** = Publikationen gelistet in SCI/SSCI/Pubmed
** Rawal, S; Kolb, D; Pritisanac, I; Keller, TP; Desfosses, A; Madl, T; Alderson, TR
Molecular Mechanism of Caspase-9 CARD Oligomerization Using Cryo-em and NMR Spectroscopy
PROTEIN SCI. 2024; 33: 155-155.
Web of Science
** Alderson, TR; Pritišanac, I; Kolarić, Đ; Moses, AM; Forman-Kay, JD
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2.
Proc Natl Acad Sci U S A. 2023; 120(44): e2304302120
Doi: 10.1073/pnas.2304302120
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** Spreitzer, E; Alderson, TR; Bourgeois, B; Eggenreich, L; Habacher, H; Brahmersdorfer, G; Pritišanac, I; Sánchez-Murcia, PA; Madl, T
FOXO transcription factors differ in their dynamics and intra/intermolecular interactions.
Curr Res Struct Biol. 2022; 4:118-133
Doi: 10.1016/j.crstbi.2022.04.001
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** Alderson, TR; Adriaenssens, E; Asselbergh, B; Pritišanac, I; Van, Lent, J; Gastall, HY; Wälti, MA; Louis, JM; Timmerman, V; Baldwin, AJ; Lp, Benesch, J
A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins.
EMBO J. 2021; 40(8):e103811
Doi: 10.15252/embj.2019103811
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** Alderson, TR; Kay, LE
NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function.
Cell. 2021; 184(3): 577-595.
Doi: 10.1016/j.cell.2020.12.034
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** Alderson, TR; Ying, J; Bax, A; Benesch, JLP; Baldwin, AJ
Conditional Disorder in Small Heat-shock Proteins.
J Mol Biol. 2020; 432(9): 3033-3049.
Doi: 10.1016/j.jmb.2020.02.003
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** Ramanujam, V; Alderson, TR; Pritišanac, I; Ying, J; Bax, A
Protein structural changes characterized by high-pressure, pulsed field gradient diffusion NMR spectroscopy.
J Magn Reson. 2020; 312:106701
Doi: 10.1016/j.jmr.2020.106701
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** Alderson, TR; Kay, LE
Unveiling invisible protein states with NMR spectroscopy.
Curr Opin Struct Biol. 2020; 60: 39-49.
Doi: 10.1016/j.sbi.2019.10.008
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** Pritišanac, I; Alderson, TR; Güntert, P
Automated assignment of methyl NMR spectra from large proteins.
Prog Nucl Magn Reson Spectrosc. 2020; 118-119:54-73
Doi: 10.1016/j.pnmrs.2020.04.001
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** Alderson, TR; Roche, J; Gastall, HY; Dias, DM; Pritišanac, I; Ying, J; Bax, A; Benesch, JLP; Baldwin, AJ
Local unfolding of the HSP27 monomer regulates chaperone activity.
Nat Commun. 2019; 10(1):1068
Doi: 10.1038/s41467-019-08557-8
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** Collier, MP; Alderson, TR; de, Villiers, CP; Nicholls, D; Gastall, HY; Allison, TM; Degiacomi, MT; Jiang, H; Mlynek, G; Fürst, DO; van, der, Ven, PFM; Djinovic-Carugo, K; Baldwin, AJ; Watkins, H; Gehmlich, K; Benesch, JLP
HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C.
Sci Adv. 2019; 5(5): eaav8421
Doi: 10.1126/sciadv.aav8421
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** Pritišanac, I; Würz, JM; Alderson, TR; Güntert, P
Automatic structure-based NMR methyl resonance assignment in large proteins.
Nat Commun. 2019; 10(1):4922
Doi: 10.1038/s41467-019-12837-8
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** Alderson, TR; Lee, JH; Charlier, C; Ying, J; Bax, A
Propensity for cis-Proline Formation in Unfolded Proteins.
Chembiochem. 2018; 19(1): 37-42.
Doi: 10.1002/cbic.201700548
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** Charlier, C; Alderson, TR; Courtney, JM; Ying, J; Anfinrud, P; Bax, A
Study of protein folding under native conditions by rapidly switching the hydrostatic pressure inside an NMR sample cell.
Proc Natl Acad Sci U S A. 2018; 115(18): E4169-E4178.
Doi: 10.1073/pnas.1803642115
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** Charlier, C; Courtney, JM; Alderson, TR; Anfinrud, P; Bax, A
Monitoring 15N Chemical Shifts During Protein Folding by Pressure-Jump NMR.
J Am Chem Soc. 2018; 140(26): 8096-8099.
Doi: 10.1021/jacs.8b04833
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** Alderson, TR; Benesch, JLP; Baldwin, AJ
Proline isomerization in the C-terminal region of HSP27.
Cell Stress Chaperones. 2017; 22(4): 639-651.
Doi: 10.1007/s12192-017-0791-z
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** Alderson, TR; Charlier, C; Torchia, DA; Anfinrud, P; Bax, A
Monitoring Hydrogen Exchange During Protein Folding by Fast Pressure Jump NMR Spectroscopy.
J Am Chem Soc. 2017; 139(32): 11036-11039.
Doi: 10.1021/jacs.7b06676
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** Pritišanac, I; Degiacomi, MT; Alderson, TR; Carneiro, MG; Ab, E; Siegal, G; Baldwin, AJ
Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory.
J Am Chem Soc. 2017; 139(28):9523-9533
Doi: 10.1021/jacs.6b11358
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** Alderson, TR; Kim, JH; Markley, JL
Dynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes.
Structure. 2016; 24(7): 1014-30.
Doi: 10.1016/j.str.2016.05.011
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** Kim, JH; Bothe, JR; Alderson, TR; Markley, JL
Tangled web of interactions among proteins involved in iron-sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies.
Biochim Biophys Acta. 2015; 1853(6): 1416-28.
Doi: 10.1016/j.bbamcr.2014.11.020
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** Alderson, TR; Kim, JH; Cai, K; Frederick, RO; Tonelli, M; Markley, JL
The specialized Hsp70 (HscA) interdomain linker binds to its nucleotide-binding domain and stimulates ATP hydrolysis in both cis and trans configurations.
Biochemistry. 2014; 53(46): 7148-59.
Doi: 10.1021/bi5010552
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** Kim, JH; Alderson, TR; Frederick, RO; Markley, JL
Nucleotide-dependent interactions within a specialized Hsp70/Hsp40 complex involved in Fe-S cluster biogenesis.
J Am Chem Soc. 2014; 136(33): 11586-9.
Doi: 10.1021/ja5055252
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** Alderson, TR; Markley, JL
Biophysical characterization of α-synuclein and its controversial structure.
Intrinsically Disord Proteins. 2013; 1(1): 18-39.
Doi: 10.4161/idp.26255
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