; Heitzer, E Latest technological developments in the analysis of circulating tumor DNA
MED GENET-BERLIN. 2016; 28(2): 234-244. Doi: 10.1007/s11825-016-0089-z [OPEN ACCESS]
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Abstract (Journal)

** Belic, J; Heitzer, E; Ulz, P; Auer, M; Fischereder, K; Bauernhofer, T; Geigl, JB; Speicher, MR Analysis of ctDNA using the mFastSeqS and plasma-Seq methods for screening and therapy monitoring in prostate cancer patients
CLIN CANCER RES. 2016; 22: -Meeting of the American-Association-for-Cancer-Research (AACR) Precision Medicine Series - Integrating Clinical Genomics and Cancer Therapy; JUN 13-16, 2015; Salt Lake, UT. Doi: 10.1158/1557-3265.PMSCLINGEN15-PR05 [Oral Communication]
Web of Science FullText FullText_MUG

** Gaksch, L; Kashofer, K; Heitzer, E; Daga, S; Hofer, S; Krisper, N; Höfler, G; Zebisch, A; Sill, H; Wölfler A Persitence of non-DNMT3A mutations predicts relapse in cytogenetically normal AML.
Oncol Res Treat 2016. 2016; 39(suppl3):140--Jahrestagung DGHO; OCT 14-18,2016; Leipzig. (ISBN: 2296-5270 ) [Oral Communication]
Web of Science

** Lieal-Atzwanger, B; Heitzer, E; Flicker, K; Muller, S; Ulz, P; Saglanm, O; Tavassoli, F; Devouassoux-Shisheboran, M; Cieigl, J; Moinfar, F Exploring chromosomal abnormalities and genetic changes in uterine smooth muscle tumours
VIRCHOWS ARCH. .. 2016; 469: S18-S19. [Poster]
Web of Science

2015

Full paper/article (Journal)

** Aoude, LG; Heitzer, E; Johansson, P; Gartside, M; Wadt, K; Pritchard, AL; Palmer, JM; Symmons, J; Gerdes, AM; Montgomery, GW; Martin, NG; Tomlinson, I; Kearsey, S; Hayward, NK POLE mutations in families predisposed to cutaneous melanoma.
Fam Cancer. 2015; 14(4):621-628 Doi: 10.1007/s10689-015-9826-8
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** Belic, J; Koch, M; Ulz, P; Auer, M; Gerhalter, T; Mohan, S; Fischereder, K; Petru, E; Bauernhofer, T; Geigl, JB; Speicher, MR; Heitzer, E Rapid Identification of Plasma DNA Samples with Increased ctDNA Levels by a Modified FAST-SeqS Approach.
Clin Chem. 2015; 61(6):838-849 Doi: 10.1373/clinchem.2014.234286 [OPEN ACCESS]
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Short report/Letter

** Schulz, E; Kashofer, K; Heitzer, E; Mhatre, KN; Speicher, MR; Hoefler, G; Sill, H Preexisting TP53 mutation in therapy-related acute myeloid leukemia.
Ann Hematol. 2015; 94(3):527-529 Doi: 10.1007/s00277-014-2191-0 (- Case Report) [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Review

** Heitzer, E; Ulz, P; Geigl, JB Circulating tumor DNA as a liquid biopsy for cancer.
Clin Chem. 2015; 61(1):112-123 Doi: 10.1373/clinchem.2014.222679 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Heitzer, E; Ulz, P; Auer, M; Belic, J; Sumitra, M; Lax, S; Hoefler, G; Augustin, H; Edgar, P; Bauernhofer, T; Geigl, J; Speicher, M Clinical utility of circulating tumor DNA in human cancers: A report of more than 300 plama-Seqs
EUR J CANCER. 2015; 51: S33-S33.-European Cancer Congress; Sep 25-29, 2015; Vienna, AUSTRIA. Doi: 10.1016/S0959-8049(16)30108-3 [Poster]
Web of Science FullText FullText_MUG

** Speicher, MR; Heitzer, E; Ulz, P; Geigl, JB; Monitoring tumor evolution by whole-genome plasma sequencing
CANCER RES. 2015; 75: -106th Annual Meeting of the American-Association-for-Cancer-Research (AACR); APR 18-22, 2015; Philadelphia, PA. Doi: 10.1158/1538-7445.AM2015-SY37-02 [Oral Communication]
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2014

Full paper/article (Journal)

** Heidary, M; Auer, M; Ulz, P; Heitzer, E; Petru, E; Gasch, C; Riethdorf, S; Mauermann, O; Lafer, I; Pristauz, G; Lax, S; Pantel, K; Geigl, JB; Speicher, MR The dynamic range of circulating tumor DNA in metastatic breast cancer.
Breast Cancer Res. 2014; 16(4):421-421 Doi: 10.1186/s13058-014-0421-y [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Heitzer, E; Artl, M; Filipits, M; Resel, M; Graf, R; Weißenbacher, B; Lax, S; Gnant, M; Wrba, F; Greil, R; Dietze, O; Hofbauer, F; Böhm, G; Höfler, G; Samonigg, H; Schaberl-Moser, R; Balic, M; Dandachi, N Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1.
Mod Pathol. 2014; 27(6):906-915 Doi: 10.1038/modpathol.2013.204 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Mohan, S; Heitzer, E; Ulz, P; Lafer, I; Lax, S; Auer, M; Pichler, M; Gerger, A; Eisner, F; Hoefler, G; Bauernhofer, T; Geigl, JB; Speicher, MR Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.
PLoS Genet. 2014; 10(3):e1004271-e1004271 Doi: 10.1371/journal.pgen.1004271 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Müller, C; Holtschmidt, J; Auer, M; Heitzer, E; Lamszus, K; Schulte, A; Matschke, J; Langer-Freitag, S; Gasch, C; Stoupiec, M; Mauermann, O; Peine, S; Glatzel, M; Speicher, MR; Geigl, JB; Westphal, M; Pantel, K; Riethdorf, S Hematogenous dissemination of glioblastoma multiforme.
Sci Transl Med. 2014; 6(247):247ra101-247ra101 Doi: 10.1126/scitranslmed.3009095 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Schulz, E; Klampfl, P; Holzapfel, S; Janecke, AR; Ulz, P; Renner, W; Kashofer, K; Nojima, S; Leitner, A; Zebisch, A; Wölfler, A; Hofer, S; Gerger, A; Lax, S; Beham-Schmid, C; Steinke, V; Heitzer, E; Geigl, JB; Windpassinger, C; Hoefler, G; Speicher, MR; Boland, CR; Kumanogoh, A; Sill, H Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.
Nat Commun. 2014; 5(10):5191-5191 Doi: 10.1038/ncomms6191 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Short report/Letter

** Stadelmeyer, E; Heitzer, E; Resel, M; Cerroni, L; Wolf, P; Dandachi, N The BRAF V600K mutation is more frequent than the BRAF V600E mutation in melanoma in situ of lentigo maligna type.
J Invest Dermatol. 2014; 134(2):548-550 Doi: 10.1038/jid.2013.338 [OPEN ACCESS]
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Review

** Heitzer, E; Tomlinson, I Replicative DNA polymerase mutations in cancer.
Curr Opin Genet Dev. 2014; 24(5):107-113 Doi: 10.1016/j.gde.2013.12.005 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Auer, M; Heitzer, E; Ulz, P; Pristauz, G; Petru, E; Jahn, S; Speicher, MR; Geigl, JB; Whole-genome sequencing of plasma DNA reveals frequently occurring copy number changes in patients with metastatic breast cancer.
EUR J CANCER. 2014; 50: S153-S153.-EACR; München. Doi: 10.1016/S0959-8049(14)50562-X [Oral Communication]
Web of Science FullText FullText_MUG

** Heitzer, E; Mohan, S; Ulz, P; Lafer, I; Auer, M; Lax, S; Hoefler, G; Bauernhofer, T; Geigl, JB; Speicher, MR; Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.
EUR J CANCER. 2014; 50: S96-S96.-EACR 2014; München. Doi: 10.1016/S0959-8049(14)50357-7 [Poster]
Web of Science FullText FullText_MUG

2013

Full paper/article (Journal)

** Balic, M; Schwarzenbacher, D; Stanzer, S; Heitzer, E; Auer, M; Geigl, JB; Cote, RJ; Datar, RH; Dandachi, N Genetic and epigenetic analysis of putative breast cancer stem cell models.
BMC Cancer. 2013; 13(7):358-358 Doi: 10.1186/1471-2407-13-358 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Brenne, E; Loge, JH; Kaasa, S; Heitzer, E; Knudsen, AK; Wasteson, E; European Palliative Care Research Collaborative (EPCRC) Depressed patients with incurable cancer: which depressive symptoms do they experience?
Palliat Support Care. 2013; 11(6):491-501 Doi: 10.1017/S1478951512000909
Web of Science PubMed FullText FullText_MUG

** Heitzer, E; Auer, M; Gasch, C; Pichler, M; Ulz, P; Hoffmann, EM; Lax, S; Waldispuehl-Geigl, J; Mauermann, O; Lackner, C; Höfler, G; Eisner, F; Sill, H; Samonigg, H; Pantel, K; Riethdorf, S; Bauernhofer, T; Geigl, JB; Speicher, MR Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.
Cancer Res. 2013; 73(10):2965-2975 Doi: 10.1158/0008-5472.CAN-12-4140 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Heitzer, E; Auer, M; Hoffmann, EM; Pichler, M; Gasch, C; Ulz, P; Lax, S; Waldispuehl-Geigl, J; Mauermann, O; Mohan, S; Pristauz, G; Lackner, C; Höfler, G; Eisner, F; Petru, E; Sill, H; Samonigg, H; Pantel, K; Riethdorf, S; Bauernhofer, T; Geigl, JB; Speicher, MR Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer.
Int J Cancer. 2013; 133(2):346-356 Doi: 10.1002/ijc.28030 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Heitzer, E; Lax, S; Lafer, I; Müller, SM; Pristauz, G; Ulz, P; Jahn, S; Högenauer, C; Petru, E; Speicher, MR; Geigl, JB Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma.
BMC Med Genet. 2013; 14(1):129-129 Doi: 10.1186/1471-2350-14-129 (- Case Report) [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

** Heitzer, E; Ulz, P; Belic, J; Gutschi, S; Quehenberger, F; Fischereder, K; Benezeder, T; Auer, M; Pischler, C; Mannweiler, S; Pichler, M; Eisner, F; Haeusler, M; Riethdorf, S; Pantel, K; Samonigg, H; Hoefler, G; Augustin, H; Geigl, JB; Speicher, MR Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing.
Genome Med. 2013; 5(4):30-30 Doi: 10.1186/gm434 [OPEN ACCESS]
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** Rayment, C; Hjermstad, MJ; Aass, N; Kaasa, S; Caraceni, A; Strasser, F; Heitzer, E; Fainsinger, R; Bennett, MI; European Palliative Care Research Collaborative (EPCRC) Neuropathic cancer pain: prevalence, severity, analgesics and impact from the European Palliative Care Research Collaborative-Computerised Symptom Assessment study.
Palliat Med. 2013; 27(8):714-721 Doi: 10.1177/0269216312464408
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Review

** Heitzer, E; Auer, M; Ulz, P; Geigl, JB; Speicher, MR Circulating tumor cells and DNA as liquid biopsies.
Genome Med. 2013; 5(8):73-73 Doi: 10.1186/gm477 [OPEN ACCESS]
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Editorial

** Auer, M; Heitzer, E; Ulz, P; Geigl, JB; Speicher, MR Single circulating tumor cell sequencing for monitoring.
Oncotarget. 2013; 4(6):812-813 Doi: 10.18632/oncotarget.1026 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Auer, M; Heitzer, E; Ulz, P; Pristauz, G; Petru, E; Jahn, S; Lafer, I; Pantel, K; Speicher, MR; Geigl, JB Complex tumor genomes inferred from plasma DNA of patients with metastatic breast cancer by whole-genome sequencing
EUR J CANCER. 2013; 49: S399-S399.-17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity; SEP 27-OCT 01, 2013; Amsterdam, NETHERLANDS. [Oral Communication]
Web of Science

** Heitzer, E; Ulz, P; Belic, J; Gutschi, S; Quehenberger, F; Auer, M; Augustin, H; Hoefler, G; Geigl, JB; Speicher, MR Tumor associated copy number changes identified by whole-genome sequencing in the circulation of patients with prostate cancer
EUR J CANCER. 2013; 49: S98-S98.-17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity; SEP 27-OCT 01, 2013; Amsterdam, NETHERLANDS. [Oral Communication]
Web of Science

2012

Full paper/article (Journal)

** Heitzer, E; Sandner-Kiesling, A; Schippinger, W; Stohscheer, I; Osprian, I; Bitsche, S; Eisner, F; Verebes, J; Hofmann, G; Samonigg, H IL-7, IL-18, MCP-1, MIP1-β, and OPG as biomarkers for pain treatment response in patients with cancer.
Pain Physician. 2012; 15(6):499-510 Doi: 10.36076/ppj.2012/15/499 [OPEN ACCESS]
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** Heitzer, E; Seidl, H; Bambach, I; Schmidbauer, U; Cerroni, L; Wolf, P Infrequent p53 gene mutation but UV gradient-like p53 protein positivity in keloids.
Exp Dermatol. 2012; 21(4):277-280 Doi: 10.1111/j.1600-0625.2012.01450.x
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** Hjermstad, MJ; Lie, HC; Caraceni, A; Currow, DC; Fainsinger, RL; Gundersen, OE; Haugen, DF; Heitzer, E; Radbruch, L; Stone, PC; Strasser, F; Kaasa, S; Loge, JH; European Palliative Care Research Collaborative (EPCRC) Computer-based symptom assessment is feasible in patients with advanced cancer: results from an international multicenter study, the EPCRC-CSA.
J Pain Symptom Manage. 2012; 44(5):639-654 Doi: 10.1016/j.jpainsymman.2011.10.025 [OPEN ACCESS]
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** Knudsen, AK; Aass, N; Heitzer, E; Klepstad, P; Hjermstad, MJ; Schippinger, W; Brenne, E; Kaasa, S; Wasteson, E; European Palliative Care Research Collaborative (EPCRC) Interviews with patients with advanced cancer--another step towards an international cancer pain classification system.
Support Care Cancer. 2012; 20(10):2491-2500 Doi: 10.1007/s00520-011-1361-z
Web of Science PubMed FullText FullText_MUG

Abstract (Journal)

** Heitzer, E; Marija, B; Resel, M; Graf, R; Weissenbacher, B; Schaberl-Moser, R; Dandachi, N; IDENTIFICATION OF PROGNOSTIC METHYLATION MARKERS IN PATIENTS WITH EARLY STAGE COLORECTAL CANCER.
ANN ONCOL. 2012; 23: 87-87.-14th World Congress on Gastrointestinal Cancer of the European-Society-for-Medical-Oncology (ESMO); JUN 27-30, 2012; Barcelona, SPAIN. [Poster]
Web of Science

2011

Full paper/article (Journal)

** Al Kaissi, A; M Roetzer, K; Ulz, P; Heitzer, E; Klaushofer, K; Grill, F Extra phenotypic features in a girl with Miller syndrome.
Clin Dysmorphol. 2011; 20(2): 66-72. Doi: 10.1097/MCD.0b013e3283416701
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** Al Kaissi, A; Roetzer, KM; Heitzer, E; Ben Chehida, F; Ben Ghachem, M; Klaushofer, K; Grill, F Facial dysmorphism associated with distinctive spine abnormalities in a girl and her mother: novel syndromic association
CLIN DYSMORPHOL. 2011; 20(4): 182-186. Doi: 10.1097/MCD.0b013e328349bc9b
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Short report/Letter

** Stadelmeyer, E; Heitzer, E; Wolf, P; Dandachi, N COLD-HRM PCR versus Conventional HRM PCR to Detect the BRAF V600E Mutation A Real Improvement?
J MOL DIAGN. 2011; 13(2): 243-243. Doi: 10.1016/j.jmoldx.2010.09.005 [OPEN ACCESS]
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2010

** Lassacher, A; Heitzer, E; Kerl, H; Wolf, P No major role for p53, RAS, BRAF, INK4a-ARF, and c-kit in merkel cell carcinomas
J INVEST DERMATOL. 126: 77-77. [Poster]
Web of Science

2005

Abstract (Journal)

** Heitzer, E; Lassacher, A; Kerl, H; Wolf, P The UV(B) fingerprint dominates the PTCH mutation spectrum of psoralen plus UVA-associated basal cell carcinomas
J INVEST DERMATOL 2005 125: A56-A56.
Web of Science

** Lassacher, A; Heitzer, E; Kerl, H; Wolf, P Activating c-Kit exon 11 mutation is absent in Merkel cell carcinoma
J INVEST DERMATOL 2005 125: A64-A64.
Web of Science

2004

Abstract (Journal)

** Wolf, P; Heitzer, E; Lassacher, A; Kreimer-Erlacher, H; Back, B; Cerroni, L; Kerl, H UVB fingerprint mutations at the INK4a-ARF locus in Merkel cell carcinoma
J INVEST DERMATOL 2004 123: 319-319.
Web of Science

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