Division of Molecular Biology and Biochemistry
Research fields, Methods and Equipment
Research Fields
- Adipocytes and obesity
- Ageing and age-related diseases
- Blood-brain barrier
- Cellular lipid homeostasis
- Cellular senescence
- Clinical Chemisry
- Endothelial function and vessel wall function
- Genetic epidemiology and molecular mechanisms of human aging
- Inflammation
- Insulin/growth factor signalling
- Lipid mediators in the signalling network and in gene expression
- Lipid-and lipoprotein metabolism
- Lipidomics
- Lipotoxicity
- Metabolomics
- Metaboslism
- Modified lipoproteins
- Molecular modelling
- Molecular pharmacology
- Mytochondrial dysfunction
- Nuclear import
- Nuclear Magnetic Resonance Spectoscopy
- Pathomechanisms and prevention of atherosclerosis
- Rational drug design
- Redox signalling
- Regulation of cellular Ion equilibrium
- RNA-binding proteins
- SAXS
- Signalling
- Statistical Genetics
- The role of Ca++ in cell function
- type 2 diabetes mellitus
- Wnt signaling
Methods
- Animal experiments
- Biophysical interaction studies
- Cell culture
- Chromatography
- DNA cloning
- Electrophoresis
- Encyme activities
- Gene expression
- High throughput DNA/RNA Analysis
- In vitro and in vivo gene transfer
- Metabolomics
- Micro arrays
- Microscopy: Confocal laser scanning microscopy, Deconvolution microscopy
- Molecular modelling
- Next generation sequencing
- NMR spektroscopy
- Northern Blot analysis
- PCR, RT-PCR
- Production of antibodies
- Programming
- Protein expression and purification
- Protein labelling
- Proteomics
- real time PCR
- siRNA
- Small-angle scattering
- Southern Blot
- Transfection of mammalian cells
- Western Blot
- wire myography
Equipment
blood pressure gauge - mouse,rat
confocal array scanning microscope
Gaschromatograph
GC-MS
Gel documentation system
HPLC
In-house SAXS machine (Anton Paar SAXSpace) equipped with a temperature-controlled autosampler (up to 2 x 96 samples), various sample holders, and detectors
Patch Clamp Technic (also applicable for all microscopes)
Pipetting robot (AndrewAlliance 1000P)
Pipetting roboter (Janus, PE)
Protein expression and purification platform, including FPLC (GE Healthcare Acta Pure)
Real Time PCR (ABI 7900)
ultra centrifuges
wire myography system
600 MHz NMR spetrometer (Bruker Biospin) equipped with BBI/TXI probeheads and a temperature-controlled autosampler (up to 500 samples)
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