| 2011 -2013
|
Sciex postdoctoral fellow, University of Zürich, Switzerland
Supervisor: Prof. John A. Robinson
Synthesis and characterization of -hairpin shaped cyclic peptidomimetics with antibacterial activities against Gram-negative bacteria.
Application of in vivo and in vitro photoaffinity labeling to examine the mode of action of antimicrobial peptidomimetics.
Study the binding interaction between antimicrobial peptidomimetics and their identified target proteins using Surface Plasmon Resonance and Isothermal Titration Calorimetry.
Expression and isolation of membrane proteins for structural determination by X-ray Crystallography and Nuclear Magnetic Resonance techniques.
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| 2010
|
Ph.D. in Organic Chemistry, Eötvös Loránd University, Budapest, Hungary.
Dissertation: DEVELOPMENT OF MICROWAVE-ASSISTED SYNTHESIS METHODS FOR
PREPARATION OF PEPTIDES
Supervisors: Prof. Gábor Dibó, Prof. Gábor Mezõ
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| 2009 -2011
|
Research fellow, Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Budapest, Hungary
Supervisor: Prof. Szilvia Bõsze
Design and synthesis of peptide conjugates containing new, in silico identified
antitubercular drug candidates in order to enhance their cellular uptake.
Characterization of the inhibitory effect of compounds in vitro on Mycobacterium
tuberculosis strains and their in vitro cytotoxicity and cytostatic effect on different cell lines.
Characterization of compounds in vivo toxicology effect and their antitubercular activity in infected guinea pigs.
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| 2006 -2008
|
Research fellow, Christian Doppler Laboratory for Microwave Chemistry, Institute of Organic and Bioorganic Chemistry, Karl-Franzens University, Graz, Austria
Supervisor: Prof. C. Oliver Kappe
Development of general synthetic methods for the synthesis of difficult peptide
sequences applying controlled microwave heating.
Examination the effect of high temperature on amino acid racemization and
optimization reaction conditions for the coupling of sensitive amino acid.
Study non-thermal microwave effect during sold phase peptide synthesis with strictly controlled comparative experiments performed under microwave and conventional heating.
|
| 2004
|
M.Sc. in Chemistry, Eötvös Loránd University, Budapest, Hungary.
Dissertation: APPLICATION OF FLUORESCENT LABELING IN COMBINATORIAL CHEMSITRY
Supervisor: Prof. Gábor Dibó
|
| 2011
|
Publication award of the Kisfaludy Lajos Foundation
Bacsa B, Bősze Sz, Kappe CO. Direct solid-phase synthesis of the -amyloid (142) peptide
using controlled microwave heating. J. Org. Chem. 2010, 75, 21032106.
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| 2006
|
Poster prize
Advances in Microwave-Assisted Organic Synthesis
International Conference on Microwave-Assisted Organic Syntheses, Budapest, Hungary
Poster entitled: Rapid solid-phase synthesis of a Calmodulin-binding nonapeptide using
thermal and controlled microwave irradiation.
|
| 2004
|
Poster Prize: 41th Japanese Peptide Symposium 2004
in conjuction with1st Asian Pacific International, Fukuoka, Japan
Poster entitled: Mass spectrometric monitoring of binding assay.
|
Bernadett Bacsa, PhD.