Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Grabner Gernot |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2025

Originalarbeit (Zeitschrift)

** Dixon, ED; Claudel, T; Nardo, AD; Riva, A; Fuchs, CD; Mlitz, V; Busslinger, G; Scharnagl, H; Stojakovic, T; Senéca, J; Hinteregger, H; Grabner, GF; Kratky, D; Verkade, H; Zimmermann, R; Haemmerle, G; Trauner, M Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice.
J Hepatol. 2024; Doi: 10.1016/j.jhep.2024.09.037
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** Rauchenwald, T; Benedikt-Kühnast, P; Eder, S; Grabner, GF; Forstreiter, S; Lang, M; Sango, R; Eisenberg, T; Rattei, T; Haschemi, A; Wolinski, H; Schweiger, M Clearing the path for whole-mount labeling and quantification of neuron- and vessel-density in adipose tissue.
J Cell Sci. 2025; Doi: 10.1242/jcs.263438 [OPEN ACCESS]
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Kurzbericht/Letter

** Schwanbeck, J; Stahnke, M; Eberlein, A; Goeritzer, M; Schulze, A; Pernitsch, D; Kolb, D; Grabner, GF; Bartolomaeus, TU; Forslund, SK; Gerhardt, H; Schiattarella, GG; Cocera, Ortega, L; López-Anguita, N; Kershaw, EE; Maatz, H; Hübner, N; Zechner, R; Foryst-Ludwig, A; Kintscher, U Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction.
JCI Insight. 2025; 10(5): Doi: 10.1172/jci.insight.187145 [OPEN ACCESS]
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2024

Originalarbeit (Zeitschrift)

** Amor, M; Diaz, M; Bianco, V; Svecla, M; Schwarz, B; Rainer, S; Pirchheim, A; Schooltink, L; Mukherjee, S; Grabner, GF; Beretta, G; Lamina, C; Norata, GD; Hackl, H; Kratky, D Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model.
Cardiovasc Diabetol. 2024; 23(1): 298 Doi: 10.1186/s12933-024-02397-7 [OPEN ACCESS]
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** Breithofer, J; Bulfon, D; Fawzy, N; Tischitz, M; Zitta, C; Hartig, L; Grabner, GF; Pirchheim, A; Hackl, H; Taschler, U; Lass, A; Tam-Amersdorfer, C; Strobl, H; Kratky, D; Zimmermann, R Phospholipase A2 group IVD mediates the transacylation of glycerophospholipids and acylglycerols.
J Lipid Res. 2024; 65(12):100685 Doi: 10.1016/j.jlr.2024.100685 [OPEN ACCESS]
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** Bulfon, D; Breithofer, J; Grabner, GF; Fawzy, N; Pirchheim, A; Wolinski, H; Kolb, D; Hartig, L; Tischitz, M; Zitta, C; Bramerdorfer, G; Lass, A; Taschler, U; Kratky, D; Greimel, P; Zimmermann, R Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells.
Nat Commun. 2024; 15(1): 9937 Doi: 10.1038/s41467-024-54213-1 [OPEN ACCESS]
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** Kohlmayr, JM; Grabner, GF; Nusser, A; Höll, A; Manojlović, V; Halwachs, B; Masser, S; Jany-Luig, E; Engelke, H; Zimmermann, R; Stelzl, U Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis.
Nat Commun. 2024; 15(1):2516 Doi: 10.1038/s41467-024-46937-x [OPEN ACCESS]
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2023

Originalarbeit (Zeitschrift)

** Hofer, P; Grabner, GF; König, M; Xie, H; Bulfon, D; Ludwig, AE; Wolinski, H; Zimmermann, R; Zechner, R; Heier, C Cooperative lipolytic control of neuronal triacylglycerol by spastic paraplegia-associated enzyme DDHD2 and ATGL.
J Lipid Res. 2023; 64(11): 100457 Doi: 10.1016/j.jlr.2023.100457 [OPEN ACCESS]
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2022

Originalarbeit (Zeitschrift)

** Bradić, I; Kuentzel, KB; Honeder, S; Grabner, GF; Vujić, N; Zimmermann, R; Birner-Gruenberger, R; Kratky, D Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases.
Mol Metab. 2022; 61:101510 Doi: 10.1016/j.molmet.2022.101510 [OPEN ACCESS]
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** Grabner, GF; Guttenberger, N; Mayer, N; Migglautsch-Sulzer, AK; Lembacher-Fadum, C; Fawzy, N; Bulfon, D; Hofer, P; Züllig, T; Hartig, L; Kulminskaya, N; Chalhoub, G; Schratter, M; Radner, FPW; Preiss-Landl, K; Masser, S; Lass, A; Zechner, R; Gruber, K; Oberer, M; Breinbauer, R; Zimmermann, R Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes.
J Am Chem Soc. 2022; 144(14): 6237-6250. Doi: 10.1021/jacs.1c10836 [OPEN ACCESS]
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** Straat, ME; Jurado-Fasoli, L; Ying, Z; Nahon, KJ; Janssen, LGM; Boon, MR; Grabner, GF; Kooijman, S; Zimmermann, R; Giera, M; Rensen, PCN; Martinez-Tellez, B Cold exposure induces dynamic changes in circulating triacylglycerol species, which is dependent on intracellular lipolysis: A randomized cross-over trial.
EBioMedicine. 2022; 86: 104349 Doi: 10.1016/j.ebiom.2022.104349 [OPEN ACCESS]
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** Thiele, A; Luettges, K; Ritter, D; Beyhoff, N; Smeir, E; Grune, J; Steinhoff, JS; Schupp, M; Klopfleisch, R; Rothe, M; Wilck, N; Bartolomaeus, H; Migglautsch, AK; Breinbauer, R; Kershaw, EE; Grabner, GF; Zechner, R; Kintscher, U; Foryst-Ludwig, A Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage.
Cardiovasc Res. 2022; 118(11): 2488-2505. Doi: 10.1093/cvr/cvab182 [OPEN ACCESS]
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** Xie, H; Heier, C; Meng, X; Bakiri, L; Pototschnig, I; Tang, Z; Schauer, S; Baumgartner, VJ; Grabner, GF; Schabbauer, G; Wolinski, H; Robertson, GR; Hoefler, G; Zeng, W; Wagner, EF; Schweiger, M; Zechner, R An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia.
Proc Natl Acad Sci U S A. 2022; 119(9): Doi: 10.1073/pnas.2112840119 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Dixon, ED; Nardo, AD; Claudel, T; Fuchs, C; Mlitz, V; Stojakovic, T; Scharnagl, H; Grabner, G; Zimmermann, R; Trauner, M Chemical suppression of adipose triglyceride lipase improves non-alcoholic steatohepatitis in a diabetic and hyperlipidemic mouse model
J HEPATOL. 2022; 77: S688-S689. [Poster]
Web of Science

 

2021

Übersichtsarbeit

** Grabner, GF; Xie, H; Schweiger, M; Zechner, R Lipolysis: cellular mechanisms for lipid mobilization from fat stores.
Nat Metab. 2021; 3(11): 1445-1465. Doi: 10.1038/s42255-021-00493-6
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2020

Originalarbeit (Zeitschrift)

** Grabner, GF; Fawzy, N; Schreiber, R; Pusch, LM; Bulfon, D; Koefeler, H; Eichmann, TO; Lass, A; Schweiger, M; Marsche, G; Schoiswohl, G; Taschler, U; Zimmermann, R Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice.
J Lipid Res. 2020; 61(7):995-1003 Doi: 10.1194/jlr.RA119000516 [OPEN ACCESS]
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** Mayer, N; Schweiger, M; Fuchs, E; Migglautsch, AK; Doler, C; Grabner, GF; Romauch, M; Melcher, MC; Zechner, R; Zimmermann, R; Breinbauer, R Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL).
Bioorg Med Chem. 2020; 28(16): 115610 Doi: 10.1016/j.bmc.2020.115610
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2019

Originalarbeit (Zeitschrift)

** Grabner, GF; Fawzy, N; Pribasnig, MA; Trieb, M; Taschler, U; Holzer, M; Schweiger, M; Wolinski, H; Kolb, D; Horvath, A; Breinbauer, R; Rülicke, T; Rabl, R; Lass, A; Stadlbauer, V; Hutter-Paier, B; Stauber, RE; Fickert, P; Zechner, R; Marsche, G; Eichmann, TO; Zimmermann, R Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans.
J Lipid Res. 2019; 60(5):1020-1031 Doi: 10.1194/jlr.M093351 [OPEN ACCESS]
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** Ruiz-Calvo, A; Bajo-Grañeras, R; Maroto, IB; Zian, D; Grabner, GF; García-Taboada, E; Resel, E; Zechner, R; Zimmermann, R; Ortega-Gutiérrez, S; Galve-Roperh, I; Bellocchio, L; Guzmán, M Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons.
Neuropharmacology. 2019; 150: 134-144. Doi: 10.1016/j.neuropharm.2019.03.027
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** Tardelli, M; Bruschi, FV; Claudel, T; Fuchs, CD; Auer, N; Kunczer, V; Stojakovic, T; Scharnagl, H; Habib, A; Grabner, GF; Zimmermann, R; Lotersztajn, S; Trauner, M Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.
J Lipid Res. 2019; 60(7):1284-1292 Doi: 10.1194/jlr.M093369 [OPEN ACCESS]
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2018

Originalarbeit (Zeitschrift)

** Padmanabha, Das, KM; Wechselberger, L; Liziczai, M; De, la, Rosa, Rodriguez, M; Grabner, GF; Heier, C; Viertlmayr, R; Radler, C; Lichtenegger, J; Zimmermann, R; Borst, JW; Zechner, R; Kersten, S; Oberer, M Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase.
J Lipid Res. 2018; 59(3): 531-541. Doi: 10.1194/jlr.M082388 [OPEN ACCESS]
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2017

Originalarbeit (Zeitschrift)

** Gao, Y; Bielohuby, M; Fleming, T; Grabner, GF; Foppen, E; Bernhard, W; Guzmán-Ruiz, M; Layritz, C; Legutko, B; Zinser, E; García-Cáceres, C; Buijs, RM; Woods, SC; Kalsbeek, A; Seeley, RJ; Nawroth, PP; Bidlingmaier, M; Tschöp, MH; Yi, CX Dietary sugars, not lipids, drive hypothalamic inflammation.
Mol Metab. 2017; 6(8): 897-908. Doi: 10.1016/j.molmet.2017.06.008 [OPEN ACCESS]
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** Grond, S; Radner, FPW; Eichmann, TO; Kolb, D; Grabner, GF; Wolinski, H; Gruber, R; Hofer, P; Heier, C; Schauer, S; Rülicke, T; Hoefler, G; Schmuth, M; Elias, PM; Lass, A; Zechner, R; Haemmerle, G Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation.
J Invest Dermatol. 2017; 137(2):403-413 Doi: 10.1016/j.jid.2016.09.025 [OPEN ACCESS]
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** Schweiger, M; Romauch, M; Schreiber, R; Grabner, GF; Hütter, S; Kotzbeck, P; Benedikt, P; Eichmann, TO; Yamada, S; Knittelfelder, O; Diwoky, C; Doler, C; Mayer, N; De, Cecco, W; Breinbauer, R; Zimmermann, R; Zechner, R Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.
Nat Commun. 2017; 8:14859 Doi: 10.1038/ncomms14859 [OPEN ACCESS]
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Übersichtsarbeit

** Grabner, GF; Zimmermann, R; Schicho, R; Taschler, U Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling.
Pharmacol Ther. 2017; 175:35-46 Doi: 10.1016/j.pharmthera.2017.02.033 [OPEN ACCESS]
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2016

Originalarbeit (Zeitschrift)

** Grabner, GF; Eichmann, TO; Wagner, B; Gao, Y; Farzi, A; Taschler, U; Radner, FP; Schweiger, M; Lass, A; Holzer, P; Zinser, E; Tschöp, MH; Yi, CX; Zimmermann, R Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation.
J Biol Chem. 2016; 291(2):913-23 Doi: 10.1074/jbc.M115.683615 [OPEN ACCESS]
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2015

Originalarbeit (Zeitschrift)

** Jaeger, D; Schoiswohl, G; Hofer, P; Schreiber, R; Schweiger, M; Eichmann, TO; Pollak, NM; Poecher, N; Grabner, GF; Zierler, KA; Eder, S; Kolb, D; Radner, FP; Preiss-Landl, K; Lass, A; Zechner, R; Kershaw, EE; Haemmerle, G Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids.
J Hepatol. 2015; 63(2):437-45 Doi: 10.1016/j.jhep.2015.02.035 [OPEN ACCESS]
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** Pribasnig, MA; Mrak, I; Grabner, GF; Taschler, U; Knittelfelder, O; Scherz, B; Eichmann, TO; Heier, C; Grumet, L; Kowaliuk, J; Romauch, M; Holler, S; Anderl, F; Wolinski, H; Lass, A; Breinbauer, R; Marsche, G; Brown, JM; Zimmermann, R α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate.
J Biol Chem. 2015; 290(50):29869-81 Doi: 10.1074/jbc.M115.669168 [OPEN ACCESS]
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** Taschler, U; Eichmann, TO; Radner, FP; Grabner, GF; Wolinski, H; Storr, M; Lass, A; Schicho, R; Zimmermann, R Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity.
Br J Pharmacol. 2015; 172(17):4419-29 Doi: 10.1111/bph.13224 [OPEN ACCESS]
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** Taschler, U; Schreiber, R; Chitraju, C; Grabner, GF; Romauch, M; Wolinski, H; Haemmerle, G; Breinbauer, R; Zechner, R; Lass, A; Zimmermann, R Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells.
Biochim Biophys Acta. 2015; 1851(7):937-45 Doi: 10.1016/j.bbalip.2015.02.017 [OPEN ACCESS]
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2013

Originalarbeit (Zeitschrift)

** Mayer, N; Schweiger, M; Romauch, M; Grabner, GF; Eichmann, TO; Fuchs, E; Ivkovic, J; Heier, C; Mrak, I; Lass, A; Höfler, G; Fledelius, C; Zechner, R; Zimmermann, R; Breinbauer, R Development of small-molecule inhibitors targeting adipose triglyceride lipase.
Nat Chem Biol. 2013; 9(12):785-7 Doi: 10.1038/nchembio.1359 [OPEN ACCESS]
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** Pollak, NM; Schweiger, M; Jaeger, D; Kolb, D; Kumari, M; Schreiber, R; Kolleritsch, S; Markolin, P; Grabner, GF; Heier, C; Zierler, KA; Rülicke, T; Zimmermann, R; Lass, A; Zechner, R; Haemmerle, G Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier.
J Lipid Res. 2013; 54(4):1092-102 Doi: 10.1194/jlr.M034710 [OPEN ACCESS]
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