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Fröhlich Leopold F. |

Presentations at scientific and public conferences

Lahiri, P; Smole, C; Kufferath, I; Schmidt, V; Ruelicke, T; Strnad, P; Froehlich, L; Zatloukal, K P62/SEQUESTOSOME-1 ACTS AS A GLUE IN THE MATURATION OF MALLORY–DENK BODIES
Journal of Hepatology. 2014; 60(1):S174--Abstracts of The International Liver Congress™ 2014 – 49th Annual meeting of the European Association for the Study of the Liver ; April 9-13, 2014; London, United Kingdom. [Poster]

Bettermann, K; Kuldeep Mehta, A; Lederer, E; Ernst, C; Kessler, SM; Kojima, K; Chen, X; Hoshida, Y; Bardeesy, N; Fuchs, B; Tanabe, KK; Müller, H; Svendova, V; Schimek, MG; Mach, M; Speicher, M; Divoky, C; Lipfert, A; Mahajan, V; Stumptner, C; Thüringer, A; Fröhlich, LF; Smole, C; Stojakovic, T; Scheideler, M; Nilsson, KPR; Kolbe, T; Rülicke, T; Longerich, T; Schirmacher, P; Magin, TM; Strnad, P; Fuchs, C; Trauner, M; Spilka, R; Kiemer, A; Teufel, A; Maass, T; Grabe, N; Müller, KM; Themanns, M; Moriggl, R; Campbell, J; Thorgeirsson, S; Pasparakis, M; Stauffer, J; Karin, M; Llovet, JM; Zatloukal, K; Denk, H; Lackner, C; Haybaeck, J Dysbalanced keratins drive steatohepatitis-associated liver carcinogenesis
8th European Conference of Intermediate filaments in health and disease. 2013; -8th European Conference of Intermediate filaments in health and disease; SEP 18-21, 2013; Amsterdam, Netherlands. [Poster]

Bettermann, K; Kuldeep Mehta, A; Lederer, EM; Ernst, C; Kessler, SM; Kojima, K; Cheng, X; Hoshida, Y; Bardessy, NM; Fuchs, BC; Tanabe, KK; Müller, HH; Svendova, V; Schimek, MG; Mach, M; Speicher, MR; Diwoky, C; Lipfert, A; Mahajan, V; Stumptner, C; Thüringer, A; Fröhlich, LF; Smole, C; Stojakovic, T; Scheideler, M; Nilsson, KPR; Kolbe, T; Rülicke, T; Longerich, T; Schirmacher, P; Magin, TM; Strnad, P; Fuchs, CD; Trauner, M; Spilka, R; Kiemer, AK; Teufel, A; Maass, T; Grabe, N; Müller, KM; Themanns, M; Moriggl, R; Campbell, JS; Thorgeirsson, S; Pasparakis, M; Stauffer, J; Karin, M; Llovet, JM; Zatloukal, K; Denk, H; Lackner, C; Haybaeck, J Dysbalanced Keratins promote Steatohepatitis-associated Liver Carcinogenesis
Der Pathologe, FP 08. 2013; 34(Issue6):591-591.-Joined Annual Meeting of the Swiss and Austrian Society for Pathology; NOV 7-9, 2013; Baden, Switzerland. [Oral Communication]

Fröhlich, LF; Mrakovcic, M; Smole, C; Chowdhury, P; Fröhlich, E; Zatloukal, K TP53 mutational status determines uterine tumor cell response towards histone deacetylase inhibitor induced apoptosis or autophagy
Gordon Research Conference on "Cell Death"; JULY 15-20, 2012; Barga, ITALY. 2012. [Poster]

Fröhlich LF, Mrakovcic M, Smole C, Chowdhury P, Fröhlich E, Zatloukal K TP53 mutational status determines uterine tumor cell response towards histone deacetylase inhibitor induced apoptosis or autophagy
4th Annual Meeting of the Austrian Association of Molecular Life Sciences and Biotechnology; SEP 17-19, 2012; Graz, AUSTRIA. 2012. [Oral Communication]

Fröhlich, LF; Mrakovcic, M; Smole, C; Lahiri, P; Fröhlich, E; Zatloukal, K P53 determines histone deacetylase inhibitor induced cytotoxic tumor cell response
ZMF Days 2012; NOV 8, 2012; Graz, Austria. 2012. [Oral Communication]

Fröhlich LF, Smole C, Moser M, Kashofer K, Osprian I, Zatloukal K Different susceptibility to Mallory-Denk body (MDB) formation in substrains of C57BL/6 mice
SYSGENET COST ACTION BM0901 Scientific Meeting; DEC 10-12; Bilbao, Spain. 2012. [Poster]

Lahiri, P; Smole, C; Fröhlich, LF, Zatloukal, K Functional Analysis of the Role of p62/Sequestosome-1 in Mallory-Denk Body Formation in mouse models of Non Alcoholic Steatohepatitis (NASH)
4th ÖGMBT Annual Meeting; SEP 17-19, 2012; Graz, AUSTRIA. 2012. [Oral Communication]

Lahiri, P; Smole, C; Fröhlich, LF, Zatloukal, K Functional Analysis of the Role of p62/Sequestosome-1 in Mallory-Denk Body (MDB) formation in mouse models of Non Alcoholic Steatohepatitis.
Liver Biology: Fundamental Mechanisms & Translational Applications; JUL 29-AUG 3, 2012; Snowmass Village, CO, USA. 2012. [Poster]

Lahiri, P; Smole, C; Fröhlich, LF; Zatloukal, K Functional Analysis of the Role of p62/Sequestosome-1 in Mallory-Denk Body (MDB) formation in mouse models of Non Alcoholic Steatohepatitis.
4th ÖGMBT Annual Meeting; SEP 17-19, 2012; Graz, Austria. 2012. [Poster]

Lahiri, P; Smole, C; Kufferath, I; Schmidt, V; Ruelicke, T; Froehlich, LF, Zatloukal, K p62/Sequestosome-1: A crucial player of Mallory-Denk body formation
2nd Scientific Retreat of the Doctoral College "Metabolic & Cardiovascular Disease"; OCT 25th-27th, 2012; Seggau Castle, Austria. 2012. [Poster]

Smole C, Moser M, Kashofer K, Osprian I, Fröhlich LF, Zatloukal K Different susceptibility to Mallory-Denk body (MDB) formation in substrains of C57BL/6 mice
4th Annual Meeting of the Austrian Association of Molecular Life Sciences and Biotechnology; SEP 17-19; Graz, Austria. 2012. [Poster]

Chowdhury, P; Smole, C; Schmidt, V; Rülicke, T; Fröhlich, LF; Zatloukal, K Functional analysis of the role of p62/Sqstm1 in Mallory-Denk Body (MDB) formation in Non Alcoholic Steatohepatitis
1st Scientific Retreat of the Doctoral College "Metabolic & Cardiovascular Disease"; OCT 20-22, 2011; Seggau Castle, Austria. 2011. [Oral Communication]

Chowdhury, P; Smole, C; Schmidt, V; Rülicke, T; Fröhlich, LF; Zatloukal, K; Functional analysis of the role of p62/Sqstm1 in Mallory-Denk Body (MDB) formation in Non Alcoholic Steatohepatitis.
1st Scientific Retreat of the Doctoral College "Metabolic & Cardiovascular Disease"; OCT 20-22, 2011; Seggau Castle, Austria . 2011. [Poster]

Chowdhury, P; Smole, C; Schmidt, V; Rülicke, T; Fröhlich, LF; Zatloukal, K; Functional analysis of the role of p62/Sqstm1 in Mallory-Denk Body (MDB) formation in Non Alcoholic Steatohepatitis.
Doctoral Day 2011; Nov 4, 2011; Graz, Austria. 2011. [Oral Communication]

Fröhlich LF Making transgenic mice
1st Technical workshop DK-MCD; NOV 23, 2011; Graz, Austria. 2011. [Oral Communication]

Fröhlich, LF Analysis of the role of p62/Sequestosome-1 (Sqstm-1) in liver disease, insulin signaling and carcinogenesis by conditional mouse mutagenesis.
Liver Retreat; February 1st, 2010; Hotel Mercure, Graz, Austria. 2010. [Oral Communication]

Fröhlich, LF Mallory-Denk-Body formation in C57BL/6 substrains
IMGUS 5th PCC Meeting; July 1st 2010; Max-Planck-Institute for Molecular Genetics, Berlin, Germany. 2010. [Oral Communication]

Kashofer, K; Ulbel, B; Siaulyte, G; Fröhlich, LF; Abuja; PM; Denk, H; Starmann, J; Sulten, M; Osprian, I; Deigner, HP; Sültmann, H; Lehrach, H; Zatloukal, K Idividual Risk Factors for Steatohepatitis-Identifying Sensitizer Genes Using Chromosome Substitution Strains in Combination with Dietary Models for Metabolic Disease
1st SYSGENET Meeting (European system Genetics Network for the study of Complex Genetic Human Diseases using Mouse Genetic Reference Populations); APR 7-9, 2010; Braunschweig, GERMANY. 2010. [Oral Communication]

Liu, L; Hiroko, H; Aydin, C; Erben, R; Weinstein, L; Marshansky, V; Fröhlich, LF; Bastepe, M Augmentation of cAMP Signaling in the Mouse Renal Proximal Tubule by Targeted in vivo Expression of the Extra-large Gsá Variant XLás
J Bone Miner Res 2010; 25(s1):1228--ASBMR 2010 Annual Meeting; OCT 15th-19th, 2010; Toronto, ON, Canada. [Oral Communication]
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Fröhlich, LF Identification of modifier genes for steatohepatitis by transgenic mouse analysis
IMGUS PCC Meeting; Jan 22nd, 2009; BioCrates, Innsbruck, Austria. 2009. [Oral Communication]

Fröhlich, LF Identification of Modifier Genes for Steatohepatitis by Transgenic Mouse Analysis
Retreat Day; April 6th 2009; Landhaus Feuerlöscher, Deutschfeistritz, Austria. 2009. [Oral Communication]

Fröhlich, LF Transgenic mouse screen for identifying susceptibility/modifier genes for Mallory-Denk-body formation
IMGUS 2nd PCC Meeting; July 6th, 2009; ZMF-Center for Medical Research, Graz, Austria . 2009. [Oral Communication]

Fröhlich, LF Epigenetic regulation of the Gnas locus.
Invited Seminar; March 31th, 2008; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna. 2008. [Oral Communication]

Fröhlich, LF Pseudohypoparathyroidism type lb and epigenetic regulation of the Gnas locus
ASBMR John Haddad Young Investigator Meeting 2008; 7th-12th, 2008; Snowmass, CO, USA. 2008. [Oral Communication]

Aydin, C; Fröhlich, LF; Ozturk, D; Bastepe, M Ability of XLas to Mimic Gsa in Mediating Parathyroid Hormone Signaling In Vivo.
JBMR 2007; 22(S1):S174--29th Annual Meeting of the American Society for Bone and Mineral Research ; September 16th-19th, 2007; Honolulu, HI, USA, September . [Poster]

Bastepe, M; Linglart, A; Fröhlich, LF; Jüppner, H Different Epigenetic Variants of Pseudohypo-parathyroidism Type-IB Are Associated with Distinct Mutations of GNAS
JBMR 2007; 20(S1):S10--27th Annual Meeting of the American Society for Bone and Mineral Research ; September 23th-27th, 2005; Nashville, TN, USA. [Oral Communication]

Kessenbrock, K; Fröhlich, L; Fässler, R; Sixt, M; Ollert, M; Jenne, DE Proteinase-3 and Neutophil Elastase enhance inflammation by inactivating anti-inflammatory progranulin
Book of Abstracts 2007; -5th Genaral Meeting of the International Proteolysis Society; October 20th to 24th, 2007; Patras, Greece. [Oral Communication]

Kessenbrock K, Fröhlich LF, Fässler R, Ollert M, and Jenne DE Proteinase-3 and Neutrophil Elastase as triggers of inflammation.
24th Winter School on Proteinases and Their Inhibitors; Febr. 28th-March 4th, 2007; Tiers, Italy. 2007. [Keynote lecture]

Fröhlich, LF Development of a mouse model of PHP-Ib: Analysis of the NESP55 imprinting control region.
Endocrine Colloquium; April 24th, 2006; Univ. of Vet. Med., Vienna, Austria. 2006. [Keynote lecture]

Fröhlich, LF; Bastepe, M; Abu-Zahra, HS; Erben, R; Jüppner, H A mouse model of pseudohypo-parathyroidism type-Ib: Deletion of the Nesp55 imprinting control region.
Bone 2006; 39(5):S14--International Conference on Progress in Bone and Mineral Research; November 16th-18th, 2006; Hofburg Vienna, Austria. [Oral Communication]

Fröhlich LF, Bastepe M, Abu-Zahra HS, Jüppner H The stx16-targeted mouse model of pseudohypoparathyroidism type-Ib provides evidence for a new intragenic transcript.
Calcif Tissue Int. 2006; 78(S1):S88--33th European Symposium on Calcified Tissues; May 10th-14th, 2006; Prague, Czech Republic. [Poster]

Erben, RG, Hesse, M, Fröhlich, LF, Lanske, B Ablation of Vitamin D Signaling Rescues Bone, Mineral, and Glucose Homeostasis in Fgf-23 Deficient Mice.
JBMR 2005; 21(S1):S51--28th Annual Meeting of the American Society for Bone and Mineral Research; September 15th-19th, 2005; Philadelphia, PA, USA. [Poster]

Fröhlich, LF Mouse models of PHP-Ib: The Stx16 & Nesp55 - imprinting control regions.
Endocrine Research Conference; June 3rd, 2005; Harvard Medical School, Boston, USA. 2005. [Oral Communication]

Bastepe, M; Fröhlich, LF; Linglart, A; Juppner, H Paternally imprinted autosomal dominant form of pseudohypoparathyroidism type 1b (AD-PHP-Ib) is associated with a heterozygous 3-kb deletion upstream of GNAS.
Pediatric Res. 2004; 55(4):160A--Pediatric Academic Society Annual Meeting; May1st-4th, 2004; San Francisco, CA, USA. [Oral Communication]

Fröhlich, LF A mouse model of PHP-Ib: Analysis of the STX16 imprinting control region.
Endocrine Research Conference; November 19th, 2004; Harvard Medical School. 2004. [Oral Communication]

Fröhlich, LF Analysis of Xlalphas transgenic mice.
Endocrine Research Conference; May 21st, 2004; Harvard Medical School, Boston, USA. 2004. [Oral Communication]

Fröhlich, LF; Chung, UI; Guo, J; Jüppner, H A Mouse Model of Jansen Metaphyseal Chondrodysplasia (JMC): Introduction of the H223R Mutation into the Murine PTH/PTHrP Receptor gene results in Delayed Endochondral Bone Formation.
JBMR 2004; 19(S1):S61--26th Annual Meeting of the American Society for Bone and Mineral Research; October 1st-5th, 2004; Seattle, WA, USA. [Oral Communication]

Bastepe, M; Fröhlich, LF; Jüppner, H Autosomal dominant pseudohypoparathyroidism type-Ib (AD-PHP-Ib) is associated with a heterozygous ~3-kb deletion which likely disrupts a putative long-range imprinting control element of GNAS1, the gene encoding Gs-alpha.
Bones & Teeth Gordon Research Conference; August 17th-22th, 2003; Kimball Union Academy, Meriden, NH, USA. 2003. [Oral Communication]

Bastepe, M; Fröhlich, LF; Jüppner, H The Paternally Imprinted Autosomal Dominant Form of Pseudohypoparathyroidism Type-Ib Is Associated With a 2998-bp Deletion Centromeric of GNAS1.
JBMR 2003; 18(s2):S34--25th Annual Meeting of the American Society for Bone and Mineral Research. ; September 19th-23th, 2003; Minneapolis, MN, USA. [Oral Communication]

Fröhlich, L Generation of a mouse model for Jansen´metaphyseal chondrodysplasia
Endocrine Research Conference; Harvard Medical School, Boston, USA; February 21st, 2003. 2003. [Oral Communication]

Fröhlich, LF Mouse Model for Jansen´s Disease & Polymorphisms in the human PTH1 Receptor.
Endocrine Research Conference; December 19th, 2003. ; Harvard Medical School, Boston, USA. 2003. [Oral Communication]

Fröhlich, LF; Gensure, RC; Jüppner, H; and Bastepe, M Linkage Disequilibrium Analysis of the PTH/PTHrP Receptor Gene across different Human Populations.
JBMR 2003; 18(supl):S209--25th Annual Meeting of the American Society for Bone and Mineral Research. ; September 19th-23th, 2003; Minneapolis, MN, USA. [Poster]

Pfister, H; Ollert, MW; Fröhlich, L; Quintanilla-Fend, L; Specks, U; Jenne, DE Anti-Neutrophil Cytoplasmic Autoantibodies (ANCA) against the Murine Homolog of Proteinase 3 are Pathogenic in vivo.
Kidney Blood Press. Res. 2003; 26(4):260--11th International Vasculitis and ANCA Workshop. ; October 2nd-5th, 2; Prague, Czech Republic. [Poster]

Fröhlich, L Patched 2 - a second regulator of Hedgehog signaling
Endocrine Research Conference ; March 22th, 2002; Harvard Medical School, Boston, USA. 2002. [Oral Communication]

Fröhlich, L Patched 2 a second regulator of hedgehog signaling.
International SymposiumRegulation of Cell and Tissue Functions by the Extracellular Matrix; December 21th-23th, 1998; Ringberg Castle/Tegernsee, Germany. 1998. [Oral Communication]

Fröhlich, L Patched 2 and skeletal development.
EMBO meeting on the Molecular Biology of Skeletal Development; November 25th-28th; Schloss Hohenkammer, Bavaria, Germany. 1998. [Oral Communication]

Fröhlich, L Gene targeting of the serine proteases proteinase-3 and elastase-2 in neutrophile granulocytes.
Invited Seminar; March 23rd; Molecular Endocrinology group, MPI for Biochemistry. 1998. [Oral Communication]

Fröhlich, L Animal models for the study of vasculitis
Retreat Max-Planck-Institute for Neurobiology; January 15th-17th; Ringberg Castle/Tegernsee. 1997. [Oral Communication]

Fröhlich, L Gene structure, recombinant expression and functional properties of murine proteinase 3.
Fifth International symposium on "Proteinase Inhibitors and Biological Control; October 4th-8th; Brdo by Ljubljana, Slovenia. 1997. [Oral Communication]

Fröhlich L, Hummel AM, Specks U, Jenne DE Proteinase-3 specific autoantibodies from patients with Wegener's granulomatosis do not recognize recombinant murine proteinase 3 and are inappropriate triggers of vasculitis in mice.
Immunobiol. 197 1997; 197(2-4):236--Annual Meeting of the German Society for Immunology; September 24th-27th; Würzburg, Germany. [Poster]

Fröhlich, L Establishment of a cell line expressing a mutant murine tenascin.
Int. Meeting Max-Planck-Society1994; -International Symposium "Molecular Mechanisms of Extracellular Matrix Development; April 10th-13th; Ringberg Castle/Tegernsee, Germany . [Oral Communication]

Fröhlich, L; Fässler R Establishment of a cell line expressing a mutant murine tenascin.
International Symposium "Molecular Mechanisms of Extracellular Matrix Development; April 10th-13th, 1994; Ringberg Castle/Tegernsee, Germany . 1994. [Poster]

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