Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Runtsch Marah |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2025

Originalarbeit (Zeitschrift)

** Zotta, A; Toller-Kawahisa, J; Palsson-McDermott, EM; O'Carroll, SM; Henry, ÓC; Day, EA; McGettrick, AF; Ward, RW; Ryan, DG; Watson, MA; Brand, MD; Runtsch, MC; Maitz, K; Lueger, A; Kargl, J; Miljkovic, JL; Lavelle, EC; O'Neill, LAJ Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion.
Sci Adv. 2025; 11(4):eadq7307 Doi: 10.1126/sciadv.adq7307 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

2024

Abstract (Zeitschrift)

** Cosic-Mujkanovic, N; Valadez-Cosmes, P; Maitz, K; Lueger, A; Mihalic, ZN; Runtsch, MC; Kienzl, M; Heinemann, A; Schicho, R; Marsche, G; Kargl, J THE ROLE OF NEUTROPHIL-DERIVED MYELOPEROXIDASE (MPO) IN NON-SMALL CELL LUNG CANCER METASTASIS
FREE RADICAL BIO MED. 2024; 218: 7-7.-Annual Meeting of the Society-for-Free-Radical-Research-Europe (SFRR-E); JUN 05-07, 2024; Istanbul, TURKEY. Doi: 10.1016/j.freeradbiomed.2024.04.032 [Poster]
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** Lueger, A; Valadez-Cosmes, P; Maitz, K; Mujkanovic, NC; Kindler, O; Runtsch, M; Kargl, J Myeloperoxidase alters T cell function and plays an immunosuppressive role in non-small cell lung cancer
EUR J IMMUNOL. 2024; 54: 1593-1593.-7th European Conference of Immunology; SEP 01-04, 2024; Dublin, IRELAND. [Poster]
Web of Science

 

** Runtsch, M; Kindler, O; Eichmann, T; Santiso, A; Maitz, K; Brcic, L; Lindenmann, J; Kargl, J The tumor microenvironment drives mitochondrial metabolic reprogramming in neutrophils during non-small cell lung cancer
EUR J IMMUNOL. 2024; 54: 176-176.-7th European Conference of Immunology; SEP 01-04, 2024; Dublin, IRELAND. [Oral Communication]
Web of Science

 

** Zotta, A; O'Carroll, S; Palsson-McDermott, E; Toller-Kawahisa, J; Day, E; Ward, RW; Ryan, D; Runtsch, M; Maitz, K; Lueger, A; Kargl, J; Watson, M; Brand, M; Lavelle, E; O'Neill, L Mitochondrial respiratory complex III sustains IL-10 production in macrophages and promotes tumor-mediated immune evasion
EUR J IMMUNOL. 2024; 54: 181-181.-7th European Conference of Immunology; SEP 01-04, 2024; Dublin, IRELAND. [Oral Communication]
Web of Science

 

2023

Originalarbeit (Zeitschrift)

** Cosic-Mujkanovic, N; Valadez-Cosmes, P; Maitz, K; Lueger, A; Mihalic, ZN; Runtsch, MC; Kienzl, M; Davies, MJ; Chuang, CY; Heinemann, A; Schicho, R; Marsche, G; Kargl, J Myeloperoxidase Alters Lung Cancer Cell Function to Benefit Their Survival.
Antioxidants (Basel). 2023; 12(8): Doi: 10.3390/antiox12081587 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Abstract (Zeitschrift)

** Lueger, A; Valadez-Cosmes, P; Maitz, K; Cosic, N; Kindler, O; Runtsch, M; Kargl, J MYELOPEROXIDASE ALTERS T CELL FUNCTION AND PLAYS AN IMMUNOSUPPRESSIVE ROLE IN NON-SMALL CELL LUNG CANCER
FREE RADICAL BIO MED. 2023; 201: 50-50.-Annual Meeting of the Society for Free Radical Research Europe (SFRR E); JUN 06-09, 2023; Vienna, AUSTRIA. Doi: 10.1016/j.freeradbiomed.2023.03.203 [Poster]
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** Valadez-Cosmes, P; Maitz, K; Kindler, O; Mujkanovic, NC; Lueger, A; Runtsch, M; Kargl, J ABILITY OF NEUTROPHILS TO CONSTRAIN IMMUNE RESPONSES AND PROMOTE TUMOUR DEVELOPMENT
FREE RADICAL BIO MED. 2023; 201: 5-6. Doi: 10.1016/j.freeradbiomed.2023.03.047 [Poster]
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2022

Originalarbeit (Zeitschrift)

** Runtsch, MC; Angiari, S; Hooftman, A; Wadhwa, R; Zhang, Y; Zheng, Y; Spina, JS; Ruzek, MC; Argiriadi, MA; McGettrick, AF; Mendez, RS; Zotta, A; Peace, CG; Walsh, A; Chirillo, R; Hams, E; Fallon, PG; Jayamaran, R; Dua, K; Brown, AC; Kim, RY; Horvat, JC; Hansbro, PM; Wang, C; O'Neill, LAJ Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.
Cell Metab. 2022; 34(3): 487-501.e8. Doi: 10.1016/j.cmet.2022.02.002
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2021

Originalarbeit (Zeitschrift)

** Huffaker, TB; Ekiz, HA; Barba, C; Lee, SH; Runtsch, MC; Nelson, MC; Bauer, KM; Tang, WW; Mosbruger, TL; Cox, JE; Round, JL; Voth, WP; O'Connell, RM A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages.
Nat Commun. 2021; 12(1): 2620 Doi: 10.1038/s41467-021-22923-5 [OPEN ACCESS]
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Übersichtsarbeit

** Runtsch, MC; Ferrara, G; Angiari, S Metabolic determinants of leukocyte pathogenicity in neurological diseases.
J Neurochem. 2021; 158(1):36-58 Doi: 10.1111/jnc.15169
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2020

Originalarbeit (Zeitschrift)

** Angiari, S; Runtsch, MC; Sutton, CE; Palsson-McDermott, EM; Kelly, B; Rana, N; Kane, H; Papadopoulou, G; Pearce, EL; Mills, KHG; O'Neill, LAJ Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity.
Cell Metab. 2020; 31(2): 391-405. Doi: 10.1016/j.cmet.2019.10.015 [OPEN ACCESS]
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** Hooftman, A; Angiari, S; Hester, S; Corcoran, SE; Runtsch, MC; Ling, C; Ruzek, MC; Slivka, PF; McGettrick, AF; Banahan, K; Hughes, MM; Irvine, AD; Fischer, R; O'Neill, LAJ The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.
Cell Metab. 2020; 32(3): 468-478. Doi: 10.1016/j.cmet.2020.07.016 [OPEN ACCESS]
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Kommentar

** Runtsch, MC; O'Neill, LAJ Pseudomonas Persists by Feeding off Itaconate.
Cell Metab. 2020; 31(6): 1045-1047. Doi: 10.1016/j.cmet.2020.05.005
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2019

Originalarbeit (Zeitschrift)

** Hughes, MM; Hooftman, A; Angiari, S; Tummala, P; Zaslona, Z; Runtsch, MC; McGettrick, AF; Sutton, CE; Diskin, C; Rooke, M; Takahashi, S; Sundararaj, S; Casarotto, MG; Dahlstrom, JE; Palsson-McDermott, EM; Corr, SC; Mills, KHG; Preston, RJS; Neamati, N; Xie, Y; Baell, JB; Board, PG; O'Neill, LAJ Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
Cell Rep. 2019; 29(1): 151-161. Doi: 10.1016/j.celrep.2019.08.072 [OPEN ACCESS]
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** Runtsch, MC; Nelson, MC; Lee, SH; Voth, W; Alexander, M; Hu, R; Wallace, J; Petersen, C; Panic, V; Villanueva, CJ; Evason, KJ; Bauer, KM; Mosbruger, T; Boudina, S; Bronner, M; Round, JL; Drummond, MJ; O'Connell, RM Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.
PLoS Genet. 2019; 15(2):e1007970 Doi: 10.1371/journal.pgen.1007970 [OPEN ACCESS]
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2018

Originalarbeit (Zeitschrift)

** Mills, EL; Ryan, DG; Prag, HA; Dikovskaya, D; Menon, D; Zaslona, Z; Jedrychowski, MP; Costa, ASH; Higgins, M; Hams, E; Szpyt, J; Runtsch, MC; King, MS; McGouran, JF; Fischer, R; Kessler, BM; McGettrick, AF; Hughes, MM; Carroll, RG; Booty, LM; Knatko, EV; Meakin, PJ; Ashford, MLJ; Modis, LK; Brunori, G; Sévin, DC; Fallon, PG; Caldwell, ST; Kunji, ERS; Chouchani, ET; Frezza, C; Dinkova-Kostova, AT; Hartley, RC; Murphy, MP; O'Neill, LA Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Nature. 2018; 556(7699): 113-117. Doi: 10.1038/nature25986 [OPEN ACCESS]
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Kommentar

** Runtsch, MC; O'Neill, LA GOTcha: lncRNA-ACOD1 targets metabolism during viral infection.
Cell Res. 2018; 28(2): 137-138. Doi: 10.1038/cr.2017.153 [OPEN ACCESS]
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2017

Originalarbeit (Zeitschrift)

** Alexander, M; Ramstead, AG; Bauer, KM; Lee, SH; Runtsch, MC; Wallace, J; Huffaker, TB; Larsen, DK; Tolmachova, T; Seabra, MC; Round, JL; Ward, DM; O'Connell, RM Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli.
J Immunol. 2017; 199(10): 3559-3570. Doi: 10.4049/jimmunol.1700904 [OPEN ACCESS]
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** Huffaker, TB; Lee, SH; Tang, WW; Wallace, JA; Alexander, M; Runtsch, MC; Larsen, DK; Thompson, J; Ramstead, AG; Voth, WP; Hu, R; Round, JL; Williams, MA; O'Connell, RM Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade.
J Biol Chem. 2017; 292(45): 18530-18541. Doi: 10.1074/jbc.M117.808121 [OPEN ACCESS]
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** Wallace, JA; Kagele, DA; Eiring, AM; Kim, CN; Hu, R; Runtsch, MC; Alexander, M; Huffaker, TB; Lee, SH; Patel, AB; Mosbruger, TL; Voth, WP; Rao, DS; Miles, RR; Round, JL; Deininger, MW; O'Connell, RM miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response.
Blood. 2017; 129(23): 3074-3086. Doi: 10.1182/blood-2016-09-740209 [OPEN ACCESS]
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2015

Originalarbeit (Zeitschrift)

** Alexander, M; Hu, R; Runtsch, MC; Kagele, DA; Mosbruger, TL; Tolmachova, T; Seabra, MC; Round, JL; Ward, DM; O'Connell, RM Exosome-delivered microRNAs modulate the inflammatory response to endotoxin.
Nat Commun. 2015; 6: 7321 Doi: 10.1038/ncomms8321 [OPEN ACCESS]
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** Kwon, OS; Tanner, RE; Barrows, KM; Runtsch, M; Symons, JD; Jalili, T; Bikman, BT; McClain, DA; O'Connell, RM; Drummond, MJ MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.
Am J Physiol Endocrinol Metab. 2015; 309(1): E11-21. Doi: 10.1152/ajpendo.00124.2015 [OPEN ACCESS]
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** Runtsch, MC; Hu, R; Alexander, M; Wallace, J; Kagele, D; Petersen, C; Valentine, JF; Welker, NC; Bronner, MP; Chen, X; Smith, DP; Ajami, NJ; Petrosino, JF; Round, JL; O'Connell, RM MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis.
Oncotarget. 2015; 6(30): 28556-72. Doi: 10.18632/oncotarget.5597 [OPEN ACCESS]
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2014

Originalarbeit (Zeitschrift)

** Hu, R; Kagele, DA; Huffaker, TB; Runtsch, MC; Alexander, M; Liu, J; Bake, E; Su, W; Williams, MA; Rao, DS; Möller, T; Garden, GA; Round, JL; O'Connell, RM miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.
Immunity. 2014; 41(4): 605-19. Doi: 10.1016/j.immuni.2014.09.015 [OPEN ACCESS]
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Übersichtsarbeit

** Runtsch, MC; Round, JL; O'Connell, RM MicroRNAs and the regulation of intestinal homeostasis.
Front Genet. 2014; 5: 347 Doi: 10.3389/fgene.2014.00347 [OPEN ACCESS]
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2013

Originalarbeit (Zeitschrift)

** Hu, R; Huffaker, TB; Kagele, DA; Runtsch, MC; Bake, E; Chaudhuri, AA; Round, JL; O'Connell, RM MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression.
J Immunol. 2013; 190(12): 5972-80. Doi: 10.4049/jimmunol.1300351 [OPEN ACCESS]
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2012

Originalarbeit (Zeitschrift)

** Huffaker, TB; Hu, R; Runtsch, MC; Bake, E; Chen, X; Zhao, J; Round, JL; Baltimore, D; O'Connell, RM Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity.
Cell Rep. 2012; 2(6): 1697-709. Doi: 10.1016/j.celrep.2012.10.025 [OPEN ACCESS]
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